JP2017538678A5 - - Google Patents
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- JP2017538678A5 JP2017538678A5 JP2017524446A JP2017524446A JP2017538678A5 JP 2017538678 A5 JP2017538678 A5 JP 2017538678A5 JP 2017524446 A JP2017524446 A JP 2017524446A JP 2017524446 A JP2017524446 A JP 2017524446A JP 2017538678 A5 JP2017538678 A5 JP 2017538678A5
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- optionally substituted
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- therapeutic agent
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- 239000003814 drug Substances 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 18
- 229940124597 therapeutic agent Drugs 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 11
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 11
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 11
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 7
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
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- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
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- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 1
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
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- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 claims 1
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- 241000701022 Cytomegalovirus Species 0.000 claims 1
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- 208000001640 Fibromyalgia Diseases 0.000 claims 1
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
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- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010062207 Mycobacterial infection Diseases 0.000 claims 1
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- 208000001132 Osteoporosis Diseases 0.000 claims 1
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- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
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- 206010060862 Prostate cancer Diseases 0.000 claims 1
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- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
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- 206010002906 aortic stenosis Diseases 0.000 claims 1
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- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
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- 206010009887 colitis Diseases 0.000 claims 1
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- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
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- 230000004761 fibrosis Effects 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
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- 210000003128 head Anatomy 0.000 claims 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
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- 229960003301 nivolumab Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
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- 244000045947 parasite Species 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
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- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
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- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462075663P | 2014-11-05 | 2014-11-05 | |
| US62/075,663 | 2014-11-05 | ||
| PCT/US2015/059271 WO2016073738A2 (en) | 2014-11-05 | 2015-11-05 | Immunoregulatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538678A JP2017538678A (ja) | 2017-12-28 |
| JP2017538678A5 true JP2017538678A5 (enExample) | 2018-11-22 |
Family
ID=55910032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524446A Pending JP2017538678A (ja) | 2014-11-05 | 2015-11-05 | 免疫調節剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11242319B2 (enExample) |
| EP (1) | EP3215141A4 (enExample) |
| JP (1) | JP2017538678A (enExample) |
| CN (1) | CN107205970A (enExample) |
| BR (1) | BR112017008809A2 (enExample) |
| CA (1) | CA2964276A1 (enExample) |
| EA (1) | EA201790806A1 (enExample) |
| MX (1) | MX2017005462A (enExample) |
| WO (1) | WO2016073738A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2016149812A (ru) | 2014-06-06 | 2018-07-17 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| MX2017005462A (es) | 2014-11-05 | 2017-07-28 | Flexus Biosciences Inc | Agentes inmunorreguladores. |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| CN109414421A (zh) | 2016-05-04 | 2019-03-01 | 百时美施贵宝公司 | 吲哚胺2,3-双加氧酶的抑制剂及其使用方法 |
