JPS63152393A
(ja)
|
1986-07-03 |
1988-06-24 |
Takeda Chem Ind Ltd |
グリコシル誘導体
|
US5231012A
(en)
|
1989-06-28 |
1993-07-27 |
Schering Corporation |
Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
|
US6217857B1
(en)
|
1989-06-28 |
2001-04-17 |
Schering Corporation |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
EP0567576B1
(en)
|
1991-01-16 |
1995-01-04 |
Schering Corporation |
Treatment of neoplastic disease with interleukin-10
|
ATE124866T1
(de)
|
1991-01-16 |
1995-07-15 |
Schering Corp |
Verwendung von interleukin-10 in der adoptive immunotherapie von krebs.
|
US5624823A
(en)
|
1991-11-22 |
1997-04-29 |
The General Hospital Corporation |
DNA encoding procine interleukin-10
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
WO1994004180A2
(en)
|
1992-08-20 |
1994-03-03 |
Schering Corporation |
Novel uses of il-4 and/or il-10, and antibodies against the same
|
EP0681589A1
(en)
|
1993-02-01 |
1995-11-15 |
Université Libre de Bruxelles |
Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10
|
US5328989A
(en)
|
1993-03-05 |
1994-07-12 |
Schering-Plough |
Purification of human interleukin-10 from a cell culture medium
|
US5665345A
(en)
|
1993-05-24 |
1997-09-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting viral replication using IL-10
|
HUT73463A
(en)
|
1993-07-26 |
1996-08-28 |
Schering Corp |
Agonists and antagonists of human interleukin-10
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
SK91696A3
(en)
|
1994-01-20 |
1997-04-09 |
Schering Plough Corp |
Use of il-10 to stimulate peripheral blood mononuclear cell cytolytic activity
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
US5866134A
(en)
|
1995-03-24 |
1999-02-02 |
Schering Corporation |
Method for enhancing the antibody response to specific antigens with Interleukin-10
|
US5770190A
(en)
|
1995-07-14 |
1998-06-23 |
Schering Corporation |
Method of treatment of acute leukemia with inteleukin-10
|
GB2304047A
(en)
|
1995-08-09 |
1997-03-12 |
Univ Manchester |
Pharmaceutical compositions containing cytokines
|
US5744451A
(en)
|
1995-09-12 |
1998-04-28 |
Warner-Lambert Company |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
US5945097A
(en)
*
|
1996-09-06 |
1999-08-31 |
Schering Corporation |
Method for lowering cholesterol levels with interleukin-10
|
EP0925072A2
(en)
*
|
1996-09-06 |
1999-06-30 |
Schering Corporation |
Method for lowering cholesterol levels
|
US5989867A
(en)
|
1996-09-23 |
1999-11-23 |
Knappe; Andrea |
DNA encoding IL-10-like homologue; related reagents
|
US6660258B1
(en)
|
1997-05-09 |
2003-12-09 |
Pharma Pacific Pty Ltd |
Oromucosal cytokine compositions and uses thereof
|
NZ502375A
(en)
|
1997-07-14 |
2001-11-30 |
Bolder Biotechnology Inc |
The addition of non-natural cysteine derivatives to cause the protein to act as antagonists of the GH family
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
US6428985B1
(en)
|
1998-12-02 |
2002-08-06 |
The Regents Of The University Of Michigan |
Immunosuppressive structural definition of IL-10
|
US6685931B1
(en)
|
1998-12-22 |
2004-02-03 |
Schering Corporation |
Treatment of hepatitis C virus infections with interleukin-10
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
WO2001005821A2
(en)
|
1999-07-16 |
2001-01-25 |
Maria Teresa Bejarano |
Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis
|
US6989377B2
(en)
|
1999-12-21 |
2006-01-24 |
Wisconsin Alumni Research Foundation |
Treating vitamin D responsive diseases
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
WO2001058950A1
(en)
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
Improved interleukin 10
|
US7052686B2
(en)
|
2000-09-29 |
2006-05-30 |
Schering Corporation |
Pegylated interleukin-10
|
JP2002142770A
(ja)
|
2000-11-08 |
2002-05-21 |
Dnavec Research Inc |
循環系への遺伝子送達用パラミクソウイルスベクター
|
US6838452B2
(en)
