BRPI0910439B8 - derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk), seu processo de preparação, e medicamentos - Google Patents
derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk), seu processo de preparação, e medicamentosInfo
- Publication number
- BRPI0910439B8 BRPI0910439B8 BRPI0910439A BRPI0910439A BRPI0910439B8 BR PI0910439 B8 BRPI0910439 B8 BR PI0910439B8 BR PI0910439 A BRPI0910439 A BR PI0910439A BR PI0910439 A BRPI0910439 A BR PI0910439A BR PI0910439 B8 BRPI0910439 B8 BR PI0910439B8
- Authority
- BR
- Brazil
- Prior art keywords
- ampk
- activators
- protein kinase
- activated protein
- medicines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk). a presente invenção refere-se aos compostos de fórmula (i) em que r1, r2 e r3 são como definidos na reivindicação 1, incluindo composições farmacêuticas das mesmas e para o seu uso no tratamento e/ou na prevenção de doenças e distúrbios modulados pelo agonistas de amp. a invenção é também dirigida aos intermediários e a um método de preparação dos compostos de fórmula (i).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP082903642 | 2008-04-11 | ||
EP08290364 | 2008-04-11 | ||
PCT/EP2009/001937 WO2009124636A1 (en) | 2008-04-11 | 2009-03-17 | Thienopyridone derivatives as amp-activated protein kinase (ampk) activators |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0910439A2 BRPI0910439A2 (pt) | 2015-09-29 |
BRPI0910439B1 BRPI0910439B1 (pt) | 2020-10-20 |
BRPI0910439B8 true BRPI0910439B8 (pt) | 2021-05-25 |
Family
ID=40671017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0910439A BRPI0910439B8 (pt) | 2008-04-11 | 2009-03-17 | derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk), seu processo de preparação, e medicamentos |
Country Status (26)
Country | Link |
---|---|
US (1) | US8563729B2 (pt) |
EP (1) | EP2262500B1 (pt) |
JP (1) | JP5592348B2 (pt) |
KR (1) | KR101630466B1 (pt) |
CN (1) | CN101998853B (pt) |
AU (1) | AU2009235784B2 (pt) |
BR (1) | BRPI0910439B8 (pt) |
CA (1) | CA2721025C (pt) |
CO (1) | CO6300954A2 (pt) |
DK (1) | DK2262500T3 (pt) |
EA (1) | EA017756B1 (pt) |
EC (1) | ECSP10010599A (pt) |
ES (1) | ES2584278T3 (pt) |
HK (1) | HK1155955A1 (pt) |
HR (1) | HRP20160907T1 (pt) |
HU (1) | HUE027857T2 (pt) |
IL (1) | IL208067A (pt) |
MX (1) | MX2010011047A (pt) |
MY (1) | MY155836A (pt) |
NZ (1) | NZ589136A (pt) |
PL (1) | PL2262500T3 (pt) |
PT (1) | PT2262500T (pt) |
SI (1) | SI2262500T1 (pt) |
UA (1) | UA103321C2 (pt) |
WO (1) | WO2009124636A1 (pt) |
ZA (1) | ZA201008050B (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2280952E (pt) * | 2008-05-05 | 2012-09-28 | Merck Patent Gmbh | Derivados de tienopiridona como ativadores da proteína-cinase ativada por amp (ampk) |
RS53282B (en) | 2009-12-29 | 2014-08-29 | Poxel | TIENO (2,3-B) PIRIDINDION AMPK ACTIVATORS AND THEIR THERAPEUTIC USES |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2552435A1 (en) | 2010-04-02 | 2013-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
CA2809492C (en) | 2010-09-01 | 2018-12-18 | Bayer Cropscience Ag | Herbicidally active ketosultams and diketopyridines |
KR101624020B1 (ko) * | 2011-03-07 | 2016-05-24 | 글락소스미스클라인 엘엘씨 | 퀴놀리논 유도체 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP2679591A1 (en) * | 2012-06-29 | 2014-01-01 | Poxel | Thienopyridone derivatives useful as activators of AMPK |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
WO2015002818A1 (en) | 2013-07-01 | 2015-01-08 | Emory University | Treating or preventing nephrogenic diabetes insipidus |
WO2015103480A1 (en) | 2014-01-02 | 2015-07-09 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
CN104945369A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途 |
CN105037321A (zh) * | 2015-06-23 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途 |
CN104892568A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途 |
CN105037322A (zh) * | 2015-06-23 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环和烷氧苯结构的黄原酸酯类化合物、其制备方法及用途 |
CN104892569A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途 |
