JP2019501223A5 - - Google Patents
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- JP2019501223A5 JP2019501223A5 JP2018554643A JP2018554643A JP2019501223A5 JP 2019501223 A5 JP2019501223 A5 JP 2019501223A5 JP 2018554643 A JP2018554643 A JP 2018554643A JP 2018554643 A JP2018554643 A JP 2018554643A JP 2019501223 A5 JP2019501223 A5 JP 2019501223A5
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- 150000001875 compounds Chemical class 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- -1 methylamino, ethylamino, dimethylamino, diethylamino, N- methyl -N- ethylamino Chemical group 0.000 claims 16
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 9
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 9
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 102100022464 5'-nucleotidase Human genes 0.000 claims 2
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 claims 2
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 2
- 241000406668 Loxodonta cyclotis Species 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 229960005475 antiinfective agent Drugs 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 208000033133 Testicular seminomatous germ cell tumor Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 206010002906 aortic stenosis Diseases 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000010749 gastric carcinoma Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 208000000649 small cell carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 201000000498 stomach carcinoma Diseases 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 208000024662 testicular seminoma Diseases 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 125000004014 thioethyl group Chemical group [H]SC([H])([H])C([H])([H])* 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021121236A JP7322104B2 (ja) | 2016-01-08 | 2021-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2023121750A JP7698677B2 (ja) | 2016-01-08 | 2023-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2025099433A JP2025123371A (ja) | 2016-01-08 | 2025-06-13 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276564P | 2016-01-08 | 2016-01-08 | |
| US62/276,564 | 2016-01-08 | ||
| US201662324077P | 2016-04-18 | 2016-04-18 | |
| US62/324,077 | 2016-04-18 | ||
| PCT/US2017/012587 WO2017120508A1 (en) | 2016-01-08 | 2017-01-06 | Modulators of 5'-nucleotidase, ecto and the use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021121236A Division JP7322104B2 (ja) | 2016-01-08 | 2021-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501223A JP2019501223A (ja) | 2019-01-17 |
| JP2019501223A5 true JP2019501223A5 (enExample) | 2020-02-13 |
| JP6920344B2 JP6920344B2 (ja) | 2021-08-18 |
Family
ID=59274491
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554643A Active JP6920344B2 (ja) | 2016-01-08 | 2017-01-06 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2021121236A Active JP7322104B2 (ja) | 2016-01-08 | 2021-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2023121750A Active JP7698677B2 (ja) | 2016-01-08 | 2023-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2025099433A Pending JP2025123371A (ja) | 2016-01-08 | 2025-06-13 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021121236A Active JP7322104B2 (ja) | 2016-01-08 | 2021-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2023121750A Active JP7698677B2 (ja) | 2016-01-08 | 2023-07-26 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
| JP2025099433A Pending JP2025123371A (ja) | 2016-01-08 | 2025-06-13 | ５’ヌクレオチダーゼ，エクトのモジュレーター及びその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US10239912B2 (enExample) |
| EP (2) | EP4306525A3 (enExample) |
| JP (4) | JP6920344B2 (enExample) |
| KR (1) | KR102772803B1 (enExample) |
| CN (3) | CN119912510A (enExample) |
| AU (2) | AU2017206061B2 (enExample) |
| BR (1) | BR112018013827B1 (enExample) |
| CA (2) | CA3009196C (enExample) |
| CL (1) | CL2018001845A1 (enExample) |
| DK (1) | DK3399984T3 (enExample) |
| EA (1) | EA038565B1 (enExample) |
| ES (1) | ES2963759T3 (enExample) |
| FI (1) | FI3399984T3 (enExample) |
| HR (1) | HRP20231155T1 (enExample) |
| HU (1) | HUE063388T2 (enExample) |
| IL (1) | IL260260B2 (enExample) |
| LT (1) | LT3399984T (enExample) |
| MX (2) | MX2018008350A (enExample) |
| MY (1) | MY204877A (enExample) |
| PH (1) | PH12018501361A1 (enExample) |
| PL (1) | PL3399984T3 (enExample) |
| PT (1) | PT3399984T (enExample) |
| SA (1) | SA518391985B1 (enExample) |
| SG (1) | SG11201805506YA (enExample) |
| SI (1) | SI3399984T1 (enExample) |
| TW (2) | TW202227095A (enExample) |
| UA (1) | UA124529C2 (enExample) |
| WO (1) | WO2017120508A1 (enExample) |
| ZA (2) | ZA201804350B (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201805506YA (en) | 2016-01-08 | 2018-07-30 | Arcus Biosciences Inc | Modulators of 5'-nucleotidase, ecto and the use thereof |
| TWI767937B (zh) | 2016-09-09 | 2022-06-21 | 美商卡利泰拉生物科技公司 | 外核苷酸酶抑制劑及其使用方法 |
| JP7150712B2 (ja) | 2016-11-18 | 2022-10-11 | アーカス バイオサイエンシズ インコーポレイティド | Ｃｄ７３媒介免疫抑制の阻害剤 |