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
EP1234583A1
(en)
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
GB0212648D0
(en)
|
2002-05-31 |
2002-07-10 |
Immunoclin Lab Ltd |
Treatment with cytokines
|
CA2498319A1
(en)
|
2002-09-09 |
2004-03-18 |
Nautilus Biotech |
Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
|
WO2004044006A1
(en)
|
2002-11-14 |
2004-05-27 |
Maxygen, Inc. |
Conjugates of interleukin-10 and polymers
|
ATE404196T1
(de)
|
2002-11-29 |
2008-08-15 |
Maria Grazia Roncarolo |
Rapamycin und il-10 zur behandlung von autoimmunerkrankungen
|
AU2003303222A1
(en)
|
2002-12-19 |
2004-07-14 |
Universiteit Gent |
Mutant proteins showing increased secretion
|
JP4511943B2
(ja)
|
2002-12-23 |
2010-07-28 |
ワイス エルエルシー |
Pd−1に対する抗体およびその使用
|
TWI364295B
(en)
|
2002-12-26 |
2012-05-21 |
Mountain View Pharmaceuticals |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
SI2949658T1
(sl)
|
2003-03-03 |
2018-10-30 |
Dyax Corp. |
Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe
|
WO2004091517A2
(en)
|
2003-04-15 |
2004-10-28 |
Smithkline Beecham Corporation |
Conjugates comprising human il-18 and substitution mutants thereof
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
US8133700B2
(en)
|
2003-11-28 |
2012-03-13 |
The University Of Sydney |
Latent phase viral interleukin-10-(VII-10) and uses thereof
|
WO2005092928A1
(en)
|
2004-03-11 |
2005-10-06 |
Fresenius Kabi Deutschland Gmbh |
Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
|
EP2409713B1
(en)
|
2004-08-10 |
2015-07-22 |
Genzyme Corporation |
Oligonucleotides for use in modulating lipoprotein and cholesterol levels in humans
|
US20060046961A1
(en)
|
2004-09-02 |
2006-03-02 |
Mckay William F |
Controlled and directed local delivery of anti-inflammatory compositions
|
CN100334112C
(zh)
|
2004-10-15 |
2007-08-29 |
上海海欣生物技术有限公司 |
人白细胞介素15与Fc融合蛋白
|
GB0500643D0
(en)
|
2005-01-13 |
2005-02-23 |
Renovo Ltd |
Medicaments
|
AR052741A1
(es)
|
2005-04-08 |
2007-03-28 |
Noxxon Pharma Ag |
Acidos nucleicos de union a ghrelin
|
WO2006119170A2
(en)
|
2005-05-02 |
2006-11-09 |
Avigen, Inc. |
Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
|
EP1891103B1
(en)
|
2005-05-31 |
2009-12-23 |
The Regents of the University of Colorado |
Mutant il-10
|
US8945857B2
(en)
|
2005-07-01 |
2015-02-03 |
John Schrader |
Methods of isolating cells and generating monoclonal antibodies
|
PL1931704T3
(pl)
|
2005-10-04 |
2011-06-30 |
Zymogenetics L L C |
Wytwarzanie i oczyszczanie IL-29
|
WO2007061657A2
(en)
|
2005-11-14 |
2007-05-31 |
The Brigham & Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
US7868139B2
(en)
|
2006-01-24 |
2011-01-11 |
Uab Research Foundation |
Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
|
WO2007139178A1
(ja)
|
2006-05-31 |
2007-12-06 |
Dnavec Corporation |
アルツハイマー病治療薬
|
NZ597098A
(en)
|
2006-09-28 |
2013-05-31 |
Merck Sharp & Dohme |
Use of pegylated il-10 to treat cancer
|
WO2008041953A2
(en)
|
2006-10-05 |
2008-04-10 |
Agency For Science, Technology And Research |
Dengue diagnosis and treatment
|
ES2409756T3
(es)
|
2006-12-04 |
2013-06-27 |
Promedior, Inc. |
Combinación de SAP y de enalapril para su uso en tratamiento de trastornos fibróticos o fibroproliferativos
|
JP2010516707A
(ja)
|
2007-01-19 |
2010-05-20 |
カイ ファーマシューティカルズ インコーポレーティッド |
ペプチド組成物の安定性および送達効率を上昇させるための修飾方法
|
DE08786222T1
(de)
|
2007-07-31 |
2010-11-25 |
Affibody Ab |
Neue albuminbindende zusammensetzungen, verfahren und anwendungen
|
WO2009036568A1
(en)
|
2007-09-19 |
2009-03-26 |
University Health Network |
Methods and compositions for treating tumors and viral infections
|
WO2009052454A2
(en)
|
2007-10-19 |
2009-04-23 |
University Of California |
Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss
|
WO2009062151A1
(en)
|
2007-11-08 |
2009-05-14 |
Cytimmune Sciences, Inc. |
