JP2017507160A5 - - Google Patents

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Publication number
JP2017507160A5
JP2017507160A5 JP2016555752A JP2016555752A JP2017507160A5 JP 2017507160 A5 JP2017507160 A5 JP 2017507160A5 JP 2016555752 A JP2016555752 A JP 2016555752A JP 2016555752 A JP2016555752 A JP 2016555752A JP 2017507160 A5 JP2017507160 A5 JP 2017507160A5
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alkyl
optionally substituted
amino
aryl
cyano
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JP2016555752A
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Japanese (ja)
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JP2017507160A (ja
JP6574435B2 (ja
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Priority claimed from PCT/US2015/019535 external-priority patent/WO2015134998A1/en
Publication of JP2017507160A publication Critical patent/JP2017507160A/ja
Publication of JP2017507160A5 publication Critical patent/JP2017507160A5/ja
Priority to JP2019149385A priority Critical patent/JP6915003B2/ja
Application granted granted Critical
Publication of JP6574435B2 publication Critical patent/JP6574435B2/ja
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JP2016555752A 2014-03-07 2015-03-09 ヒト血漿カリクレイン阻害剤 Active JP6574435B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019149385A JP6915003B2 (ja) 2014-03-07 2019-08-16 ヒト血漿カリクレイン阻害剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461949808P 2014-03-07 2014-03-07
US61/949,808 2014-03-07
US201461981515P 2014-04-18 2014-04-18
US61/981,515 2014-04-18
PCT/US2015/019535 WO2015134998A1 (en) 2014-03-07 2015-03-09 Human plasma kallikrein inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019149385A Division JP6915003B2 (ja) 2014-03-07 2019-08-16 ヒト血漿カリクレイン阻害剤

Publications (3)

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JP2017507160A JP2017507160A (ja) 2017-03-16
JP2017507160A5 true JP2017507160A5 (enExample) 2018-08-09
JP6574435B2 JP6574435B2 (ja) 2019-09-11

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ID=54055948

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JP2016555752A Active JP6574435B2 (ja) 2014-03-07 2015-03-09 ヒト血漿カリクレイン阻害剤
JP2019149385A Active JP6915003B2 (ja) 2014-03-07 2019-08-16 ヒト血漿カリクレイン阻害剤
JP2021116716A Active JP7825343B2 (ja) 2014-03-07 2021-07-14 ヒト血漿カリクレイン阻害剤
JP2023189564A Pending JP2023181543A (ja) 2014-03-07 2023-11-06 ヒト血漿カリクレイン阻害剤

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JP2019149385A Active JP6915003B2 (ja) 2014-03-07 2019-08-16 ヒト血漿カリクレイン阻害剤
JP2021116716A Active JP7825343B2 (ja) 2014-03-07 2021-07-14 ヒト血漿カリクレイン阻害剤
JP2023189564A Pending JP2023181543A (ja) 2014-03-07 2023-11-06 ヒト血漿カリクレイン阻害剤

Country Status (33)

