MX2013006887A - Indoles como agentes antivirales para el virus sincitial respiratorio. - Google Patents

Indoles como agentes antivirales para el virus sincitial respiratorio.

Info

Publication number
MX2013006887A
MX2013006887A MX2013006887A MX2013006887A MX2013006887A MX 2013006887 A MX2013006887 A MX 2013006887A MX 2013006887 A MX2013006887 A MX 2013006887A MX 2013006887 A MX2013006887 A MX 2013006887A MX 2013006887 A MX2013006887 A MX 2013006887A
Authority
MX
Mexico
Prior art keywords
indoles
respiratory syncytial
antiviral agents
syncytial virus
virus antiviral
Prior art date
Application number
MX2013006887A
Other languages
English (en)
Other versions
MX339944B (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuel Dominique Demin
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of MX2013006887A publication Critical patent/MX2013006887A/es
Publication of MX339944B publication Critical patent/MX339944B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Indoles que tienen actividad inhibidora sobre la replicación del RSV y que tienen la fórmula I (Ver Formula) sus profármacos, N-óxidos, sales de adición, aminas cuaternarias, complejos metálicos y formas estereoquímicamente isoméricas; composiciones que contienen estos compuestos as principio activo y procedimientos para preparar estos compuestos y composiciones.
MX2013006887A 2010-12-16 2011-12-16 Indoles como agentes antivirales para el virus sincitial respiratorio. MX339944B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195468 2010-12-16
PCT/EP2011/073011 WO2012080447A1 (en) 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents

Publications (2)

Publication Number Publication Date
MX2013006887A true MX2013006887A (es) 2013-07-05
MX339944B MX339944B (es) 2016-06-17

Family

ID=43875270

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006887A MX339944B (es) 2010-12-16 2011-12-16 Indoles como agentes antivirales para el virus sincitial respiratorio.

Country Status (31)

Country Link
US (3) US8921560B2 (es)
EP (1) EP2651922B1 (es)
JP (2) JP5945278B2 (es)
KR (1) KR101914606B1 (es)
CN (1) CN103347875B (es)
AR (1) AR084335A1 (es)
AU (1) AU2011343256C1 (es)
BR (1) BR112013011949B1 (es)
CA (1) CA2822000C (es)
CL (1) CL2013001715A1 (es)
CY (1) CY1117763T1 (es)
DK (1) DK2651922T3 (es)
EA (1) EA022339B1 (es)
ES (1) ES2572258T3 (es)
HK (1) HK1185613A1 (es)
HR (1) HRP20160533T1 (es)
HU (1) HUE028009T2 (es)
IL (1) IL225641A (es)
ME (1) ME02406B (es)
MX (1) MX339944B (es)
MY (1) MY163981A (es)
NZ (1) NZ609487A (es)
PL (1) PL2651922T3 (es)
RS (1) RS54746B1 (es)
SG (1) SG189866A1 (es)
SI (1) SI2651922T1 (es)
SM (1) SMT201600142B (es)
TW (1) TWI515187B (es)
UA (1) UA109792C2 (es)
WO (1) WO2012080447A1 (es)
ZA (1) ZA201304423B (es)

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Also Published As

Publication number Publication date
CA2822000C (en) 2019-01-15
US9944638B2 (en) 2018-04-17
JP5945278B2 (ja) 2016-07-05
KR20140037800A (ko) 2014-03-27
ZA201304423B (en) 2014-12-23
EA022339B1 (ru) 2015-12-30
KR101914606B1 (ko) 2018-11-02
HUE028009T2 (en) 2016-11-28
HRP20160533T1 (hr) 2016-07-01
AU2011343256B2 (en) 2015-02-05
US8921560B2 (en) 2014-12-30
NZ609487A (en) 2014-10-31
RS54746B1 (sr) 2016-10-31
CA2822000A1 (en) 2012-06-21
JP2014503525A (ja) 2014-02-13
WO2012080447A1 (en) 2012-06-21
CY1117763T1 (el) 2017-05-17
CN103347875B (zh) 2016-03-30
TW201307325A (zh) 2013-02-16
PL2651922T3 (pl) 2016-10-31
ME02406B (me) 2016-09-20
HK1185613A1 (zh) 2014-02-21
AU2011343256C1 (en) 2015-08-13
AU2011343256A1 (en) 2013-05-02
CN103347875A (zh) 2013-10-09
AR084335A1 (es) 2013-05-08
EP2651922A1 (en) 2013-10-23
US20160237083A1 (en) 2016-08-18
BR112013011949B1 (pt) 2021-11-23
SMT201600142B (it) 2016-07-01
DK2651922T3 (en) 2016-05-30
JP2016145236A (ja) 2016-08-12
MY163981A (en) 2017-11-15
US20150073013A1 (en) 2015-03-12
SI2651922T1 (sl) 2016-08-31
CL2013001715A1 (es) 2013-12-20
ES2572258T3 (es) 2016-05-31
MX339944B (es) 2016-06-17
TWI515187B (zh) 2016-01-01
IL225641A0 (en) 2013-06-27
IL225641A (en) 2016-09-29
US20130267555A1 (en) 2013-10-10
US9321768B2 (en) 2016-04-26
SG189866A1 (en) 2013-07-31
EP2651922B1 (en) 2016-02-24
EA201390883A1 (ru) 2013-10-30
BR112013011949A2 (pt) 2016-08-23
UA109792C2 (uk) 2015-10-12

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