JP2014503525A5 - - Google Patents
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- Publication number
- JP2014503525A5 JP2014503525A5 JP2013543801A JP2013543801A JP2014503525A5 JP 2014503525 A5 JP2014503525 A5 JP 2014503525A5 JP 2013543801 A JP2013543801 A JP 2013543801A JP 2013543801 A JP2013543801 A JP 2013543801A JP 2014503525 A5 JP2014503525 A5 JP 2014503525A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- group
- alkyl
- motomeko
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 241000023320 Luma <angiosperm> Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 150000004696 coordination complex Chemical group 0.000 claims 1
- -1 cycloalkyl luma Chemical compound 0.000 claims 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000002184 metal Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195468.3 | 2010-12-16 | ||
| EP10195468 | 2010-12-16 | ||
| PCT/EP2011/073011 WO2012080447A1 (en) | 2010-12-16 | 2011-12-16 | Indoles as respiratory syncytial virus antiviral agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016048038A Division JP2016145236A (ja) | 2010-12-16 | 2016-03-11 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503525A JP2014503525A (ja) | 2014-02-13 |
| JP2014503525A5 true JP2014503525A5 (enExample) | 2014-07-10 |
| JP5945278B2 JP5945278B2 (ja) | 2016-07-05 |
Family
ID=43875270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543801A Active JP5945278B2 (ja) | 2010-12-16 | 2011-12-16 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
| JP2016048038A Pending JP2016145236A (ja) | 2010-12-16 | 2016-03-11 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016048038A Pending JP2016145236A (ja) | 2010-12-16 | 2016-03-11 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US8921560B2 (enExample) |
| EP (1) | EP2651922B1 (enExample) |
| JP (2) | JP5945278B2 (enExample) |
| KR (1) | KR101914606B1 (enExample) |
| CN (1) | CN103347875B (enExample) |
| AR (1) | AR084335A1 (enExample) |
| AU (1) | AU2011343256C1 (enExample) |
| BR (1) | BR112013011949B1 (enExample) |
| CA (1) | CA2822000C (enExample) |
| CL (1) | CL2013001715A1 (enExample) |
| CY (1) | CY1117763T1 (enExample) |
| DK (1) | DK2651922T3 (enExample) |
| EA (1) | EA022339B1 (enExample) |
| ES (1) | ES2572258T3 (enExample) |
| HR (1) | HRP20160533T1 (enExample) |
| HU (1) | HUE028009T2 (enExample) |
| IL (1) | IL225641A (enExample) |
| ME (1) | ME02406B (enExample) |
| MX (1) | MX339944B (enExample) |
| MY (1) | MY163981A (enExample) |
| NZ (1) | NZ609487A (enExample) |
| PH (1) | PH12013500797A1 (enExample) |
| PL (1) | PL2651922T3 (enExample) |
| RS (1) | RS54746B1 (enExample) |
| SG (1) | SG189866A1 (enExample) |
| SI (1) | SI2651922T1 (enExample) |
| SM (1) | SMT201600142B (enExample) |
| TW (1) | TWI515187B (enExample) |
| UA (1) | UA109792C2 (enExample) |
| WO (1) | WO2012080447A1 (enExample) |
| ZA (1) | ZA201304423B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| HUE033848T2 (en) * | 2012-06-15 | 2018-01-29 | Janssen Sciences Ireland Uc | Heterocyclic-Substituted 1,3-Dihydro-2H-Benzimidazol-2-one Derivatives as Air Giant Cell Virus Virus |
| AU2013276521A1 (en) * | 2012-06-15 | 2014-12-04 | Janssen Sciences Ireland Uc | 1,3 -dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| BR112015000392A2 (pt) * | 2012-07-10 | 2017-06-27 | Hoffmann La Roche | novos indazóis para o tratamento e profilaxia da infecção por vírus sincicial respiratório |
| ES2640446T3 (es) | 2012-10-16 | 2017-11-03 | Janssen Sciences Ireland Uc | Compuestos antivíricos para el VSR |
| BR112016003348B1 (pt) | 2013-08-21 | 2023-03-07 | Alios Biopharma, Inc | Compostos antivirais ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e seus usos |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| AU2015301334A1 (en) * | 2014-08-05 | 2017-02-23 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| MX2017011778A (es) | 2015-03-13 | 2017-12-04 | Forma Therapeutics Inc | Compuestos y composiciones de alfa-cinamida como inhibidores de histona desacetilasa 8 (hdac8). |
