NZ609487A - Indoles as respiratory syncytial virus antiviral agents - Google Patents

Indoles as respiratory syncytial virus antiviral agents

Info

Publication number
NZ609487A
NZ609487A NZ609487A NZ60948711A NZ609487A NZ 609487 A NZ609487 A NZ 609487A NZ 609487 A NZ609487 A NZ 609487A NZ 60948711 A NZ60948711 A NZ 60948711A NZ 609487 A NZ609487 A NZ 609487A
Authority
NZ
New Zealand
Prior art keywords
indoles
imidazo
pyridin
indole
cyclopropyl
Prior art date
Application number
NZ609487A
Other languages
English (en)
Inventor
Ludwig Paul Cooymans
Samuël Dominique Demin
Lili Hu
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Abdellah Tahri
Sandrine Marie Helene Vendeville
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of NZ609487A publication Critical patent/NZ609487A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ609487A 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents NZ609487A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195468 2010-12-16
PCT/EP2011/073011 WO2012080447A1 (en) 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents

Publications (1)

Publication Number Publication Date
NZ609487A true NZ609487A (en) 2014-10-31

Family

ID=43875270

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ609487A NZ609487A (en) 2010-12-16 2011-12-16 Indoles as respiratory syncytial virus antiviral agents

Country Status (31)

Country Link
US (3) US8921560B2 (enExample)
EP (1) EP2651922B1 (enExample)
JP (2) JP5945278B2 (enExample)
KR (1) KR101914606B1 (enExample)
CN (1) CN103347875B (enExample)
AR (1) AR084335A1 (enExample)
AU (1) AU2011343256C1 (enExample)
BR (1) BR112013011949B1 (enExample)
CA (1) CA2822000C (enExample)
CL (1) CL2013001715A1 (enExample)
CY (1) CY1117763T1 (enExample)
DK (1) DK2651922T3 (enExample)
EA (1) EA022339B1 (enExample)
ES (1) ES2572258T3 (enExample)
HR (1) HRP20160533T1 (enExample)
HU (1) HUE028009T2 (enExample)
IL (1) IL225641A (enExample)
ME (1) ME02406B (enExample)
MX (1) MX339944B (enExample)
MY (1) MY163981A (enExample)
NZ (1) NZ609487A (enExample)
PH (1) PH12013500797A1 (enExample)
PL (1) PL2651922T3 (enExample)
RS (1) RS54746B1 (enExample)
SG (1) SG189866A1 (enExample)
SI (1) SI2651922T1 (enExample)
SM (1) SMT201600142B (enExample)
TW (1) TWI515187B (enExample)
UA (1) UA109792C2 (enExample)
WO (1) WO2012080447A1 (enExample)
ZA (1) ZA201304423B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
EA201590021A1 (ru) * 2012-06-15 2015-04-30 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Новые замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса
PT2864323T (pt) * 2012-06-15 2017-07-14 Janssen Sciences Ireland Uc Derivados de 1,3-di-hidro-2h-benzimidazol-2-ona substituídos com heterociclos como agentes antivirais do vírus sincicial respiratório
CN104487431B (zh) * 2012-07-10 2017-06-09 弗·哈夫曼-拉罗切有限公司 治疗和预防呼吸道合胞体病毒感染的新吲唑类化合物
LT2909195T (lt) 2012-10-16 2017-09-25 Janssen Sciences Ireland Uc Antivirusiniai rsv junginiai
HK1225716A1 (zh) 2013-08-21 2017-09-15 Alios Biopharma, Inc. 抗病毒化合物
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為ｒｓｖ抗病毒化合物之螺脲化合物
EP3177299A4 (en) * 2014-08-05 2018-04-04 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
EA201792028A1 (ru) 2015-03-13 2018-04-30 Форма Терапьютикс, Инк. Альфа-цинамидные соединения и композиции как ингибиторы hdac8
AU2016297024B2 (en) 2015-07-22 2021-03-04 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
RU2750151C2 (ru) 2015-11-20 2021-06-22 Форма Терапьютикс, Инк. Гипоксантины в качестве ингибиторов убиквитин-специфической протеазы 1
EP3402799B1 (en) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
EA202092250A1 (ru) * 2016-02-03 2020-12-11 Янссен Сайенсиз Айрлэнд Юси Комбинированные продукты для лечения rsv
WO2017157735A1 (de) 2016-03-15 2017-09-21 Bayer Cropscience Aktiengesellschaft Substituierte sulfonylamide zur bekämpfung tierischer schädlinge
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
AU2018221820B2 (en) 2017-02-16 2023-11-02 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
WO2019067864A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV
MX394621B (es) 2017-11-13 2025-03-24 Enanta Pharm Inc Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona
TW201936193A (zh) * 2017-12-05 2019-09-16 愛爾蘭商健生科學愛爾蘭無限公司 使用組合產品治療ｒｓｖ
JP7558189B2 (ja) 2019-03-18 2024-09-30 エナンタ ファーマシューティカルズ インコーポレイテッド Ｒｓｖ阻害剤としてのベンゾジアゼピン誘導体
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CA3153297A1 (en) 2019-10-04 2021-04-08 Adam SZYMANIAK Antiviral heterocyclic compounds
MX2022005257A (es) * 2019-10-30 2022-06-09 Janssen Sciences Ireland Unlimited Co Sintesis de 3-({5-cloro-1-[3-(metilsulfonil)propil]-1h-indol-2-il} metil)-1-(2,2,2-trifluoroetil)-1,3-dihidro-2h-imidazo[4,5-c]pirid in-2-ona.
BR112022007208A2 (pt) * 2019-10-30 2022-07-26 Janssen Sciences Ireland Unlimited Co Síntese de 3-nitro-n-(2,2,2-trifluoroetil)-4-piridinamina
CN114641467A (zh) 2019-11-07 2022-06-17 拜耳公司 用于防治动物有害物的取代的磺酰胺
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2021250180A1 (en) 2020-06-11 2021-12-16 Janssen Sciences Ireland Unlimited Company Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
CN116528850B (zh) 2020-10-28 2025-08-22 盐野义制药株式会社 具有抗病毒活性的酰胺衍生物
WO2022182861A1 (en) 2021-02-26 2022-09-01 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
WO2022184606A1 (en) 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
CN114014856B (zh) * 2021-11-26 2023-12-22 嘉兴安谛康生物科技有限公司 作为呼吸道合胞病毒抗病毒剂的咪唑并吡啶类衍生物
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
WO2023211997A1 (en) 2022-04-27 2023-11-02 Enanta Pharmaceuticals, Inc. Antiviral compounds
WO2024174953A1 (zh) * 2023-02-21 2024-08-29 苏州隆博泰药业有限公司 苯并咪唑类衍生物及其医药用途