| UA125524C2 (uk) | 2016-12-08 | 2022-04-13 | Ф. Хоффманн-Ля Рош Аг | Ефірні похідні ізоксазолу як позитивні алостеричні модулятори рецептора гамк а альфа-5 |
| CA3047988A1 (en) * | 2016-12-22 | 2018-06-28 | Antengene Therapeutics Limited | Ectonucleotidase inhibitors and methods of use thereof |
| CN110382544B (zh) | 2017-03-16 | 2023-12-22 | 先天制药公司 | 用于治疗癌症的组合物和方法 |
| WO2018208980A1 (en) | 2017-05-10 | 2018-11-15 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| WO2019068907A1 (en) | 2017-10-06 | 2019-04-11 | Innate Pharma | RESTORATION OF T CELL ACTIVITY BY AXIS CD39 / CD73 |
| WO2019090111A1 (en) * | 2017-11-03 | 2019-05-09 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| WO2019129059A1 (zh) * | 2017-12-29 | 2019-07-04 | 上海和誉生物医药科技有限公司 | 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用 |
| TWI702954B (zh) * | 2018-03-01 | 2020-09-01 | 美商美國禮來大藥廠 | Cd73抑制劑 |
| AU2019231781B2 (en) * | 2018-03-09 | 2025-02-13 | Arcus Biosciences, Inc. | Parenterally administered immune enhancing drugs |
| CN112423764A (zh) | 2018-04-30 | 2021-02-26 | 欧瑞克制药公司 | Cd73抑制剂 |
| WO2019232319A1 (en) | 2018-05-31 | 2019-12-05 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting cd73 |
| AU2019289646B2 (en) | 2018-06-18 | 2025-10-23 | Innate Pharma | Compositions and methods for treating cancer |
| WO2020037275A1 (en) * | 2018-08-17 | 2020-02-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors |
| EP3843742A4 (en) | 2018-08-28 | 2022-04-20 | Jiangsu Hengrui Medicine Co., Ltd. | CD73 INHIBITORS AND THEIR THERAPEUTIC USES |
| EP3849992A4 (en) | 2018-09-11 | 2022-06-29 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cd73 inhibitors and pharmaceutical uses thereof |
| US11530234B2 (en) | 2018-09-11 | 2022-12-20 | Risen (Suzhou) Pharma Tech Co., Ltd. | CD73 inhibitors and pharmaceutical uses thereof |
| CN110885352B (zh) * | 2018-09-11 | 2023-02-24 | 润佳（苏州）医药科技有限公司 | Cd73抑制剂及其药学应用 |
| EP3893891A4 (en) * | 2018-12-13 | 2022-08-03 | Arcus Biosciences, Inc. | SOLID FORMS OF A CD73 INHIBITOR AND THEIR USE |
| CN113727999A (zh) | 2019-01-11 | 2021-11-30 | 奥默罗斯公司 | 用于治疗癌症的方法和组合物 |
| CN112955444B (zh) * | 2019-01-22 | 2023-12-12 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| WO2020185859A1 (en) | 2019-03-12 | 2020-09-17 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| EP3947463A4 (en) | 2019-03-29 | 2022-12-21 | Arcus Biosciences, Inc. | TREATMENT OF CANCER USING AN IDENTIFIED ADENOSINE FINGERPRINT |
| CN113905743B (zh) * | 2019-03-29 | 2024-04-16 | 江苏恒瑞医药股份有限公司 | Cd73抑制剂及其治疗用途 |
| WO2020206289A1 (en) * | 2019-04-05 | 2020-10-08 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 |
| WO2020210938A1 (en) * | 2019-04-15 | 2020-10-22 | Bioardis Llc | Quinazoline derivatives as cd73 inhibitors |
| WO2020210970A1 (en) * | 2019-04-16 | 2020-10-22 | Bioardis Llc | Imidazotriazine derivatives as cd73 inhibitors |
| TWI821559B (zh) * | 2019-04-28 | 2023-11-11 | 大陸商上海和譽生物醫藥科技有限公司 | 一種cd73抑制劑，其製備方法和應用 |
| US20220251134A1 (en) * | 2019-06-14 | 2022-08-11 | Southern Research Institute | 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof |
| EP3999517A4 (en) | 2019-07-16 | 2023-07-12 | Oric Pharmaceuticals, Inc. | CD73 INHIBITORS |
| WO2021040356A1 (en) * | 2019-08-23 | 2021-03-04 | Kainos Medicine, Inc. | C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition |
| MX2022002398A (es) * | 2019-08-29 | 2022-03-17 | Lilly Co Eli | Formas cristalinas de un inhibidor de cd73. |
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| TW202131932A (zh) * | 2019-11-05 | 2021-09-01 | 美商博奥阿迪斯有限公司 | 作為cd73抑制劑的化合物 |
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| IL295569B1 (en) | 2020-03-19 | 2026-04-01 | Arcus Biosciences Inc | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2ALPHA |
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| TW202220976A (zh) * | 2020-09-08 | 2022-06-01 | 大陸商貝達藥業股份有限公司 | Cd73抑制劑及其在醫藥上的應用 |
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| JP7651694B2 (ja) * | 2020-11-05 | 2025-03-26 | 武漢人福創新薬物研発中心有限公司 | 化合物、前記化合物の互変異性体、前記化合物の立体異性体、前記化合物の水和物、前記化合物の溶媒和物または前記化合物の薬学的に許容される塩、及び薬物組成物 |
| CN114539340B (zh) * | 2020-11-25 | 2024-06-07 | 润佳（苏州）医药科技有限公司 | Cd73抑制剂及其药学应用 |
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| JP2024502068A (ja) * | 2020-12-29 | 2024-01-17 | チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド | Ａ３アデノシン受容体アゴニスト及びその調製方法と用途 |
| TW202308657A (zh) | 2021-05-11 | 2023-03-01 | 大陸商四川海思科製藥有限公司 | 小分子cd73拮抗劑及其用途 |
| US20240226115A1 (en) | 2021-05-21 | 2024-07-11 | Arcus Biosciences, Inc. | Axl inhibitor compounds |
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| WO2023061319A1 (zh) * | 2021-10-11 | 2023-04-20 | 南京明德新药研发有限公司 | 三并环杂环衍生物 |
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| KR20250004779A (ko) | 2022-04-13 | 2025-01-08 | 길리애드 사이언시즈, 인코포레이티드 | Trop-2 발현 암을 치료하기 위한 병용 요법 |
| WO2023215719A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
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