ATE459647T1 - Humane il-18 substitutionsmutanten und deren konjugate - Google Patents

Humane il-18 substitutionsmutanten und deren konjugate

Info

Publication number
ATE459647T1
ATE459647T1 AT04759472T AT04759472T ATE459647T1 AT E459647 T1 ATE459647 T1 AT E459647T1 AT 04759472 T AT04759472 T AT 04759472T AT 04759472 T AT04759472 T AT 04759472T AT E459647 T1 ATE459647 T1 AT E459647T1
Authority
AT
Austria
Prior art keywords
conjugates
human
substitution mutants
mutants
substitution
Prior art date
Application number
AT04759472T
Other languages
English (en)
Inventor
Narendra Bam
Jacab Bongers
Robert Kirkpatrick
Cheryl JANSON
Kyung Johanson
Zdenka Jonak
Xiayang Qiu
Ping-Yang Yeh
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Application granted granted Critical
Publication of ATE459647T1 publication Critical patent/ATE459647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04759472T 2003-04-15 2004-04-13 Humane il-18 substitutionsmutanten und deren konjugate ATE459647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46294703P 2003-04-15 2003-04-15
PCT/US2004/011309 WO2004091517A2 (en) 2003-04-15 2004-04-13 Conjugates comprising human il-18 and substitution mutants thereof

Publications (1)

Publication Number Publication Date
ATE459647T1 true ATE459647T1 (de) 2010-03-15

Family

ID=33300018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04759472T ATE459647T1 (de) 2003-04-15 2004-04-13 Humane il-18 substitutionsmutanten und deren konjugate

Country Status (9)

Country Link
US (2) US7311902B2 (de)
EP (2) EP2261244A3 (de)
JP (2) JP4753867B2 (de)
AR (1) AR044024A1 (de)
AT (1) ATE459647T1 (de)
DE (1) DE602004025799D1 (de)
ES (1) ES2340494T3 (de)
TW (1) TW200510454A (de)
WO (1) WO2004091517A2 (de)

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Also Published As

Publication number Publication date
EP1613274A4 (de) 2008-04-16
US20080206189A1 (en) 2008-08-28
WO2004091517A2 (en) 2004-10-28
JP2007526207A (ja) 2007-09-13
EP2261244A2 (de) 2010-12-15
JP4753867B2 (ja) 2011-08-24
US7736639B2 (en) 2010-06-15
EP1613274A2 (de) 2006-01-11
AR044024A1 (es) 2005-08-24
US7311902B2 (en) 2007-12-25
EP1613274B1 (de) 2010-03-03
JP2011105737A (ja) 2011-06-02
DE602004025799D1 (de) 2010-04-15
WO2004091517A3 (en) 2006-07-27
TW200510454A (en) 2005-03-16
US20050008615A1 (en) 2005-01-13
ES2340494T3 (es) 2010-06-04
EP2261244A3 (de) 2011-02-23

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