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2259573A1 (en) 1996-07-08 1998-01-15 Ruth Richmond Wexler Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin
WO2000020400A1 (en) 1998-10-05 2000-04-13 Axys Pharmaceuticals, Inc. Novel compounds and compositions for treating hepatitis c infections
JP2002532479A (ja) 1998-12-18 2002-10-02 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼインヒビター
CA2376781A1 (en) 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors
EA005027B1 (ru) 1999-06-28 2004-10-28 Янссен Фармацевтика Н.В. Ингибиторы репликации респираторно-синцитиального вируса
AU6762400A (en) * 1999-08-12 2001-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
US20020072530A1 (en) * 2000-02-01 2002-06-13 Bing-Yan Zhu Indole and benzimidazole inhibitors of factor Xa
EP1263754A1 (en) * 2000-02-01 2002-12-11 Millennium Pharmaceuticals, Inc. INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) * 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2003049688A2 (en) 2001-12-10 2003-06-19 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
GB2384778A (en) 2001-12-21 2003-08-06 Sense Proteomic Ltd Probe for mass spectrometry
AU2003294249A1 (en) 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
PE20050068A1 (es) 2003-02-06 2005-03-11 Novartis Ag 2-cianopirrolopirimidinas como inhibidores de la catepsina s
US7343930B2 (en) 2004-12-03 2008-03-18 Masco Corporation Of Indiana Sprayer with non-faucet control
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
US9150556B2 (en) 2007-05-22 2015-10-06 Boehringer Ingelheim International Gmbh Benzimidazolone chymase inhibitors
FR2926556B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) * 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
DK3603704T3 (da) 2010-12-17 2023-07-24 Sanofi Aventis Deutschland Indgivelse af medikament
AU2013276520A1 (en) 2012-06-15 2014-12-04 Janssen Sciences Ireland Uc 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
PT2864323T (pt) 2012-06-15 2017-07-14 Janssen Sciences Ireland Uc Derivados de 1,3-di-hidro-2h-benzimidazol-2-ona substituídos com heterociclos como agentes antivirais do vírus sincicial respiratório
KR20150028969A (ko) 2012-06-15 2015-03-17 얀센 알 앤드 디 아일랜드 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 4-치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
EA201590021A1 (ru) 2012-06-15 2015-04-30 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Новые замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса
LT2909195T (lt) 2012-10-16 2017-09-25 Janssen Sciences Ireland Uc Antivirusiniai rsv junginiai

