BR112013001341A2 - compostos de pirimidina como inibidores de proteínas quinases ikk épsilon e/ou tbk-1, processo para a preparação dos mesmos e suas composições farmacêuticas - Google Patents

compostos de pirimidina como inibidores de proteínas quinases ikk épsilon e/ou tbk-1, processo para a preparação dos mesmos e suas composições farmacêuticas

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Publication number
BR112013001341A2
BR112013001341A2 BR112013001341A BR112013001341A BR112013001341A2 BR 112013001341 A2 BR112013001341 A2 BR 112013001341A2 BR 112013001341 A BR112013001341 A BR 112013001341A BR 112013001341 A BR112013001341 A BR 112013001341A BR 112013001341 A2 BR112013001341 A2 BR 112013001341A2
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Prior art keywords
tbk
inhibitors
preparation
pharmaceutical compositions
protein kinases
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BR112013001341A
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English (en)
Inventor
Gary Karl Newton
Mark Richard Stewart
Rehan Aqil
Trevor Robert Perrior
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Domainex Ltd
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Publication of BR112013001341A2 publication Critical patent/BR112013001341A2/pt

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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

compostos de pirimida como inibidores de proteínas quinases ikk épsilon e/ou tbk-1, processo para a preparação dos mesmos e suas composições farmacêuticas. os compostos de fórmula geral i e os seus sais são úteis no tratamento de doenças associadas com a atividade aberrante da proteína quinase ikk<sym> e/ou tbk-1; em que: r^ 1^ representa um grupo alifático heterocíclico com 4,5,6 ou 7 átomos de anel, ligados ao grupo fenila representado na fórmula i, através de um átomo de nitrogênio de anel, e opcionalmente substituído por um ou mais substituintes definidos no relatório descritivo; r^ 2^ representa um grupo fenila ou heteroarila que é opcionalmente substituído por um ou mais substituintes definidos no relatório descritivo; e cada um de r^ 3^ e r^ 4^ representa independentemente um átomo de hidrogênio ou um grupo c~ 1-4~alquila.
BR112013001341A 2010-07-19 2011-07-18 compostos de pirimidina como inibidores de proteínas quinases ikk épsilon e/ou tbk-1, processo para a preparação dos mesmos e suas composições farmacêuticas BR112013001341A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1012105.1A GB201012105D0 (en) 2010-07-19 2010-07-19 Novel pyrimidine compounds
PCT/GB2011/001075 WO2012010826A1 (en) 2010-07-19 2011-07-18 Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BR112013001341A2 true BR112013001341A2 (pt) 2016-05-17

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Country Status (9)

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US (1) US8962609B2 (pt)
EP (1) EP2595964B1 (pt)
JP (1) JP2013531055A (pt)
CN (1) CN103119025B (pt)
BR (1) BR112013001341A2 (pt)
CA (1) CA2805567A1 (pt)
GB (1) GB201012105D0 (pt)
HK (1) HK1181753A1 (pt)
WO (1) WO2012010826A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111247135A (zh) * 2017-10-17 2020-06-05 默克专利股份公司 嘧啶ΤΒΚ/ΙΚΚε抑制剂化合物及其用途

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140048873A (ko) * 2011-04-12 2014-04-24 알츠하이머즈 인스티튜트 오브 아메리카, 인크. Ｉｋｋ－관련 키나제 엡실론 및 ｔａｎｋ 결합 키나제 1 억제제의 조성물 및 치료학적 용도
GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
DE102011112978A1 (de) * 2011-09-09 2013-03-14 Merck Patent Gmbh Benzonitrilderivate
ES2606637T3 (es) * 2012-02-09 2017-03-24 Merck Patent Gmbh Derivados de furo [3,2- b]piridina como inhibidores de TBK1 e IKK
GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
AU2015240465B2 (en) 2014-04-04 2020-02-27 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
EA201790395A1 (ru) 2014-09-26 2017-08-31 Джилид Сайэнс, Инк. Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
ES2796276T3 (es) * 2015-02-05 2020-11-26 Ab Science Compuestos con actividad antitumoral
JP2018527362A (ja) 2015-09-11 2018-09-20 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 置換されたヘテロアリール化合物および使用方法
CU20180059A7 (es) 2015-12-17 2018-10-04 Gilead Sciences Inc Compuestos inhibidores de la quinasa de unión a tank
US10894784B2 (en) 2015-12-18 2021-01-19 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
GB201702947D0 (en) * 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
EP3697773A1 (en) 2017-10-17 2020-08-26 Merck Patent GmbH PYRIMIDINE TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
US7429599B2 (en) 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
JP2005500294A (ja) 2001-06-19 2005-01-06 ブリストル−マイヤーズ　スクイブ　カンパニー ホスホジエステラーゼ７に対するピリミジン阻害剤
GB0317841D0 (en) * 2003-07-30 2003-09-03 Cyclacel Ltd Compound
AU2004261484A1 (en) 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
WO2006044457A1 (en) 2004-10-13 2006-04-27 Wyeth N-benzenesulfonyl substituted anilino-pyrimidine analogs
BRPI0706747A2 (pt) 2006-01-30 2011-04-05 Exelixis Inc 4-aril-2-amino-pirimidinas ou 4-aril-2-aminoalquil-pirimidinas como moduladores jak-2 e composições farmacêuticas que os contenham
MX2008013203A (es) 2006-04-12 2008-10-22 Wyeth Corp Analogos de anilino-pirimidina fenilo y benzotiofeno.
EP2094645A1 (en) 2006-11-23 2009-09-02 Novartis AG 2-hydroxy-1,3-diaminopropane derivatives
FR2911139A1 (fr) * 2007-01-05 2008-07-11 Sanofi Aventis Sa Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
KR101737753B1 (ko) 2007-03-12 2017-05-18 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 페닐 아미노 피리미딘 화합물 및 이의 용도
WO2008124085A2 (en) 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
US20090048282A1 (en) 2007-08-14 2009-02-19 Wyeth Pyrimidine sulfonamide analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
CA2698511C (en) * 2007-09-04 2016-10-11 The Scripps Research Institute Substituted pyrimidinyl-amines as protein kinase inhibitors
NZ599826A (en) * 2009-10-12 2014-08-29 Myrexis Inc Amino-pyrimidine compounds as inhibitors of ikk epsilon and/or tbk1
KR20140048873A (ko) 2011-04-12 2014-04-24 알츠하이머즈 인스티튜트 오브 아메리카, 인크. Ｉｋｋ－관련 키나제 엡실론 및 ｔａｎｋ 결합 키나제 1 억제제의 조성물 및 치료학적 용도

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111247135A (zh) * 2017-10-17 2020-06-05 默克专利股份公司 嘧啶ΤΒΚ/ΙΚΚε抑制剂化合物及其用途

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CA2805567A1 (en) 2012-01-26
HK1181753A1 (en) 2013-11-15
CN103119025B (zh) 2015-09-09
EP2595964A1 (en) 2013-05-29
EP2595964B1 (en) 2015-04-29
US8962609B2 (en) 2015-02-24
US20130267491A1 (en) 2013-10-10
CN103119025A (zh) 2013-05-22
WO2012010826A1 (en) 2012-01-26
GB201012105D0 (en) 2010-09-01
JP2013531055A (ja) 2013-08-01

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