BR0211900A - Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste - Google Patents

Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste

Info

Publication number
BR0211900A
BR0211900A BR0211900-5A BR0211900A BR0211900A BR 0211900 A BR0211900 A BR 0211900A BR 0211900 A BR0211900 A BR 0211900A BR 0211900 A BR0211900 A BR 0211900A
Authority
BR
Brazil
Prior art keywords
pyrazine
salt
rna polymerase
polymerase inhibitor
nucleotide
Prior art date
Application number
BR0211900-5A
Other languages
English (en)
Inventor
Yousuke Furuta
Hiroyuki Egawa
Kazumi Takahashi
Yasuhiro Tsutsui
Sayuri Uehara
Makoto Murakami
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of BR0211900A publication Critical patent/BR0211900A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MéTODO PARA INIBIçãO DO DESENVOLVIMENTO DE VìRUS E/OU VIRUCIDA, ANáLOGOS DE NUCLEOTìDEO DE PIRAZINA E DE NUCLEOSìDEO DE PIRAZINA, PRECURSOR DO INIBIDOR DA POLIMERASE DE RNA, INIBIDOR DA POLIMERASE DE RNA, MéTODO PARA TRATAR PACIENTES INFECTADOS POR VìRUS, E, USOS DE UM ANáLOGO DE NUCLEOTìDEO DE PIRAZINA OU UM SAL DESTE E DE UM ANáLOGO DE NUCLEOSìDEO DE PIRAZINA OU UM SAL DESTE". Nas fórmulas R1, R2, R3, R4, R5, R6, R7, R8, R9 e A têm os mesmos significados como no relatório descritivo. Um método em que os análogos de nucleotídeo de piradina e nucleosídeo de piradina [2] e [3z] passam pela conversão in vivo e são ainda decompostos e fosforilados para se tornarem um análogo de nucleotídeo de piradina [1b], que tem uma atividade inibidora da proliferação de vírus e/ou atividade virucida. O método é útil como remédio para doenças infecciosas virais. Também é fornecido um análogo de piradinocarboxamida ou um sal deste que são úteis como um preventivo/remédio para doenças infecciosas virais.
BR0211900-5A 2001-08-14 2002-08-13 Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste BR0211900A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001245896 2001-08-14
PCT/JP2002/008250 WO2003015798A1 (en) 2001-08-14 2002-08-13 Novel virus proliferation inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue

Publications (1)

Publication Number Publication Date
BR0211900A true BR0211900A (pt) 2004-08-24

Family

ID=19075560

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211900-5A BR0211900A (pt) 2001-08-14 2002-08-13 Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste

Country Status (12)

