IL274534A - Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives - Google Patents

Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives

Info

Publication number
IL274534A
IL274534A IL274534A IL27453420A IL274534A IL 274534 A IL274534 A IL 274534A IL 274534 A IL274534 A IL 274534A IL 27453420 A IL27453420 A IL 27453420A IL 274534 A IL274534 A IL 274534A
Authority
IL
Israel
Prior art keywords
benzodiazepin
resolution
derivatives
processes
Prior art date
Application number
IL274534A
Other languages
Hebrew (he)
Other versions
IL274534B (en
Inventor
Andrew Hague
Original Assignee
Enanta Pharm Inc
Andrew Hague
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc, Andrew Hague filed Critical Enanta Pharm Inc
Publication of IL274534A publication Critical patent/IL274534A/en
Publication of IL274534B publication Critical patent/IL274534B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL274534A 2017-11-13 2018-11-13 Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives IL274534B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762585192P 2017-11-13 2017-11-13
PCT/US2018/060666 WO2019094903A1 (en) 2017-11-13 2018-11-13 Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives

Publications (2)

Publication Number Publication Date
IL274534A true IL274534A (en) 2020-06-30
IL274534B IL274534B (en) 2022-07-01

Family

ID=66438977

Family Applications (1)

Application Number Title Priority Date Filing Date
IL274534A IL274534B (en) 2017-11-13 2018-11-13 Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives

Country Status (11)

