JP2016539138A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016539138A5 JP2016539138A5 JP2016536145A JP2016536145A JP2016539138A5 JP 2016539138 A5 JP2016539138 A5 JP 2016539138A5 JP 2016536145 A JP2016536145 A JP 2016536145A JP 2016536145 A JP2016536145 A JP 2016536145A JP 2016539138 A5 JP2016539138 A5 JP 2016539138A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- benzo
- cyclohepta
- pyridazin
- triazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1321227.9 | 2013-12-02 | ||
| GB201321227A GB201321227D0 (en) | 2013-12-02 | 2013-12-02 | Use of kinase inhibitors |
| GB1323021.4 | 2013-12-24 | ||
| GB201323021A GB201323021D0 (en) | 2013-12-24 | 2013-12-24 | Use of kinase inhibitors |
| PCT/GB2014/053548 WO2015082887A2 (en) | 2013-12-02 | 2014-11-28 | Use of kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080908A Division JP2020128402A (ja) | 2013-12-02 | 2020-05-01 | キナーゼ阻害剤の用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539138A JP2016539138A (ja) | 2016-12-15 |
| JP2016539138A5 true JP2016539138A5 (enExample) | 2017-12-28 |
| JP6992960B2 JP6992960B2 (ja) | 2022-02-03 |
Family
ID=52016110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536145A Expired - Fee Related JP6992960B2 (ja) | 2013-12-02 | 2014-11-28 | キナーゼ阻害剤の用途 |
| JP2020080908A Pending JP2020128402A (ja) | 2013-12-02 | 2020-05-01 | キナーゼ阻害剤の用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080908A Pending JP2020128402A (ja) | 2013-12-02 | 2020-05-01 | キナーゼ阻害剤の用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9801880B2 (enExample) |
| EP (1) | EP3076966A2 (enExample) |
| JP (2) | JP6992960B2 (enExample) |
| WO (1) | WO2015082887A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE044025T2 (hu) | 2010-05-20 | 2019-09-30 | Array Biopharma Inc | Makrociklusos vegyületek mint TRK-kináz inhibitorok |
| ES2857081T3 (es) | 2015-07-16 | 2021-09-28 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| ES2948194T3 (es) | 2017-01-18 | 2023-09-01 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| US11603374B2 (en) | 2018-01-18 | 2023-03-14 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| TW201932464A (zh) | 2018-01-18 | 2019-08-16 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物 |
| EP3849986B1 (en) | 2018-09-10 | 2022-06-08 | Array Biopharma, Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| EP3873608A1 (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| EP4371987B9 (en) | 2018-10-31 | 2025-11-26 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| CN115504967A (zh) * | 2021-06-23 | 2022-12-23 | 南京正大天晴制药有限公司 | 作为axl抑制剂的1,2,4-三唑化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1483400A4 (en) * | 2002-02-12 | 2007-07-11 | Quark Biotech Inc | USE OF THE AXL RECEPTOR FOR THE DIAGNOSIS AND TREATMENT OF A KIDNEY DISEASE |
| EP1673399B1 (en) * | 2003-08-11 | 2017-04-05 | Monogram BioSciences, Inc. | Detecting and profiling molecular complexes |
| PL1686997T3 (pl) * | 2003-11-18 | 2009-09-30 | Novartis Ag | Inhibitory zmutowanej formy KIT |
| PL2078010T3 (pl) * | 2006-12-29 | 2014-07-31 | Rigel Pharmaceuticals Inc | Triazole podstawione policyklicznym heteroarylem użyteczne jako inhibitory Axl |
| KR100900289B1 (ko) | 2007-06-21 | 2009-05-29 | 엘지전자 주식회사 | 직교 주파수 분할 다중화 시스템에서 제어 채널을 송수신하는 방법 |
| WO2009054939A2 (en) * | 2007-10-19 | 2009-04-30 | Cell Signaling Technology, Inc. | Cancer classification and methods of use |
| JP5908728B2 (ja) * | 2009-01-06 | 2016-04-26 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | ピリミド−ジアゼピノンキナーゼ骨格化合物及び疾患を治療する方法 |
| US8546433B2 (en) * | 2009-01-16 | 2013-10-01 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| US9050341B2 (en) * | 2009-07-14 | 2015-06-09 | Natco Pharma Limited | Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives |
| US8603740B2 (en) * | 2010-12-29 | 2013-12-10 | Quest Diagnostics Investments Incorporated | BCR-ABL1 splice variants and uses thereof |
| WO2012143143A1 (en) * | 2011-04-21 | 2012-10-26 | Origenis Gmbh | Heterocyclic compounds as kinase inhibitors |
-
2014
- 2014-11-28 EP EP14809501.1A patent/EP3076966A2/en not_active Withdrawn
- 2014-11-28 JP JP2016536145A patent/JP6992960B2/ja not_active Expired - Fee Related
- 2014-11-28 WO PCT/GB2014/053548 patent/WO2015082887A2/en not_active Ceased
- 2014-11-28 US US15/100,891 patent/US9801880B2/en not_active Expired - Fee Related
-
2020
- 2020-05-01 JP JP2020080908A patent/JP2020128402A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016539138A5 (enExample) | ||
| JP2020105211A5 (enExample) | ||
| JP5529004B2 (ja) | Ｈｓｐ９０阻害剤として有用なトリアジノンおよびジアジノン誘導体 | |
| JP5441691B2 (ja) | Ｈｓｐ９０活性を調節するトリアゾール化合物 | |
| JP7014731B2 (ja) | 置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 | |
| CN105492439B (zh) | 作为溴结构域抑制剂的取代的双环化合物 | |
| AU2014272776C1 (en) | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | |
| JP6078639B2 (ja) | Ａｂｌ１、ａｂｌ２およびｂｃｒ−ａｂｌ１の活性を阻害するためのベンズアミド誘導体 | |
| JP2012515225A5 (enExample) | ||
| TW201408298A (zh) | 免疫相關及發炎疾病之治療 | |
| JP2016517857A5 (enExample) | ||
| JP2017511360A5 (enExample) | ||
| JP2015515469A (ja) | Ｈｓｐ９０阻害剤としてのトリアゾール誘導体 | |
| WO2015082887A2 (en) | Use of kinase inhibitors | |
| AU2018335617B2 (en) | Combination of a BTK inhibitor and an inhibitor of CDK9 to treat cancer | |
| JP2018516963A (ja) | ＲＯＲγのアゴニストとしての使用及び疾患の治療のためのアリールジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物 | |
| JP2016525104A5 (enExample) | ||
| Mounika et al. | An overview of CDK enzyme inhibitors in cancer therapy | |
| CN109069461A (zh) | 与髓源性抑制细胞相关的病症的治疗方法 | |
| JP2015515477A (ja) | Ｈｓｐ９０活性を調節する新規トリアゾール化合物 | |
| WO2024067631A1 (zh) | Fak抑制剂及诱导免疫原性细胞死亡的物质的药物组合及用途 | |
| AR044648A1 (es) | Combinaciones terapeuticas | |
| TW202131917A (zh) | 併用醫藥 | |
| CA3212085A1 (en) | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer | |
| WO2018213712A1 (en) | Pyrazoloquinazolinone antitumor agents |