JP2020510091A5 - - Google Patents
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- Publication number
- JP2020510091A5 JP2020510091A5 JP2019571788A JP2019571788A JP2020510091A5 JP 2020510091 A5 JP2020510091 A5 JP 2020510091A5 JP 2019571788 A JP2019571788 A JP 2019571788A JP 2019571788 A JP2019571788 A JP 2019571788A JP 2020510091 A5 JP2020510091 A5 JP 2020510091A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- solvate
- hydrate
- aryl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)(*)C(*)(*)C(*)(*)*C(N(*)*)=O Chemical compound *C(*)(*)C(*)(*)C(*)(*)*C(N(*)*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1704327.4A GB201704327D0 (en) | 2017-03-17 | 2017-03-17 | Compounds |
| GB1704327.4 | 2017-03-17 | ||
| PCT/EP2018/056663 WO2018167269A1 (en) | 2017-03-17 | 2018-03-16 | Compounds useful in the treatment or prevention of a prmt5-mediated disorder |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510091A JP2020510091A (ja) | 2020-04-02 |
| JP2020510091A5 true JP2020510091A5 (enExample) | 2021-04-30 |
| JP7211982B2 JP7211982B2 (ja) | 2023-01-24 |
Family
ID=58688233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571788A Active JP7211982B2 (ja) | 2017-03-17 | 2018-03-16 | Ｐｒｍｔ５媒介性障害の治療又は予防に有用な化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11485731B2 (enExample) |
| EP (1) | EP3596061B1 (enExample) |
| JP (1) | JP7211982B2 (enExample) |
| KR (1) | KR102616970B1 (enExample) |
| CN (1) | CN110650950B (enExample) |
| AU (2) | AU2018235139A1 (enExample) |
| CA (1) | CA3056724A1 (enExample) |
| GB (1) | GB201704327D0 (enExample) |
| IL (1) | IL269354B2 (enExample) |
| MX (1) | MX2019011061A (enExample) |
| SG (1) | SG11201908598PA (enExample) |
| WO (1) | WO2018167269A1 (enExample) |
| ZA (1) | ZA201906269B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10689360B1 (en) * | 2019-01-30 | 2020-06-23 | Insilico Medicine Ip Limited | TLR inhibitors |
| US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
| GB201905780D0 (en) | 2019-04-25 | 2019-06-05 | La Thangue Nicholas | Cancer therapy |
| AU2020289537A1 (en) | 2019-06-06 | 2021-11-25 | Aligos Therapeutics, Inc. | Heterocyclic compounds |
| CN110950841A (zh) * | 2019-11-22 | 2020-04-03 | 济南大学 | 一类新型三唑类化合物的合成及应用 |
| WO2021126728A1 (en) * | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| US12522584B2 (en) | 2020-06-02 | 2026-01-13 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd | 3,4-dihydroisoquinoline compound and use thereof |
| MX2022015207A (es) | 2020-06-10 | 2023-02-13 | Aligos Therapeutics Inc | Compuestos antivirales para tratar infecciones por coronavirus, picornavirus, y norovirus. |
| WO2022002142A1 (zh) * | 2020-06-30 | 2022-01-06 | 江苏先声药业有限公司 | 四氢异喹啉类化合物及其用途 |
| EP4209485A4 (en) | 2020-09-04 | 2025-02-19 | Innovstone Therapeutics Limited | ASSOCIATES WITH ANTI-TUMOOR ACTIVITY AND USE THEREOF |
| TW202246233A (zh) | 2021-02-19 | 2022-12-01 | 英商蘇多生物科學有限公司 | Tyk2抑制劑及其用途 |
| TW202246232A (zh) | 2021-02-19 | 2022-12-01 | 英商蘇多生物科學有限公司 | Ｔｙｋ２抑制劑及其用途 |
| US20250206717A1 (en) | 2021-05-13 | 2025-06-26 | Innovstone Therapeutics Limited | Compound having anti-tumor activity and use thereof |
| GB202108383D0 (en) | 2021-06-11 | 2021-07-28 | Argonaut Therapeutics Ltd | Compounds useful in the treatment or prevention of a prmt5-mediated disorder |
| KR20240035513A (ko) | 2021-07-09 | 2024-03-15 | 알리고스 테라퓨틱스 인코포레이티드 | 항바이러스 화합물 |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| GB202117230D0 (en) | 2021-11-29 | 2022-01-12 | Argonaut Therapeutics Ltd | Peptide vaccine |
| US20250051307A1 (en) * | 2021-12-08 | 2025-02-13 | Cspc Zhongqi Pharmaceutical Technology(Shijiazhuang) Co., Ltd | Salt of 3,4-dihydroisoquinoline compound and use thereof |
| CN118475569A (zh) * | 2021-12-30 | 2024-08-09 | 南京再明医药有限公司 | 四氢异喹啉类化合物的可药用盐、晶型及其用途 |
| WO2023131305A1 (zh) * | 2022-01-06 | 2023-07-13 | 江苏先声药业有限公司 | Prmt5抑制剂和抗癌治疗剂的组合 |
| GB202203588D0 (en) | 2022-03-15 | 2022-04-27 | Argonaut Therapeutics Ltd | Cancer diagnostic |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016511744A (ja) | 2012-12-21 | 2016-04-21 | エピザイム，インコーポレイティド | Ｐｒｍｔ５を阻害する方法 |
| WO2014100695A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US8940726B2 (en) | 2012-12-21 | 2015-01-27 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| PL2935222T3 (pl) * | 2012-12-21 | 2019-02-28 | Epizyme Inc | Inhibitory PRMT5 i ich zastosowania |
| WO2015200677A2 (en) * | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3160477A4 (en) * | 2014-06-25 | 2018-07-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US10494376B2 (en) * | 2014-09-03 | 2019-12-03 | Ctxt Pty. Ltd. | Tetrahydroisoquinoline derived PRMT5-inhibitors |
| GB201415573D0 (en) | 2014-09-03 | 2014-10-15 | Cancer Therapeutics Crc Pty Ltd | Compounds |
-
2017
- 2017-03-17 GB GBGB1704327.4A patent/GB201704327D0/en not_active Ceased
-
2018
- 2018-03-16 WO PCT/EP2018/056663 patent/WO2018167269A1/en not_active Ceased
- 2018-03-16 KR KR1020197030311A patent/KR102616970B1/ko active Active
- 2018-03-16 CA CA3056724A patent/CA3056724A1/en active Pending
- 2018-03-16 EP EP18714178.3A patent/EP3596061B1/en active Active
- 2018-03-16 CN CN201880032332.4A patent/CN110650950B/zh active Active
- 2018-03-16 MX MX2019011061A patent/MX2019011061A/es unknown
- 2018-03-16 AU AU2018235139A patent/AU2018235139A1/en not_active Abandoned
- 2018-03-16 SG SG11201908598P patent/SG11201908598PA/en unknown
- 2018-03-16 JP JP2019571788A patent/JP7211982B2/ja active Active
- 2018-03-16 US US16/494,532 patent/US11485731B2/en active Active
- 2018-03-16 IL IL269354A patent/IL269354B2/en unknown
-
2019
- 2019-09-23 ZA ZA2019/06269A patent/ZA201906269B/en unknown
-
2022
- 2022-04-11 AU AU2022202389A patent/AU2022202389B2/en active Active
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