BR112022004316A2 - Caracterização espacial quantitativa para terapia de antagonista lag-3 - Google Patents

Caracterização espacial quantitativa para terapia de antagonista lag-3

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Publication number
BR112022004316A2
BR112022004316A2 BR112022004316A BR112022004316A BR112022004316A2 BR 112022004316 A2 BR112022004316 A2 BR 112022004316A2 BR 112022004316 A BR112022004316 A BR 112022004316A BR 112022004316 A BR112022004316 A BR 112022004316A BR 112022004316 A2 BR112022004316 A2 BR 112022004316A2
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lag
antagonist therapy
spatial characterization
quantitative spatial
subject
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BR112022004316A
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English (en)
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Cyrus Hedvat
C Lee George
Robin Edwards
Atulkumar Baxi Vipul
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Bristol Myers Squibb Co
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Publication of BR112022004316A2 publication Critical patent/BR112022004316A2/pt

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity

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Abstract

a presente invenção refere-se a antagonistas de lag-3 e métodos que compreendem o mesmo, para o tratamento de um câncer em um indivíduo, com base em um escore de densidade de lag-3 e/ou um escore de proporção de lag-3 em uma amostra de tumor do indivíduo. a invenção também provê a identificação de um indivíduo responsivo a uma terapia antagonista lag-3.
BR112022004316A 2019-09-22 2020-09-22 Caracterização espacial quantitativa para terapia de antagonista lag-3 BR112022004316A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962903887P 2019-09-22 2019-09-22
PCT/US2020/052021 WO2021055994A1 (en) 2019-09-22 2020-09-22 Quantitative spatial profiling for lag-3 antagonist therapy

Publications (1)

Publication Number Publication Date
BR112022004316A2 true BR112022004316A2 (pt) 2022-06-21

Family

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BR112022004316A BR112022004316A2 (pt) 2019-09-22 2020-09-22 Caracterização espacial quantitativa para terapia de antagonista lag-3

Country Status (11)

Country Link
US (1) US20220348653A1 (pt)
EP (1) EP4031873A1 (pt)
JP (1) JP2022549273A (pt)
KR (1) KR20220066334A (pt)
CN (1) CN114450028A (pt)
AU (1) AU2020350795A1 (pt)
BR (1) BR112022004316A2 (pt)
CA (1) CA3153777A1 (pt)
IL (1) IL291534A (pt)
MX (1) MX2022003197A (pt)
WO (1) WO2021055994A1 (pt)

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CA3153777A1 (en) 2021-03-25
KR20220066334A (ko) 2022-05-24
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