|
WO1981001145A1
(en)
|
1979-10-18 |
1981-04-30 |
Univ Illinois |
Hydrolytic enzyme-activatible pro-drugs
|
|
US4698420A
(en)
|
1985-02-25 |
1987-10-06 |
Xoma Corporation |
Antibody hybrid molecules and process for their preparation
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
JP4667543B2
(ja)
|
1996-07-03 |
2011-04-13 |
大日本住友製薬株式会社 |
新規プリン誘導体
|
|
TW572758B
(en)
|
1997-12-22 |
2004-01-21 |
Sumitomo Pharma |
Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
|
|
US7425541B2
(en)
|
1998-12-11 |
2008-09-16 |
Medarex, Inc. |
Enzyme-cleavable prodrug compounds
|
|
NZ517202A
(en)
|
1999-08-24 |
2004-05-28 |
Medarex Inc |
Human CTLA-4 antibodies and their uses
|
|
WO2002015700A1
(en)
|
2000-08-24 |
2002-02-28 |
Coulter Pharmaceutical, Inc. |
Prodrugs activated by plasmin and their use in cancer chemotherapy
|
|
US7571211B1
(en)
|
2002-04-15 |
2009-08-04 |
Lightwaves Systems, Inc. |
Method for routing messages over a network based on location
|
|
JP4331944B2
(ja)
|
2001-04-17 |
2009-09-16 |
大日本住友製薬株式会社 |
新規アデニン誘導体
|
|
KR20030033007A
(ko)
|
2001-05-31 |
2003-04-26 |
코울터 파머수티컬, 인코포레이티드 |
세포독소, 약물전구체, 링커 및 이에 유용한 안정화제
|
|
ES2364452T3
(es)
|
2001-06-11 |
2011-09-02 |
Medarex, Inc. |
Método para diseñar compuestos profármacos activados por cd10.
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
EP1440072A4
(en)
|
2001-10-30 |
2005-02-02 |
Conforma Therapeutic Corp |
PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
|
|
EP1471938A4
(en)
|
2002-01-09 |
2008-03-05 |
Medarex Inc |
HUMAN MONOCLONAL ANTIBODIES AGAINST CD30
|
|
CA2497765A1
(en)
|
2002-09-27 |
2004-04-08 |
Sumitomo Pharmaceuticals Co., Ltd. |
8-hydroxy substituted adenine compounds and uses thereof
|
|
JP2004137157A
(ja)
|
2002-10-16 |
2004-05-13 |
Sumitomo Pharmaceut Co Ltd |
新規アデニン誘導体を有効成分として含有する医薬
|
|
EP1613274B1
(en)
|
2003-04-15 |
2010-03-03 |
GlaxoSmithKline LLC |
Human il-18 substitution mutants and their conjugates
|
|
PE20050712A1
(es)
|
2003-07-22 |
2005-11-02 |
Schering Ag |
Anticuerpos rg1
|
|
WO2005051976A2
(en)
|
2003-11-20 |
2005-06-09 |
Ansata Therapeutics, Inc. |
Protein and peptide ligation processes and one-step purification processes
|
|
DK2383295T3
(en)
|
2003-12-10 |
2015-06-15 |
Squibb & Sons Llc |
Ip-10 antibodies and uses thereof
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
WO2005092892A1
(ja)
|
2004-03-26 |
2005-10-06 |
Dainippon Sumitomo Pharma Co., Ltd. |
８−オキソアデニン化合物
|
|
BRPI0510909A2
(pt)
|
2004-05-19 |
2008-12-16 |
Medarex Inc |
composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
EP1809632A2
(en)
|
2004-10-28 |
2007-07-25 |
Pharmacia & Upjohn Company LLC |
Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors
|
|
CA2598454C
(en)
|
2005-02-18 |
2013-04-09 |
Medarex, Inc. |
Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues
|
|
ES2386366T3
(es)
|
2005-02-18 |
2012-08-17 |
Medarex, Inc. |
Anticuerpo monoclonal humano contra el antígeno de membrana específico de la próstata (PSMA)
