TWI781960B - 腺核苷5'-核苷酸酶之抑制劑及相關用途 - Google Patents

腺核苷5'-核苷酸酶之抑制劑及相關用途 Download PDF

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TWI781960B
TWI781960B TW106134280A TW106134280A TWI781960B TW I781960 B TWI781960 B TW I781960B TW 106134280 A TW106134280 A TW 106134280A TW 106134280 A TW106134280 A TW 106134280A TW I781960 B TWI781960 B TW I781960B
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cancer
optionally substituted
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alkyl
pharmaceutically acceptable
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TW106134280A
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TW201817739A (zh
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勞倫特 皮爾 保羅 戴賓
傑洛斯勒 卡里斯卡
肯尼斯 V 勞森
曼摩漢 瑞迪 賴勒提
艾瑞克 艾倫 林德西
迪倫 哈汀 邁爾斯
艾瑞克 紐康
傑 派翠克 包爾斯
布蘭登 里德 羅森
荷森 厄爾 莎瑞菲
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美商阿克思生物科學有限公司
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TW106134280A 2016-10-03 2017-10-03 腺核苷5'-核苷酸酶之抑制劑及相關用途 TWI781960B (zh)

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US201662403598P 2016-10-03 2016-10-03
US62/403,598 2016-10-03

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TWI781960B true TWI781960B (zh) 2022-11-01

