TWI781960B - 腺核苷5'-核苷酸酶之抑制劑及相關用途 - Google Patents
腺核苷5'-核苷酸酶之抑制劑及相關用途 Download PDFInfo
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- TWI781960B TWI781960B TW106134280A TW106134280A TWI781960B TW I781960 B TWI781960 B TW I781960B TW 106134280 A TW106134280 A TW 106134280A TW 106134280 A TW106134280 A TW 106134280A TW I781960 B TWI781960 B TW I781960B
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/16—Purine radicals
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- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403598P | 2016-10-03 | 2016-10-03 | |
| US62/403,598 | 2016-10-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201817739A TW201817739A (zh) | 2018-05-16 |
| TWI781960B true TWI781960B (zh) | 2022-11-01 |
Family
ID=61831914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW106134280A TWI781960B (zh) | 2016-10-03 | 2017-10-03 | 腺核苷5'-核苷酸酶之抑制劑及相關用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11058704B2 (enExample) |
| EP (1) | EP3518934A4 (enExample) |
| JP (2) | JP7184761B2 (enExample) |
| CN (1) | CN110049767B (enExample) |
| TW (1) | TWI781960B (enExample) |
| WO (1) | WO2018067424A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018067424A1 (en) | 2016-10-03 | 2018-04-12 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5'-nucleotidase |
| WO2018183635A1 (en) * | 2017-03-31 | 2018-10-04 | Peloton Therapeutics, Inc. | Cd73 inhibitors and uses thereof |
| US11129841B2 (en) | 2017-05-10 | 2021-09-28 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
| WO2019090111A1 (en) | 2017-11-03 | 2019-05-09 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| CN111094317B (zh) * | 2017-12-29 | 2023-03-31 | 上海和誉生物医药科技有限公司 | 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用 |
| CN112004541A (zh) * | 2018-03-09 | 2020-11-27 | 艾库斯生物科学有限公司 | 肠道外给药的免疫增强药物 |
| BR112020022068A2 (pt) | 2018-04-30 | 2021-04-20 | Oric Pharmaceuticals, Inc. | inibidores de cd73 |
| WO2019232319A1 (en) | 2018-05-31 | 2019-12-05 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting cd73 |
| JP2021535102A (ja) * | 2018-08-28 | 2021-12-16 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co., Ltd. | Cd73阻害剤およびその治療的使用 |
| JP7625524B2 (ja) | 2019-01-11 | 2025-02-03 | オメロス コーポレーション | がんを処置するための方法および組成物 |
| CN112955444B (zh) * | 2019-01-22 | 2023-12-12 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| EP3937964A4 (en) | 2019-03-12 | 2022-11-16 | Arcus Biosciences, Inc. | TREATMENT OF ONCOGENE-DRIVEN CANCERS |
| US20220160747A1 (en) * | 2019-03-20 | 2022-05-26 | Korea Research Institute Of Chemical Technology | Pharmaceutical composition comprising novel azolopyrimidine heterocyclic compound as active ingredient |
| WO2020205527A1 (en) | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| WO2020210970A1 (en) * | 2019-04-16 | 2020-10-22 | Bioardis Llc | Imidazotriazine derivatives as cd73 inhibitors |
| TWI821559B (zh) | 2019-04-28 | 2023-11-11 | 大陸商上海和譽生物醫藥科技有限公司 | 一種cd73抑制劑,其製備方法和應用 |
| KR20220034780A (ko) | 2019-06-14 | 2022-03-18 | 써던 리서취 인스티튜트 | 2,4,7-치환된-7-데아자-2'-데옥시-2'-플루오로아라비노실 뉴클레오사이드 및 뉴클레오타이드 전구약물 및 이의 용도 |
| JP7557522B2 (ja) * | 2019-07-16 | 2024-09-27 | オリック ファーマシューティカルズ,インク. | Cd73阻害剤 |
| WO2021040356A1 (en) * | 2019-08-23 | 2021-03-04 | Kainos Medicine, Inc. | C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition |
| ES3034168T3 (en) | 2019-10-30 | 2025-08-13 | Oric Pharmaceuticals Inc | Cd73 inhibitors |