| RU2738232C2 (ru) | 2015-07-22 | 2020-12-09 | Энанта Фармасьютикалс, Инк. | Производные бензодиазепина как ингибиторы rsv |
| KR102708936B1 (ko) | 2015-11-20 | 2024-09-25 | 포르마 세라퓨틱스 인크. | 유비퀴틴-특이적 프로테아제 1 억제제로서의 퓨리논 |
| EP3402799B1 (en) | 2016-01-15 | 2022-05-04 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| KR20180108598A (ko) * | 2016-02-03 | 2018-10-04 | 얀센 사이언시즈 아일랜드 유씨 | Rsv의 치료를 위한 조합 생성물 |
| ES2775782T3 (es) | 2016-03-15 | 2020-07-28 | Bayer Cropscience Ag | Sulfonilamidas sustituidas para combatir parásitos animales |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| MX379326B (es) | 2017-02-16 | 2025-03-11 | Enanta Pharm Inc | Procesos para la preparación de derivados de benzodiazepina |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| AU2018339068B2 (en) | 2017-09-29 | 2022-12-15 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| TW201936193A (zh) * | 2017-12-05 | 2019-09-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 使用組合產品治療ｒｓｖ |
| PH12021552201A1 (en) | 2019-03-18 | 2022-05-30 | Enanta Pharm Inc | Benzodiazepine derivatives as rsv inhibitors |
| TWI864048B (zh) | 2019-10-04 | 2024-12-01 | 美商安塔製藥公司 | 抗病毒雜環化合物、其醫藥組成物及其用途 |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| WO2021083998A1 (en) * | 2019-10-30 | 2021-05-06 | Janssen Sciences Ireland Unlimited Company | Synthesis of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one |
| JP2023500213A (ja) * | 2019-10-30 | 2023-01-05 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ３－ニトロ－ｎ－（２，２，２－トリフルオロエチル）－４－ピリジンアミンの合成 |
| KR20220098170A (ko) | 2019-11-07 | 2022-07-11 | 바이엘 악티엔게젤샤프트 | 동물 해충 방제를 위한 치환된 술포닐 아미드 |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| CN115776982A (zh) * | 2020-06-11 | 2023-03-10 | 爱尔兰詹森科学公司 | 半(L)-酒石酸盐形式的3-({5-氯-1-[3-(甲基磺酰基)丙基]-1H-吲哚-2-基}甲基)-1-(2,2,2-三氟乙基)-1,3-二氢-2H-咪唑并[4,5-c]吡啶-2-酮和包含其的药物组合物 |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| JP2024507561A (ja) | 2021-02-26 | 2024-02-20 | エナンタ ファーマシューティカルズ インコーポレイテッド | 抗ウイルス複素環式化合物 |
| WO2022184606A1 (en) | 2021-03-01 | 2022-09-09 | Janssen Sciences Ireland Unlimited Company | Synthesis of rilematovir |
| CN114014856B (zh) * | 2021-11-26 | 2023-12-22 | 嘉兴安谛康生物科技有限公司 | 作为呼吸道合胞病毒抗病毒剂的咪唑并吡啶类衍生物 |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ333696A (en) | 1996-07-08 | 2000-06-23 | Du Pont Pharm Co | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor |
| WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| CZ20012006A3 (cs) | 1998-12-18 | 2002-03-13 | Axys Pharmaceuticals, Inc. | Sloučenina a farmaceutický prostředek |
| WO2001000612A2 (en) | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| AP1552A (en) | 1999-06-28 | 2006-01-17 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors. |
| US6534535B1 (en) * | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US20020019395A1 (en) * | 2000-02-01 | 2002-02-14 | Bing-Yan Zhu | Indalone and benzimidazolone inhibitors of factor Xa |
| US20020072530A1 (en) * | 2000-02-01 | 2002-06-13 | Bing-Yan Zhu | Indole and benzimidazole inhibitors of factor Xa |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) * | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| HUP0402535A2 (hu) | 2001-12-10 | 2005-04-28 | Bristol-Myers Squibb Co. | RSV fúzió inhibitor hatású imidazo-piridin-vegyület dihidroklorid-monohidrát sója és az ezt tartalmazó gyógyszerkészítmények |
| US20030180957A1 (en) | 2001-12-21 | 2003-09-25 | Sense Proteomic Limited | Target and method |
