JP2018524403A5 - - Google Patents
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- JP2018524403A5 JP2018524403A5 JP2018520047A JP2018520047A JP2018524403A5 JP 2018524403 A5 JP2018524403 A5 JP 2018524403A5 JP 2018520047 A JP2018520047 A JP 2018520047A JP 2018520047 A JP2018520047 A JP 2018520047A JP 2018524403 A5 JP2018524403 A5 JP 2018524403A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- membered
- substituted
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims description 51
- 150000001875 compounds Chemical class 0.000 claims description 45
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 29
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 25
- 125000005843 halogen group Chemical group 0.000 claims description 25
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000004429 atom Chemical group 0.000 claims description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 125000001153 fluoro group Chemical group F* 0.000 claims description 21
- 210000004027 cell Anatomy 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
- 229910052717 sulfur Inorganic materials 0.000 claims description 13
- 102100023933 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Human genes 0.000 claims description 12
- 108010011219 dUTP pyrophosphatase Proteins 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 9
- 206010009944 Colon cancer Diseases 0.000 claims description 8
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 229910052805 deuterium Inorganic materials 0.000 claims description 8
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 230000014509 gene expression Effects 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 230000002018 overexpression Effects 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- 239000011593 sulfur Substances 0.000 claims description 6
- 238000002560 therapeutic procedure Methods 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 3
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000012453 solvate Substances 0.000 claims description 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 210000000601 blood cell Anatomy 0.000 claims description 2
- 230000005907 cancer growth Effects 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 2
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 125000005647 linker group Chemical group 0.000 description 5
- 125000004450 alkenylene group Chemical group 0.000 description 3
- 125000004474 heteroalkylene group Chemical group 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- -1 substituted Chemical class 0.000 description 2
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 description 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 description 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
- 125000004419 alkynylene group Chemical group 0.000 description 1
- 125000000732 arylene group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 125000004404 heteroalkyl group Chemical group 0.000 description 1
- 125000005549 heteroarylene group Chemical group 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical group O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN740/KOL/2015 | 2015-07-08 | ||
| IN740KO2015 | 2015-07-08 | ||
| PCT/IB2016/054091 WO2017006282A1 (en) | 2015-07-08 | 2016-07-07 | Hydantoin containing deoxyuridine triphosphatase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020170594A Division JP7071044B2 (ja) | 2015-07-08 | 2020-10-08 | ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524403A JP2018524403A (ja) | 2018-08-30 |
| JP2018524403A5 true JP2018524403A5 (enExample) | 2019-08-22 |
| JP6836589B2 JP6836589B2 (ja) | 2021-03-03 |
Family
ID=56740270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520047A Active JP6836589B2 (ja) | 2015-07-08 | 2016-07-07 | ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤 |
| JP2020170594A Active JP7071044B2 (ja) | 2015-07-08 | 2020-10-08 | ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020170594A Active JP7071044B2 (ja) | 2015-07-08 | 2020-10-08 | ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US10570098B2 (enExample) |
| EP (1) | EP3319939B1 (enExample) |
| JP (2) | JP6836589B2 (enExample) |
| CN (2) | CN107922330A (enExample) |
| AU (1) | AU2016290987C1 (enExample) |
| CA (1) | CA2991468C (enExample) |
| DK (1) | DK3319939T3 (enExample) |
| EA (1) | EA037990B1 (enExample) |
| ES (1) | ES3016670T3 (enExample) |
| FI (1) | FI3319939T3 (enExample) |
| HU (1) | HUE070225T2 (enExample) |
| IL (1) | IL256221B (enExample) |
| PL (1) | PL3319939T4 (enExample) |
