JP2013531055A5 - - Google Patents
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- Publication number
- JP2013531055A5 JP2013531055A5 JP2013520197A JP2013520197A JP2013531055A5 JP 2013531055 A5 JP2013531055 A5 JP 2013531055A5 JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013531055 A5 JP2013531055 A5 JP 2013531055A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- group
- pyrimidin
- ylamino
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c(c(C#N)c1)ccc1-c1nc(N*)nc(*)c1* Chemical compound *c(c(C#N)c1)ccc1-c1nc(N*)nc(*)c1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1012105.1 | 2010-07-19 | ||
| GBGB1012105.1A GB201012105D0 (en) | 2010-07-19 | 2010-07-19 | Novel pyrimidine compounds |
| PCT/GB2011/001075 WO2012010826A1 (en) | 2010-07-19 | 2011-07-18 | Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013531055A JP2013531055A (ja) | 2013-08-01 |
| JP2013531055A5 true JP2013531055A5 (enExample) | 2014-09-04 |
Family
ID=42735153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520197A Pending JP2013531055A (ja) | 2010-07-19 | 2011-07-18 | プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8962609B2 (enExample) |
| EP (1) | EP2595964B1 (enExample) |
| JP (1) | JP2013531055A (enExample) |
| CN (1) | CN103119025B (enExample) |
| BR (1) | BR112013001341A2 (enExample) |
| CA (1) | CA2805567A1 (enExample) |
| GB (1) | GB201012105D0 (enExample) |
| WO (1) | WO2012010826A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013026202A2 (pt) * | 2011-04-12 | 2017-07-25 | Myrexis Inc | composições e usos terapêuticos de inibidores quinase epsilon relacionado a ikk e quinase i de ligação a tank |
| GB201114051D0 (en) | 2011-08-15 | 2011-09-28 | Domainex Ltd | Compounds and their uses |
| DE102011112978A1 (de) * | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
| SG11201404630UA (en) * | 2012-02-09 | 2014-09-26 | Merck Patent Gmbh | Furo [3, 2 - b] - and thieno [3, 2 - b] pyridine derivatives as tbk1 and ikk inhibitors |
| GB201303109D0 (en) * | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| JP6783224B2 (ja) | 2014-04-04 | 2020-11-11 | デル マー ファーマシューティカルズ | 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用 |
| TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
| NZ729618A (en) * | 2014-09-26 | 2018-07-27 | Gilead Sciences Inc | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| EP3347097B1 (en) | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
| EP3394044A1 (en) | 2015-12-17 | 2018-10-31 | Gilead Sciences, Inc. | Tank-binding kinase inhibitor compounds |
| US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| GB201702947D0 (en) * | 2017-02-23 | 2017-04-12 | Domainex Ltd | Novel compounds |
| RU2020115596A (ru) * | 2017-10-17 | 2021-11-18 | Мерк Патент Гмбх | ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ TBK/IKKε И ИХ ПРИМЕНЕНИЯ |
| CA3078583A1 (en) | 2017-10-17 | 2019-04-25 | Merck Patent Gmbh | Pyrimidine tbk/ikk.epsilon. inhibitor compounds and uses thereof |
| WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| CN110862380A (zh) | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| WO2002102313A2 (en) | 2001-06-19 | 2002-12-27 | Bristol-Myers Squibb Company | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
| GB0317841D0 (en) * | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
| EP1648875A1 (en) | 2003-07-30 | 2006-04-26 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| EP1799652A1 (en) | 2004-10-13 | 2007-06-27 | Wyeth | N-benzenesulfonyl substituted anilino-pyrimidine analogs |
| KR20080110998A (ko) | 2006-01-30 | 2008-12-22 | 엑셀리시스, 인코포레이티드 | Ｊａｋ２ 조절자로서 ４아릴２아미노피리미딘 또는 4아릴２아미노알킬피리미딘 및 이들을 포함하는 약제학적 조성물 |
| MX2008013203A (es) | 2006-04-12 | 2008-10-22 | Wyeth Corp | Analogos de anilino-pirimidina fenilo y benzotiofeno. |
| EP2094645A1 (en) | 2006-11-23 | 2009-09-02 | Novartis AG | 2-hydroxy-1,3-diaminopropane derivatives |
| FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| US8486941B2 (en) | 2007-03-12 | 2013-07-16 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine compounds and uses thereof |
| WO2008124085A2 (en) | 2007-04-03 | 2008-10-16 | Exelixis, Inc. | Methods of using combinations of mek and jak-2 inhibitors |
| US20090048282A1 (en) | 2007-08-14 | 2009-02-19 | Wyeth | Pyrimidine sulfonamide analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
| ES2535166T3 (es) * | 2007-09-04 | 2015-05-06 | The Scripps Research Institute | Pirimidinil-aminas sustituidas como inhibidores de proteína-quinasas |
| CN102791697A (zh) | 2009-10-12 | 2012-11-21 | 瑞科西有限公司 | 作为TBKL和/或IKKε抑制剂的氨基-嘧啶化合物 |
| BR112013026202A2 (pt) | 2011-04-12 | 2017-07-25 | Myrexis Inc | composições e usos terapêuticos de inibidores quinase epsilon relacionado a ikk e quinase i de ligação a tank |
-
2010
- 2010-07-19 GB GBGB1012105.1A patent/GB201012105D0/en not_active Ceased
-
2011
- 2011-07-18 JP JP2013520197A patent/JP2013531055A/ja active Pending
- 2011-07-18 CA CA2805567A patent/CA2805567A1/en not_active Abandoned
- 2011-07-18 EP EP20110738026 patent/EP2595964B1/en not_active Not-in-force
- 2011-07-18 WO PCT/GB2011/001075 patent/WO2012010826A1/en not_active Ceased
- 2011-07-18 BR BR112013001341A patent/BR112013001341A2/pt not_active IP Right Cessation
- 2011-07-18 CN CN201180045048.9A patent/CN103119025B/zh not_active Expired - Fee Related
- 2011-07-18 US US13/811,164 patent/US8962609B2/en not_active Expired - Fee Related