JP2022141811A5 - - Google Patents
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- Publication number
- JP2022141811A5 JP2022141811A5 JP2022114274A JP2022114274A JP2022141811A5 JP 2022141811 A5 JP2022141811 A5 JP 2022141811A5 JP 2022114274 A JP2022114274 A JP 2022114274A JP 2022114274 A JP2022114274 A JP 2022114274A JP 2022141811 A5 JP2022141811 A5 JP 2022141811A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- cancer
- heteroaryl
- group
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 9
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 5
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 claims 4
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims 4
- 125000000262 haloalkenyl group Chemical group 0.000 claims 4
- 125000000232 haloalkynyl group Chemical group 0.000 claims 4
- 125000004447 heteroarylalkenyl group Chemical group 0.000 claims 4
- 125000005312 heteroarylalkynyl group Chemical group 0.000 claims 4
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000000464 thioxo group Chemical group S=* 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 201000005969 Uveal melanoma Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1509338.8 | 2015-05-29 | ||
| GBGB1509338.8A GB201509338D0 (en) | 2015-05-29 | 2015-05-29 | Combination therapy |
| GBGB1516442.9A GB201516442D0 (en) | 2015-05-29 | 2015-09-16 | Combination therapy |
| GB1516442.9 | 2015-09-16 | ||
| JP2020038089A JP7229194B2 (ja) | 2015-05-29 | 2020-03-05 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020038089A Division JP7229194B2 (ja) | 2015-05-29 | 2020-03-05 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022141811A JP2022141811A (ja) | 2022-09-29 |
| JP2022141811A5 true JP2022141811A5 (enExample) | 2023-04-10 |
| JP7549627B2 JP7549627B2 (ja) | 2024-09-11 |
Family
ID=53677482
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513923A Active JP6795585B2 (ja) | 2015-05-29 | 2016-05-27 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
| JP2020038089A Active JP7229194B2 (ja) | 2015-05-29 | 2020-03-05 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
| JP2022114274A Active JP7549627B2 (ja) | 2015-05-29 | 2022-07-15 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513923A Active JP6795585B2 (ja) | 2015-05-29 | 2016-05-27 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
| JP2020038089A Active JP7229194B2 (ja) | 2015-05-29 | 2020-03-05 | Axlインヒビタおよび免疫チェックポイントモジュレータまたは腫瘍溶解性ウィルスによる併用療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20180153888A1 (enExample) |
| EP (2) | EP3302481A1 (enExample) |
| JP (3) | JP6795585B2 (enExample) |
| GB (2) | GB201509338D0 (enExample) |
| WO (1) | WO2016193680A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201509338D0 (en) * | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
| WO2017146236A1 (ja) | 2016-02-26 | 2017-08-31 | 小野薬品工業株式会社 | Axl阻害剤と免疫チェックポイント阻害剤とを組み合わせて投与することを特徴とする癌治療のための医薬 |
| TWI781934B (zh) | 2016-05-27 | 2022-11-01 | 美商艾吉納斯公司 | 抗-tim-3抗體及其使用方法 |
| TW202436356A (zh) | 2016-10-11 | 2024-09-16 | 美商艾吉納斯公司 | 抗lag-3抗體及其使用方法 |
| AU2018244925A1 (en) | 2017-03-31 | 2019-11-21 | The Curators Of The University Of Missouri | Compositions for the treatment of drug-resistant tumors and methods of use thereof |
| WO2019039525A1 (ja) * | 2017-08-23 | 2019-02-28 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含むがん治療剤 |
| JP7223998B2 (ja) | 2017-10-13 | 2023-02-17 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含む固形がん治療剤 |
| BR112020026641A2 (pt) * | 2018-06-27 | 2021-03-30 | Oscotec Inc. | Derivados de piridopirimidinona para o uso como inibidores de axl |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| GB202006072D0 (en) * | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
| EP4359439A1 (en) | 2021-06-24 | 2024-05-01 | Yeda Research and Development Co. Ltd | Combination therapy for the treatment of cancer comprising an anti-egfr antibody and an axl-inhibitor |
| GB202209285D0 (en) | 2022-06-24 | 2022-08-10 | Bergenbio Asa | Dosage regimen for AXL inhibitor |
| AR129722A1 (es) | 2022-06-28 | 2024-09-18 | Arcus Biosciences Inc | Compuestos inhibidores de axl |
| KR20240156104A (ko) * | 2023-04-21 | 2024-10-29 | 아주대학교산학협력단 | 면역 관문 억제제 저항성 극복을 위한 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2226211A1 (de) | 1972-05-30 | 1973-12-13 | Basf Ag | N-substituierte iminocumarinfarbstoffe |
| WO2000054795A1 (en) * | 1999-03-15 | 2000-09-21 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| US6149495A (en) | 1999-03-15 | 2000-11-21 | Austin; Joseph James | Confetti and theatrical snow delivery device |
| EP1382969A1 (en) | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| EP1563094A4 (en) | 2002-10-29 | 2007-04-25 | Rigel Pharmaceuticals Inc | MODULATORS OF ANGIOGENESIS AND TUMORIGENESIS |
