AR103093A1 - Péptidos macrocíclicos que inhiben interacciones proteína / proteína de proteína de la muerte (pd-1 / pd-l1) e inhiben interacción cd80 / pd-l1 - Google Patents

Péptidos macrocíclicos que inhiben interacciones proteína / proteína de proteína de la muerte (pd-1 / pd-l1) e inhiben interacción cd80 / pd-l1

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Publication number
AR103093A1
AR103093A1 ARP150104168A ARP150104168A AR103093A1 AR 103093 A1 AR103093 A1 AR 103093A1 AR P150104168 A ARP150104168 A AR P150104168A AR P150104168 A ARP150104168 A AR P150104168A AR 103093 A1 AR103093 A1 AR 103093A1
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Argentina
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alkyl
hydrogen
halo
independently selected
phenyl
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ARP150104168A
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English (en)
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Michael Scola Paul
Mull Eric
Patrick Allen Martin
Zhao Qian
Sun Li
P Qiang - Gillis Eric
Mapelli Claudio
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Bristol Myers Squibb Co
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Publication of AR103093A1 publication Critical patent/AR103093A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Immunology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Péptidos macrocíclicos que inhiben las interacciones proteína / proteína PPD-1 / PD-L1 y PD-L1 / CD80, y por ende, son útiles para la mejora de varias enfermedades, que incluyen el cáncer y las enfermedades infecciosas. Reivindicación 1: Un compuesto, caracterizado porque tiene la fórmula (1) o una sal de este aceptable desde el punto de vista farmacéutico, en donde: A se selecciona de un enlace del grupo de fórmulas (2), en donde: la línea ondulada * indica el punto de unión al grupo carbonilo y la línea ondulada indica el punto de unión al átomo de nitrógeno; z es 0, 1 ó 2; w es 1 ó 2; n es 0 ó 1; m es 1 ó 2; m es 0 ó 1; p es 0, 1 ó 2; Rˣ se selecciona de hidrógeno, amino, hidroxi y metilo; R¹⁴ y R¹⁵ se seleccionan independientemente de hidrógeno y metilo; y Rᶻ se selecciona de hidrógeno y -C(O)NHR¹⁶; en donde R¹⁶ se selecciona de hidrógeno, -CHR¹⁷C(O)NH₂, -CHR¹⁷C(O)NHCHR¹⁸C(O)NH₂ y -CHR¹⁷C(O)NHCHR¹⁸C(O)NHCH₂C(O)NH₂; en donde R¹⁷ se seleccione de hidrogeno y -CH₂OH, y en donde R¹⁸ se selecciona de hidrógeno y metilo; Rᵛ es hidrógeno o una cadena lateral de aminoácido natural; Rᶜ, Rᶠ, Rʰ, Rⁱ y Rᵐ son hidrogeno; Rⁿ es hidrógeno o metilo, o Rᵛ y Rⁿ forman un anillo de pirrolidina; Rᵃ es hidrógeno o metilo; Rʲ se selecciona de hidrógeno, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₁₋₆ alquilo, carboxi-C₁₋₆ alquilo, halo-C₁₋₆ alquilo, hidroxi-C₁₋₆ alquilo, (NRᵃRᵇ)C₁₋₆ alquilo, en donde Rᵃ y Rᵇ se seleccionan independientemente de hidrógeno y C₁₋₆ alquilo; y fenil-C₁₋₆ alquilo, en donde fenilo se sustituye opcionalmente con 1, 2, 3, 4 ó 5 grupos seleccionados independientemente de C₁₋₆ alcoxi, C₁₋₆ alquilo, ciano, halo y nitro; R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² y R¹³ se seleccionan independientemente de una cadena lateral de aminoácido natural y una cadena lateral de aminoácido no natural; o R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² y R¹³ pueden formar, cada uno independientemente, un anillo con el grupo R próximo correspondiente como se describe más adelante; Rᵇ se selecciona de C₁₋₆ alcoxi-C₁₋₆ alquilo, C₁₋₆ alquilo, carboxi-C₁₋₆ alquilo, halo-C₁₋₆ alquilo, hidroxi-C₁₋₆ alquilo, (NRᵃRᵇ)C₁₋₆ alquilo, en donde Rᵃ y Rᵇ se seleccionan independientemente de hidrógeno y C₁₋₆ alquilo; y fenil-C₁₋₆ alquilo, en donde fenilo se sustituye opcionalmente con 1, 2, 3, 4 ó 5 grupos seleccionados independientemente de C₁₋₆ alcoxi, C₁₋₆ alquilo, ciano, halo y nitro; o Rᵇ y R², junto con los átomos a los que están unidos, forman un anillo seleccionado de