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
EA200702235A1
(ru)
|
2005-05-04 |
2008-04-28 |
Пфайзер Лимитед |
Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
WO2007002223A2
(en)
|
2005-06-20 |
2007-01-04 |
Medarex, Inc. |
Cd19 antibodies and their uses
|
|
KR101704734B1
(ko)
|
2005-07-01 |
2017-02-09 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
HUE035853T2
(en)
|
2005-07-18 |
2018-05-28 |
Seattle Genetics Inc |
Beta-glucuronide-linker-drug conjugates
|
|
CN101253173A
(zh)
|
2005-09-02 |
2008-08-27 |
辉瑞有限公司 |
羟基取代的1h-咪唑并吡啶和方法
|
|
EP1939202A4
(en)
|
2005-09-22 |
2010-06-16 |
Dainippon Sumitomo Pharma Co |
NEW ADENINE CONNECTION
|
|
WO2007034917A1
(ja)
|
2005-09-22 |
2007-03-29 |
Dainippon Sumitomo Pharma Co., Ltd. |
新規なアデニン化合物
|
|
EP1934261B1
(en)
|
2005-09-26 |
2014-10-29 |
Medarex, L.L.C. |
Human monoclonal antibodies to cd70
|
|
EA016577B1
(ru)
|
2005-09-26 |
2012-06-29 |
Медарекс, Инк. |
Конъюгаты антитело-лекарство и их применение
|
|
BRPI0619331A2
(pt)
|
2005-10-26 |
2011-09-27 |
Medarex Inc |
método para fazer um composto para preparar um análogo de cbi cc-1065, método para preparar um análogo de cbi cc-1065 e composto
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
NZ569236A
(en)
|
2005-12-08 |
2012-06-29 |
Medarex Inc |
Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and their use
|
|
US8609816B2
(en)
|
2005-12-08 |
2013-12-17 |
Medarex, L.L.C. |
Human monoclonal antibodies to O8E
|
|
AU2007216247A1
(en)
|
2006-02-17 |
2007-08-23 |
Pfizer Limited |
3 -deazapurine derivatives as TLR7 modulators
|
|
DK2035554T3
(da)
|
2006-06-29 |
2013-06-17 |
Univ Leland Stanford Junior |
Celle-fri syntese af proteiner indeholdende ikke-naturlige aminosyrer
|
|
JP2010500885A
(ja)
|
2006-08-18 |
2010-01-14 |
ノボ ノルディスク ヘルス ケア アーゲー |
改善された特異性を有するトランスグルタミナーゼ変異体
|
|
CN101528914B
(zh)
|
2006-09-08 |
2014-12-03 |
Ambrx公司 |
通过脊椎动物细胞位点特异性并入非天然氨基酸
|
|
SI2066351T1
(sl)
|
2006-10-02 |
2016-02-29 |
E.R. Squibb & Sons, L.L.C. |
Humana protitelesa, ki vežejo cxcr4 in njihova uporaba
|
|
SG177168A1
(en)
|
2006-12-01 |
2012-01-30 |
Medarex Inc |
Human antibodies that bind cd22 and uses thereof
|
|
UY30776A1
(es)
|
2006-12-21 |
2008-07-03 |
Medarex Inc |
Anticuerpos cd44
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
EP2510946B1
(en)
|
2007-02-07 |
2015-08-05 |
The Regents of The University of California |
Conjugates of synthetic tlr agonists and uses therefor
|
|
JP2010519310A
(ja)
|
2007-02-21 |
2010-06-03 |
メダレックス インコーポレイテッド |
単一のアミノ酸を有する化学リンカーおよびその複合体
|
|
WO2008102007A1
(en)
|
2007-02-22 |
2008-08-28 |
Novo Nordisk Health Care Ag |
Transglutaminase variants with improved specificity
|
|
TW200902018A
(en)
|
2007-03-20 |
2009-01-16 |
Dainippon Sumitomo Pharma Co |
Novel adenine compound
|
|
CA2680783C
(en)
|
2007-03-23 |
2012-04-24 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
EP2170888B1
(en)
|
2007-06-29 |
2015-04-22 |
Gilead Sciences, Inc. |
Purine derivatives and their use as modulators of toll-like receptor 7
