MX2022006322A - Moduladores de 5'-nucleotidasa, ecto y el uso de los mismos. - Google Patents

Moduladores de 5'-nucleotidasa, ecto y el uso de los mismos.

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Publication number
MX2022006322A
MX2022006322A MX2022006322A MX2022006322A MX2022006322A MX 2022006322 A MX2022006322 A MX 2022006322A MX 2022006322 A MX2022006322 A MX 2022006322A MX 2022006322 A MX2022006322 A MX 2022006322A MX 2022006322 A MX2022006322 A MX 2022006322A
Authority
MX
Mexico
Prior art keywords
nucleotidase
ecto
compounds
modulators
disorders
Prior art date
Application number
MX2022006322A
Other languages
English (en)
Inventor
Manmohan Reddy Leleti
Jay Patrick Powers
Juan Carlos Jaen
Dillon Harding Miles
Brandon Reid Rosen
Laurent Pierre Paul Debien
Jaroslaw Kalisiak
Kenneth V Lawson
Erick Allen Lindsey
Eric Newcomb
Ehesan Ul Sharif
Original Assignee
Arcus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcus Biosciences Inc filed Critical Arcus Biosciences Inc
Publication of MX2022006322A publication Critical patent/MX2022006322A/es

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Abstract

Los compuestos que modulan la conversión de AMP a adenosina mediante 5'-nucleotidasa, ecto, y composiciones que contienen los compuestos y métodos para sintetizar los compuestos, son descritos en la presente. También se proporcionar el uso de estos compuestos y composiciones para el tratamiento y/o prevención de un arreglo diverso de enfermedades, trastornos y condiciones, que incluyen cáncer trastornos relacionados a cáncer e inmunitarios, que se medían pro 5'-nucleotidasa, ecto.
MX2022006322A 2016-01-08 2018-07-05 Moduladores de 5'-nucleotidasa, ecto y el uso de los mismos. MX2022006322A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662276564P 2016-01-08 2016-01-08
US201662324077P 2016-04-18 2016-04-18

Publications (1)

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MX2022006322A true MX2022006322A (es) 2022-06-22

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MX2018008350A MX2018008350A (es) 2016-01-08 2017-01-06 Moduladores de 5´-nucleotidasa, ecto y el uso de los mismos.
MX2022006322A MX2022006322A (es) 2016-01-08 2018-07-05 Moduladores de 5'-nucleotidasa, ecto y el uso de los mismos.

