CL2013001715A1 - Compuestos derivados de indol, inhibidores de la replicacion del rsv; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la infeccion por el virus sincicial respiratorio. - Google Patents

Compuestos derivados de indol, inhibidores de la replicacion del rsv; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la infeccion por el virus sincicial respiratorio.

Info

Publication number
CL2013001715A1
CL2013001715A1 CL2013001715A CL2013001715A CL2013001715A1 CL 2013001715 A1 CL2013001715 A1 CL 2013001715A1 CL 2013001715 A CL2013001715 A CL 2013001715A CL 2013001715 A CL2013001715 A CL 2013001715A CL 2013001715 A1 CL2013001715 A1 CL 2013001715A1
Authority
CL
Chile
Prior art keywords
indole
inhibitors
treatment
pharmaceutical composition
virus infection
Prior art date
Application number
CL2013001715A
Other languages
English (en)
Spanish (es)
Inventor
Pierre Jean-Marie Bernard Raboisson
Samuel Dominique Demin
Lili Hu
Tim Hugo Maria Jonckers
Abdellah Tahri
Ludwig Paul Cooymans
Sandrine Marie Vendeville
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of CL2013001715A1 publication Critical patent/CL2013001715A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CL2013001715A 2010-12-16 2013-06-13 Compuestos derivados de indol, inhibidores de la replicacion del rsv; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la infeccion por el virus sincicial respiratorio. CL2013001715A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10195468 2010-12-16

Publications (1)

Publication Number Publication Date
CL2013001715A1 true CL2013001715A1 (es) 2013-12-20

Family

ID=43875270

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013001715A CL2013001715A1 (es) 2010-12-16 2013-06-13 Compuestos derivados de indol, inhibidores de la replicacion del rsv; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la infeccion por el virus sincicial respiratorio.

Country Status (31)

Country Link
US (3) US8921560B2 (enExample)
EP (1) EP2651922B1 (enExample)
JP (2) JP5945278B2 (enExample)
KR (1) KR101914606B1 (enExample)
CN (1) CN103347875B (enExample)
AR (1) AR084335A1 (enExample)
AU (1) AU2011343256C1 (enExample)
BR (1) BR112013011949B1 (enExample)
CA (1) CA2822000C (enExample)
CL (1) CL2013001715A1 (enExample)
CY (1) CY1117763T1 (enExample)
DK (1) DK2651922T3 (enExample)
EA (1) EA022339B1 (enExample)
ES (1) ES2572258T3 (enExample)
HR (1) HRP20160533T1 (enExample)
HU (1) HUE028009T2 (enExample)
IL (1) IL225641A (enExample)
ME (1) ME02406B (enExample)
MX (1) MX339944B (enExample)
MY (1) MY163981A (enExample)
NZ (1) NZ609487A (enExample)
PH (1) PH12013500797A1 (enExample)
PL (1) PL2651922T3 (enExample)
RS (1) RS54746B1 (enExample)
SG (1) SG189866A1 (enExample)
SI (1) SI2651922T1 (enExample)
SM (1) SMT201600142B (enExample)
TW (1) TWI515187B (enExample)
UA (1) UA109792C2 (enExample)
WO (1) WO2012080447A1 (enExample)
ZA (1) ZA201304423B (enExample)

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Also Published As

Publication number Publication date
KR101914606B1 (ko) 2018-11-02
TWI515187B (zh) 2016-01-01
EA201390883A1 (ru) 2013-10-30
EA022339B1 (ru) 2015-12-30
US20130267555A1 (en) 2013-10-10
DK2651922T3 (en) 2016-05-30
US8921560B2 (en) 2014-12-30
JP2016145236A (ja) 2016-08-12
CN103347875B (zh) 2016-03-30
HUE028009T2 (en) 2016-11-28
AR084335A1 (es) 2013-05-08
BR112013011949B1 (pt) 2021-11-23
WO2012080447A1 (en) 2012-06-21
ES2572258T3 (es) 2016-05-31
TW201307325A (zh) 2013-02-16
EP2651922A1 (en) 2013-10-23
AU2011343256A1 (en) 2013-05-02
ME02406B (me) 2016-09-20
US20160237083A1 (en) 2016-08-18
AU2011343256C1 (en) 2015-08-13
CA2822000C (en) 2019-01-15
JP2014503525A (ja) 2014-02-13
SMT201600142B (it) 2016-07-01
HK1185613A1 (zh) 2014-02-21
CN103347875A (zh) 2013-10-09
RS54746B1 (sr) 2016-10-31
SI2651922T1 (sl) 2016-08-31
BR112013011949A2 (pt) 2016-08-23
US9321768B2 (en) 2016-04-26
UA109792C2 (uk) 2015-10-12
MX339944B (es) 2016-06-17
US9944638B2 (en) 2018-04-17
CA2822000A1 (en) 2012-06-21
CY1117763T1 (el) 2017-05-17
KR20140037800A (ko) 2014-03-27
US20150073013A1 (en) 2015-03-12
SG189866A1 (en) 2013-07-31
IL225641A0 (en) 2013-06-27
JP5945278B2 (ja) 2016-07-05
EP2651922B1 (en) 2016-02-24
IL225641A (en) 2016-09-29
MX2013006887A (es) 2013-07-05
ZA201304423B (en) 2014-12-23
PL2651922T3 (pl) 2016-10-31
HRP20160533T1 (hr) 2016-07-01
PH12013500797A1 (en) 2013-06-24
NZ609487A (en) 2014-10-31
AU2011343256B2 (en) 2015-02-05
MY163981A (en) 2017-11-15

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