| JP2019516681A (ja) | 2016-05-04 | 2019-06-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法 |
| WO2017192813A1 (en) | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| EP3452029A4 (en) | 2016-05-04 | 2019-10-30 | Bristol-Myers Squibb Company | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE |
| KR20190003685A (ko) | 2016-05-04 | 2019-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법 |
| CN106552265A (zh) * | 2016-06-21 | 2017-04-05 | 聊城市奥润生物医药科技有限公司 | Sting激动剂与ido1抑制剂联合用药在抗肿瘤中的应用 |
| CN106075454A (zh) * | 2016-07-12 | 2016-11-09 | 中国医学科学院基础医学研究所 | 一种抗肿瘤药物制剂组合 |
| WO2018024188A1 (zh) * | 2016-08-02 | 2018-02-08 | 上海迪诺医药科技有限公司 | 多环化合物、其制备方法、药物组合物及应用 |
| EP3505517A4 (en) | 2016-08-23 | 2020-01-15 | Beijing InnoCare Pharma Tech Co., Ltd. | Fused heterocyclic derivative, preparation method therefor and medical use thereof |
| CN109843322A (zh) | 2016-08-26 | 2019-06-04 | 百时美施贵宝公司 | 吲哚胺2,3-双加氧酶的抑制剂及其使用方法 |
| EP3515914A4 (en) | 2016-09-24 | 2020-04-15 | BeiGene, Ltd. | INNOVATIVE 5- OR 8-SUBSTITUTED IMIDAZO [1,5-A] PYRIDINE AS SELECTIVE INHIBITORS OF INDOLEAMINE AND / OR TRYPTOPHANE-2,3-DIOXYGENASES |
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| JP2020506895A (ja) * | 2017-01-17 | 2020-03-05 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | インドールアミン２，３−ジオキシゲナーゼおよび／またはトリプトファンジオキシゲナーゼの阻害剤として有用な化合物 |
| US11066392B2 (en) | 2017-05-12 | 2021-07-20 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| US11266640B2 (en) | 2017-09-20 | 2022-03-08 | Hangzhou Innogate Pharma Co., Ltd. | Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor |
| WO2019074822A1 (en) | 2017-10-09 | 2019-04-18 | Bristol-Myers Squibb Company | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE |
| US11203592B2 (en) | 2017-10-09 | 2021-12-21 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| US11180497B2 (en) | 2017-10-18 | 2021-11-23 | Angex Pharmaceutical, Inc. | Cyclic compounds as immunomodulating agents |
| US11447449B2 (en) | 2018-01-05 | 2022-09-20 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| CN111247119B (zh) * | 2018-01-19 | 2023-02-03 | 四川科伦博泰生物医药股份有限公司 | 脒类和胍类衍生物、其制备方法及其在医药上的应用 |
| CN110066271B (zh) * | 2018-01-23 | 2023-04-07 | 上海迪诺医药科技有限公司 | 吡咯衍生物、其制备方法、药物组合物及应用 |
| CN110092750B (zh) * | 2018-01-29 | 2023-07-21 | 北京诺诚健华医药科技有限公司 | 五氟硫烷基取代的酰胺类化合物、其制备方法及其在医药学上的应用 |
| CN111868032B (zh) * | 2018-02-11 | 2021-09-03 | 基石药业（苏州）有限公司 | 犬尿氨酸通路抑制剂 |
| CN117185987A (zh) * | 2018-03-19 | 2023-12-08 | 四川科伦博泰生物医药股份有限公司 | 脒类和胍类衍生物、其制备方法及其在医药上的应用 |
| CN110357813A (zh) * | 2018-04-09 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途 |
| TW201945388A (zh) | 2018-04-12 | 2019-12-01 | 美商精密生物科學公司 | 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶 |
| CN110526898A (zh) | 2018-05-25 | 2019-12-03 | 北京诺诚健华医药科技有限公司 | 3-吲唑啉酮类化合物、其制备方法及其在医药学上的应用 |
| WO2020018670A1 (en) | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| US12059420B2 (en) | 2018-07-23 | 2024-08-13 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2020023356A1 (en) | 2018-07-23 | 2020-01-30 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| US11253525B2 (en) | 2018-08-29 | 2022-02-22 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| US10959986B2 (en) | 2018-08-29 | 2021-03-30 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
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| PE20211655A1 (es) | 2018-10-31 | 2021-08-24 | Gilead Sciences Inc | Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1 |
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2015
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- 2015-11-05 JP JP2017524446A patent/JP2017538678A/ja active Pending
- 2015-11-05 CN CN201580060428.8A patent/CN107205970A/zh active Pending
- 2015-11-05 CA CA2964276A patent/CA2964276A1/en not_active Abandoned
- 2015-11-05 BR BR112017008809A patent/BR112017008809A2/pt not_active IP Right Cessation
- 2015-11-05 EP EP15856241.3A patent/EP3215141A4/en not_active Withdrawn
- 2015-11-05 EA EA201790806A patent/EA201790806A1/ru unknown
- 2015-11-05 US US15/524,113 patent/US11242319B2/en active Active
- 2015-11-05 WO PCT/US2015/059271 patent/WO2016073738A2/en not_active Ceased
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2021
- 2021-12-16 US US17/552,517 patent/US11932601B2/en active Active