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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202227095A (zh) 2016-01-08 2022-07-16 美商阿克思生物科學有限公司 胞外5'-核苷酸酶之調節劑及其用途
CN110234656B (zh) 2016-09-09 2023-02-28 卡利泰拉生物科技公司 外核苷酸酶抑制剂及其使用方法
EP3541396A4 (en) 2016-11-18 2020-07-22 Arcus Biosciences, Inc. CD73-MEDIATED IMMUNOSUPPRESSION INHIBITORS
UA125524C2 (uk) 2016-12-08 2022-04-13 Ф. Хоффманн-Ля Рош Аг Ефірні похідні ізоксазолу як позитивні алостеричні модулятори рецептора гамк а альфа-5
CA3047988A1 (en) * 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
US11578136B2 (en) 2017-03-16 2023-02-14 Innate Pharma Compositions and methods for treating cancer
WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
CA3074588A1 (en) 2017-10-06 2019-04-11 Innate Pharma Restoration of t cell activity via the cd39/cd73 axis
WO2019090111A1 (en) * 2017-11-03 2019-05-09 Oric Pharmaceuticals, Inc. Cd73 inhibitors
CN111094317B (zh) * 2017-12-29 2023-03-31 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
TWI702954B (zh) * 2018-03-01 2020-09-01 美商美國禮來大藥廠 Cd73抑制劑
JP7417530B2 (ja) * 2018-03-09 2024-01-18 アーカス バイオサイエンシズ インコーポレイティド 優先投与される免疫増強薬
KR20210018255A (ko) 2018-04-30 2021-02-17 오릭 파마슈티칼스, 인크. Cd73 억제제
KR20210023983A (ko) 2018-06-18 2021-03-04 이나뜨 파르마 암을 치료하기 위한 조성물 및 방법
WO2020037275A1 (en) * 2018-08-17 2020-02-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors
EP3843742A4 (en) 2018-08-28 2022-04-20 Jiangsu Hengrui Medicine Co., Ltd. CD73 INHIBITORS AND THEIR THERAPEUTIC USES
US11530234B2 (en) 2018-09-11 2022-12-20 Risen (Suzhou) Pharma Tech Co., Ltd. CD73 inhibitors and pharmaceutical uses thereof
MX2021002878A (es) * 2018-09-11 2021-08-16 Risen Suzhou Pharma Tech Co Ltd Inhibidores de cd73 y usos farmaceuticos de los mismos.
CN110885352B (zh) * 2018-09-11 2023-02-24 润佳（苏州）医药科技有限公司 Cd73抑制剂及其药学应用
WO2020123772A1 (en) * 2018-12-13 2020-06-18 Arcus Biosciences, Inc. Solid forms of a cd73 inhibitor and the use thereof
JP2022517978A (ja) 2019-01-11 2022-03-11 オメロス コーポレーション がんを処置するための方法および組成物
WO2020151707A1 (zh) * 2019-01-22 2020-07-30 江苏恒瑞医药股份有限公司 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用
WO2020185859A1 (en) * 2019-03-12 2020-09-17 Arcus Biosciences, Inc. Treatment of oncogene-driven cancers
CN113905743B (zh) * 2019-03-29 2024-04-16 江苏恒瑞医药股份有限公司 Cd73抑制剂及其治疗用途
JP2022527476A (ja) * 2019-03-29 2022-06-02 アーカス バイオサイエンシーズ，インコーポレーテッド 同定されたアデノシンフィンガープリントを利用したがんの処置
US20220152072A1 (en) * 2019-04-05 2022-05-19 Prelude Therapeutics, Incorporated Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
WO2020210938A1 (en) * 2019-04-15 2020-10-22 Bioardis Llc Quinazoline derivatives as cd73 inhibitors
WO2020210970A1 (en) * 2019-04-16 2020-10-22 Bioardis Llc Imidazotriazine derivatives as cd73 inhibitors
TWI821559B (zh) * 2019-04-28 2023-11-11 大陸商上海和譽生物醫藥科技有限公司 一種cd73抑制劑，其製備方法和應用
WO2021040356A1 (en) * 2019-08-23 2021-03-04 Kainos Medicine, Inc. C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition
CN114502548A (zh) * 2019-08-29 2022-05-13 伊莱利利公司 Cd73抑制剂的结晶形式
TWI830962B (zh) * 2019-10-30 2024-02-01 美商歐瑞克製藥公司 Cd73抑制劑
TW202131932A (zh) * 2019-11-05 2021-09-01 美商博奥阿迪斯有限公司 作為cd73抑制劑的化合物
US11633416B1 (en) 2020-03-06 2023-04-25 Arcus Biosciences, Inc. Oral formulations of CD73 compounds
CN115298165A (zh) 2020-03-19 2022-11-04 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
PE20231078A1 (es) 2020-06-02 2023-07-17 Arcus Biosciences Inc Anticuerpos anti-tigit