azetidina, pirrolidina, morfolina, piperidina, piperazina y tetrahidrotiazol; en donde cada anillo se sustituye opcionalmente con 1 a 4 grupos seleccionados independientemente de amino, ciano, metilo, halo e hidroxi; Rᵈ se selecciona de hidrógeno, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₁₋₆ alquilo, carboxi-C₁₋₆ alquilo, halo-C₁₋₆ alquilo, hidroxi-C₁₋₆ alquilo, (NRᵃRᵇ)C₁₋₆ alquilo, en donde Rᵃ y Rᵇ se seleccionan independientemente de hidrógeno y C₁₋₆ alquilo; y fenil-C₁₋₆ alquilo, en donde fenilo se sustituye opcionalmente con 1, 2, 3, 4 ó 5 grupos seleccionados independientemente de C₁₋₆ alcoxi, C₁₋₆ alquilo, ciano, halo y nitro; o Rᵈ y R⁴, junto con los átomos a los que están unidos, pueden formar un anillo seleccionado de azetidina, pirrolidina, morfolina, piperidina, piperazina y tetrahidrotiazol; en donde cada anillo se sustituye opcionalmente con 1 a 4 grupos seleccionados independientemente de amino, ciano, metilo, halo, hidroxi y fenilo; Rᵉ se selecciona de hidrógeno, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₁₋₆ alquilo, carboxi-C₁₋₆ alquilo, halo-C₁₋₆ alquilo, hidroxi-C₁₋₆ alquilo, (NRᵃRᵇ)C₁₋₆ alquilo, en donde Rᵃ y Rᵇ se seleccionan independientemente de hidrógeno y C₁₋₆ alquilo; y fenil C₁₋₆ alquilo, en donde fenilo se sustituye opcionalmente con 1, 2, 3, 4 ó 5 grupos seleccionados independientemente de C₁₋₆ alcoxi, C₁₋₆ alquilo, ciano, halo y nitro; o Rᵉ y R⁵, junto con los átomos a los que están unidos, pueden formar un anillo seleccionado de azetidina, pirrolidina, morfolina, piperidina, piperazina y tetrahidrotiazol; en donde cada anillo se sustituye opcionalmente con 1 a 4 grupos seleccionados independientemente de amino, ciano, metilo, halo e hidroxi; Rᵍ se selecciona de hidrógeno, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₁₋₆ alquilo, carboxi-C₁₋₆ alquilo, halo-C₁₋₆ alquilo, hidroxi-C₁₋₆ alquilo, (NRᵃRᵇ)C₁₋₆ alquilo, en donde Rᵃ y Rᵇ se seleccionan independientemente de hidrógeno y C₁₋₆ alquilo; y fenil-C₁₋₆ alquilo, en donde fenilo se sustituye opcionalmente con 1, 2, 3, 4 ó 5 grupos seleccionados independientemente de C₁₋₆ alcoxi, C₁₋₆ alquilo, ciano, halo y nitro; o Rᵍ y R⁷, junto con los átomos a los que están unidos, pueden formar un anillo seleccionado de azetidina, pirrolidina, morfolina, piperidina, piperazina y tetrahidrotiazol; en donde cada anillo se sustituye opcionalmente con 1 a 4 grupos seleccionados independientemente de amino, bencilo opcionalmente sustituido con un grupo halo, benciloxi, ciano, ciclohexilo, metilo, halo, hidroxi, isoquinoliniloxi opcionalmente sustituido con un grupo metoxi, quinolíniloxi sustituido opcionalmente con un grupo halo, y tetrazolilo; y en donde el anillo de pirrolidina y el anillo de piperidina se fusionan opcionalmente a un grupo ciclohexilo, fenilo o indol; siempre que al menos uno de Rᵃ, Rᵇ, Rᵈ, Rᵉ, Rᵍ, Rʲ, Rᵏ y Rˡ se seleccione de C₁₋₆ alcoxi-C₁₋₆ alquilo, C₂₋₆ alquilo, carboxi-C₁₋₆ alquilo, halo-C₁₋₆ alquilo, hidroxi-C₁₋₆ alquilo, (NRᵃRᵇ)C₁₋₆ alquilo, en donde Rᵃ y Rᵇ se seleccionan independientemente de hidrógeno y C₁₋₆ alquilo; y fenil-C₁₋₆ alquilo, en donde fenilo se sustituye opcionalmente con 1, 2, 3, 4 ó 5 grupos seleccionados independientemente de C₁₋₆ alcoxi, C₁₋₆ alquilo, ciano, halo y nitro.
ARP150104168A 2014-12-18 2015-12-17 Péptidos macrocíclicos que inhiben interacciones proteína / proteína de proteína de la muerte (pd-1 / pd-l1) e inhiben interacción cd80 / pd-l1 AR103093A1 (es)

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US (1) US9861680B2 (es)
EP (1) EP3233888B1 (es)
JP (1) JP6625129B2 (es)
KR (1) KR102602643B1 (es)
CN (1) CN107108697B (es)
AR (1) AR103093A1 (es)
AU (1) AU2015362703A1 (es)
BR (1) BR112017012679A2 (es)
CA (1) CA2971189A1 (es)
EA (1) EA033894B1 (es)
ES (1) ES2940632T3 (es)
IL (1) IL252853A0 (es)
MX (1) MX2017007677A (es)
SG (1) SG11201704823TA (es)
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