JP2013531055A - プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 - Google Patents

プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 Download PDF

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JP2013531055A
JP2013531055A JP2013520197A JP2013520197A JP2013531055A JP 2013531055 A JP2013531055 A JP 2013531055A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013531055 A JP2013531055 A JP 2013531055A
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pyrimidin
pyrrolidin
ylamino
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JP2013531055A5 (enExample
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ペリアー，トレバー，ロバート
ニュートン，ガリー，カール
スチュワート，マーク，リチャード
アキル，レハン
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ドメイネクス リミテッド
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  • Child & Adolescent Psychology (AREA)
JP2013520197A 2010-07-19 2011-07-18 プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 Pending JP2013531055A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1012105.1A GB201012105D0 (en) 2010-07-19 2010-07-19 Novel pyrimidine compounds
GB1012105.1 2010-07-19
PCT/GB2011/001075 WO2012010826A1 (en) 2010-07-19 2011-07-18 Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

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JP2013531055A true JP2013531055A (ja) 2013-08-01
JP2013531055A5 JP2013531055A5 (enExample) 2014-09-04

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US (1) US8962609B2 (enExample)
EP (1) EP2595964B1 (enExample)
JP (1) JP2013531055A (enExample)
CN (1) CN103119025B (enExample)
BR (1) BR112013001341A2 (enExample)
CA (1) CA2805567A1 (enExample)
GB (1) GB201012105D0 (enExample)
WO (1) WO2012010826A1 (enExample)

Cited By (4)

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JP2018504415A (ja) * 2015-02-05 2018-02-15 エービー サイエンス 抗腫瘍活性を有する化合物
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP2022529309A (ja) * 2019-04-08 2022-06-21 リンク ファーマシューティカルズ シーオー．エルティーディー． ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
DE102011112978A1 (de) 2011-09-09 2013-03-14 Merck Patent Gmbh Benzonitrilderivate
US9045493B2 (en) * 2012-02-09 2015-06-02 Merck Patent Gmbh Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives
GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
JP6783224B2 (ja) 2014-04-04 2020-11-11 デル マー ファーマシューティカルズ 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
WO2016049211A1 (en) 2014-09-26 2016-03-31 Gilead Sciences, Inc. Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
US9938257B2 (en) 2015-09-11 2018-04-10 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
KR20180094976A (ko) 2015-12-17 2018-08-24 길리애드 사이언시즈, 인코포레이티드 Tank-결합 키나제 억제제 화합물
EP3390387B1 (en) 2015-12-18 2021-11-17 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
EP3697773A1 (en) 2017-10-17 2020-08-26 Merck Patent GmbH PYRIMIDINE TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504415A (ja) * 2015-02-05 2018-02-15 エービー サイエンス 抗腫瘍活性を有する化合物
US10570122B2 (en) 2015-02-05 2020-02-25 Ab Science Compounds with anti-tumoral activity
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP7136793B2 (ja) 2017-02-23 2022-09-13 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５－（ピリミジン－４－イル）－２－（ピロリジン－１－イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP7266592B2 (ja) 2017-10-17 2023-04-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP2022529309A (ja) * 2019-04-08 2022-06-21 リンク ファーマシューティカルズ シーオー．エルティーディー． ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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