JP2018531218A5 - - Google Patents

Info

Publication number

JP2018531218A5

JP2018531218A5 JP2018507641A JP2018507641A JP2018531218A5 JP 2018531218 A5 JP2018531218 A5 JP 2018531218A5 JP 2018507641 A JP2018507641 A JP 2018507641A JP 2018507641 A JP2018507641 A JP 2018507641A JP 2018531218 A5 JP2018531218 A5 JP 2018531218A5

Authority

JP

Japan

Prior art keywords

group

tautomer

pharmaceutically acceptable

acceptable salt

membered

Prior art date

2016-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 19
• 150000003839 salts Chemical class 0.000 claims 13
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
• 229910052794 bromium Inorganic materials 0.000 claims 6
• 229910052801 chlorine Inorganic materials 0.000 claims 6
• 229910052731 fluorine Inorganic materials 0.000 claims 6
• 229910052740 iodine Inorganic materials 0.000 claims 6
• 125000005842 heteroatom Chemical group 0.000 claims 5
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 3
• 125000003118 aryl group Chemical group 0.000 claims 3
• 125000004429 atom Chemical group 0.000 claims 3
• 229910052799 carbon Inorganic materials 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
• 125000001072 heteroaryl group Chemical group 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 125000004404 heteroalkyl group Chemical group 0.000 claims 2
• -1 hydroxyethyl group Chemical group 0.000 claims 2
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 1
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
• 125000005257 alkyl acyl group Chemical group 0.000 claims 1
• 125000003282 alkyl amino group Chemical group 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
• 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
• 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
• 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims 1
• 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• 125000002883 imidazolyl group Chemical group 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
• 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 claims 1
• 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
• 125000002757 morpholinyl group Chemical group 0.000 claims 1
• 229910052698 phosphorus Inorganic materials 0.000 claims 1
• 125000004193 piperazinyl group Chemical group 0.000 claims 1
• 125000003386 piperidinyl group Chemical group 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000006239 protecting group Chemical group 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 125000000335 thiazolyl group Chemical group 0.000 claims 1