MX2020004917A - Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona. - Google Patents

Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona.

Info

Publication number
MX2020004917A
MX2020004917A MX2020004917A MX2020004917A MX2020004917A MX 2020004917 A MX2020004917 A MX 2020004917A MX 2020004917 A MX2020004917 A MX 2020004917A MX 2020004917 A MX2020004917 A MX 2020004917A MX 2020004917 A MX2020004917 A MX 2020004917A
Authority
MX
Mexico
Prior art keywords
processes
benzoazepin
benzodiazepin
resolution
derivatives
Prior art date
Application number
MX2020004917A
Other languages
English (en)
Inventor
Andrew Hague
Matthew Ronsheim
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of MX2020004917A publication Critical patent/MX2020004917A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a procesos e intermediarios útiles en la preparación de moléculas biológicamente activas, especialmente en la síntesis de inhibidores del Virus Sincitial Respiratorio (RSV). La presente invención también se refiere a procesos e intermediarios para la preparación de compuestos de Fórmula (I-0) y Fórmula (I) (VER FORMULA).
MX2020004917A 2017-11-13 2018-11-13 Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona. MX2020004917A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762585192P 2017-11-13 2017-11-13
PCT/US2018/060666 WO2019094903A1 (en) 2017-11-13 2018-11-13 Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives

Publications (1)

Publication Number Publication Date
MX2020004917A true MX2020004917A (es) 2020-08-06

Family

ID=66438977

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004917A MX2020004917A (es) 2017-11-13 2018-11-13 Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona.

Country Status (11)

Country Link
US (2) US10501422B2 (es)
EP (1) EP3710009A4 (es)
JP (1) JP7228588B2 (es)
KR (1) KR102634720B1 (es)
CN (1) CN111343990B (es)
AU (1) AU2018365174B2 (es)
BR (1) BR112020009210A2 (es)
CA (1) CA3080138A1 (es)
IL (1) IL274534B (es)
MX (1) MX2020004917A (es)
WO (1) WO2019094903A1 (es)

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WO2018226801A1 (en) 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as rsv inhibitors
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019067864A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV
WO2019094920A1 (en) 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as rsv inhibitors
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
WO2020190935A1 (en) 2019-03-18 2020-09-24 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as rsv inhibitors
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
WO2021066922A1 (en) 2019-10-04 2021-04-08 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents

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Also Published As

Publication number Publication date
AU2018365174B2 (en) 2023-03-30
US10851070B2 (en) 2020-12-01
JP7228588B2 (ja) 2023-02-24
RU2020116739A (ru) 2021-12-16
CN111343990B (zh) 2023-08-04
KR20200086696A (ko) 2020-07-17
WO2019094903A1 (en) 2019-05-16
CN111343990A (zh) 2020-06-26
US20190177283A1 (en) 2019-06-13
JP2021502367A (ja) 2021-01-28
KR102634720B1 (ko) 2024-02-06
AU2018365174A1 (en) 2020-06-11
EP3710009A1 (en) 2020-09-23
IL274534B (en) 2022-07-01
CA3080138A1 (en) 2019-05-16
US10501422B2 (en) 2019-12-10
IL274534A (en) 2020-06-30
US20200157057A1 (en) 2020-05-21
BR112020009210A2 (pt) 2020-10-20
EP3710009A4 (en) 2021-08-25

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