HRP20130111T1 - Farmaceutski pripravak koji sadržava derivat pirazina i postupak upotrebe derivata pirazina u kombinaciji - Google Patents
Farmaceutski pripravak koji sadržava derivat pirazina i postupak upotrebe derivata pirazina u kombinaciji Download PDFInfo
- Publication number
- HRP20130111T1 HRP20130111T1 HRP20130111AT HRP20130111T HRP20130111T1 HR P20130111 T1 HRP20130111 T1 HR P20130111T1 HR P20130111A T HRP20130111A T HR P20130111AT HR P20130111 T HRP20130111 T HR P20130111T HR P20130111 T1 HRP20130111 T1 HR P20130111T1
- Authority
- HR
- Croatia
- Prior art keywords
- pyrazine derivative
- pharmaceutical preparation
- neuraminidase inhibitor
- atom
- zanamivir
- Prior art date
Links
- 150000003216 pyrazines Chemical class 0.000 title claims 8
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- 239000002911 sialidase inhibitor Substances 0.000 claims 8
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 229960003752 oseltamivir Drugs 0.000 claims 4
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical group CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 4
- 229960001028 zanamivir Drugs 0.000 claims 4
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Description
FARMACEUTSKI PRIPRAVAK KOJI SADRŽAVA DERIVAT PIRAZINA, I POSTUPAK UPOTREBE DERIVATA PIRAZINA U KOMBINACIJI
Claims (10)
1. Farmaceutski pripravak za liječenje infekcije uzrokovane virusom gripe, koji sadržava derivat pirazina predstavljen općom formulom, ili njegove soli i jednim ili više neuraminidaza inhibitorom, naznačen time da su R1 i R2 isti ili različiti i svaki predstavlja atom vodika ili halogen i R3 predstavlja atom vodika.
[image]
2. Farmaceutski pripravak u skladu sa zahtjevom 1, naznačen time, da je R1 atom vodika i R2 je atom fluora.
3. Farmaceutski pripravak u skladu sa zahtjevom 1 ili 2, naznačen time, da je neuraminidaza inhibitor oseltamivir ili zanamivir.
4. Farmaceutski pripravak u skladu sa zahtjevom 1 ili 2, naznačen time, da je neuraminidaza inhibitor oseltamivir.
5. Farmaceutski pripravak u skladu sa zahtjevom 1 ili 2, naznačen time, da je neuraminidaza inhibitor zanamivir.
6. Derivat pirazina predstavljen slijedećom općom formulom, ili njegove soli u kombinaciji sa jednim ili više neuraminidaza inhibitora za upotrebu pri liječenju infekcije uzrokovane virusom gripe, naznačen time da su R1 i R2 isti ili različiti i svaki predstavlja atom vodika ili halogen i R3 predstavlja atom vodika.
[image]
7. Derivat pirazina u skladu sa zahtjevom 6, naznačen time , da je R1 atom vodika i R2 je atom fluora.
8. Derivat pirazina u skladu sa zahtjevom 6 ili 7, naznačen time, da je neuraminidaza inhibitor oseltamivir ili zanamivir.
