JP2016539138A5 - - Google Patents
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- Publication number
- JP2016539138A5 JP2016539138A5 JP2016536145A JP2016536145A JP2016539138A5 JP 2016539138 A5 JP2016539138 A5 JP 2016539138A5 JP 2016536145 A JP2016536145 A JP 2016536145A JP 2016536145 A JP2016536145 A JP 2016536145A JP 2016539138 A5 JP2016539138 A5 JP 2016539138A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- benzo
- cyclohepta
- pyridazin
- triazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1321227.9 | 2013-12-02 | ||
| GB201321227A GB201321227D0 (en) | 2013-12-02 | 2013-12-02 | Use of kinase inhibitors |
| GB201323021A GB201323021D0 (en) | 2013-12-24 | 2013-12-24 | Use of kinase inhibitors |
| GB1323021.4 | 2013-12-24 | ||
| PCT/GB2014/053548 WO2015082887A2 (en) | 2013-12-02 | 2014-11-28 | Use of kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080908A Division JP2020128402A (ja) | 2013-12-02 | 2020-05-01 | キナーゼ阻害剤の用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539138A JP2016539138A (ja) | 2016-12-15 |
| JP2016539138A5 true JP2016539138A5 (enExample) | 2017-12-28 |
| JP6992960B2 JP6992960B2 (ja) | 2022-02-03 |
Family
ID=52016110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536145A Expired - Fee Related JP6992960B2 (ja) | 2013-12-02 | 2014-11-28 | キナーゼ阻害剤の用途 |
| JP2020080908A Pending JP2020128402A (ja) | 2013-12-02 | 2020-05-01 | キナーゼ阻害剤の用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080908A Pending JP2020128402A (ja) | 2013-12-02 | 2020-05-01 | キナーゼ阻害剤の用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9801880B2 (enExample) |
| EP (1) | EP3076966A2 (enExample) |
| JP (2) | JP6992960B2 (enExample) |
| WO (1) | WO2015082887A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3205654T3 (pl) | 2010-05-20 | 2019-08-30 | Array Biopharma, Inc. | Związki makrocykliczne jako inhibitory kinazy TRK |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
| WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| TW201932464A (zh) | 2018-01-18 | 2019-08-16 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物 |
| WO2020055672A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| CN117105933A (zh) | 2018-10-31 | 2023-11-24 | 吉利德科学公司 | 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物 |
| LT3873903T (lt) | 2018-10-31 | 2024-05-10 | Gilead Sciences, Inc. | Pakeistieji 6-azabenzimidazolo junginiai, kaip hpk1 inhibitoriai |
| TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
| CN115504967A (zh) * | 2021-06-23 | 2022-12-23 | 南京正大天晴制药有限公司 | 作为axl抑制剂的1,2,4-三唑化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL163547A0 (en) * | 2002-02-12 | 2005-12-18 | Quark Biotech Inc | Use of the axl receptor for diagnosis and treatment of renal disease |
| AU2004267420A1 (en) * | 2003-08-11 | 2005-03-03 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| EP1917965A1 (en) * | 2003-11-18 | 2008-05-07 | Novartis AG | Inhibitors of the mutant form of KIT |
| PL2078010T3 (pl) * | 2006-12-29 | 2014-07-31 | Rigel Pharmaceuticals Inc | Triazole podstawione policyklicznym heteroarylem użyteczne jako inhibitory Axl |
| KR100900289B1 (ko) | 2007-06-21 | 2009-05-29 | 엘지전자 주식회사 | 직교 주파수 분할 다중화 시스템에서 제어 채널을 송수신하는 방법 |
| JP2011522212A (ja) | 2007-10-19 | 2011-07-28 | セル・シグナリング・テクノロジー・インコーポレイテツド | 癌の分類および使用法 |
| US9266890B2 (en) * | 2009-01-06 | 2016-02-23 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders |
| EP2387395B1 (en) | 2009-01-16 | 2014-10-15 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| US9050341B2 (en) | 2009-07-14 | 2015-06-09 | Natco Pharma Limited | Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives |
| US8603740B2 (en) | 2010-12-29 | 2013-12-10 | Quest Diagnostics Investments Incorporated | BCR-ABL1 splice variants and uses thereof |
| BR112013026744B1 (pt) * | 2011-04-21 | 2022-05-17 | Origenis Gmbh | Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica |
-
2014
- 2014-11-28 JP JP2016536145A patent/JP6992960B2/ja not_active Expired - Fee Related
- 2014-11-28 US US15/100,891 patent/US9801880B2/en not_active Expired - Fee Related
- 2014-11-28 WO PCT/GB2014/053548 patent/WO2015082887A2/en not_active Ceased
- 2014-11-28 EP EP14809501.1A patent/EP3076966A2/en not_active Withdrawn
-
2020
- 2020-05-01 JP JP2020080908A patent/JP2020128402A/ja active Pending
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