JP2013531055A5 - - Google Patents
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- Publication number
- JP2013531055A5 JP2013531055A5 JP2013520197A JP2013520197A JP2013531055A5 JP 2013531055 A5 JP2013531055 A5 JP 2013531055A5 JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013531055 A5 JP2013531055 A5 JP 2013531055A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- group
- pyrimidin
- ylamino
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c(c(C#N)c1)ccc1-c1nc(N*)nc(*)c1* Chemical compound *c(c(C#N)c1)ccc1-c1nc(N*)nc(*)c1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1012105.1A GB201012105D0 (en) | 2010-07-19 | 2010-07-19 | Novel pyrimidine compounds |
| GB1012105.1 | 2010-07-19 | ||
| PCT/GB2011/001075 WO2012010826A1 (en) | 2010-07-19 | 2011-07-18 | Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013531055A JP2013531055A (ja) | 2013-08-01 |
| JP2013531055A5 true JP2013531055A5 (enExample) | 2014-09-04 |
Family
ID=42735153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520197A Pending JP2013531055A (ja) | 2010-07-19 | 2011-07-18 | プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8962609B2 (enExample) |
| EP (1) | EP2595964B1 (enExample) |
| JP (1) | JP2013531055A (enExample) |
| CN (1) | CN103119025B (enExample) |
| BR (1) | BR112013001341A2 (enExample) |
| CA (1) | CA2805567A1 (enExample) |
| GB (1) | GB201012105D0 (enExample) |
| WO (1) | WO2012010826A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012242777A1 (en) * | 2011-04-12 | 2013-10-31 | Alzheimer's Institute Of America, Inc. | Compositions and therapeutic uses of IKK-related kinase epsilon and TANKbinding kinase 1 inhibitors |
| GB201114051D0 (en) | 2011-08-15 | 2011-09-28 | Domainex Ltd | Compounds and their uses |
| DE102011112978A1 (de) * | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
| RS55388B1 (sr) * | 2012-02-09 | 2017-03-31 | Merck Patent Gmbh | Furo[3, 2 - b]piridin derivati kao tbk1 i ikk inhibitori |
| GB201303109D0 (en) * | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| EP3125920B1 (en) | 2014-04-04 | 2020-12-23 | Del Mar Pharmaceuticals | Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer |
| TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
| EP3517536B1 (en) | 2014-09-26 | 2021-05-05 | Gilead Sciences, Inc. | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
| EP3053920B1 (en) | 2015-02-05 | 2020-04-08 | AB Science | Compounds with anti-tumoral activity |
| EP3347097B1 (en) | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
| MX2018007421A (es) | 2015-12-17 | 2018-08-15 | Gilead Sciences Inc | Compuestos inhibidores de quinasa de union a tank. |
| EP3390387B1 (en) | 2015-12-18 | 2021-11-17 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| GB201702947D0 (en) * | 2017-02-23 | 2017-04-12 | Domainex Ltd | Novel compounds |
| BR112020007549A2 (pt) | 2017-10-17 | 2020-09-24 | Merck Patent Gmbh | compostos inibidores de pirimidina tbk/ikképsilon e uso dos mesmos |
| AU2018352699A1 (en) * | 2017-10-17 | 2020-05-28 | Merck Patent Gmbh | Pyrimidine TBK/IKKE inhibitor compounds and uses thereof |
| WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| CN110862380A (zh) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| EP1397142A4 (en) | 2001-06-19 | 2004-11-03 | Bristol Myers Squibb Co | PYRIMIDINE PHOSPHODIESTERASE (PDE) INHIBITORS 7 |
| JP2007500179A (ja) | 2003-07-30 | 2007-01-11 | サイクラセル・リミテッド | キナーゼ阻害剤としての２−アミノフェニル−４−フェニルピリミジン |
| GB0317841D0 (en) * | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
| TW200626559A (en) | 2004-10-13 | 2006-08-01 | Wyeth Corp | Anilino-pyrimidine analogs |
| EA200870217A1 (ru) | 2006-01-30 | 2009-02-27 | Экселиксис, Инк. | 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции |
| WO2007120593A1 (en) | 2006-04-12 | 2007-10-25 | Wyeth | Anilino-pyrimidine phenyl and benzothiophene analogs |
| MX2009005182A (es) | 2006-11-23 | 2009-05-25 | Novartis Ag | Derivados de 2-hidroxi-1,3-diamino-propano. |
| FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| CN104030990B (zh) | 2007-03-12 | 2017-01-04 | Ym生物科学澳大利亚私人有限公司 | 苯基氨基嘧啶化合物及其用途 |
| WO2008124085A2 (en) | 2007-04-03 | 2008-10-16 | Exelixis, Inc. | Methods of using combinations of mek and jak-2 inhibitors |
| US20090048282A1 (en) | 2007-08-14 | 2009-02-19 | Wyeth | Pyrimidine sulfonamide analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
| CA2698511C (en) * | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| MX2012004313A (es) * | 2009-10-12 | 2012-07-20 | Myrexis Inc | Compuestos de amino-pirimidina como inhibidores de cinasa 1 de union a tank (tbk1) y/o i-kappa-b-cinasa epsilon (ikk epsilon). |
| AU2012242777A1 (en) | 2011-04-12 | 2013-10-31 | Alzheimer's Institute Of America, Inc. | Compositions and therapeutic uses of IKK-related kinase epsilon and TANKbinding kinase 1 inhibitors |
-
2010
- 2010-07-19 GB GBGB1012105.1A patent/GB201012105D0/en not_active Ceased
-
2011
- 2011-07-18 CN CN201180045048.9A patent/CN103119025B/zh not_active Expired - Fee Related
- 2011-07-18 WO PCT/GB2011/001075 patent/WO2012010826A1/en not_active Ceased
- 2011-07-18 EP EP20110738026 patent/EP2595964B1/en not_active Not-in-force
- 2011-07-18 CA CA2805567A patent/CA2805567A1/en not_active Abandoned
- 2011-07-18 BR BR112013001341A patent/BR112013001341A2/pt not_active IP Right Cessation
- 2011-07-18 US US13/811,164 patent/US8962609B2/en not_active Expired - Fee Related
- 2011-07-18 JP JP2013520197A patent/JP2013531055A/ja active Pending
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