Country Link
US (1) US20040235761A1 (pt)
EP (1) EP1417967A4 (pt)
JP (1) JP4370164B2 (pt)
KR (1) KR100894167B1 (pt)
CN (1) CN100434079C (pt)
BR (1) BR0211900A (pt)
CA (1) CA2456292A1 (pt)
MX (1) MXPA04001361A (pt)
PL (1) PL209765B1 (pt)
RU (1) RU2292894C2 (pt)
WO (1) WO2003015798A1 (pt)
ZA (1) ZA200400925B (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100828453B1 (ko) 2001-01-22 2008-05-13 머크 앤드 캄파니 인코포레이티드 Ｒｎａ 의존성 ｒｎａ 바이러스 폴리머라제의억제제로서의 뉴클레오시드 유도체
US8481712B2 (en) 2001-01-22 2013-07-09 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
US7105499B2 (en) 2001-01-22 2006-09-12 Merck & Co., Inc. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP2008514639A (ja) * 2004-09-24 2008-05-08 イデニクス（ケイマン）リミテツド フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法
WO2008099874A1 (ja) 2007-02-16 2008-08-21 Toyama Chemical Co., Ltd. ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法
PT2155758E (pt) * 2007-05-10 2012-11-12 Biocryst Pharm Inc Compostos de tetrahidrofuro[3,4-d]dioxolano para utilização no tratamento de infecções virais e do cancro
CL2008003301A1 (es) 2007-11-06 2009-10-16 Astrazeneca Ab Compuestos derivados de 3,4-dihidropirazina-2-carboxamida, inhibidores de la elastasa de neutrofilos humanos; composiciones farmacéuticas; procesos de preparación de compuestos y composición farmacéutica; y uso en el tratamiento de síndrome de dificultad respiratoria de los adultos, fibrosis quística, cáncer, entre otras.
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
TWI576352B (zh) * 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
AP3631A (en) 2009-06-17 2016-03-08 Vertex Pharma Inhibitors of influenza viruses replication
WO2011039528A1 (en) * 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
WO2011076923A1 (en) * 2009-12-23 2011-06-30 Institut National De La Sante Et De La Recherche Medicale Inhibitor for inosine monophosphate (imp) dehydrogenase and/or viral rna polymerase for treatment of hepatitis e
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
KR20130128435A (ko) 2010-12-16 2013-11-26 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
JP2013545817A (ja) 2010-12-16 2013-12-26 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルス複製阻害物質
WO2012142075A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
CA2832449A1 (en) 2011-04-13 2012-10-18 Vinay GIRIJAVALLABHAN 2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
CA2832459A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2731433A4 (en) 2011-07-13 2014-12-31 Merck Sharp & Dohme 5'-SUBSTITUTED NUCLEOSIDE ANALOGUES AND METHODS OF USE FOR THE TREATMENT OF VIRAL DISEASES
US9416154B2 (en) 2011-07-13 2016-08-16 Merck Sharp & Dohme Corp. 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MX356509B (es) 2011-12-22 2018-05-30 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013184985A1 (en) 2012-06-08 2013-12-12 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
CN102775358B (zh) * 2012-08-22 2015-05-27 山东齐都药业有限公司 6-氟-3-羟基-2-吡嗪酰胺的制备方法
CN103833812A (zh) * 2012-11-23 2014-06-04 中国人民解放军军事医学科学院毒物药物研究所 吡嗪衍生物及其医药用途
KR102338461B1 (ko) 2013-11-13 2021-12-13 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제 억제제의 제조 방법
RU2700415C1 (ru) 2013-11-13 2019-09-17 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
MA40772A (fr) 2014-10-02 2017-08-08 Vertex Pharma Variants du virus de la grippe a
MA40773A (fr) 2014-10-02 2017-08-08 Vertex Pharma Variants du virus influenza a
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
CN110603041A (zh) 2017-04-12 2019-12-20 沃泰克斯药物股份有限公司 用于治疗流感病毒感染的组合治疗
JP7165721B2 (ja) 2017-04-24 2022-11-04 コクリスタル ファーマ，インコーポレイテッド インフルエンザウイルス複製の阻害剤として有用なピロロピリミジン誘導体
MX2021000917A (es) 2018-07-27 2021-06-23 Cocrystal Pharma Inc Derivados de pirrolo[2,3-b]piridina como inhibidores de la replicación del virus de la gripe.
US12037333B2 (en) 2018-09-10 2024-07-16 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
WO2020112716A1 (en) 2018-11-26 2020-06-04 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
TW202114678A (zh) 2019-06-20 2021-04-16 美商健生醫藥公司 氮雜吲哚化合物之調配物
CN113444132A (zh) * 2020-03-25 2021-09-28 药康众拓(江苏)医药科技有限公司 吡嗪甲酰胺核苷酸类似物或药学上可接受的盐、异构体、代谢产物、前药及制备方法和用途
CN111995649A (zh) * 2020-04-09 2020-11-27 瀚海新拓(杭州)生物医药有限公司 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途
KR20230060504A (ko) 2020-07-31 2023-05-04 파인트리 테라퓨틱스 인코포레이티드 바이러스 감염 치료를 위한 뉴로필린 및 안지오텐신 전환 효소 2 융합 펩티드
CN112661801A (zh) * 2020-12-18 2021-04-16 成都阿奇生物医药科技有限公司 一种核苷类似物及其氘代物及其制备方法和用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3094530A (en) * 1961-02-01 1963-06-18 Humphrey I X Mager 5-azidocarbonyl pyrazinamide
US3336289A (en) * 1965-09-20 1967-08-15 Upjohn Co 9-beta-d-ribofuranosyl-7-deazapurine 5'-phosphate esters
US3824229A (en) * 1972-07-20 1974-07-16 Int Chem & Nuclear Corp 3-oxo-1,2,4-triazine nucleosides
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US5744600A (en) * 1988-11-14 1998-04-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxy carbocyclic nucleosides and nucleotides
US5192764A (en) * 1991-05-30 1993-03-09 Research Foundation Of State Of N.Y. Pyrazinone n-oxide nucleosides and analogs thereof
FR2688003B1 (fr) * 1992-02-28 1995-06-30 Univ Limoges Derives de nucleosides, leur preparation et leurs applications biologiques.
US6677310B1 (en) * 1999-04-21 2004-01-13 Nabi Ring-expanded nucleosides and nucleotides
US5525711A (en) * 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6248878B1 (en) * 1996-12-24 2001-06-19 Ribozyme Pharmaceuticals, Inc. Nucleoside analogs
ATE413881T1 (de) * 1997-08-08 2008-11-15 Celmed Oncology Usa Inc Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden
EP1167972B1 (en) * 1998-01-23 2017-03-08 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
US6160118A (en) * 1998-07-01 2000-12-12 Merck & Co., Inc. Process for the synthesis of substituted piperazinones via Mitsunobu reaction
PL200955B1 (pl) * 1998-08-20 2009-02-27 Toyama Chemical Co Ltd Przeciwwirusowa kompozycja farmaceutyczna i jej zastosowanie oraz zawierająca azot heterocykliczna pochodna karboksamidu
PT1256588E (pt) * 2000-02-16 2005-05-31 Toyama Chemical Co Ltd Derivados de pirazina originais ou os seus sais, preparacoes farmaceuticas, contendo os derivados ou os seus sais e produtos intermedios para a preparacao de ambos
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
WO2002024650A2 (en) * 2000-09-19 2002-03-28 Centre National De La Recherche Scientifique (Cnrs) Pyridinone and pyridinethione derivatives having hiv inhibiting properties