Compositions and methods for generating antibodies
|
GB0724231D0
(en)
|
2007-12-12 |
2008-01-30 |
Renono Ltd |
Methods for inhibiting scarring
|
US20090311187A1
(en)
|
2008-05-29 |
2009-12-17 |
Bristol-Myers Squibb Company |
Methods for predicting patient response to modulation of the Co-stimulatory pathway
|
WO2010022227A1
(en)
|
2008-08-20 |
2010-02-25 |
Schering Corporation |
Methods for monitoring il-10 therapy
|
WO2010059315A1
(en)
|
2008-11-18 |
2010-05-27 |
Merrimack Pharmaceuticals, Inc. |
Human serum albumin linkers and conjugates thereof
|
HUE037936T2
(hu)
|
2008-12-17 |
2018-09-28 |
Merck Sharp & Dohme |
Mono- és di-pegil IL-10 elõállítása és alkalmazása
|
CA2777053A1
(en)
|
2009-10-06 |
2011-04-14 |
The Board Of Trustees Of The University Of Illinois |
Human single-chain t cell receptors
|
BR112012008665A2
(pt)
|
2009-10-12 |
2016-11-22 |
Pfizer |
tratamento de câncer
|
CN105567699A
(zh)
|
2009-10-30 |
2016-05-11 |
诺维信生物制药丹麦公司 |
白蛋白变体
|
CN102711829B
(zh)
|
2009-11-30 |
2016-03-16 |
生物测试股份公司 |
治疗系统性红斑狼疮(sle)的人源化抗il-10抗体
|
AU2011268310A1
(en)
|
2010-06-16 |
2013-01-10 |
Abbvie Inc. |
Comparison of protein samples
|
JP2013532153A
(ja)
|
2010-06-18 |
2013-08-15 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体
|
KR101884654B1
(ko)
|
2010-07-09 |
2018-08-02 |
애피바디 에이비 |
폴리펩타이드
|
ES2641869T3
(es)
|
2010-09-28 |
2017-11-14 |
Aegerion Pharmaceuticals, Inc. |
Polipéptidos de fusión de leptina-ABD con duración de acción aumentada
|
CN103370083B
(zh)
|
2010-09-28 |
2016-11-16 |
艾米琳制药有限责任公司 |
具有增强的作用持续时间的工程化多肽
|
US8895536B2
(en)
|
2010-10-29 |
2014-11-25 |
Infirst Healthcare Ltd. |
Compositions and methods for treating chronic inflammation and inflammatory diseases
|
GB201018289D0
(en)
|
2010-10-29 |
2010-12-15 |
Biocopea Ltd |
Treatment of respiratory disorders
|
BR112013024395B1
(pt)
|
2011-03-23 |
2021-10-26 |
Fred Hutchinson Cancer Research Center |
Composições adotivas de imunoterapia celular e método para fabricação da dita composição
|
CN102145178B
(zh)
|
2011-04-15 |
2012-09-26 |
北京凯因科技股份有限公司 |
Peg化白介素15
|
US20140256626A1
(en)
|
2011-10-18 |
2014-09-11 |
Prolynx Llc |
Peg conjugates of exenatide
|
US10391126B2
(en)
|
2011-11-18 |
2019-08-27 |
Board Of Regents, The University Of Texas System |
CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
|
US9714276B2
(en)
|
2012-01-26 |
2017-07-25 |
Amgen Inc. |
Growth differentiation factor 15 (GDF-15) polypeptides
|
WO2013130913A1
(en)
|
2012-02-29 |
2013-09-06 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates and their uses
|
WO2013169971A1
(en)
|
2012-05-10 |
2013-11-14 |
Bristol-Myers Squibb Company |
Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
|
EP2947111B1
(en)
|
2013-01-17 |
2018-03-07 |
Xiamen Sinopeg Biotech Co., Ltd. |
Monofunctional branched polyethyleneglycol and bio-related substance modified by same
|
EP2986306A4
(en)
*
|
2013-04-18 |
2016-12-07 |
Armo Biosciences Inc |
METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING
|
WO2014176373A2
(en)
*
|
2013-04-24 |
2014-10-30 |
Armo Biosciences, Inc. |
Interleukin-10 compositions and uses thereof
|
CA2914837A1
(en)
*
|
2013-06-17 |
2014-12-24 |
Armo Biosciences, Inc. |
Method for assessing protein identity and stability
|
JP6660297B2
(ja)
|
2013-11-11 |
2020-03-11 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
疾患及び障害を処置するためのインターロイキン−10の使用方法
|
WO2015108785A1
(en)
|
2014-01-15 |
2015-07-23 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
EP4303229A3
(en)
|
2014-01-21 |
2024-04-17 |
Novartis AG |
Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
|
MA39711A
(fr)
|
2014-04-03 |
2015-10-08 |
Nektar Therapeutics |
Conjugués d'une fraction d'il-15 et d'un polymère
|
AU2016268403A1
(en)
|
2015-05-28 |
2017-12-07 |
Armo Biosciences, Inc. |
Pegylated interleukin-10 for use in treating cancer
|