Country Link
US (14) US10125102B2 (enExample)
EP (4) EP3113772B8 (enExample)
JP (4) JP6574435B2 (enExample)
KR (2) KR102736869B1 (enExample)
CN (2) CN113307772B (enExample)
AU (3) AU2015226855C1 (enExample)
BR (1) BR112016020199A8 (enExample)
CA (2) CA2941380C (enExample)
CY (2) CY1123810T1 (enExample)
DK (2) DK3828173T3 (enExample)
EA (1) EA036251B1 (enExample)
ES (3) ES3039514T3 (enExample)
FR (1) FR21C1048I2 (enExample)
HR (2) HRP20221373T1 (enExample)
HU (3) HUE060660T2 (enExample)
IL (2) IL280785B2 (enExample)
LT (3) LT3828173T (enExample)
LU (1) LUC00233I2 (enExample)
MA (1) MA53399B1 (enExample)
MX (2) MX2020013059A (enExample)
MY (1) MY199131A (enExample)
NL (1) NL301142I2 (enExample)
NO (1) NO2022046I1 (enExample)
NZ (2) NZ762034A (enExample)
PH (1) PH12016501750B1 (enExample)
PL (2) PL3828173T3 (enExample)
PT (2) PT3828173T (enExample)
RS (2) RS61159B1 (enExample)
SG (2) SG11201607267SA (enExample)
SI (1) SI3113772T1 (enExample)
SM (2) SMT202100031T1 (enExample)
WO (1) WO2015134998A1 (enExample)
ZA (1) ZA201606320B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
TWI688564B (zh) 2014-01-31 2020-03-21 美商必治妥美雅史谷比公司 作為凝血因子ｘｉａ抑制劑之具有雜環p2'基團之巨環化合物
NO2760821T3 (enExample) 2014-01-31 2018-03-10
PL3828173T3 (pl) * 2014-03-07 2022-12-19 Biocryst Pharmaceuticals, Inc. Podstawiane pirazole jako inhibitory ludzkiej kalikreiny osoczowej
WO2016036893A1 (en) 2014-09-04 2016-03-10 Bristol-Myers Squibb Company Diamide macrocycles that are fxia inhibitors
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
EP4019022B1 (en) 2015-10-01 2024-01-31 BioCryst Pharmaceuticals, Inc. Human plasma kallikrein inhibitors
RS60600B1 (sr) 2016-05-31 2020-08-31 Kalvista Pharmaceuticals Ltd Derivati pirazola kao inhibitori kalikreina plazme
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
GB201721515D0 (en) * 2017-12-21 2018-02-07 Kalvista Pharmaceuticals Ltd Dosage forms comprising a plasma kallikrein inhibtor
IL274557B2 (en) 2017-11-29 2024-09-01 Kalvista Pharmaceuticals Ltd Dosage forms comprising a plasma kallikrein inhibitor
JP7538113B2 (ja) 2018-08-20 2024-08-21 アキリオン ファーマシューティカルズ，インコーポレーテッド 補体ｄ因子の医学的障害の治療のための医薬化合物
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
AR116951A1 (es) * 2018-11-02 2021-06-30 Biocryst Pharm Inc Sales cristalinas de un inhibidor de calicreína plasmática
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
AU2020273154A1 (en) * 2019-04-08 2021-12-02 Biocryst Pharmaceuticals, Inc. Plasma kallikrein inhibitors and methods of use thereof in ocular disorders
WO2021025969A1 (en) 2019-08-02 2021-02-11 Teva Pharmaceuticals International Gmbh Solid state forms of berotralstat
UA130182C2 (uk) * 2019-08-06 2025-12-10 Байокріст Фармасьютикалз, Інк. Синтез інгібітора плазмового калікреїну в технологічному обсязі
CN114206852A (zh) 2019-08-09 2022-03-18 卡尔维斯塔制药有限公司 血浆激肽释放酶抑制剂
EP4017850A1 (en) * 2019-08-21 2022-06-29 Kalvista Pharmaceuticals Limited Enzyme inhibitors
TW202144331A (zh) * 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
CN115362162A (zh) 2020-02-20 2022-11-18 艾其林医药公司 用于治疗补体因子d介导的障碍的杂芳基化合物
JP7245397B2 (ja) * 2020-03-04 2023-03-23 メッドシャイン ディスカバリー インコーポレイテッド 複素環化合物
BR112022025528A2 (pt) * 2020-06-16 2023-01-17 Merck Sharp & Dohme Llc Composto, composição farmacêutica, e, métodos para tratar atividade visual prejudicada, retinopatia diabética, edema macular diabético, oclusão de veia retinal, angioedema hereditário, diabete, pancreatite, hemorragia cerebral, nefropatia, cardiomiopatia, neuropatia, doença intestinal inflamatória, artrite, inflamação, choque séptico, hipotensão, câncer, síndrome da angústia respiratória do adulto, coagulação intravascular disseminada, coagulação sanguínea durante cirurgia de desvio cardiopulmonar ou hemorragia do pós-operatório de cirurgia e para tratar uveíte, uveíte posterior, edema macular relacionado com a idade úmido
WO2022010828A1 (en) * 2020-07-10 2022-01-13 Merck Sharp & Dohme Corp. Plasma kallikrein inhibitors
WO2022060842A1 (en) * 2020-09-15 2022-03-24 The Trustees Of Columbia University In The City Of New York Systems and methods for predicting graft dysfunction with exosome proteins
MX2023009059A (es) 2021-02-02 2023-09-15 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.
CN116375648A (zh) * 2023-03-22 2023-07-04 苏州农平科技发展有限公司 贝罗司他中间体的制备方法
AU2024395540A1 (en) * 2023-12-05 2026-03-12 Valo Health, Inc. S1p 1 receptor agonists and uses thereof