Also Published As

Publication number Publication date
PL368313A1 (en) 2005-03-21
JPWO2003015798A1 (ja) 2004-12-02
JP4370164B2 (ja) 2009-11-25
RU2004107499A (ru) 2005-04-20
EP1417967A4 (en) 2007-03-28
PL209765B1 (pl) 2011-10-31
RU2292894C2 (ru) 2007-02-10
KR100894167B1 (ko) 2009-04-22
WO2003015798A1 (en) 2003-02-27
US20040235761A1 (en) 2004-11-25
MXPA04001361A (es) 2004-05-27
CN100434079C (zh) 2008-11-19
KR20040030099A (ko) 2004-04-08
CA2456292A1 (en) 2003-02-27
CN1551777A (zh) 2004-12-01
ZA200400925B (en) 2005-04-26
EP1417967A1 (en) 2004-05-12

Similar Documents

Publication Publication Date Title
BR0211900A (pt) Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste
ATE512973T1 (de) Nukleosid-arylphosphoramidate und ihre verwendung als antivirale mittel zur behandlung von hepatitis-c-virus
UY27333A1 (es) Nucleótidos 4` sustituidos
BR0008131A (pt) Composto ou um sal deste, análogo de oligonucleotìdeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotìdeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antìgeno
DE10399025I2 (de) Wirkstoffvorläufer von Phosphonaten
BR0210344A (pt) Inibidores da hiv protease, composições contendo os mesmos, seus usos farmacêuticos e materiais para a sua sìntese
UY28084A1 (es) Derivados antivirales de nucleosidos
IL170894A (en) Phosphonate analogues with antiviral activity
BR0305426A (pt) Compostos inibidores de ns5b polimerase de hcv, bem como composição farmacêutica compreendendo os mesmos
BG100455A (en) Hiv protease inhibitors
BRPI1012781A8 (pt) N-[(2'r)-2'-deóxi-2'-fluor-2'-metil-p-fenil-5'-uridil]-l-alanina 1-metiletil éster e processo para sua produção
NI200500090A (es) Compuestos de benzofurano, composiciones y metodos para tratamiento y profilafixis de infecciones virales de hepatitis c y enfermedades asociadas
DK0823428T3 (da) Neuraminsyrederivater, deres fremstilling og deres medicinske anvendelse
BRPI0514476A (pt) inibidores da formação de cápsideo hiv-1: aril aminometil tiazol uréias substituìdas e análogos destas
DE60036862D1 (de) Synergistische hemmung von viralreplikation durch langkettigen kohlenwasserstoffe und nucleosid-analoge
Valiaeva et al. Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy) propyl] nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication
BR0212676A (pt) compostos terapêuticos ligantes de 5-ht, composições farmacêuticas compreendendo tais compostos e seus usos
HUP0101224A2 (hu) Neuraminidáz inhibitor hatású pirrolidinszármazékok és ezeket a vegyületeket tartalmazó gyógyászati készítmények
DK1135401T3 (da) Glycerylnucleotider, fremgangsmåder til deres fremstilling og deres anvendelse
WO2023245040A1 (en) Flex-nucleoside analogues, novel therapeutics against viruses
WO2023225042A1 (en) Flex-nucleoside analogues, novel therapeutics against viruses
ATE301997T1 (de) Antivirale therapie
BRPI0409766A (pt) análogos de fosfonato antiviral
BRPI0409691A (pt) compostos de fosfonato tendo atividade imuno-moduladora
TH83125B (th) อนุพันธ์เนยูรามินิคแอซิดการเตรียมของมันและการใช้ประโยชน์ของมันทางการแพทย์

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: PEDIDO INDEFERIDO DE ACORDO COM O ART. 37, UMA VEZ QUE NAO ATENDE AO REQUISITO DE NOVIDADE.

B12B Appeal: appeal against refusal