| AU2003294249A1 (en) | 2002-11-08 | 2004-06-03 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| AR043692A1 (es) | 2003-02-06 | 2005-08-10 | Novartis Ag | 2-cianopirrolopirimidinas y sus usos farmaceuticos |
| US7343930B2 (en) | 2004-12-03 | 2008-03-18 | Masco Corporation Of Indiana | Sprayer with non-faucet control |
| MY140748A (en) * | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| US9150556B2 (en) | 2007-05-22 | 2015-10-06 | Boehringer Ingelheim International Gmbh | Benzimidazolone chymase inhibitors |
| FR2926556B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI530495B (zh) * | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| WO2012080481A1 (en) | 2010-12-17 | 2012-06-21 | Sanofi-Aventis Deutschland Gmbh | Medicament administration |
| US20150166533A1 (en) | 2012-06-15 | 2015-06-18 | Janssen R&D Ireland | Novel 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| AU2013276521A1 (en) | 2012-06-15 | 2014-12-04 | Janssen Sciences Ireland Uc | 1,3 -dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| HUE033848T2 (en) | 2012-06-15 | 2018-01-29 | Janssen Sciences Ireland Uc | Heterocyclic-Substituted 1,3-Dihydro-2H-Benzimidazol-2-one Derivatives as Air Giant Cell Virus Virus |
| EP2864299A1 (en) | 2012-06-15 | 2015-04-29 | Janssen Sciences Ireland UC | 4 - substituted 1, 3 - dihydro - 2h - benzimidazol - 2 - one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| ES2640446T3 (es) | 2012-10-16 | 2017-11-03 | Janssen Sciences Ireland Uc | Compuestos antivíricos para el VSR |
-
2011
- 2011-12-15 TW TW100146391A patent/TWI515187B/zh not_active IP Right Cessation
- 2011-12-16 CN CN201180060358.8A patent/CN103347875B/zh not_active Expired - Fee Related
- 2011-12-16 KR KR1020137016980A patent/KR101914606B1/ko not_active Expired - Fee Related
- 2011-12-16 AR ARP110104740A patent/AR084335A1/es active IP Right Grant
- 2011-12-16 AU AU2011343256A patent/AU2011343256C1/en not_active Ceased
- 2011-12-16 SI SI201130824A patent/SI2651922T1/sl unknown
- 2011-12-16 JP JP2013543801A patent/JP5945278B2/ja active Active
- 2011-12-16 SG SG2013026729A patent/SG189866A1/en unknown
- 2011-12-16 BR BR112013011949-7A patent/BR112013011949B1/pt not_active IP Right Cessation
- 2011-12-16 UA UAA201304193A patent/UA109792C2/ru unknown
- 2011-12-16 HU HUE11794793A patent/HUE028009T2/en unknown
- 2011-12-16 MX MX2013006887A patent/MX339944B/es active IP Right Grant
- 2011-12-16 ME MEP-2016-97A patent/ME02406B/me unknown
- 2011-12-16 PL PL11794793.7T patent/PL2651922T3/pl unknown
- 2011-12-16 WO PCT/EP2011/073011 patent/WO2012080447A1/en not_active Ceased
- 2011-12-16 EP EP11794793.7A patent/EP2651922B1/en active Active
- 2011-12-16 US US13/993,200 patent/US8921560B2/en active Active
- 2011-12-16 HR HRP20160533TT patent/HRP20160533T1/hr unknown
- 2011-12-16 MY MYPI2013001279A patent/MY163981A/en unknown
- 2011-12-16 CA CA2822000A patent/CA2822000C/en active Active
- 2011-12-16 DK DK11794793.7T patent/DK2651922T3/en active
- 2011-12-16 EA EA201390883A patent/EA022339B1/ru unknown
- 2011-12-16 ES ES11794793T patent/ES2572258T3/es active Active
- 2011-12-16 RS RS20160332A patent/RS54746B1/sr unknown
- 2011-12-16 PH PH1/2013/500797A patent/PH12013500797A1/en unknown
- 2011-12-16 NZ NZ609487A patent/NZ609487A/en not_active IP Right Cessation
-
2013
- 2013-04-09 IL IL225641A patent/IL225641A/en active IP Right Grant
- 2013-06-13 CL CL2013001715A patent/CL2013001715A1/es unknown
- 2013-06-14 ZA ZA2013/04423A patent/ZA201304423B/en unknown
-
2014
- 2014-11-18 US US14/546,289 patent/US9321768B2/en active Active
-
2016
- 2016-03-11 JP JP2016048038A patent/JP2016145236A/ja active Pending
- 2016-04-22 US US15/136,769 patent/US9944638B2/en active Active
- 2016-05-20 SM SM201600142T patent/SMT201600142B/it unknown
- 2016-05-24 CY CY20161100449T patent/CY1117763T1/el unknown
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