| EP4121409A1 (en) | 2020-03-19 | 2023-01-25 | Arcus Biosciences, Inc. | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
| PH12022553257A1 (en) | 2020-06-02 | 2024-02-19 | Arcus Biosciences Inc | Antibodies to tigit |
| WO2022246179A1 (en) | 2021-05-21 | 2022-11-24 | Arcus Biosciences, Inc. | Axl inhibitor compounds |
| TW202313602A (zh) | 2021-05-21 | 2023-04-01 | 美商阿克思生物科學有限公司 | Axl化合物 |
| CA3236553A1 (en) | 2021-10-29 | 2023-05-04 | Joel Worley BEATTY | Inhibitors of hif-2alpha and methods of use thereof |
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| WO2025113498A1 (zh) * | 2023-12-01 | 2025-06-05 | 无锡和誉生物医药科技有限公司 | 一种cd73抑制剂碱式盐及其制备方法和应用 |
| CN117562915A (zh) * | 2023-12-05 | 2024-02-20 | 中国药科大学 | 一种腺苷衍生物在制备预防、缓解或治疗纤维化疾病的药物中的应用 |
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| WO2025193759A1 (en) | 2024-03-12 | 2025-09-18 | Gilead Sciences, Inc. | Solid forms of an azolopyrimidine compound |
| CN119552122B (zh) * | 2025-01-27 | 2025-05-09 | 北京悦康科创医药科技股份有限公司 | 5'-磷酸酯修饰核苷及其制备方法与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008523098A (ja) * | 2004-12-10 | 2008-07-03 | エモリー・ユニバーシテイ | ウィルス感染および異常細胞増殖の治療用の2′および3′−置換シクロブチルヌクレオシド類縁体 |
| TW200902034A (en) * | 2007-03-28 | 2009-01-16 | Vioquest Pharmaceuticals Inc | Effective treatment of tumors and cancer with prodrugs of triciribine |
| US20090156545A1 (en) * | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
| CN101528260A (zh) * | 2006-10-26 | 2009-09-09 | 协和发酵麒麟株式会社 | 肠易激综合症治疗剂 |
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| EP0468119A1 (en) | 1990-07-24 | 1992-01-29 | Merrell Dow Pharmaceuticals Inc. | Novel carbocyclic analogs of certain nucleosides |
| US6617439B1 (en) * | 2000-06-09 | 2003-09-09 | Bar-Ilan University | C8-substituted purine nucleotide analogs |
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| WO2007107598A1 (en) * | 2006-03-21 | 2007-09-27 | Heinrich-Heine-Universität Düsseldorf | Phosphorylated a2a receptor agonists |
| US8846896B2 (en) * | 2012-03-21 | 2014-09-30 | Alios Biopharma, Inc. | Methods of preparing substituted nucleotide analogs |
| US9090697B2 (en) | 2013-03-15 | 2015-07-28 | Bayer Healthcare Llc | Methods for treating bleeding disorders |
| JP6657182B2 (ja) * | 2014-04-25 | 2020-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌治療用のcd73阻害剤としてのプリン誘導体 |
| WO2018067424A1 (en) | 2016-10-03 | 2018-04-12 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5'-nucleotidase |
| WO2018183635A1 (en) * | 2017-03-31 | 2018-10-04 | Peloton Therapeutics, Inc. | Cd73 inhibitors and uses thereof |
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| JP2008523098A (ja) * | 2004-12-10 | 2008-07-03 | エモリー・ユニバーシテイ | ウィルス感染および異常細胞増殖の治療用の2′および3′−置換シクロブチルヌクレオシド類縁体 |
| US20090156545A1 (en) * | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3518934A4 (en) | 2020-06-24 |
| JP2019529500A (ja) | 2019-10-17 |
| WO2018067424A1 (en) | 2018-04-12 |
| US20240285665A1 (en) | 2024-08-29 |
| CN110049767A (zh) | 2019-07-23 |
| US11058704B2 (en) | 2021-07-13 |
| US12168023B2 (en) | 2024-12-17 |
| CN110049767B (zh) | 2023-04-04 |
| JP2022173493A (ja) | 2022-11-18 |
| JP7184761B2 (ja) | 2022-12-06 |
| TW201817739A (zh) | 2018-05-16 |
| US20250319113A1 (en) | 2025-10-16 |
| US20200222441A1 (en) | 2020-07-16 |
| EP3518934A1 (en) | 2019-08-07 |
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