IL274534A - Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives - Google Patents
Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivativesInfo
- Publication number
- IL274534A IL274534A IL274534A IL27453420A IL274534A IL 274534 A IL274534 A IL 274534A IL 274534 A IL274534 A IL 274534A IL 27453420 A IL27453420 A IL 27453420A IL 274534 A IL274534 A IL 274534A
- Authority
- IL
- Israel
- Prior art keywords
- benzodiazepin
- resolution
- derivatives
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762585192P | 2017-11-13 | 2017-11-13 | |
| PCT/US2018/060666 WO2019094903A1 (en) | 2017-11-13 | 2018-11-13 | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL274534A true IL274534A (en) | 2020-06-30 |
| IL274534B IL274534B (en) | 2022-07-01 |
Family
ID=66438977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL274534A IL274534B (en) | 2017-11-13 | 2018-11-13 | Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10501422B2 (en) |
| EP (1) | EP3710009A4 (en) |
| JP (1) | JP7228588B2 (en) |
| KR (1) | KR102634720B1 (en) |
| CN (1) | CN111343990B (en) |
| AU (1) | AU2018365174B2 (en) |
| BR (1) | BR112020009210A2 (en) |
| CA (1) | CA3080138A1 (en) |
| IL (1) | IL274534B (en) |
| MX (1) | MX2020004917A (en) |
| WO (1) | WO2019094903A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7112324B2 (en) | 2015-07-22 | 2022-08-03 | エナンタ ファーマシューティカルズ インコーポレイテッド | Benzodiazepine derivatives as RSV inhibitors |
| JP7076459B2 (en) | 2017-02-16 | 2022-05-27 | エナンタ ファーマシューティカルズ インコーポレイテッド | Benzodiazepine derivative manufacturing process |
| US10752598B2 (en) | 2017-06-07 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as RSV inhibitors |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as rsv inhibitors |
| WO2019094920A1 (en) | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as rsv inhibitors |
| US10975094B2 (en) | 2018-04-11 | 2021-04-13 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| CN113710276B (en) | 2019-03-18 | 2024-03-29 | 英安塔制药有限公司 | Benzodiazepine derivatives as RSV inhibitors |
| US11179400B2 (en) | 2019-04-09 | 2021-11-23 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| KR20220101083A (en) | 2019-10-04 | 2022-07-19 | 이난타 파마슈티칼스, 인코포레이티드 | Antiviral Heterocyclic Compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (en) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | HETEROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH573928A5 (en) * | 1973-07-30 | 1976-03-31 | Crc Ricerca Chim | |
| IT1087017B (en) * | 1977-10-18 | 1985-05-31 | Ravizza Spa | PROCESS FOR THE PREPARATION OF A 7-CHLORO-5- (2-CHLOROPHENYL) -BENZODIAZE PINONE |
| US5571809A (en) | 1989-04-20 | 1996-11-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | The treatment of HIV-1 infection using certain pyridodiazepines |
| AU2759692A (en) | 1991-10-24 | 1993-05-21 | Glaxo Group Limited | Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin |
| EP0636123A1 (en) * | 1992-03-24 | 1995-02-01 | MERCK SHARP & DOHME LTD. | 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy |
| EP0703222A1 (en) | 1993-05-13 | 1996-03-27 | Yoshitomi Pharmaceutical Industries, Ltd. | 3-aminoazepine compound and pharmaceutical use thereof |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| EP2062583B1 (en) | 1999-04-30 | 2012-12-26 | The Regents of the University of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| JP4719466B2 (en) | 2002-09-20 | 2011-07-06 | アロー セラピューティクス リミテッド | Benzodiazepine derivatives and pharmaceutical compositions containing them |
| GB0312365D0 (en) | 2003-05-30 | 2003-07-02 | Univ Aston | Novel 3-substituted-1, 4-benzodiazepines |
| JP4537407B2 (en) | 2003-10-30 | 2010-09-01 | ベーリンガー インゲルハイム （カナダ） リミテッド | RSV polymerase inhibitor |
| GB0406279D0 (en) | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| GB0406280D0 (en) | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Chemical compounds |