|
|
ATE501136T1
(de)
|
2007-08-03 |
2011-03-15 |
Pfizer Ltd |
Imidazopyridinone
|
|
EP2185188B1
(en)
|
2007-08-22 |
2014-08-06 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
|
|
HRP20150074T1
(hr)
|
2007-10-01 |
2015-03-13 |
Bristol-Myers Squibb Company |
Humana antitijela koja se vežu za mezotelin i njihove uporabe
|
|
UY32306A
(es)
|
2008-12-09 |
2010-07-30 |
Gilead Sciences Inc |
Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos
|
|
US8940501B2
(en)
|
2009-01-30 |
2015-01-27 |
Whitehead Institute For Biomedical Research |
Methods for ligation and uses thereof
|
|
KR20110117705A
(ko)
|
2009-02-11 |
2011-10-27 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
톨-유사 수용체 조정제 및 질병의 치료
|
|
BR112012009329A2
(pt)
|
2009-10-22 |
2016-06-07 |
Gilead Sciences Inc |
derivados de purina ou deazapurina úteis para o tratamento de infecções virais (inter alia)
|
|
EP2563366A4
(en)
|
2010-04-30 |
2013-11-20 |
Univ California |
USE OF PHOSPHOLIPID CONJUGATES FROM SYNTHETIC TLR7 AGONISTS
|
|
EP2563404B1
(en)
|
2010-04-30 |
2016-09-21 |
Urogen Pharma Ltd. |
Phospholipid drug analogs
|
|
WO2011134669A1
(en)
|
2010-04-30 |
2011-11-03 |
Telormedix Sa |
Methods for inducing an immune response
|
|
WO2012038058A1
(en)
|
2010-09-21 |
2012-03-29 |
Telormedix Sa |
Treatment of conditions by toll-like receptor modulators
|
|
CA2813411C
(en)
|
2010-11-05 |
2016-08-02 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
WO2012122396A1
(en)
|
2011-03-08 |
2012-09-13 |
Baylor Research Institute |
Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
|
|
JP2014521687A
(ja)
|
2011-07-29 |
2014-08-28 |
セレクタ バイオサイエンシーズ インコーポレーテッド |
体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア
|
|
DK2776439T3
(en)
|
2011-11-09 |
2018-10-22 |
Janssen Sciences Ireland Uc |
PURINE DERIVATIVES FOR TREATING VIRUS INFECTIONS
|
|
DK2872515T3
(en)
|
2012-07-13 |
2016-09-19 |
Janssen Sciences Ireland Uc |
MACROCYCLIC PURINES FOR TREATING VIRUS INFECTIONS
|
|
US9173872B2
(en)
|
2012-08-24 |
2015-11-03 |
Glaxosmithkline Llc |
Pyrazolopyrimidine compounds
|
|
MX386924B
(es)
|
2012-10-10 |
2025-03-19 |
Janssen Sciences Ireland Uc |
Derivados pirrolo[3,2-d]pirimidínicos para el tratamiento de infecciones víricas y otras enfermedades.
|
|
EP2732825B1
(en)
|
2012-11-19 |
2015-07-01 |
Invivogen |
Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist
|
|
DK2956173T3
(en)
|
2013-02-14 |
2017-07-17 |
Bristol Myers Squibb Co |
TUBULYSIS RELATIONSHIPS, METHODS OF PRODUCING AND USING THEREOF
|
|
US9295732B2
(en)
|
2013-02-22 |
2016-03-29 |
Invivogen |
Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
|
|
WO2014154859A1
(en)
|
2013-03-29 |
2014-10-02 |
Janssen R&D Ireland |
Macrocyclic deaza-purinones for the treatment of viral infections
|
|
MX392130B
(es)
|
2013-06-27 |
2025-03-21 |
Janssen Sciences Ireland Uc |
Derivados de pirrolo[3,2-d]pirimidina para el tratamiento de infecciones víricas y otras enfermedades.