Country Link
US (2) US10501422B2 (en)
EP (1) EP3710009A4 (en)
JP (1) JP7228588B2 (en)
KR (1) KR102634720B1 (en)
CN (1) CN111343990B (en)
AU (1) AU2018365174B2 (en)
BR (1) BR112020009210A2 (en)
CA (1) CA3080138A1 (en)
IL (1) IL274534B (en)
MX (1) MX2020004917A (en)
WO (1) WO2019094903A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE060259T2 (en) 2015-07-22 2023-02-28 Enanta Pharm Inc Benzodiazepine derivatives as rsv inhibitors
CA3065368A1 (en) 2017-02-16 2018-08-23 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
BR112020006334A2 (en) 2017-09-29 2020-09-24 Enanta Pharmaceuticals, Inc. combination of pharmaceutical agents such as rsv inhibitors
WO2019094920A1 (en) 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as rsv inhibitors
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
KR20210138684A (en) 2019-03-18 2021-11-19 이난타 파마슈티칼스, 인코포레이티드 Benzodiazepine derivatives as RSV inhibitors
US11179400B2 (en) 2019-04-09 2021-11-23 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
AU2020357452A1 (en) 2019-10-04 2022-05-12 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (en) 2020-01-24 2021-07-30 Enanta Pharm Inc HETEROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH573928A5 (en) * 1973-07-30 1976-03-31 Crc Ricerca Chim
IT1087017B (en) * 1977-10-18 1985-05-31 Ravizza Spa PROCESS FOR THE PREPARATION OF A 7-CHLORO-5- (2-CHLOROPHENYL) -BENZODIAZE PINONE
US5571809A (en) 1989-04-20 1996-11-05 Boehringer Ingelheim Pharmaceuticals, Inc. The treatment of HIV-1 infection using certain pyridodiazepines
AU2759692A (en) 1991-10-24 1993-05-21 Glaxo Group Limited Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin
CA2130196A1 (en) * 1992-03-24 1993-09-30 Jose Luis Castro Pineiro Benzodiazepine derivatives
EP0703222A1 (en) 1993-05-13 1996-03-27 Yoshitomi Pharmaceutical Industries, Ltd. 3-aminoazepine compound and pharmaceutical use thereof
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
ATE258439T1 (en) 1999-04-30 2004-02-15 Univ Michigan USE OF BENZODIAZEPINES TO TREAT APOPTOSIS-INDUCED AUTOIMMUNE DISEASES
US7582624B2 (en) 2002-09-20 2009-09-01 Arrow Therapeutics Limited Benzodiazepine derivatives and pharmaceutical compositions containing them
GB0312365D0 (en) 2003-05-30 2003-07-02 Univ Aston Novel 3-substituted-1, 4-benzodiazepines
EP1682547B1 (en) 2003-10-30 2012-10-24 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
GB0406279D0 (en) 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406282D0 (en) 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
WO2005090319A1 (en) 2004-03-19 2005-09-29 Arrow Therapeutics Limited Process for preparing benzodiazepines
GB0406280D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
US20060083741A1 (en) 2004-10-08 2006-04-20 Hoffman Rebecca S Treatment of respiratory syncytial virus (RSV) infection
CA2595000C (en) 2005-01-25 2013-10-15 Synta Pharmaceuticals Corp. Thiophene compounds for inflammation and immune-related uses
JP2010510191A (en) 2006-11-17 2010-04-02 スミスクライン ビーチャム コーポレーション 2-Carboxythiophene derivatives as antiviral agents
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
US8999969B2 (en) 2009-07-09 2015-04-07 Gilead Sciences, Inc. Anti-RSV compounds
ES2654423T3 (en) 2009-11-05 2018-02-13 Glaxosmithkline Llc Benzodiazepine Bromodomain Inhibitor
WO2011151651A1 (en) * 2010-06-03 2011-12-08 Arrow Therapeutics Limited Benzodiazepine compounds useful for the treatment of hepatitis c
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI501967B (en) 2010-12-16 2015-10-01 Janssen R&D Ireland Azaindoles as respiratory syncytial virus antiviral agents
TWI527814B (en) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 Azabenzimidazoles as respiratory syncytial virus antiviral agents
TWI541241B (en) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 Imidazopyridines as respiratory syncytial virus antiviral agents
TWI530495B (en) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 Benzimidazole respiratory syncytial virus inhibitors
TWI515187B (en) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 Indoles as respiratory syncytial virus antiviral agents
TWI530489B (en) * 2011-03-22 2016-04-21 必治妥美雅史谷比公司 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds
GB201114183D0 (en) 2011-08-17 2011-10-05 Dyson Technology Ltd A hand dryer
JP6122868B2 (en) 2011-12-22 2017-04-26 ギリアード サイエンシーズ， インコーポレイテッド Pyrazolo [1,5-A] pyrimidine as an antiviral agent
US10460075B2 (en) 2012-06-14 2019-10-29 Sony Corporation Information processing apparatus and method to move a display area of a needle biopsy image
EP2864325A1 (en) 2012-06-15 2015-04-29 Janssen Sciences Ireland UC 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
EA201590023A1 (en) 2012-06-15 2015-05-29 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД NEW 4-SUBSTITUTED DERIVATIVES WITH 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-SHE, SUBSTITUTED WITH BENZIMIDAZOLES, AS ANTI-VIRUS MEANS AGAINST RESPIRATORY SYNCIAL VIRUS
WO2014047397A1 (en) * 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch|inhibitors
CN104822677A (en) * 2012-09-21 2015-08-05 百时美施贵宝公司 Fluoroalkyl-1,4-benzodiazepinone compounds
WO2014047369A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Substituted 1,5-benzodiazepinone compounds
CN104903313B (en) 2012-10-16 2017-12-29 爱尔兰詹森科学公司 Rsv antiviral compounds
TWI648274B (en) 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 Heterocyclic guanamines as kinase inhibitors (2)
JO3603B1 (en) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
UA123854C2 (en) 2013-08-21 2021-06-16 Аліос Біофарма, Інк. Antiviral compounds
EP3204389B1 (en) 2014-10-10 2019-06-26 Pulmocide Limited Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative
EP3233867B1 (en) 2014-12-18 2018-10-17 Pulmocide Limited 4,5-dihydro-6h-thieno[3,2-d]benzazepine derivatives and their use to treat respiratory syncytial virus (rsv) infections
HUE060259T2 (en) 2015-07-22 2023-02-28 Enanta Pharm Inc Benzodiazepine derivatives as rsv inhibitors
CN108699077B (en) 2016-01-15 2021-03-02 英安塔制药有限公司 Heterocyclic compounds as RSV inhibitors
JP6974331B2 (en) 2016-02-05 2021-12-01 デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. Compounds, compositions and methods
WO2018129287A1 (en) 2017-01-06 2018-07-12 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as rsv inhibitors
CA3065368A1 (en) 2017-02-16 2018-08-23 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors

Also Published As

Publication number Publication date
WO2019094903A1 (en) 2019-05-16
AU2018365174B2 (en) 2023-03-30
CN111343990A (en) 2020-06-26
JP7228588B2 (en) 2023-02-24
KR20200086696A (en) 2020-07-17
US20190177283A1 (en) 2019-06-13
KR102634720B1 (en) 2024-02-06
CA3080138A1 (en) 2019-05-16
US20200157057A1 (en) 2020-05-21
RU2020116739A (en) 2021-12-16
AU2018365174A1 (en) 2020-06-11
BR112020009210A2 (en) 2020-10-20
IL274534B (en) 2022-07-01
EP3710009A1 (en) 2020-09-23
JP2021502367A (en) 2021-01-28
MX2020004917A (en) 2020-08-06
EP3710009A4 (en) 2021-08-25
US10851070B2 (en) 2020-12-01
CN111343990B (en) 2023-08-04
US10501422B2 (en) 2019-12-10

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