| WO2005090319A1 (en) | 2004-03-19 | 2005-09-29 | Arrow Therapeutics Limited | Process for preparing benzodiazepines |
| GB0406282D0 (en) | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| WO2006041970A2 (en) | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
| EP1846388A4 (en) | 2005-01-25 | 2011-12-07 | Synta Pharmaceuticals Corp | Thiophene compounds for inflammation and immune-related uses |
| ATE524465T1 (en) | 2006-11-17 | 2011-09-15 | Glaxosmithkline Llc | 2-CARBOXY-THIOPHENE DERIVATIVES AS VIRUCIDES |
| US20100278835A1 (en) | 2009-03-10 | 2010-11-04 | Astrazeneca Uk Limited | Novel compounds 660 |
| WO2011005842A1 (en) | 2009-07-09 | 2011-01-13 | Gilead Sciences, Inc. | Anti-rsv compounds |
| ME02356B (en) | 2009-11-05 | 2016-06-20 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
| WO2011151651A1 (en) | 2010-06-03 | 2011-12-08 | Arrow Therapeutics Limited | Benzodiazepine compounds useful for the treatment of hepatitis c |
| US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
| TWI501967B (en) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | Azaindoles as respiratory syncytial virus antiviral agents |
| TWI541241B (en) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | Imidazopyridines as respiratory syncytial virus antiviral agents |
| TWI530495B (en) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | Benzimidazole respiratory syncytial virus inhibitors |
| TWI515187B (en) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | Indoles as respiratory syncytial virus antiviral agents |
| TWI527814B (en) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | Azabenzimidazoles as respiratory syncytial virus antiviral agents |
| TWI530489B (en) * | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
| GB201114183D0 (en) | 2011-08-17 | 2011-10-05 | Dyson Technology Ltd | A hand dryer |
| JP6122868B2 (en) | 2011-12-22 | 2017-04-26 | ギリアード サイエンシーズ， インコーポレイテッド | Pyrazolo [1,5-A] pyrimidine as an antiviral agent |
| EP3276332A3 (en) | 2012-06-14 | 2018-04-18 | Sony Corporation | Information processing apparatus, information processing method, and information processing program |
| US20150175608A1 (en) | 2012-06-15 | 2015-06-25 | Janssen R&D Ireland | Novel 4-substituted 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| WO2013186334A1 (en) | 2012-06-15 | 2013-12-19 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| CN104822665A (en) * | 2012-09-21 | 2015-08-05 | 百时美施贵宝公司 | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch inhibitors |
| EP2897944B1 (en) | 2012-09-21 | 2016-10-26 | Bristol-Myers Squibb Company | Substituted 1,5-benzodiazepinone compounds |
| CN104822677A (en) | 2012-09-21 | 2015-08-05 | 百时美施贵宝公司 | Fluoroalkyl-1,4-benzodiazepinone compounds |
| PL2909195T3 (en) | 2012-10-16 | 2017-12-29 | Janssen Sciences Ireland Uc | Rsv antiviral compounds |
| TWI648274B (en) | 2013-02-15 | 2019-01-21 | 英商葛蘭素史克智慧財產發展有限公司 | Heterocyclic guanamines as kinase inhibitors (2) |
| JO3603B1 (en) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| AU2014308991B2 (en) | 2013-08-21 | 2019-02-14 | Janssen Biopharma, Inc. | Antiviral compounds |
| EP3204388B1 (en) | 2014-10-10 | 2018-12-12 | Pulmocide Limited | Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivatives |
| WO2016097761A1 (en) | 2014-12-18 | 2016-06-23 | Pulmocide Limited | 4,5-dihydro-6h-thieno[3,2-d]benzazepine derivatives and their use to treat respiratory syncytial virus (rsv) infections |
| JP7112324B2 (en) | 2015-07-22 | 2022-08-03 | エナンタ ファーマシューティカルズ インコーポレイテッド | Benzodiazepine derivatives as RSV inhibitors |
| CN108699077B (en) | 2016-01-15 | 2021-03-02 | 英安塔制药有限公司 | Heterocyclic compounds as RSV inhibitors |
| EP3414239A2 (en) | 2016-02-05 | 2018-12-19 | Denali Therapeutics Inc. | Inhibitors of receptor-interacting protein kinase 1 |
| US10398706B2 (en) | 2017-01-06 | 2019-09-03 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as RSV inhibitors |
