SMT201600142B - Indoli come agenti antivirali contro il virus respiratorio sinciziale - Google Patents

Indoli come agenti antivirali contro il virus respiratorio sinciziale

Info

Publication number
SMT201600142B
SMT201600142B SM201600142T SM201600142T SMT201600142B SM T201600142 B SMT201600142 B SM T201600142B SM 201600142 T SM201600142 T SM 201600142T SM 201600142 T SM201600142 T SM 201600142T SM T201600142 B SMT201600142 B SM T201600142B
Authority
SM
San Marino
Prior art keywords
sincitial
indules
viral agents
agents against
respiratory virus
Prior art date
Application number
SM201600142T
Other languages
English (en)
Inventor
Ludwig Paul Cooymans
Samuel Dominique Demin
Lili Hu
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Abdellah Tahri
Sandrine Marie Helene Vendeville
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of SMT201600142B publication Critical patent/SMT201600142B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SM201600142T 2010-12-16 2016-05-20 Indoli come agenti antivirali contro il virus respiratorio sinciziale SMT201600142B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10195468 2010-12-16
EP11794793.7A EP2651922B1 (en) 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents
PCT/EP2011/073011 WO2012080447A1 (en) 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents

Publications (1)

Publication Number Publication Date
SMT201600142B true SMT201600142B (it) 2016-07-01

Family

ID=43875270

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600142T SMT201600142B (it) 2010-12-16 2016-05-20 Indoli come agenti antivirali contro il virus respiratorio sinciziale

Country Status (31)

Country Link
US (3) US8921560B2 (it)
EP (1) EP2651922B1 (it)
JP (2) JP5945278B2 (it)
KR (1) KR101914606B1 (it)
CN (1) CN103347875B (it)
AR (1) AR084335A1 (it)
AU (1) AU2011343256C1 (it)
BR (1) BR112013011949B1 (it)
CA (1) CA2822000C (it)
CL (1) CL2013001715A1 (it)
CY (1) CY1117763T1 (it)
DK (1) DK2651922T3 (it)
EA (1) EA022339B1 (it)
ES (1) ES2572258T3 (it)
HR (1) HRP20160533T1 (it)
HU (1) HUE028009T2 (it)
IL (1) IL225641A (it)
ME (1) ME02406B (it)
MX (1) MX339944B (it)
MY (1) MY163981A (it)
NZ (1) NZ609487A (it)
PH (1) PH12013500797A1 (it)
PL (1) PL2651922T3 (it)
RS (1) RS54746B1 (it)
SG (1) SG189866A1 (it)
SI (1) SI2651922T1 (it)
SM (1) SMT201600142B (it)
TW (1) TWI515187B (it)
UA (1) UA109792C2 (it)
WO (1) WO2012080447A1 (it)
ZA (1) ZA201304423B (it)

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TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
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TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
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Also Published As

Publication number Publication date
TW201307325A (zh) 2013-02-16
CL2013001715A1 (es) 2013-12-20
AU2011343256B2 (en) 2015-02-05
US8921560B2 (en) 2014-12-30
US20150073013A1 (en) 2015-03-12
CN103347875B (zh) 2016-03-30
PL2651922T3 (pl) 2016-10-31
SG189866A1 (en) 2013-07-31
KR101914606B1 (ko) 2018-11-02
ME02406B (me) 2016-09-20
AU2011343256A1 (en) 2013-05-02
JP2014503525A (ja) 2014-02-13
DK2651922T3 (en) 2016-05-30
PH12013500797A1 (en) 2013-06-24
ES2572258T3 (es) 2016-05-31
CA2822000C (en) 2019-01-15
TWI515187B (zh) 2016-01-01
JP5945278B2 (ja) 2016-07-05
HUE028009T2 (en) 2016-11-28
MX2013006887A (es) 2013-07-05
ZA201304423B (en) 2014-12-23
HRP20160533T1 (hr) 2016-07-01
BR112013011949A2 (pt) 2016-08-23
JP2016145236A (ja) 2016-08-12
WO2012080447A1 (en) 2012-06-21
AU2011343256C1 (en) 2015-08-13
BR112013011949B1 (pt) 2021-11-23
EA022339B1 (ru) 2015-12-30
CA2822000A1 (en) 2012-06-21
EA201390883A1 (ru) 2013-10-30
HK1185613A1 (zh) 2014-02-21
EP2651922A1 (en) 2013-10-23
SI2651922T1 (sl) 2016-08-31
EP2651922B1 (en) 2016-02-24
CN103347875A (zh) 2013-10-09
US9944638B2 (en) 2018-04-17
US20130267555A1 (en) 2013-10-10
UA109792C2 (uk) 2015-10-12
MY163981A (en) 2017-11-15
KR20140037800A (ko) 2014-03-27
NZ609487A (en) 2014-10-31
IL225641A0 (en) 2013-06-27
IL225641A (en) 2016-09-29
MX339944B (es) 2016-06-17
RS54746B1 (sr) 2016-10-31
US9321768B2 (en) 2016-04-26
AR084335A1 (es) 2013-05-08
US20160237083A1 (en) 2016-08-18
CY1117763T1 (el) 2017-05-17

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