Also Published As

Publication number Publication date
IL225641A (en) 2016-09-29
JP2014503525A (ja) 2014-02-13
BR112013011949A2 (pt) 2016-08-23
US9321768B2 (en) 2016-04-26
ES2572258T3 (es) 2016-05-31
RS54746B1 (sr) 2016-10-31
HK1185613A1 (zh) 2014-02-21
CN103347875B (zh) 2016-03-30
ZA201304423B (en) 2014-12-23
CY1117763T1 (el) 2017-05-17
TWI515187B (zh) 2016-01-01
CA2822000A1 (en) 2012-06-21
US8921560B2 (en) 2014-12-30
AU2011343256A1 (en) 2013-05-02
EA022339B1 (ru) 2015-12-30
BR112013011949B1 (pt) 2021-11-23
US20130267555A1 (en) 2013-10-10
AU2011343256C1 (en) 2015-08-13
AR084335A1 (es) 2013-05-08
PL2651922T3 (pl) 2016-10-31
JP2016145236A (ja) 2016-08-12
AU2011343256B2 (en) 2015-02-05
CL2013001715A1 (es) 2013-12-20
SG189866A1 (en) 2013-07-31
US9944638B2 (en) 2018-04-17
HRP20160533T1 (hr) 2016-07-01
KR20140037800A (ko) 2014-03-27
CN103347875A (zh) 2013-10-09
MX339944B (es) 2016-06-17
ME02406B (me) 2016-09-20
SMT201600142B (it) 2016-07-01
JP5945278B2 (ja) 2016-07-05
IL225641A0 (en) 2013-06-27
MY163981A (en) 2017-11-15
CA2822000C (en) 2019-01-15
TW201307325A (zh) 2013-02-16
SI2651922T1 (sl) 2016-08-31
EA201390883A1 (ru) 2013-10-30
HUE028009T2 (en) 2016-11-28
UA109792C2 (uk) 2015-10-12
KR101914606B1 (ko) 2018-11-02
WO2012080447A1 (en) 2012-06-21
EP2651922A1 (en) 2013-10-23
DK2651922T3 (en) 2016-05-30
MX2013006887A (es) 2013-07-05
PH12013500797A1 (en) 2013-06-24
US20160237083A1 (en) 2016-08-18
EP2651922B1 (en) 2016-02-24
US20150073013A1 (en) 2015-03-12

Similar Documents

Publication Publication Date Title
NZ609487A (en) Indoles as respiratory syncytial virus antiviral agents
MY156641A (en) Benzimidazole respiratory syncytial virus inhibitors
NZ547615A (en) Quinoline derivatives and use thereof as mycobacterial inhibitors
PH12015500457A1 (en) Alkoxy pyrazoles as soluble guanylate cyclase activators
MX2013001805A (es) Derivados de 2-(arilamino)-3h-imidazo [4,5-b] piridina-6-carboxamida y su uso como inhibidores de mpges-1.
MX2010004232A (es) Compuesto de indolina de pirimidilo.
MX2010012390A (es) Derivados de indazoles sustituidos con fenilo o piridinilo.
EA201390884A1 (ru) Азабензимидазолы в качестве противовирусных средств в отношении респираторного синцитиального вируса
EP4219465A3 (en) Prmt5 inhibitors and uses thereof
MX2021008356A (es) Inhibidores de jak2 y alk2 y metodos para su uso.
NZ600801A (en) Substituted imidazopyridinyl-aminopyridine compounds
NZ604716A (en) 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
WO2009080836A3 (en) Macrocyclic indoles as hepatitis c virus inhibitors
MX2012000414A (es) Derivados piridin-4-ilo.
MX351305B (es) Antagonistas del receptor de mineralocorticoides.
JO3115B1 (ar) مركبات بيريدازينون واستخدامها كمثبطات daao
MX2010001338A (es) Derivados de pirimidina y piridina y su uso y composiciones farmaceuticas.
WO2008099874A1 (ja) ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法
TN2016000556A1 (en) Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators
TN2012000031A1 (en) Tablet
CO6341560A2 (es) Proceso para la preparacion de derivados de pirimidina sustituidos.
WO2014014794A3 (en) Mineralocorticoid receptor antagonists
TN2012000093A1 (en) Therapeutic agent for anxiety disorders
MX2010008778A (es) Derivados de 3-alquil-piperazina y usos de la misma.
MX2009013240A (es) Derivados de carboxamida heterociclicos, su uso farmaceutico y composiciones.

Legal Events

Date Code Title Description
PSEA Patent sealed
ASS Change of ownership

Owner name: JANSSEN SCIENCES IRELAND UC, IE

Effective date: 20150723

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2016 BY CPA GLOBAL

Effective date: 20151030

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2017 BY CPA GLOBAL

Effective date: 20161108

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2018 BY CPA GLOBAL

Effective date: 20171102

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2019 BY CPA GLOBAL

Effective date: 20181102

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2020 BY CPA GLOBAL

Effective date: 20191031

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2021 BY CPA GLOBAL

Effective date: 20201030

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2022 BY CPA GLOBAL

Effective date: 20211104

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2023 BY CPA GLOBAL

Effective date: 20221108

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2024 BY CPA GLOBAL

Effective date: 20231102

LAPS Patent lapsed