| JP7076459B2 (en) | 2017-02-16 | 2022-05-27 | エナンタ ファーマシューティカルズ インコーポレイテッド | Benzodiazepine derivative manufacturing process |
| US10752598B2 (en) | 2017-06-07 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as RSV inhibitors |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
-
2018
- 2018-11-13 WO PCT/US2018/060666 patent/WO2019094903A1/en unknown
- 2018-11-13 AU AU2018365174A patent/AU2018365174B2/en active Active
- 2018-11-13 US US16/188,954 patent/US10501422B2/en active Active
- 2018-11-13 BR BR112020009210-0A patent/BR112020009210A2/en unknown
- 2018-11-13 KR KR1020207016471A patent/KR102634720B1/en active IP Right Grant
- 2018-11-13 CN CN201880072467.3A patent/CN111343990B/en active Active
- 2018-11-13 IL IL274534A patent/IL274534B/en unknown
- 2018-11-13 EP EP18875856.9A patent/EP3710009A4/en active Pending
- 2018-11-13 JP JP2020525856A patent/JP7228588B2/en active Active
- 2018-11-13 MX MX2020004917A patent/MX2020004917A/en unknown
- 2018-11-13 CA CA3080138A patent/CA3080138A1/en active Pending
-
2019
- 2019-11-14 US US16/683,303 patent/US10851070B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7228588B2 (en) | 2023-02-24 |
| MX2020004917A (en) | 2020-08-06 |
| RU2020116739A (en) | 2021-12-16 |
| US20190177283A1 (en) | 2019-06-13 |
| JP2021502367A (en) | 2021-01-28 |
| EP3710009A1 (en) | 2020-09-23 |
| WO2019094903A1 (en) | 2019-05-16 |
| AU2018365174A1 (en) | 2020-06-11 |
| CA3080138A1 (en) | 2019-05-16 |
| KR20200086696A (en) | 2020-07-17 |
| CN111343990A (en) | 2020-06-26 |
| BR112020009210A2 (en) | 2020-10-20 |
| AU2018365174B2 (en) | 2023-03-30 |
| US20200157057A1 (en) | 2020-05-21 |
| IL274534B (en) | 2022-07-01 |
| US10501422B2 (en) | 2019-12-10 |
| CN111343990B (en) | 2023-08-04 |
| EP3710009A4 (en) | 2021-08-25 |
| US10851070B2 (en) | 2020-12-01 |
| KR102634720B1 (en) | 2024-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL274534A (en) | Processes for the resolution of benzodiazepin-2-one and benzodiazepin-2-one derivatives | |
| IL268737A (en) | Processes for the preparation of benzodiazepine derivatives | |
| HK1249175A1 (en) | Imaging systems and methods of using the same | |
| IL273236A (en) | Pyrazolopyrimidinone compounds and uses thereof | |
| IL271025A (en) | Multibiotic agents and methods of using the same | |
| EP3468973A4 (en) | Solid forms of venetoclax and processes for the preparation of venetoclax | |
| IL261414B (en) | Solid state forms of venetoclax and processes for preparation of venetoclax | |
| IL273440A (en) | Potentiating the effect of atp release | |
| IL292488B1 (en) | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds | |
| IL266132A (en) | Pharmaceutical formulations and methods of making the same | |
| SG11202008543RA (en) | Pyrrolidineamide derivatives and uses thereof | |
| IL263969A (en) | Benzodioxane derivatives and their pharmaceutical use | |
| IL278973A (en) | Novel benzodiazepine derivatives and uses thereof | |
| HUE062956T2 (en) | Processes for the preparation of niraparib and intermediates thereof | |
| SG11201706048SA (en) | Magnetoresistive device and method of forming the same | |
| PT3796975T (en) | Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives | |
| EP3659125C0 (en) | Lock and apparatus comprising the same | |
| IL292482B1 (en) | Azaindolylpyridone and diazaindolylpyridone compounds | |
| ZA201607353B (en) | Bicyclic derivatives and pharmaceutical composition including the same | |
| GB201700404D0 (en) | Compounds and composistions | |
| IL273539A (en) | Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same | |
| ZA202000959B (en) | Adamantylmethylamine derivative and use thereof as pharmaceutical | |
| PL3476256T3 (en) | Bed system and use of the bed system | |
| GB201710557D0 (en) | Lock and apparatus comprising the same | |
| TWI560711B (en) | Fastening device and method of using the same |