CN103119025B - 作为蛋白激酶IKKε和/或TBK-1抑制剂的嘧啶化合物、其制备方法、以及含有其的药物组合物 - Google Patents

作为蛋白激酶IKKε和/或TBK-1抑制剂的嘧啶化合物、其制备方法、以及含有其的药物组合物 Download PDF

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CN103119025B
CN103119025B CN201180045048.9A CN201180045048A CN103119025B CN 103119025 B CN103119025 B CN 103119025B CN 201180045048 A CN201180045048 A CN 201180045048A CN 103119025 B CN103119025 B CN 103119025B
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pyrimidine
amino
pyrrolidin
compound
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CN103119025A (zh
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T·R·佩里尔
G·K·牛顿
M·R·斯图尔特
R·阿齐尔
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Domainex Ltd
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CN201180045048.9A 2010-07-19 2011-07-18 作为蛋白激酶IKKε和/或TBK-1抑制剂的嘧啶化合物、其制备方法、以及含有其的药物组合物 Expired - Fee Related CN103119025B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1012105.1 2010-07-19
GBGB1012105.1A GB201012105D0 (en) 2010-07-19 2010-07-19 Novel pyrimidine compounds
PCT/GB2011/001075 WO2012010826A1 (en) 2010-07-19 2011-07-18 Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

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Publication Number Publication Date
CN103119025A CN103119025A (zh) 2013-05-22
CN103119025B true CN103119025B (zh) 2015-09-09

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US (1) US8962609B2 (enExample)
EP (1) EP2595964B1 (enExample)
JP (1) JP2013531055A (enExample)
CN (1) CN103119025B (enExample)
BR (1) BR112013001341A2 (enExample)
CA (1) CA2805567A1 (enExample)
GB (1) GB201012105D0 (enExample)
WO (1) WO2012010826A1 (enExample)

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JP2019500368A (ja) 2015-12-17 2019-01-10 ギリアード サイエンシーズ， インコーポレイテッド Ｔａｎｋ結合キナーゼ阻害剤化合物
US10894784B2 (en) 2015-12-18 2021-01-19 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
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WO2019079375A1 (en) 2017-10-17 2019-04-25 Merck Patent Gmbh IN / ΙΚΚΕ PYRIMIDINE INHIBITOR COMPOUNDS AND USES THEREOF
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CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物

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CN101600697A (zh) * 2007-01-05 2009-12-09 赛诺菲-安万特 作为药物、药物组合物和特别地作为ikk抑制剂的新型苯基(4-苯基嘧啶-2-基)胺衍生物、它们的制备
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Publication number Priority date Publication date Assignee Title
US12509447B2 (en) 2019-10-24 2025-12-30 Technoderma Medicines, Inc. Small molecule compound

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JP2013531055A (ja) 2013-08-01
US20130267491A1 (en) 2013-10-10
EP2595964B1 (en) 2015-04-29
CA2805567A1 (en) 2012-01-26
EP2595964A1 (en) 2013-05-29
US8962609B2 (en) 2015-02-24
BR112013001341A2 (pt) 2016-05-17
GB201012105D0 (en) 2010-09-01
HK1181753A1 (en) 2013-11-15
CN103119025A (zh) 2013-05-22

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