ES2704056T3 - Compuestos de epoxicetona para la inhibición de enzimas - Google Patents
Compuestos de epoxicetona para la inhibición de enzimas Download PDFInfo
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- ES2704056T3 ES2704056T3 ES15821964T ES15821964T ES2704056T3 ES 2704056 T3 ES2704056 T3 ES 2704056T3 ES 15821964 T ES15821964 T ES 15821964T ES 15821964 T ES15821964 T ES 15821964T ES 2704056 T3 ES2704056 T3 ES 2704056T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462024024P | 2014-07-14 | 2014-07-14 | |
| PCT/US2015/040459 WO2016011088A2 (en) | 2014-07-14 | 2015-07-14 | Epoxyketone compounds for enzyme inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2704056T3 true ES2704056T3 (es) | 2019-03-14 |
Family
ID=55079165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15821964T Active ES2704056T3 (es) | 2014-07-14 | 2015-07-14 | Compuestos de epoxicetona para la inhibición de enzimas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10640533B2 (enExample) |
| EP (1) | EP3166933B1 (enExample) |
| JP (1) | JP6608442B2 (enExample) |
| KR (2) | KR102462240B1 (enExample) |
| CN (1) | CN105960399B (enExample) |
| DK (1) | DK3166933T3 (enExample) |
| ES (1) | ES2704056T3 (enExample) |
| PT (1) | PT3166933T (enExample) |
| TR (1) | TR201816372T4 (enExample) |
| WO (1) | WO2016011088A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3166933B1 (en) | 2014-07-14 | 2018-08-01 | Centrax International Inc. | Epoxyketone compounds for enzyme inhibition |
| US20240092831A1 (en) * | 2019-10-11 | 2024-03-21 | Mayo Foundation For Medical Education And Research | Proteasome Inhibitors |
| CN118255835A (zh) * | 2022-12-27 | 2024-06-28 | 上海美悦生物科技发展有限公司 | 三肽环氧酮化合物、药物组合物及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105827A2 (en) * | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for proteasome enzyme inhibition |
| AU2005243140A1 (en) * | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
| WO2006063154A1 (en) * | 2004-12-07 | 2006-06-15 | Proteolix, Inc. | Composition for proteasome inhibition |
| EP2623113B1 (en) | 2005-11-09 | 2017-05-31 | Onyx Therapeutics, Inc. | Compound for enzyme inhibition |
| WO2008140782A2 (en) * | 2007-05-10 | 2008-11-20 | Proteolix, Inc. | Compounds for enzyme inhibition |
| KR20110073584A (ko) | 2008-10-21 | 2011-06-29 | 오닉스 세라퓨틱스, 인크. | 펩티드 에폭시케톤과의 병용 요법 |
| MX2012011604A (es) * | 2010-04-07 | 2013-02-27 | Onyx Therapeutics Inc | Inhibidor de inmunoproteasoma de péptido epoxicetona cristalino. |
| EP4144354B1 (en) | 2011-08-30 | 2025-11-26 | Trustees Of Tufts College | Fap-activated proteasome inhibitors for treating solid tumors |
| CA2879454A1 (en) | 2012-07-19 | 2014-01-23 | Drexel University | Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| WO2014018807A1 (en) * | 2012-07-26 | 2014-01-30 | Centrax International, Inc. | Peptide epoxyketone compounds |
| JP2015526433A (ja) * | 2012-08-14 | 2015-09-10 | フルオリノブ ファーマ インコーポレイテッド | フッ素化エポキシケトン系化合物、およびプロテアソーム阻害物質としてのその使用 |
| CA2881986A1 (en) * | 2012-08-21 | 2014-02-27 | Fluorinov Pharma Inc. | Fluorinated epoxyketone-based tetrapeptide compounds and uses thereof as proteasome inhibitors |
| EP3166933B1 (en) | 2014-07-14 | 2018-08-01 | Centrax International Inc. | Epoxyketone compounds for enzyme inhibition |
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2015
- 2015-07-14 EP EP15821964.2A patent/EP3166933B1/en active Active
- 2015-07-14 WO PCT/US2015/040459 patent/WO2016011088A2/en not_active Ceased
- 2015-07-14 JP JP2017523185A patent/JP6608442B2/ja active Active
- 2015-07-14 DK DK15821964.2T patent/DK3166933T3/en active
- 2015-07-14 CN CN201580002532.1A patent/CN105960399B/zh active Active
- 2015-07-14 TR TR2018/16372T patent/TR201816372T4/tr unknown
- 2015-07-14 KR KR1020217022768A patent/KR102462240B1/ko active Active
- 2015-07-14 US US15/325,998 patent/US10640533B2/en active Active
- 2015-07-14 ES ES15821964T patent/ES2704056T3/es active Active
- 2015-07-14 KR KR1020177004070A patent/KR102360356B1/ko active Active
- 2015-07-14 PT PT15821964T patent/PT3166933T/pt unknown
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2019
- 2019-10-28 US US16/665,010 patent/US10787482B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170158734A1 (en) | 2017-06-08 |
| WO2016011088A2 (en) | 2016-01-21 |
| EP3166933B1 (en) | 2018-08-01 |
| KR20210093378A (ko) | 2021-07-27 |
| EP3166933A4 (en) | 2017-07-19 |
| US10640533B2 (en) | 2020-05-05 |
| KR20170041747A (ko) | 2017-04-17 |
| US20200087343A1 (en) | 2020-03-19 |
| WO2016011088A3 (en) | 2016-08-11 |
| EP3166933A2 (en) | 2017-05-17 |
| JP6608442B2 (ja) | 2019-11-20 |
| KR102462240B1 (ko) | 2022-11-03 |
| KR102360356B1 (ko) | 2022-02-08 |
| CN105960399A (zh) | 2016-09-21 |
| CN105960399B (zh) | 2018-09-25 |
| PT3166933T (pt) | 2018-12-06 |
| JP2017522383A (ja) | 2017-08-10 |
| TR201816372T4 (tr) | 2018-11-21 |
| DK3166933T3 (en) | 2018-11-26 |
| US10787482B2 (en) | 2020-09-29 |
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