|
|
EP3033089A2
(en)
|
2013-08-16 |
2016-06-22 |
The Regents of The University of California |
Uses of phospholipid conjugates of synthetic tlr7 agonists
|
|
WO2015036044A1
(en)
|
2013-09-13 |
2015-03-19 |
Telormedix Sa |
Cationic lipid vehicles for delivery of tlr7 agonists for specific targeting of human cd14+ monocytes in whole blood
|
|
WO2015157504A1
(en)
*
|
2014-04-11 |
2015-10-15 |
Taipei Medical University |
Histone deacetylase inhibitors
|
|
WO2015168269A1
(en)
|
2014-05-01 |
2015-11-05 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
|
SG11201608299TA
(en)
|
2014-05-01 |
2016-11-29 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
|
WO2015171527A1
(en)
*
|
2014-05-05 |
2015-11-12 |
Global Blood Therapeutics, Inc. |
Pyrazolopyridine pyrazolopyrimidine and related compounds
|
|
PE20161475A1
(es)
*
|
2014-05-14 |
2017-01-08 |
Pfizer |
Pirazolopiridinas y pirazolopirimidinas
|
|
CN112898308B
(zh)
|
2014-08-15 |
2026-08-07 |
正大天晴药业集团股份有限公司 |
作为tlr7激动剂的吡咯并嘧啶化合物
|
|
CN105367576A
(zh)
*
|
2014-08-15 |
2016-03-02 |
正大天晴药业集团股份有限公司 |
作为tlr7激动剂的吡咯并嘧啶化合物
|
|
AR102537A1
(es)
*
|
2014-11-05 |
2017-03-08 |
Flexus Biosciences Inc |
Agentes inmunomoduladores
|
|
CN105732635A
(zh)
|
2014-12-29 |
2016-07-06 |
南京明德新药研发股份有限公司 |
一类Toll样受体7激动剂
|
|
ES2736106T3
(es)
|
2015-03-10 |
2019-12-26 |
Bristol Myers Squibb Co |
Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos
|
|
CA2992406A1
(en)
*
|
2015-07-15 |
2017-01-19 |
Aurigene Discovery Technologies Limited |
Indazole and azaindazole compounds as irak-4 inhibitors
|
|
CN108472386A
(zh)
|
2015-10-02 |
2018-08-31 |
百时美施贵宝公司 |
用于缀合抗体的转谷氨酰胺酶变体
|
|
CR20180229A
(es)
*
|
2015-10-29 |
2018-08-24 |
Novartis Ag |
Conjugados de anticuerpos que comprenden un agonista del receptor tipo toll
|
|
KR102112192B1
(ko)
|
2015-11-05 |
2020-05-19 |
치아타이 티안큉 파마수티컬 그룹 주식회사 |
Tlr7 효능제로서의 7-(티아졸-5-일)피롤로피리미딘 화합물
|
|
WO2017100557A1
(en)
|
2015-12-11 |
2017-06-15 |
Graphic Packaging International, Inc. |
Container with absorption features
|
|
WO2017197056A1
(en)
*
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Bromodomain targeting degronimers for target protein degradation
|
|
EA037871B1
(ru)
|
2016-06-16 |
2021-05-28 |
Янссен Фармацевтика Нв |
Производные азабензимидазола в качестве ингибиторов pi3k beta
|
|
CA3034185A1
(en)
*
|
2016-09-13 |
2018-03-22 |
F. Hoffmann-La Roche Ag |
Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
|
|
KR20190084991A
(ko)
|
2016-11-28 |
2019-07-17 |
지앙수 헨그루이 메디슨 컴퍼니 리미티드 |
피라졸로-헤테로아릴 유도체, 이의 제조 방법 및 의학적 용도
|
|
US10494370B2
(en)
|
2017-08-16 |
2019-12-03 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
|
|
US10487084B2
(en)
|
2017-08-16 |
2019-11-26 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
|
|
US10472361B2
(en)
|
2017-08-16 |
2019-11-12 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
|
|
US10457681B2
(en)
|
2017-08-16 |
2019-10-29 |
Bristol_Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
|
|
US10508115B2
(en)
|
2017-08-16 |
2019-12-17 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
|
|
RU2020124007A
(ru)
|
2017-12-21 |
2022-01-21 |
Сумитомо Дайниппон Фарма Ко., Лтд. |
Комбинированный препарат, включающий агонист tlr7
|
|
WO2019209811A1
(en)
|
2018-04-24 |
2019-10-31 |
Bristol-Myers Squibb Company |
Macrocyclic toll-like receptor 7 (tlr7) agonists
|
|
US11554120B2
(en)
*
|
2018-08-03 |
2023-01-17 |
Bristol-Myers Squibb Company |
1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
|
|
US11664120B1
(en)
*
|
2020-05-11 |
2023-05-30 |
Walgreen Co. |
Apparatuses, systems, and methods for reducing return of prescriptions to stock
|