9. Derivat pirazina u skladu sa zahtjevom 6 ili 7, naznačen time, da je neuraminidaza inhibitor oseltamivir.
10. Derivat pirazina u skladu sa zahtjevom 6 ili 7, naznačen time, da je neuraminidaza inhibitor zanamivir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007035975 | 2007-02-16 | ||
| PCT/JP2008/052425 WO2008099874A1 (ja) | 2007-02-16 | 2008-02-14 | ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130111T1 true HRP20130111T1 (hr) | 2013-02-28 |
Family
ID=39690101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130111AT HRP20130111T1 (hr) | 2007-02-16 | 2013-02-07 | Farmaceutski pripravak koji sadržava derivat pirazina i postupak upotrebe derivata pirazina u kombinaciji |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8759354B2 (hr) |
| EP (1) | EP2123276B1 (hr) |
| JP (1) | JP5255456B2 (hr) |
| KR (1) | KR101479083B1 (hr) |
| CN (1) | CN101610772B (hr) |
| AU (1) | AU2008215397B2 (hr) |
| BR (1) | BRPI0807597B8 (hr) |
| CA (1) | CA2677905C (hr) |
| CY (1) | CY1113435T1 (hr) |
| DK (1) | DK2123276T3 (hr) |
| ES (1) | ES2396595T3 (hr) |
| HR (1) | HRP20130111T1 (hr) |
| IL (1) | IL200285A (hr) |
| MX (1) | MX2009008779A (hr) |
| NZ (1) | NZ578989A (hr) |
| PL (1) | PL2123276T3 (hr) |
| PT (1) | PT2123276E (hr) |
| RU (1) | RU2463051C2 (hr) |
| SI (1) | SI2123276T1 (hr) |
| WO (1) | WO2008099874A1 (hr) |
| ZA (1) | ZA200905536B (hr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2417617A4 (en) * | 2009-04-09 | 2012-09-26 | Lg Electronics Inc | DISPLAY APPARATUS |
| JP5947289B2 (ja) * | 2010-05-10 | 2016-07-06 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 抗インフルエンザ活性を有するザナミビルホスホネート同族体およびインフルエンザウイルスのオセルタミビルに対する感受性の決定 |
| SI2623498T1 (sl) | 2010-09-30 | 2016-03-31 | Toyama Chemical Co., Ltd. | Natrijeva sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida |
| MY161757A (en) | 2010-09-30 | 2017-05-15 | Toyama Chemical Co Ltd | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| AT510585B1 (de) * | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase |
| CA2911424C (en) * | 2013-05-14 | 2021-11-30 | Biocryst Pharmaceuticals, Inc. | Anti-influenza imino-ribose pyrrolopyrimidine derivatives |
| CN104447583B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
| CN104447585B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 吡嗪类化合物及其组合物及用途 |
| CN104447584B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
| CN104402833B (zh) * | 2014-11-20 | 2016-08-24 | 广东东阳光药业有限公司 | 含有环丁烷取代基的吡嗪类化合物及其组合物及用途 |
| CN104496918B (zh) * | 2014-12-10 | 2016-08-24 | 广东东阳光药业有限公司 | 吡嗪衍生物及其用途 |
| CN104817511B (zh) * | 2015-04-27 | 2017-04-19 | 济南大学 | 一种丁烯二酸酐制备法匹拉韦关键中间体的方法 |
| SG10201911957QA (en) * | 2015-12-15 | 2020-02-27 | Shionogi & Co | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| EP3903783A4 (en) * | 2018-12-25 | 2022-03-30 | FUJIFILM Toyama Chemical Co., Ltd. | THERAPEUTIC AGENT FOR RNA VIRAL INFECTION OBTAINED BY COMBINING A PYRAZINE DERIVATIVE AND A COMPOUND THAT INCREASES THE AMOUNT OF PYRAZINE DERIVATIVE RIBOSE TRIPHOSPHATE BODY IN A CELL |
| EP4159215A4 (en) | 2020-05-27 | 2023-11-22 | FUJIFILM Toyama Chemical Co., Ltd. | THERAPEUTIC AGENT FOR RNA VIRAL INFECTION OBTAINED BY COMBINATION OF A PYRAZINE DERIVATIVE AND A THIOPURINE DERIVATIVE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01197437A (ja) | 1988-01-29 | 1989-08-09 | Dso Pharmachim | 抗ウイルス薬 |
