JP2018518518A5 - - Google Patents
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- Publication number
- JP2018518518A5 JP2018518518A5 JP2017567146A JP2017567146A JP2018518518A5 JP 2018518518 A5 JP2018518518 A5 JP 2018518518A5 JP 2017567146 A JP2017567146 A JP 2017567146A JP 2017567146 A JP2017567146 A JP 2017567146A JP 2018518518 A5 JP2018518518 A5 JP 2018518518A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- pharmaceutical composition
- cycloalkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims 43
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 19
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000004043 oxo group Chemical group O=* 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940034982 antineoplastic agent Drugs 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562185223P | 2015-06-26 | 2015-06-26 | |
| US62/185,223 | 2015-06-26 | ||
| PCT/US2016/039365 WO2016210330A1 (en) | 2015-06-26 | 2016-06-24 | Glucose uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518518A JP2018518518A (ja) | 2018-07-12 |
| JP2018518518A5 true JP2018518518A5 (enExample) | 2019-07-25 |
Family
ID=57586425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567146A Ceased JP2018518518A (ja) | 2015-06-26 | 2016-06-24 | グルコース取り込み阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10273248B2 (enExample) |
| EP (1) | EP3313825A4 (enExample) |
| JP (1) | JP2018518518A (enExample) |
| CN (1) | CN108349910A (enExample) |
| CA (1) | CA3028355A1 (enExample) |
| EA (1) | EA201890153A1 (enExample) |
| HK (1) | HK1254835A1 (enExample) |
| WO (1) | WO2016210330A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3573992B1 (en) * | 2017-01-26 | 2022-04-13 | Youla S. Tsantrizos | Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof |
| WO2018201006A1 (en) * | 2017-04-28 | 2018-11-01 | Kadmon Corporation, Llc | Treatment of inflammatory conditions and autoimmune diseases with glucose uptake inhibitors |
| CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
| KR102563325B1 (ko) | 2017-06-30 | 2023-08-03 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | Ｒｈｏ-관련 단백질 키나아제 억제제, Ｒｈｏ-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도 |
| WO2019001572A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho 相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| WO2019000683A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| CN109384782A (zh) * | 2017-08-04 | 2019-02-26 | 厦门大学 | 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途 |
| WO2019126739A1 (en) | 2017-12-21 | 2019-06-27 | Shepherd Therapeutics, Inc. | Pyrvinium pamoate anti-cancer therapies |
| US10689386B2 (en) | 2018-03-07 | 2020-06-23 | Duquesne University Of The Holy Spirit | Pyrazolo[4,3-d]pyrimidines as antitumor agents |
| US12030857B2 (en) | 2018-06-25 | 2024-07-09 | Kadmon Corporation, Llc | Glucose uptake inhibitors |
| IL292515A (en) * | 2019-11-13 | 2022-06-01 | Metabomed Ltd | Glucose uptake inhibitors and uses thereof |
| US20220315598A1 (en) * | 2019-12-02 | 2022-10-06 | Shanghai Yingli Pharmaceutical Co., Ltd | Oxygen-containing Heterocyclic Compound, Preparation Method Therefor and Use Thereof |
| JP7772771B2 (ja) * | 2020-07-14 | 2025-11-18 | 武漢朗来科技発展有限公司 | Ｒｏｃｋ阻害剤及びその製造方法と用途 |
| CN112479913A (zh) * | 2020-11-19 | 2021-03-12 | 安徽修一制药有限公司 | 一种n,n-二乙基氯代乙酰胺的制备方法 |
| CN112741828B (zh) * | 2021-01-08 | 2022-04-26 | 武汉大学 | 药物联用物及其制备方法和用途 |
| US20240109868A1 (en) * | 2022-08-29 | 2024-04-04 | Miracure Biotechnology Limited | Ep300/cbp modulator, preparation method therefor and use thereof |
| CN117820328A (zh) * | 2023-11-21 | 2024-04-05 | 苏州楚凯药业有限公司 | 一种2,4-二氯-6,7-二氢呋喃并[3,2-d]嘧啶的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2472619A1 (en) * | 2002-01-10 | 2003-07-24 | Bayer Corporation | Fused pyrimidine derivates as rho-kinase inhibitors |
| ES2389752T3 (es) * | 2007-12-14 | 2012-10-31 | Ardea Biosciences, Inc. | Inhibidores de la transcriptasa inversa |
| BR112012008677A2 (pt) * | 2009-10-12 | 2018-03-20 | Myrexis Inc | compostos amino-pirimidina como inibidores de tbkl e/ou ikk epsilon |
| WO2012040499A2 (en) * | 2010-09-22 | 2012-03-29 | Surface Logix, Inc. | Metabolic inhibitors |
| PE20140928A1 (es) * | 2011-04-21 | 2014-08-24 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas |
| CN102901456B (zh) | 2012-09-12 | 2015-10-28 | 深圳深蓝精机有限公司 | 检测装置及检测圆轴的外径、跳动值、真圆度的方法 |
| WO2014055996A2 (en) * | 2012-10-05 | 2014-04-10 | Kadmon Corporation, Llc | Rho kinase inhibitors |
| US10729691B2 (en) * | 2015-06-26 | 2020-08-04 | Kadmon Corporation, Llc | Treatment of infectious diseases with glucose uptake inhibitors |
-
2016
- 2016-06-24 WO PCT/US2016/039365 patent/WO2016210330A1/en not_active Ceased
- 2016-06-24 CN CN201680048825.8A patent/CN108349910A/zh active Pending
- 2016-06-24 CA CA3028355A patent/CA3028355A1/en not_active Abandoned
- 2016-06-24 US US15/737,911 patent/US10273248B2/en active Active
- 2016-06-24 EP EP16815426.8A patent/EP3313825A4/en not_active Withdrawn
- 2016-06-24 HK HK18113929.9A patent/HK1254835A1/zh unknown
- 2016-06-24 EA EA201890153A patent/EA201890153A1/ru unknown
- 2016-06-24 JP JP2017567146A patent/JP2018518518A/ja not_active Ceased
-
2019
- 2019-04-29 US US16/397,043 patent/US10988484B2/en active Active
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