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US (3) US11058704B2 (enExample)
EP (1) EP3518934A4 (enExample)
JP (2) JP7184761B2 (enExample)
CN (1) CN110049767B (enExample)
TW (1) TWI781960B (enExample)
WO (1) WO2018067424A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018067424A1 (en) 2016-10-03 2018-04-12 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
WO2018183635A1 (en) * 2017-03-31 2018-10-04 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof
US11129841B2 (en) 2017-05-10 2021-09-28 Oric Pharmaceuticals, Inc. CD73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
CN111094317B (zh) * 2017-12-29 2023-03-31 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
WO2019173682A1 (en) 2018-03-09 2019-09-12 Arcus Biosciences, Inc. Parenterally administered immune enhancing drugs
CA3098493A1 (en) * 2018-04-30 2019-11-07 Oric Pharmaceuticals, Inc. Cd73 inhibitors
TW202017569A (zh) 2018-05-31 2020-05-16 美商佩樂敦治療公司 用於抑制cd73之組合物及方法
CN112638389A (zh) * 2018-08-28 2021-04-09 江苏恒瑞医药股份有限公司 Cd73抑制剂及其治疗用途
WO2020146795A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
WO2020151707A1 (zh) * 2019-01-22 2020-07-30 江苏恒瑞医药股份有限公司 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用
ES3070946T3 (en) 2019-03-12 2026-06-18 Arcus Biosciences Inc Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation
EP3939988A4 (en) * 2019-03-20 2022-08-24 Korea Research Institute of Chemical Technology PHARMACEUTICAL COMPOSITION WITH NOVEL HETEROCYCLIC AZOLOPYRIMIDINE COMPOUND AS THE ACTIVE SUBSTANCE
CA3135487A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
WO2020210970A1 (en) * 2019-04-16 2020-10-22 Bioardis Llc Imidazotriazine derivatives as cd73 inhibitors
TWI821559B (zh) * 2019-04-28 2023-11-11 大陸商上海和譽生物醫藥科技有限公司 一種cd73抑制劑,其製備方法和應用
KR20220034780A (ko) * 2019-06-14 2022-03-18 써던 리서취 인스티튜트 2,4,7-치환된-7-데아자-2'-데옥시-2'-플루오로아라비노실 뉴클레오사이드 및 뉴클레오타이드 전구약물 및 이의 용도
US12544391B2 (en) 2019-07-16 2026-02-10 Oric Pharmaceuticals, Inc. CD73 inhibitors
WO2021040356A1 (en) * 2019-08-23 2021-03-04 Kainos Medicine, Inc. C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition
CN116854758A (zh) * 2019-10-30 2023-10-10 欧瑞克制药公司 Cd73抑制剂
CA3173831A1 (en) 2020-03-19 2021-09-23 Arcus Biosciences, Inc. Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
TW202210514A (zh) 2020-06-02 2022-03-16 美商阿克思生物科學有限公司 針對tigit的抗體
WO2022246177A1 (en) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl compounds
EP4341262A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl inhibitor compounds
TW202325279A (zh) 2021-10-29 2023-07-01 美商阿克思生物科學有限公司 HIF-2α抑制劑及其使用方法
AU2023252914A1 (en) 2022-04-13 2024-10-17 Arcus Biosciences, Inc. Combination therapy for treating trop-2 expressing cancers
CN119156228A (zh) 2022-05-02 2024-12-17 艾库斯生物科学有限公司 抗tigit抗体及其用途
CN116768949B (zh) * 2022-07-12 2026-03-03 南京工业大学 一种基于3’-脱氧腺苷经化学修饰改性的具有抗癌效应的化合物
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202421150A (zh) 2022-09-14 2024-06-01 美商阿克思生物科學有限公司 艾魯美冷之分散體
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
EP4704829A2 (en) * 2023-04-26 2026-03-11 Lakewood Amedex, Inc. Substituted bicyclic heterocycle compounds, compositions, and uses thereof
EP4705292A1 (en) 2023-05-05 2026-03-11 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024243502A1 (en) 2023-05-25 2024-11-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025054339A1 (en) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Triazolopyridine compounds as inhibitors of kit
WO2025072330A1 (en) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Kit inhibitor compounds and methods of use thereof
EP4788432A1 (en) 2023-10-06 2026-08-12 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
US12384773B2 (en) 2023-11-02 2025-08-12 Arcus Biosciences, Inc. Thiazole compounds and methods of use thereof
WO2025113498A1 (zh) * 2023-12-01 2025-06-05 无锡和誉生物医药科技有限公司 一种cd73抑制剂碱式盐及其制备方法和应用
CN117562915A (zh) * 2023-12-05 2024-02-20 中国药科大学 一种腺苷衍生物在制备预防、缓解或治疗纤维化疾病的药物中的应用
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound
WO2026006759A1 (en) 2024-06-28 2026-01-02 Arcus Biosciences, Inc. Pharmaceutical compositions, dosage forms, and methods of making and using same
CN119552122B (zh) * 2025-01-27 2025-05-09 北京悦康科创医药科技股份有限公司 5'-磷酸酯修饰核苷及其制备方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008523098A (ja) * 2004-12-10 2008-07-03 エモリー・ユニバーシテイ ウィルス感染および異常細胞増殖の治療用の2′および3′−置換シクロブチルヌクレオシド類縁体
TW200902034A (en) * 2007-03-28 2009-01-16 Vioquest Pharmaceuticals Inc Effective treatment of tumors and cancer with prodrugs of triciribine
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
CN101528260A (zh) * 2006-10-26 2009-09-09 协和发酵麒麟株式会社 肠易激综合症治疗剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
US6617439B1 (en) * 2000-06-09 2003-09-09 Bar-Ilan University C8-substituted purine nucleotide analogs
WO2004096233A2 (en) * 2003-04-25 2004-11-11 Gilead Sciences, Inc. Nucleoside phosphonate conjugates
WO2007107598A1 (en) * 2006-03-21 2007-09-27 Heinrich-Heine-Universität Düsseldorf Phosphorylated a2a receptor agonists
HK1203513A1 (en) 2012-03-21 2015-10-30 艾丽奥斯生物制药有限公司 Methods of preparing substituted nucleotide analogs
US9090697B2 (en) 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
EP3134411B1 (en) * 2014-04-25 2021-06-30 Boehringer Ingelheim International GmbH Purine derivatives as cd73 inhibitors for the treatment of cancer
WO2018067424A1 (en) 2016-10-03 2018-04-12 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
WO2018183635A1 (en) 2017-03-31 2018-10-04 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008523098A (ja) * 2004-12-10 2008-07-03 エモリー・ユニバーシテイ ウィルス感染および異常細胞増殖の治療用の2′および3′−置換シクロブチルヌクレオシド類縁体
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
CN101528260A (zh) * 2006-10-26 2009-09-09 协和发酵麒麟株式会社 肠易激综合症治疗剂
TW200902034A (en) * 2007-03-28 2009-01-16 Vioquest Pharmaceuticals Inc Effective treatment of tumors and cancer with prodrugs of triciribine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ondrej Pav, Ivana Kosiova, Ivan Barvık, Radek Pohl, Milos Budesınskya and Ivan Rosenberg," Synthesis of oligoribonucleotides with phosphonate-modified linkages", Organic & Biomolecular Chemistry,2011 Sep 7, vol9, P6120–P6126 *
Ondrej Pav, Ivana Kosiova, Ivan Barvık, Radek Pohl, Milos Budesınskya and Ivan Rosenberg," Synthesis of oligoribonucleotides with phosphonate-modified linkages", Organic & Biomolecular Chemistry,2011 Sep 7, vol9, P6120–P6126

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