| CN1154493C (zh) | 1998-08-20 | 2004-06-23 | 富山化学工业株式会社 | 含氮杂环羧酰胺衍生物或其盐以及含有二者的抗病毒药 |
| US20040235761A1 (en) | 2001-08-14 | 2004-11-25 | Yousuke Furuta | Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue |
| JP2005354833A (ja) * | 2004-06-11 | 2005-12-22 | Fujinon Corp | アクチュエータ |
| JP4689989B2 (ja) * | 2004-08-27 | 2011-06-01 | オリンパス株式会社 | 振動波リニアモータ及びそれを用いたレンズ装置 |
| DE102008031715A1 (de) | 2008-07-04 | 2010-01-07 | Henkel Ag & Co. Kgaa | Haarkonditionierende Mittel mit Imidazolinen |
-
2008
- 2008-02-14 KR KR20097017506A patent/KR101479083B1/ko active IP Right Grant
- 2008-02-14 EP EP08711267A patent/EP2123276B1/en active Active
- 2008-02-14 PL PL08711267T patent/PL2123276T3/pl unknown
- 2008-02-14 RU RU2009134516/15A patent/RU2463051C2/ru active
- 2008-02-14 ZA ZA200905536A patent/ZA200905536B/xx unknown
- 2008-02-14 US US12/527,260 patent/US8759354B2/en active Active
- 2008-02-14 ES ES08711267T patent/ES2396595T3/es active Active
- 2008-02-14 WO PCT/JP2008/052425 patent/WO2008099874A1/ja active Application Filing
- 2008-02-14 JP JP2008558114A patent/JP5255456B2/ja active Active
- 2008-02-14 SI SI200830895T patent/SI2123276T1/sl unknown
- 2008-02-14 DK DK08711267.8T patent/DK2123276T3/da active
- 2008-02-14 NZ NZ578989A patent/NZ578989A/en unknown
- 2008-02-14 BR BRPI0807597A patent/BRPI0807597B8/pt active IP Right Grant
- 2008-02-14 MX MX2009008779A patent/MX2009008779A/es active IP Right Grant
- 2008-02-14 CN CN200880005061XA patent/CN101610772B/zh active Active
- 2008-02-14 CA CA2677905A patent/CA2677905C/en active Active
- 2008-02-14 AU AU2008215397A patent/AU2008215397B2/en active Active
- 2008-02-14 PT PT87112678T patent/PT2123276E/pt unknown
-
2009
- 2009-08-06 IL IL200285A patent/IL200285A/en not_active IP Right Cessation
-
2012
- 2012-12-03 CY CY20121101175T patent/CY1113435T1/el unknown
-
2013
- 2013-02-07 HR HRP20130111AT patent/HRP20130111T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101479083B1 (ko) | 2015-01-07 |
| EP2123276A1 (en) | 2009-11-25 |
| CA2677905C (en) | 2015-03-24 |
| ES2396595T3 (es) | 2013-02-22 |
| JP5255456B2 (ja) | 2013-08-07 |
| EP2123276B1 (en) | 2012-11-28 |
| IL200285A0 (en) | 2010-04-29 |
| US8759354B2 (en) | 2014-06-24 |
| US20100087447A1 (en) | 2010-04-08 |
| CY1113435T1 (el) | 2016-06-22 |
| AU2008215397B2 (en) | 2012-09-06 |
| BRPI0807597A2 (pt) | 2014-05-06 |
| CN101610772A (zh) | 2009-12-23 |
| RU2009134516A (ru) | 2011-03-27 |
| EP2123276A4 (en) | 2011-05-18 |
| RU2463051C2 (ru) | 2012-10-10 |
| CN101610772B (zh) | 2013-01-16 |
| BRPI0807597B8 (pt) | 2021-05-25 |
| JPWO2008099874A1 (ja) | 2010-05-27 |
| MX2009008779A (es) | 2009-11-05 |
| NZ578989A (en) | 2011-07-29 |
| IL200285A (en) | 2014-06-30 |
| KR20090121289A (ko) | 2009-11-25 |
| AU2008215397A1 (en) | 2008-08-21 |
| ZA200905536B (en) | 2010-10-27 |
| BRPI0807597B1 (pt) | 2021-03-02 |
| WO2008099874A1 (ja) | 2008-08-21 |
| PT2123276E (pt) | 2013-01-16 |
| DK2123276T3 (da) | 2013-01-02 |
| PL2123276T3 (pl) | 2013-04-30 |
| SI2123276T1 (sl) | 2013-03-29 |
| CA2677905A1 (en) | 2008-08-21 |
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