MX2009008779A - Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación. - Google Patents

Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación.

Info

Publication number
MX2009008779A
MX2009008779A MX2009008779A MX2009008779A MX2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A MX 2009008779 A MX2009008779 A MX 2009008779A
Authority
MX
Mexico
Prior art keywords
pyrazine derivative
pharmaceutical composition
combination
treatment
influenza
Prior art date
Application number
MX2009008779A
Other languages
English (en)
Inventor
Masako Maekawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of MX2009008779A publication Critical patent/MX2009008779A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se divulga una composición farmacéutica que comprende un derivado de pirazina representado por la formula general: [En donde R1 y R2 representan un átomo de hidrogeno o un átomo de halógeno y R3 representa un átomo de hidrogeno o un grupo protector de amino] o una sal del mismo y por lo menos un inhibidor de neuraminidasa. La composición farmacéutica es útil para el tra5tamiento incluyendo el tratamiento o prevención de la influenza. También se divulga un método para usar estos compuestos en combinación. El método es útil para el tratamiento que incluye el tratamiento prevención de la influenza.
MX2009008779A 2007-02-16 2008-02-14 Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación. MX2009008779A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007035975 2007-02-16
PCT/JP2008/052425 WO2008099874A1 (ja) 2007-02-16 2008-02-14 ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法

Publications (1)

Publication Number Publication Date
MX2009008779A true MX2009008779A (es) 2009-11-05

Family

ID=39690101

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008779A MX2009008779A (es) 2007-02-16 2008-02-14 Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación.

Country Status (21)

Country Link
US (1) US8759354B2 (es)
EP (1) EP2123276B1 (es)
JP (1) JP5255456B2 (es)
KR (1) KR101479083B1 (es)
CN (1) CN101610772B (es)
AU (1) AU2008215397B2 (es)
BR (1) BRPI0807597B8 (es)
CA (1) CA2677905C (es)
CY (1) CY1113435T1 (es)
DK (1) DK2123276T3 (es)
ES (1) ES2396595T3 (es)
HR (1) HRP20130111T1 (es)
IL (1) IL200285A (es)
MX (1) MX2009008779A (es)
NZ (1) NZ578989A (es)
PL (1) PL2123276T3 (es)
PT (1) PT2123276E (es)
RU (1) RU2463051C2 (es)
SI (1) SI2123276T1 (es)
WO (1) WO2008099874A1 (es)
ZA (1) ZA200905536B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2417617A4 (en) * 2009-04-09 2012-09-26 Lg Electronics Inc DISPLAY APPARATUS
CN104777301B (zh) * 2010-05-10 2018-04-20 中央研究院 具有抗流感活性的扎那米韦膦酸酯同类物及流感病毒的奥司他韦易感性的测定
PL2623498T3 (pl) * 2010-09-30 2016-05-31 Toyama Chemical Co Ltd Sól sodowa 6-fluoro-3-hydroksy-2-pirazynokarboksamidu
HUE026794T2 (en) 2010-09-30 2016-07-28 Toyama Chemical Co Ltd The oleum salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
WO2014186465A1 (en) * 2013-05-14 2014-11-20 Biocryst Pharmaceuticals, Inc. Anti-influenza compositions and methods
CN104402833B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104447585B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 吡嗪类化合物及其组合物及用途
CN104447583B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104447584B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104496918B (zh) * 2014-12-10 2016-08-24 广东东阳光药业有限公司 吡嗪衍生物及其用途
CN104817511B (zh) * 2015-04-27 2017-04-19 济南大学 一种丁烯二酸酐制备法匹拉韦关键中间体的方法
RU2745071C2 (ru) * 2015-12-15 2021-03-18 Сионоги Энд Ко., Лтд. Лекарственный препарат для лечения гриппа, характеризующийся тем, что в нем объединены ингибитор кэп-зависимой эндонуклеазы и лекарственное средство против гриппа
WO2020138067A1 (ja) 2018-12-25 2020-07-02 富士フイルム富山化学株式会社 ピラジン誘導体と細胞内におけるピラジン誘導体リボース三リン酸体の量を増加させる化合物とを組み合わせてなるｒｎａウイルス感染症治療剤
JP7449379B2 (ja) 2020-05-27 2024-03-13 富士フイルム富山化学株式会社 ピラジン誘導体とチオプリン誘導体を組み合わせてなるｒｎａウイルス感染症治療剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197437A (ja) * 1988-01-29 1989-08-09 Dso Pharmachim 抗ウイルス薬
BRPI9913097B8 (pt) * 1998-08-20 2021-05-25 Fujifilm Toyama Chemical Co Ltd derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmo
WO2003015798A1 (en) 2001-08-14 2003-02-27 Toyama Chemical Co., Ltd. Novel virus proliferation inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue
JP2005354833A (ja) * 2004-06-11 2005-12-22 Fujinon Corp アクチュエータ
JP4689989B2 (ja) * 2004-08-27 2011-06-01 オリンパス株式会社 振動波リニアモータ及びそれを用いたレンズ装置
DE102008031715A1 (de) 2008-07-04 2010-01-07 Henkel Ag & Co. Kgaa Haarkonditionierende Mittel mit Imidazolinen

Also Published As

Publication number Publication date
JP5255456B2 (ja) 2013-08-07
US8759354B2 (en) 2014-06-24
PL2123276T3 (pl) 2013-04-30
RU2463051C2 (ru) 2012-10-10
JPWO2008099874A1 (ja) 2010-05-27
KR101479083B1 (ko) 2015-01-07
IL200285A0 (en) 2010-04-29
US20100087447A1 (en) 2010-04-08
EP2123276B1 (en) 2012-11-28
HRP20130111T1 (hr) 2013-02-28
ES2396595T3 (es) 2013-02-22
ZA200905536B (en) 2010-10-27
KR20090121289A (ko) 2009-11-25
WO2008099874A1 (ja) 2008-08-21
CN101610772B (zh) 2013-01-16
CN101610772A (zh) 2009-12-23
SI2123276T1 (sl) 2013-03-29
CA2677905A1 (en) 2008-08-21
RU2009134516A (ru) 2011-03-27
AU2008215397B2 (en) 2012-09-06
EP2123276A1 (en) 2009-11-25
CY1113435T1 (el) 2016-06-22
IL200285A (en) 2014-06-30
BRPI0807597B8 (pt) 2021-05-25
PT2123276E (pt) 2013-01-16
BRPI0807597B1 (pt) 2021-03-02
DK2123276T3 (da) 2013-01-02
CA2677905C (en) 2015-03-24
EP2123276A4 (en) 2011-05-18
NZ578989A (en) 2011-07-29
BRPI0807597A2 (pt) 2014-05-06
AU2008215397A1 (en) 2008-08-21

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