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
LU86084A1 (fr) 1985-09-20 1987-04-02 Faco Sa Apparei de massage electrique
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
DE3633840A1 (de) 1986-10-04 1988-04-14 Hoechst Ag Phenylpyrazolcarbonsaeurederivate, ihre herstellung und verwendung als pflanzenwachstumsregulatoren und safener
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
WO1990013332A1 (en) 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Stent with sustained drug delivery
WO1991012779A1 (en) 1990-02-28 1991-09-05 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
AU730224B2 (en) * 1996-12-23 2001-03-01 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
ZA985247B (en) 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
IL133526A0 (en) * 1997-06-19 2001-04-30 Du Pont Pharm Co Inhibitors of factor xa with a neutral p1 specificity group
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
US6271237B1 (en) * 1997-12-22 2001-08-07 Dupont Pharmaceuticals Company Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
WO1999032454A1 (en) * 1997-12-22 1999-07-01 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
US7015218B1 (en) * 1999-02-10 2006-03-21 Mitsubishi Pharma Corporation Amide compounds and medicinal use thereof
AU4327600A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Aryl sulfonyls as factor xa inhibitors
US20010044445A1 (en) 1999-04-08 2001-11-22 Bamaung Nwe Y. Azole inhibitors of cytokine production
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6329527B1 (en) 1999-10-21 2001-12-11 Bristol-Myers Squibb Pharma Company Synthesis of 1,3,5-trisubstituted pyrazoles
AU2001266100B9 (en) 2000-06-27 2005-10-06 Laboratorios S.A.L.V.A.T., S.A. Carbamates derived from arylalkylamines
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
JP2004529853A (ja) 2000-09-22 2004-09-30 ブリストル−マイヤーズ スクイブ ファーマ カンパニー 第Ｘａ因子阻害剤の効率的な製造方法
CA2442557C (en) 2001-04-12 2008-12-23 F. Hoffmann-La Roche Ag Dihydro-benzo¬b|¬1,4|diazepin-2-one derivatives as mglur2 antagonists ii
CA2454298A1 (en) 2001-08-13 2003-02-27 Gary David Annis Substituted 1h-dihydropyrazoles, their preparation and use
TWI325302B (en) 2001-08-13 2010-06-01 Du Pont Benzoxazinone compounds
TWI283164B (en) 2001-09-21 2007-07-01 Du Pont Anthranilamide arthropodicide treatment
MXPA04002649A (es) * 2001-09-21 2004-06-07 Du Pont Diamidas insecticidas.
US7030141B2 (en) 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
TW200303309A (en) 2001-12-04 2003-09-01 Bristol Myers Squibb Co Novel n-[4-(1h-imidazol-1-yl)-2-fluorophenyl]-3-trifluoromethyl)-1h-pyrazole-5-carboxamides as factor Xa inhibitors
WO2003099793A1 (en) 2002-05-24 2003-12-04 Takeda Pharmaceutical Company Limited 1,2-azole derivatives with hypoglycemic and hypolipidemic activity
EP1511733A2 (en) * 2002-06-13 2005-03-09 E.I. Du Pont De Nemours And Company Pyrazole and pyrrole carboxamide insecticides
DE10229070A1 (de) * 2002-06-28 2004-01-15 Merck Patent Gmbh Phenylderivate 5
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
AU2004218260A1 (en) 2003-01-28 2004-09-16 Aventis Pharma S.A. N-aryl heteroaromatic products, compositions containing same and use thereof
EP1670787B1 (en) 2003-09-11 2012-05-30 iTherX Pharma, Inc. Cytokine inhibitors
WO2005094805A1 (ja) * 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
KR20060135881A (ko) 2004-04-13 2006-12-29 이 아이 듀폰 디 네모아 앤드 캄파니 안트라닐아미드 살충제
WO2005113522A1 (en) 2004-05-07 2005-12-01 Janssen Pharmaceutica, N.V. Azole carboxamide inhibitors of bacterial type iii protein secretion systems
US20060069270A1 (en) 2004-09-27 2006-03-30 Rafael Shapiro Process for the preparation of 1,3,5-trisubstituted pyrazoles via [3+2] cycloaddition
