MX2010004232A - Compuesto de indolina de pirimidilo. - Google Patents

Compuesto de indolina de pirimidilo.

Info

Publication number
MX2010004232A
MX2010004232A MX2010004232A MX2010004232A MX2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A
Authority
MX
Mexico
Prior art keywords
compound
indoline compound
pyrimidyl
pyrimidyl indoline
disclosed
Prior art date
Application number
MX2010004232A
Other languages
English (en)
Inventor
Toshio Kaneko
Takeshi Shida
Takayuki Baba
Koji Matsumoto
Kazumasa Aoki
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2010004232A publication Critical patent/MX2010004232A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe un compuesto de indolina de pirimidilo que tiene una estructura diferente a la de un compuesto utilizado como un ingrediente activo para un agente hiperglucémico oral convencional, y que tiene una excelente actividad hipergiucémica. Se describe en forma específica un compuesto representado por la fórmula general (I) o una sal farmacéuticamente aceptable del mismo.
MX2010004232A 2007-10-16 2008-10-15 Compuesto de indolina de pirimidilo. MX2010004232A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007268937 2007-10-16
PCT/JP2008/068607 WO2009051119A1 (ja) 2007-10-16 2008-10-15 ピリミジルインドリン化合物

Publications (1)

Publication Number Publication Date
MX2010004232A true MX2010004232A (es) 2010-09-30

Family

ID=40567381

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004232A MX2010004232A (es) 2007-10-16 2008-10-15 Compuesto de indolina de pirimidilo.

Country Status (16)

Country Link
US (1) US8232287B2 (es)
EP (1) EP2210886B1 (es)
JP (1) JP5317354B2 (es)
KR (1) KR101536021B1 (es)
CN (1) CN101896481B (es)
AU (1) AU2008312948C1 (es)
BR (1) BRPI0818338A2 (es)
CA (1) CA2710182C (es)
IL (1) IL205057A0 (es)
MX (1) MX2010004232A (es)
MY (1) MY151295A (es)
NZ (1) NZ585284A (es)
RU (1) RU2464269C2 (es)
TW (1) TWI421074B (es)
WO (1) WO2009051119A1 (es)
ZA (1) ZA201002552B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2399914A4 (en) * 2009-02-18 2012-08-29 Takeda Pharmaceutical FUSED HETEROCYCLIC CORE COMPOUND
CA2759843A1 (en) * 2009-05-08 2010-11-10 Pfizer Inc. Gpr 119 modulators
US20120052130A1 (en) * 2009-05-08 2012-03-01 Pfizer Inc. Gpr 119 modulators
NZ596445A (en) 2009-06-24 2013-04-26 Boehringer Ingelheim Int New compounds, pharmaceutical composition and methods relating thereto
TW201113269A (en) * 2009-06-24 2011-04-16 Boehringer Ingelheim Int New compounds, pharmaceutical composition and methods relating thereto
EP2462123B1 (en) * 2009-08-04 2013-10-02 Merck Sharp & Dohme Corp. 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
EP2474540A4 (en) * 2009-08-31 2013-03-13 Nippon Chemiphar Co GPR119 AGONIST
JP2013511571A (ja) * 2009-11-23 2013-04-04 ファイザー・インク Ｇｐｒ１１９阻害剤としてのイミダゾ−ピラゾール
RU2012135525A (ru) 2010-01-20 2014-02-27 Санофи Производные алкилгетероциклических карбаматов, их получение и применение в терапии
FR2955580A1 (fr) * 2010-01-28 2011-07-29 Sanofi Aventis Derives de carbamate d'alkyl-heterocycles, leur preparation et leur application en therapeutique
TW201204733A (en) 2010-06-25 2012-02-01 Kowa Co Novel condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same
WO2012025811A1 (en) * 2010-08-23 2012-03-01 Lupin Limited Indolylpyrimidines as modulators of gpr119
DK2625177T3 (en) * 2010-10-08 2015-10-12 Cadila Healthcare Ltd New GPR 119 agonists
CA2818050A1 (en) 2010-11-26 2012-05-31 Lupin Limited Bicyclic gpr119 modulators
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3009433B1 (en) 2012-01-18 2017-06-21 Daiichi Sankyo Company, Limited 2-phenyl-1,3-oxazole and 5-phenyl-1,2,4-oxadiazole derivatives for the treatment of diabetes
US20160060235A1 (en) * 2013-03-29 2016-03-03 National University Corporation Kumamoto University Therapeutic Agent for Type 2 Diabetes
US12577217B2 (en) * 2019-01-08 2026-03-17 Kyorin Pharmaceutical Co., Ltd. 15-PGDH inhibitor
JP7532385B2 (ja) 2019-01-31 2024-08-13 杏林製薬株式会社 １５－ｐｇｄｈ阻害薬

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
IL149103A0 (en) 1999-11-30 2002-11-10 Pfizer Prod Inc 2,4-diaminopyrimidine compounds useful as immunosuppressants
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
SI1645558T1 (sl) 2002-06-19 2008-10-31 Biovitrum Ab Publ Piperazinilpirazini kot modulatorji serotonin 5-HT2C receptorja
US7078419B2 (en) * 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
CN100509798C (zh) * 2003-07-11 2009-07-08 艾尼纳制药公司 作为新陈代谢调节剂的三取代芳基和杂芳基衍生物以及预防和治疗与其相关之病症
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
FR2866884B1 (fr) 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
HRP20090093T3 (en) * 2004-06-04 2009-03-31 Arena Pharmaceuticals Inc. Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
EP2308840A1 (en) 2005-06-30 2011-04-13 Prosidion Limited GPCR agonists
CN101511429A (zh) * 2006-07-13 2009-08-19 史密丝克莱恩比彻姆公司 二氢吲哚衍生物和gpr119激动剂

Also Published As

Publication number Publication date
CN101896481B (zh) 2014-04-30
ZA201002552B (en) 2011-10-26
EP2210886A1 (en) 2010-07-28
US20100292259A1 (en) 2010-11-18
AU2008312948C1 (en) 2012-08-09
AU2008312948A1 (en) 2009-04-23
RU2010119487A (ru) 2011-11-27
WO2009051119A1 (ja) 2009-04-23
CN101896481A (zh) 2010-11-24
EP2210886A4 (en) 2011-08-17
NZ585284A (en) 2011-03-31
CA2710182C (en) 2012-08-14
TW200922588A (en) 2009-06-01
KR101536021B1 (ko) 2015-07-10
EP2210886B1 (en) 2015-09-23
RU2464269C2 (ru) 2012-10-20
TWI421074B (zh) 2014-01-01
IL205057A0 (en) 2010-11-30
JPWO2009051119A1 (ja) 2011-03-03
BRPI0818338A2 (pt) 2015-04-22
KR20100071068A (ko) 2010-06-28
CA2710182A1 (en) 2009-04-23
JP5317354B2 (ja) 2013-10-16
MY151295A (en) 2014-04-30
AU2008312948B2 (en) 2012-03-01
US8232287B2 (en) 2012-07-31

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