| EP1922310A2 (en) | 2005-09-07 | 2008-05-21 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| CA2647282A1 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| CN101646449A (zh) | 2006-10-10 | 2010-02-10 | 斯奎科公司 | 用于治疗和诊断癌症的组合物和方法 |
| WO2008045978A1 (en) | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| JP2008130120A (ja) | 2006-11-17 | 2008-06-05 | Sharp Corp | 光ピックアップ装置 |
| WO2008080134A2 (en) | 2006-12-22 | 2008-07-03 | Rigel Pharmaceuticals, Inc. | 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors |
| JP2010514810A (ja) | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用な置換トリアゾール |
| WO2008083353A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| JP5546250B2 (ja) * | 2006-12-29 | 2014-07-09 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用な多環式ヘテロアリール置換トリアゾール |
| DK2114955T3 (da) | 2006-12-29 | 2013-05-06 | Rigel Pharmaceuticals Inc | Broforbundet, bicyklisk aryl og broforbundet, bicyklisk heteroaryl subsitiuerede triazoler, der er anvendelige som axl-inhibitorer |
| WO2008083354A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as axl inhibitors |
| WO2008086342A2 (en) | 2007-01-09 | 2008-07-17 | Bristol-Myers Squibb Company | Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in prostate cells |
| US20100255004A1 (en) | 2007-04-13 | 2010-10-07 | Dana Farber Cancer Institute | Receptor tyrosine kinase profiling |
| CA2682733A1 (en) * | 2007-04-13 | 2008-10-23 | Supergen, Inc. | Axl kinase inhibitors |
| SI2205592T1 (sl) | 2007-10-26 | 2013-09-30 | Rigel Pharmaceuticals, Inc. | Triazoli substituirani s policikličnim arilom in triazoli substituirani s policikličnim heteroarilom uporabni kot Axl inhibitorji |
| CN101939336B (zh) | 2007-11-12 | 2014-05-14 | U3制药有限公司 | Axl抗体 |
| TW200936160A (en) | 2007-11-15 | 2009-09-01 | Chugai Pharmaceutical Co Ltd | Monoclonal antibodies that bind to anexelekto and uses thereof |
| HUE032735T2 (en) | 2007-12-14 | 2017-10-30 | Bristol Myers Squibb Co | Binding molecules for the human OX40 receptor |
| US8735064B2 (en) | 2007-12-24 | 2014-05-27 | Bergenbio As | Methods for creating and identifying functional RNA interference elements |
| PT2387395E (pt) * | 2009-01-16 | 2015-02-04 | Rigel Pharmaceuticals Inc | Inibidores de axl para utilização em terapia de combinação para prevenir, tratar ou gerir cancro metastático |
| MX2011011825A (es) | 2009-05-11 | 2011-12-06 | U3 Pharma Gmbh | Anticuerpos humanizados para axl. |
| CN102459344A (zh) | 2009-05-15 | 2012-05-16 | 中外制药株式会社 | 抗axl抗体 |
| EP2482849B1 (en) * | 2009-09-30 | 2018-06-06 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for the treatment of cancer |
| EP2571577A1 (en) | 2010-05-17 | 2013-03-27 | Bristol-Myers Squibb Company | Improved immunotherapeutic dosing regimens and combinations thereof |
| WO2011159980A1 (en) * | 2010-06-18 | 2011-12-22 | Genentech, Inc. | Anti-axl antibodies and methods of use |
| CN103221428B (zh) * | 2010-09-09 | 2016-02-10 | 辉瑞公司 | 4-1bb结合分子 |
| JP6033293B2 (ja) | 2011-06-22 | 2016-11-30 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル)Inserm(Institut National Dela Sante Et De La Recherche Medicale) | 抗Axl抗体及びその使用 |
| WO2012175692A1 (en) | 2011-06-22 | 2012-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
| AU2014241843B2 (en) | 2013-03-14 | 2019-05-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| TWI649308B (zh) * | 2013-07-24 | 2019-02-01 | 小野藥品工業股份有限公司 | 喹啉衍生物 |
| GB201410826D0 (en) * | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| GB201410825D0 (en) * | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| MX2017007321A (es) | 2014-12-02 | 2017-08-25 | Celgene Corp | Terapias de combinacion. |
| AU2015366213B2 (en) * | 2014-12-18 | 2021-10-07 | Bergenbio Asa | Anti-Axl antagonistic antibodies |
| GB201509338D0 (en) * | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
-
2015
- 2015-05-29 GB GBGB1509338.8A patent/GB201509338D0/en not_active Ceased
- 2015-09-16 GB GBGB1516442.9A patent/GB201516442D0/en not_active Ceased
-
2016
- 2016-05-27 EP EP16726396.1A patent/EP3302481A1/en active Pending
- 2016-05-27 JP JP2018513923A patent/JP6795585B2/ja active Active
- 2016-05-27 WO PCT/GB2016/051542 patent/WO2016193680A1/en not_active Ceased
- 2016-05-27 EP EP20211207.4A patent/EP3804723A1/en not_active Withdrawn
- 2016-05-27 US US15/577,804 patent/US20180153888A1/en not_active Abandoned
-
2020
- 2020-01-09 US US16/738,103 patent/US11534440B2/en active Active
- 2020-03-05 JP JP2020038089A patent/JP7229194B2/ja active Active
-
2022
- 2022-07-15 JP JP2022114274A patent/JP7549627B2/ja active Active
- 2022-12-16 US US18/067,408 patent/US20230149397A1/en active Pending
-
2024
- 2024-03-26 US US18/616,625 patent/US20240277707A1/en active Pending
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