CA2805567A1 - Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them - Google Patents
Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- CA2805567A1 CA2805567A1 CA2805567A CA2805567A CA2805567A1 CA 2805567 A1 CA2805567 A1 CA 2805567A1 CA 2805567 A CA2805567 A CA 2805567A CA 2805567 A CA2805567 A CA 2805567A CA 2805567 A1 CA2805567 A1 CA 2805567A1
- Authority
- CA
- Canada
- Prior art keywords
- pyrimidin
- group
- ylamino
- pyrrolidin
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1012105.1A GB201012105D0 (en) | 2010-07-19 | 2010-07-19 | Novel pyrimidine compounds |
| GB1012105.1 | 2010-07-19 | ||
| PCT/GB2011/001075 WO2012010826A1 (en) | 2010-07-19 | 2011-07-18 | Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2805567A1 true CA2805567A1 (en) | 2012-01-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2805567A Abandoned CA2805567A1 (en) | 2010-07-19 | 2011-07-18 | Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8962609B2 (enExample) |
| EP (1) | EP2595964B1 (enExample) |
| JP (1) | JP2013531055A (enExample) |
| CN (1) | CN103119025B (enExample) |
| BR (1) | BR112013001341A2 (enExample) |
| CA (1) | CA2805567A1 (enExample) |
| GB (1) | GB201012105D0 (enExample) |
| WO (1) | WO2012010826A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2696683A4 (en) * | 2011-04-12 | 2014-08-13 | Alzheimer S Inst Of America Inc | COMPOSITIONS AND THERAPEUTIC APPLICATIONS OF IKK-MEDIATED KINASE EPSILON AND TANK BINDING KINASE-1 HEMMER |
| GB201114051D0 (en) | 2011-08-15 | 2011-09-28 | Domainex Ltd | Compounds and their uses |
| DE102011112978A1 (de) | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
| US9045493B2 (en) * | 2012-02-09 | 2015-06-02 | Merck Patent Gmbh | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives |
| GB201303109D0 (en) * | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| JP6783224B2 (ja) | 2014-04-04 | 2020-11-11 | デル マー ファーマシューティカルズ | 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用 |
| TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
| WO2016049211A1 (en) | 2014-09-26 | 2016-03-31 | Gilead Sciences, Inc. | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
| ES2796276T3 (es) | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| US9938257B2 (en) | 2015-09-11 | 2018-04-10 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| KR20180094976A (ko) | 2015-12-17 | 2018-08-24 | 길리애드 사이언시즈, 인코포레이티드 | Tank-결합 키나제 억제제 화합물 |
| EP3390387B1 (en) | 2015-12-18 | 2021-11-17 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| GB201702947D0 (en) * | 2017-02-23 | 2017-04-12 | Domainex Ltd | Novel compounds |
| EP3697773A1 (en) | 2017-10-17 | 2020-08-26 | Merck Patent GmbH | PYRIMIDINE TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF |
| CA3078579A1 (en) * | 2017-10-17 | 2019-04-25 | Merck Patent Gmbh | Pyrimidine tbk/ikk.epsilon. inhibitor compounds and uses thereof |
| WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| CN110862380A (zh) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
| EP1397142A4 (en) | 2001-06-19 | 2004-11-03 | Bristol Myers Squibb Co | PYRIMIDINE PHOSPHODIESTERASE (PDE) INHIBITORS 7 |
| GB0317841D0 (en) * | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
| WO2005012262A1 (en) | 2003-07-30 | 2005-02-10 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| GT200500286A (es) | 2004-10-13 | 2006-06-13 | Analogos de anilino-pirimidina | |
| KR20080110998A (ko) | 2006-01-30 | 2008-12-22 | 엑셀리시스, 인코포레이티드 | Ｊａｋ２ 조절자로서 ４아릴２아미노피리미딘 또는 4아릴２아미노알킬피리미딘 및 이들을 포함하는 약제학적 조성물 |
| CN101460491A (zh) | 2006-04-12 | 2009-06-17 | 惠氏公司 | 苯胺基嘧啶苯基和苯并噻吩类似物 |
| KR20090091139A (ko) | 2006-11-23 | 2009-08-26 | 노파르티스 아게 | ２-히드록시-１,３-디아미노프로판 유도체 |
| FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| MX2009009792A (es) | 2007-03-12 | 2009-09-23 | Cytopia Res Pty Ltd | Compuestos de fenil amino pirimidina y usos de los mismos. |
| WO2008124085A2 (en) | 2007-04-03 | 2008-10-16 | Exelixis, Inc. | Methods of using combinations of mek and jak-2 inhibitors |
| US20090048282A1 (en) | 2007-08-14 | 2009-02-19 | Wyeth | Pyrimidine sulfonamide analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
| CA2698511C (en) | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| NZ599826A (en) | 2009-10-12 | 2014-08-29 | Myrexis Inc | Amino-pyrimidine compounds as inhibitors of ikk epsilon and/or tbk1 |
| EP2696683A4 (en) | 2011-04-12 | 2014-08-13 | Alzheimer S Inst Of America Inc | COMPOSITIONS AND THERAPEUTIC APPLICATIONS OF IKK-MEDIATED KINASE EPSILON AND TANK BINDING KINASE-1 HEMMER |
-
2010
- 2010-07-19 GB GBGB1012105.1A patent/GB201012105D0/en not_active Ceased
-
2011
- 2011-07-18 JP JP2013520197A patent/JP2013531055A/ja active Pending
- 2011-07-18 CA CA2805567A patent/CA2805567A1/en not_active Abandoned
- 2011-07-18 WO PCT/GB2011/001075 patent/WO2012010826A1/en not_active Ceased
- 2011-07-18 BR BR112013001341A patent/BR112013001341A2/pt not_active IP Right Cessation
- 2011-07-18 EP EP20110738026 patent/EP2595964B1/en not_active Not-in-force
- 2011-07-18 CN CN201180045048.9A patent/CN103119025B/zh not_active Expired - Fee Related
- 2011-07-18 US US13/811,164 patent/US8962609B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1181753A1 (en) | 2013-11-15 |
| EP2595964B1 (en) | 2015-04-29 |
| WO2012010826A1 (en) | 2012-01-26 |
| BR112013001341A2 (pt) | 2016-05-17 |
| US20130267491A1 (en) | 2013-10-10 |
| CN103119025B (zh) | 2015-09-09 |
| CN103119025A (zh) | 2013-05-22 |
| JP2013531055A (ja) | 2013-08-01 |
| US8962609B2 (en) | 2015-02-24 |
| EP2595964A1 (en) | 2013-05-29 |
| GB201012105D0 (en) | 2010-09-01 |
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| FZDE | Discontinued |
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