WO2021247188A1 (en) 2020-06-05 2021-12-09 Bristol-Myers Squibb Company Cd73 antagonist potency assay and methods of use thereof
KR20230026312A (ko) * 2020-06-17 2023-02-24 아르커스 바이오사이언시즈 인코포레이티드 Cd73 억제제의 결정형 및 이의 용도
CN115702150A (zh) * 2020-07-07 2023-02-14 贝达药业股份有限公司 Cd73抑制剂及其在医药上的应用
WO2022052886A1 (zh) * 2020-09-08 2022-03-17 贝达药业股份有限公司 Cd73抑制剂及其在医药上的应用
CN114437038A (zh) * 2020-11-05 2022-05-06 武汉人福创新药物研发中心有限公司 哒嗪炔烃类化合物及其用途
US20230399314A1 (en) * 2020-11-05 2023-12-14 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Cd73 inhibitor and use thereof
CA3200232A1 (en) * 2020-11-25 2022-06-02 Yuhua Zhang Cd73 inhibitors and pharmaceutical uses thereof
AU2021413448A1 (en) * 2020-12-29 2023-07-20 Zhejiang Vimgreen Pharmaceuticals, Ltd Adenosine a3 receptor agonists, preparation methods and uses thereof
CN117642411A (zh) * 2021-05-11 2024-03-01 西藏海思科制药有限公司 小分子cd73拮抗剂及其用途
TW202313603A (zh) 2021-05-21 2023-04-01 美商阿克思生物科學有限公司 Axl抑制劑化合物
EP4341261A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl compounds
WO2023061319A1 (zh) * 2021-10-11 2023-04-20 南京明德新药研发有限公司 三并环杂环衍生物
AU2022375666A1 (en) * 2021-10-26 2024-05-09 Southern Research Institute Development of novel clofarabine analogs for cancer therapy
CA3236553A1 (en) 2021-10-29 2023-05-04 Joel Worley BEATTY Inhibitors of hif-2alpha and methods of use thereof
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2023215719A1 (en) 2022-05-02 2023-11-09 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024059142A1 (en) 2022-09-14 2024-03-21 Arcus Biosciences, Inc. Dispersions of etrumadenant
US20240140979A1 (en) * 2022-10-03 2024-05-02 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024076873A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024081385A1 (en) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
WO2024086718A1 (en) 2022-10-20 2024-04-25 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569650A (en) * 1993-06-11 1996-10-29 Sloan-Kettering Institute For Cancer Research C-nucleoside isosters of analogs thereof and pharmaceutical compositions
AU4815197A (en) * 1996-10-09 1998-05-05 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
AU2002232660A1 (en) * 2000-12-15 2002-06-24 Pharmasset Ltd. Antiviral agents for treatment of flaviviridae infections
WO2012032513A1 (en) * 2010-09-07 2012-03-15 Bar-Ilan University Boranophosphate derivatives for the treatment of osteoarthritis
US9090697B2 (en) 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
FR3011240A1 (fr) * 2013-10-01 2015-04-03 Centre Nat Rech Scient Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques
US10144778B2 (en) 2014-03-12 2018-12-04 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
WO2015164573A1 (en) 2014-04-25 2015-10-29 Vitae Pharmaceuticals, Inc. Purine derivatives as cd73 inhibitors for the treatment of cancer
WO2017029601A1 (en) 2015-08-17 2017-02-23 Lupin Limited Heteroaryl derivatives as parp inhibitors
CN113662941A (zh) 2016-01-08 2021-11-19 细胞基因公司 抗增殖化合物以及其药物组合物和用途
UY37062A (es) 2016-01-08 2017-08-31 Syngenta Participations Ag Derivados de aryl oxadiazol fungicidas
TW202227095A (zh) 2016-01-08 2022-07-16 美商阿克思生物科學有限公司 胞外5'-核苷酸酶之調節劑及其用途
JP7417530B2 (ja) 2018-03-09 2024-01-18 アーカス バイオサイエンシズ インコーポレイティド 優先投与される免疫増強薬
WO2020123772A1 (en) 2018-12-13 2020-06-18 Arcus Biosciences, Inc. Solid forms of a cd73 inhibitor and the use thereof
KR20230026312A (ko) 2020-06-17 2023-02-24 아르커스 바이오사이언시즈 인코포레이티드 Cd73 억제제의 결정형 및 이의 용도

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