US7381732B2 (en) 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
EA012929B1 (ru) 2004-11-18 2010-02-26 Е.И. Дюпон Де Немур Энд Компани Антраниламидные инсектициды
AU2005312721B9 (en) * 2004-12-07 2012-08-02 Toyama Chemical Co., Ltd. Novel anthranilic acid derivative or salt thereof
US20070060589A1 (en) 2004-12-21 2007-03-15 Purandare Ashok V Inhibitors of protein arginine methyl transferases
GB0516703D0 (en) 2005-08-15 2005-09-21 Syngenta Participations Ag Novel insecticides
JP5186751B2 (ja) * 2005-10-14 2013-04-24 住友化学株式会社 ヒドラジド化合物およびその有害生物防除用途
DK1937664T3 (da) 2005-10-14 2011-07-18 Sumitomo Chemical Co Hydrazidforbindelse og pesticid anvendelse af den samme
TWI325423B (en) 2005-10-28 2010-06-01 Lilly Co Eli Kinase inhibitors
DK1988777T3 (da) 2006-02-09 2012-01-16 Athersys Inc Pyrazoler til behandling af fedme og andre cns-lidelser
ES2395538T3 (es) * 2006-05-16 2013-02-13 Boehringer Ingelheim International Gmbh Prolinamidas sustituidas, su preparación y su uso como medicamentos
US7910747B2 (en) 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
AU2007281220B2 (en) 2006-07-31 2013-08-15 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein
CN101495468A (zh) * 2006-07-31 2009-07-29 艾克提弗赛特制药股份有限公司 血浆激肽释放酶抑制剂
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20120225057A1 (en) 2006-10-11 2012-09-06 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
CA2668190A1 (en) * 2006-11-03 2008-05-15 Irm Llc Compounds and compositions as protein kinase inhibitors
CN101679297B (zh) * 2006-12-08 2012-01-11 埃克塞利希斯股份有限公司 Lxr和fxr调节剂
US8338437B2 (en) 2007-02-28 2012-12-25 Methylgene Inc. Amines as small molecule inhibitors
CN101298451B (zh) 2007-04-30 2013-01-30 中国中化股份有限公司 苯甲酰胺类化合物及其应用
WO2008134969A1 (fr) 2007-04-30 2008-11-13 Sinochem Corporation Composés benzamides et leurs applications
PE20110838A1 (es) * 2008-12-18 2011-11-19 Bayer Cropscience Ag Amidas del acido antranilico sustituidas con tetrazol como plaguicidas
WO2010108733A1 (en) 2009-03-26 2010-09-30 Syngenta Participations Ag Insecticidal compounds
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
JP2013515000A (ja) 2009-12-18 2013-05-02 アクティベサイト ファーマシューティカルズ インコーポレイティッド 血漿カリクレインの阻害薬のプロドラッグ
NZ706154A (en) 2010-02-01 2016-09-30 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
WO2011118818A1 (ja) 2010-03-26 2011-09-29 味の素株式会社 アミジノアニリン誘導体
CN102285963B (zh) 2010-06-21 2014-04-09 中国中化股份有限公司 3-甲氧基吡唑酰胺类化合物及其应用
EP2606033A1 (de) 2010-08-20 2013-06-26 Grünenthal GmbH Substituierte cyclische carboxamid- und harnstoff-derivate als liganden des vanilloid-rezeptors
JP2013545740A (ja) 2010-11-10 2013-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング バニロイド受容体リガンドとしての置換された複素芳香族カルボキサミド誘導体および尿素誘導体
EP2702055A1 (en) 2011-04-11 2014-03-05 Nerviano Medical Sciences S.r.l. Pyrazolyl-pyrimidine derivatives as kinase inhibitors
US8691861B2 (en) * 2011-04-13 2014-04-08 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
WO2013036232A2 (en) 2011-09-08 2013-03-14 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
KR20140091041A (ko) 2011-11-09 2014-07-18 그뤼넨탈 게엠베하 바닐로이드 수용체 리간드로서의 so2-함유 그룹으로 치환된 페닐 모이어티를 갖는 치환된 피라졸릴계 카복사미드 및 우레아 유도체들
CN103467380B (zh) 2013-09-29 2015-06-24 南开大学 一类取代苯基吡唑酰胺衍生物及其制备方法和应用
PL3828173T3 (pl) 2014-03-07 2022-12-19 Biocryst Pharmaceuticals, Inc. Podstawiane pirazole jako inhibitory ludzkiej kalikreiny osoczowej
AR116951A1 (es) 2018-11-02 2021-06-30 Biocryst Pharm Inc Sales cristalinas de un inhibidor de calicreína plasmática
UA130182C2 (uk) 2019-08-06 2025-12-10 Байокріст Фармасьютикалз, Інк. Синтез інгібітора плазмового калікреїну в технологічному обсязі

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