| PT (1) | PT3319939T (enExample) |
| SI (1) | SI3319939T1 (enExample) |
| WO (1) | WO2017006282A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014107622A1 (en) | 2013-01-07 | 2014-07-10 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2015103489A1 (en) | 2014-01-03 | 2015-07-09 | University Of Southern California | Heteroatom containing deoxyuridine triphosphatase inhibitors |
| DK3319939T3 (da) | 2015-07-08 | 2025-02-24 | Cv6 Therapeutics Ni Ltd | Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| EP3464274B1 (en) | 2016-05-23 | 2020-05-27 | H. Hoffnabb-La Roche Ag | Benzazepine dicarboxamide compounds with secondary amide function |
| WO2017202704A1 (en) | 2016-05-23 | 2017-11-30 | F. Hoffmann-La Roche Ag | Benzazepine dicarboxamide compounds with tertiary amide function |
| EP3468963B1 (en) | 2016-06-12 | 2021-10-27 | F. Hoffmann-La Roche AG | Dihydropyrimidinyl benzazepine carboxamide compounds |
| WO2018098209A1 (en) * | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| US10858344B2 (en) * | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US11247984B2 (en) | 2017-01-05 | 2022-02-15 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| BR112022026247A2 (pt) | 2020-06-26 | 2023-01-17 | Cv6 Therapeutics Ni Ltd | Método para aumentar a eficácia terapêutica de um agente de imunoterapia, método de tratamento de câncer e método de inibição do crescimento de uma célula de câncer |
| US20230357239A1 (en) | 2020-09-18 | 2023-11-09 | Bayer Aktiengesellschaft | Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| EP4448492B1 (en) | 2021-12-17 | 2026-03-04 | Reglagene, Inc. | Compositions and methods of making and using small molecules in the treatment of cancer |
| JP7894535B2 (ja) | 2023-02-28 | 2026-07-23 | レグラジーン、インコーポレイテッド | 健康状態の治療のための小分子を作製および使用するための組成物および方法 |
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| WO2026156174A1 (en) | 2025-01-16 | 2026-07-23 | Cv6 Therapeutics (Ni) Limited | Parp inhibitor combination therapy with deoxyuridine triphosphatase inhibitors |
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| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| DK3319939T3 (da) | 2015-07-08 | 2025-02-24 | Cv6 Therapeutics Ni Ltd | Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer |
| EP3693019A1 (en) | 2016-01-08 | 2020-08-12 | Taiho Pharmaceutical Co., Ltd. | Anti-tumor agent containing immunomodulator |
| US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| WO2018098209A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| US11247984B2 (en) | 2017-01-05 | 2022-02-15 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
-
2016
- 2016-07-07 DK DK16753974.1T patent/DK3319939T3/da active
- 2016-07-07 AU AU2016290987A patent/AU2016290987C1/en active Active
- 2016-07-07 US US15/741,202 patent/US10570098B2/en active Active
- 2016-07-07 CN CN201680051434.1A patent/CN107922330A/zh active Pending
- 2016-07-07 FI FIEP16753974.1T patent/FI3319939T3/fi active
- 2016-07-07 EA EA201890247A patent/EA037990B1/ru not_active IP Right Cessation
- 2016-07-07 PT PT167539741T patent/PT3319939T/pt unknown
- 2016-07-07 CA CA2991468A patent/CA2991468C/en active Active
- 2016-07-07 HU HUE16753974A patent/HUE070225T2/hu unknown
- 2016-07-07 PL PL16753974.1T patent/PL3319939T4/pl unknown
- 2016-07-07 JP JP2018520047A patent/JP6836589B2/ja active Active
- 2016-07-07 CN CN202511760190.1A patent/CN121779334A/zh active Pending
- 2016-07-07 SI SI201631891T patent/SI3319939T1/sl unknown
- 2016-07-07 WO PCT/IB2016/054091 patent/WO2017006282A1/en not_active Ceased
- 2016-07-07 EP EP16753974.1A patent/EP3319939B1/en active Active
- 2016-07-07 ES ES16753974T patent/ES3016670T3/es active Active
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2017
- 2017-12-10 IL IL256221A patent/IL256221B/en active IP Right Grant
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2018
- 2018-03-07 US US15/914,958 patent/US10562860B2/en not_active Expired - Fee Related
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2020
- 2020-05-04 US US16/789,687 patent/US11104649B2/en active Active
- 2020-10-08 JP JP2020170594A patent/JP7071044B2/ja active Active
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2021
- 2021-05-14 US US17/320,650 patent/US11584723B2/en active Active
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2022
- 2022-12-05 US US18/075,316 patent/US12098133B2/en active Active
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2024
- 2024-08-16 US US18/807,770 patent/US20250188039A1/en active Pending
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