EA201390883A1 - Индолы как противовирусные агенты в отношении респираторного синтициального вируса - Google Patents

Индолы как противовирусные агенты в отношении респираторного синтициального вируса

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Publication number
EA201390883A1
EA201390883A1 EA201390883A EA201390883A EA201390883A1 EA 201390883 A1 EA201390883 A1 EA 201390883A1 EA 201390883 A EA201390883 A EA 201390883A EA 201390883 A EA201390883 A EA 201390883A EA 201390883 A1 EA201390883 A1 EA 201390883A1
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EA
Eurasian Patent Office
Prior art keywords
indols
viral agents
virus
respiratory
compounds
Prior art date
Application number
EA201390883A
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English (en)
Other versions
EA022339B1 (ru
Inventor
Людвиг Поль Коиманс
Самюэль Доминик Демэн
Лили Ху
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Абделлах Тахри
Сандрин Мари Элен Вендевилль
Original Assignee
ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
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Application filed by ЯНССЕН Ар ЭНД Ди АЙРЛЭНД filed Critical ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
Publication of EA201390883A1 publication Critical patent/EA201390883A1/ru
Publication of EA022339B1 publication Critical patent/EA022339B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Индолы, обладающие ингибирующей активностью в отношении репликации RSV, и имеющие формулу I, их пролекарства, N-оксиды, аддитивные соли, четвертичные амины, комплексы с металлами и стереохимические изомерные формы, композиции, содержащие данные соединения в качестве активного ингредиента, и способы получения данных соединений и композиций.
EA201390883A 2010-12-16 2011-12-16 Индолы как противовирусные агенты в отношении респираторного синтициального вируса EA022339B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195468 2010-12-16
PCT/EP2011/073011 WO2012080447A1 (en) 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents

Publications (2)

Publication Number Publication Date
EA201390883A1 true EA201390883A1 (ru) 2013-10-30
EA022339B1 EA022339B1 (ru) 2015-12-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390883A EA022339B1 (ru) 2010-12-16 2011-12-16 Индолы как противовирусные агенты в отношении респираторного синтициального вируса

Country Status (31)

Country Link
US (3) US8921560B2 (ru)
EP (1) EP2651922B1 (ru)
JP (2) JP5945278B2 (ru)
KR (1) KR101914606B1 (ru)
CN (1) CN103347875B (ru)
AR (1) AR084335A1 (ru)
AU (1) AU2011343256C1 (ru)
BR (1) BR112013011949B1 (ru)
CA (1) CA2822000C (ru)
CL (1) CL2013001715A1 (ru)
CY (1) CY1117763T1 (ru)
DK (1) DK2651922T3 (ru)
EA (1) EA022339B1 (ru)
ES (1) ES2572258T3 (ru)
HK (1) HK1185613A1 (ru)
HR (1) HRP20160533T1 (ru)
HU (1) HUE028009T2 (ru)
IL (1) IL225641A (ru)
ME (1) ME02406B (ru)
MX (1) MX339944B (ru)
MY (1) MY163981A (ru)
NZ (1) NZ609487A (ru)
PL (1) PL2651922T3 (ru)
RS (1) RS54746B1 (ru)
SG (1) SG189866A1 (ru)
SI (1) SI2651922T1 (ru)
SM (1) SMT201600142B (ru)
TW (1) TWI515187B (ru)
UA (1) UA109792C2 (ru)
WO (1) WO2012080447A1 (ru)
ZA (1) ZA201304423B (ru)

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CL2013001715A1 (es) 2013-12-20
HK1185613A1 (zh) 2014-02-21
UA109792C2 (uk) 2015-10-12
US9944638B2 (en) 2018-04-17
DK2651922T3 (en) 2016-05-30
EA022339B1 (ru) 2015-12-30
US8921560B2 (en) 2014-12-30
TWI515187B (zh) 2016-01-01
JP2014503525A (ja) 2014-02-13
JP5945278B2 (ja) 2016-07-05
AU2011343256B2 (en) 2015-02-05
CN103347875B (zh) 2016-03-30
BR112013011949B1 (pt) 2021-11-23
WO2012080447A1 (en) 2012-06-21
IL225641A0 (en) 2013-06-27
US9321768B2 (en) 2016-04-26
NZ609487A (en) 2014-10-31
TW201307325A (zh) 2013-02-16
SI2651922T1 (sl) 2016-08-31
KR101914606B1 (ko) 2018-11-02
EP2651922A1 (en) 2013-10-23
ES2572258T3 (es) 2016-05-31
BR112013011949A2 (pt) 2016-08-23
IL225641A (en) 2016-09-29
HUE028009T2 (en) 2016-11-28
JP2016145236A (ja) 2016-08-12
US20150073013A1 (en) 2015-03-12
HRP20160533T1 (hr) 2016-07-01
ZA201304423B (en) 2014-12-23
MX339944B (es) 2016-06-17
SMT201600142B (it) 2016-07-01
AU2011343256C1 (en) 2015-08-13
ME02406B (me) 2016-09-20
MX2013006887A (es) 2013-07-05
AU2011343256A1 (en) 2013-05-02
PL2651922T3 (pl) 2016-10-31
CA2822000C (en) 2019-01-15
MY163981A (en) 2017-11-15
EP2651922B1 (en) 2016-02-24
CA2822000A1 (en) 2012-06-21
US20130267555A1 (en) 2013-10-10
SG189866A1 (en) 2013-07-31
RS54746B1 (sr) 2016-10-31
KR20140037800A (ko) 2014-03-27
US20160237083A1 (en) 2016-08-18
AR084335A1 (es) 2013-05-08
CN103347875A (zh) 2013-10-09
CY1117763T1 (el) 2017-05-17

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