JP2017522383A5 - - Google Patents

Info

Publication number

JP2017522383A5

JP2017522383A5 JP2017523185A JP2017523185A JP2017522383A5 JP 2017522383 A5 JP2017522383 A5 JP 2017522383A5 JP 2017523185 A JP2017523185 A JP 2017523185A JP 2017523185 A JP2017523185 A JP 2017523185A JP 2017522383 A5 JP2017522383 A5 JP 2017522383A5

Authority

JP

Japan

Prior art keywords

compound

pharmaceutical composition

alkyl

disease

compound according

Prior art date

2015-07-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 19
• 239000008194 pharmaceutical composition Substances 0.000 claims 17
• 125000000217 alkyl group Chemical group 0.000 claims 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 5
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 3
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
• 125000003710 aryl alkyl group Chemical group 0.000 claims 3
• 125000003118 aryl group Chemical group 0.000 claims 3
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 3
• 125000001072 heteroaryl group Chemical group 0.000 claims 3
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
• 125000002947 alkylene group Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
• 238000007913 intrathecal administration Methods 0.000 claims 2
• 239000002184 metal Substances 0.000 claims 2
• -1 methyl - oxy - methyl Chemical group 0.000 claims 2
• 239000000651 prodrug Substances 0.000 claims 2
• 229940002612 prodrug Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
• 208000010444 Acidosis Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000019693 Lung disease Diseases 0.000 claims 1
• 206010028289 Muscle atrophy Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000030852 Parasitic disease Diseases 0.000 claims 1
• 206010040070 Septic Shock Diseases 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 230000007950 acidosis Effects 0.000 claims 1
• 208000026545 acidosis disease Diseases 0.000 claims 1
• 125000003342 alkenyl group Chemical group 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 230000030741 antigen processing and presentation Effects 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 230000008468 bone growth Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000004452 carbocyclyl group Chemical group 0.000 claims 1
• 230000003197 catalytic effect Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000003176 fibrotic effect Effects 0.000 claims 1
• 208000037824 growth disorder Diseases 0.000 claims 1
• 230000003779 hair growth Effects 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 238000001361 intraarterial administration Methods 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 208000002780 macular degeneration Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 201000000585 muscular atrophy Diseases 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 231100000189 neurotoxic Toxicity 0.000 claims 1
• 230000002887 neurotoxic effect Effects 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 230000036303 septic shock Effects 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 230000006648 viral gene expression Effects 0.000 claims 1