CN104945370A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
CN104945371A (zh) * | 2015-06-24 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
CN104926755A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途 |
CN105001181A (zh) * | 2015-06-24 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 一类双酰基苄胺类的ampk激活剂、其制备方法及用途 |
CN104926756A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途 |
CN104945372A (zh) * | 2015-06-24 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
CN105037296A (zh) * | 2015-06-24 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途 |
CN105001194A (zh) * | 2015-06-24 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 一种含氨基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
CN104926757A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途 |
LT3322711T (lt) | 2015-06-25 | 2021-05-10 | University Health Network | Hpk1 inhibitoriai ir jų panaudojimo būdai |
EP3355876A2 (en) | 2015-09-30 | 2018-08-08 | Instituto de Medicina Molecular | Methods for attenuating parasite virulence |
US20190350955A1 (en) | 2016-06-30 | 2019-11-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Methods and pharmaceutical compositions for the treatment of cardiomyopathies |
JP7266676B2 (ja) * | 2018-11-16 | 2023-04-28 | ポクセル | チエノピリドン誘導体のカリウム塩一水和物及びその調製方法 |
WO2020201263A1 (en) | 2019-04-01 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling |
AU2021244824A1 (en) * | 2020-03-26 | 2022-10-27 | Poxel | Use of a thienopyridone derivative in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy |
BR112022019403A2 (pt) | 2020-04-02 | 2022-12-06 | Poxel | Uso de um derivado de tienopiridona no tratamento de doença renal policística autossômica dominante (drpad) |
JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ,インク. | Ampkアクチベーター |
CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
JP2023544026A (ja) | 2020-09-30 | 2023-10-19 | バイオベラティブ セラピューティクス インコーポレイテッド | Ampk活性化因子及びその使用方法 |
WO2022106892A1 (en) | 2020-11-17 | 2022-05-27 | Instituto De Medicina Molecular | Anti-malarial compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA903588B (en) | 1989-05-16 | 1991-02-27 | Merrell Dow Pharma | Excitatory amino acid antagonists |
DE4444815A1 (de) | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
EP1754483A1 (en) | 2005-08-18 | 2007-02-21 | Merck Sante | Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them |
JP5525456B2 (ja) | 2008-02-04 | 2014-06-18 | マーキュリー セラピューティクス,インコーポレイテッド | Ampk調節因子 |
-
2009
- 2009-03-17 ES ES09731265.6T patent/ES2584278T3/es active Active
- 2009-03-17 PT PT97312656T patent/PT2262500T/pt unknown
- 2009-03-17 UA UAA201013392A patent/UA103321C2/ru unknown
- 2009-03-17 MY MYPI2010004711A patent/MY155836A/en unknown
- 2009-03-17 WO PCT/EP2009/001937 patent/WO2009124636A1/en active Application Filing
- 2009-03-17 SI SI200931484A patent/SI2262500T1/sl unknown
- 2009-03-17 EA EA201001585A patent/EA017756B1/ru unknown
- 2009-03-17 EP EP09731265.6A patent/EP2262500B1/en active Active
- 2009-03-17 US US12/937,147 patent/US8563729B2/en active Active
- 2009-03-17 HU HUE09731265A patent/HUE027857T2/en unknown
- 2009-03-17 BR BRPI0910439A patent/BRPI0910439B8/pt active IP Right Grant
- 2009-03-17 PL PL09731265.6T patent/PL2262500T3/pl unknown
- 2009-03-17 MX MX2010011047A patent/MX2010011047A/es active IP Right Grant
- 2009-03-17 CA CA2721025A patent/CA2721025C/en active Active
- 2009-03-17 NZ NZ589136A patent/NZ589136A/en unknown
- 2009-03-17 JP JP2011503353A patent/JP5592348B2/ja active Active
- 2009-03-17 DK DK09731265.6T patent/DK2262500T3/en active
- 2009-03-17 AU AU2009235784A patent/AU2009235784B2/en active Active
- 2009-03-17 KR KR1020107025218A patent/KR101630466B1/ko active IP Right Grant
- 2009-03-17 CN CN200980112692.6A patent/CN101998853B/zh active Active
-
2010
- 2010-09-07 IL IL208067A patent/IL208067A/en active IP Right Grant
- 2010-10-07 CO CO10124423A patent/CO6300954A2/es not_active Application Discontinuation
- 2010-11-09 EC EC2010010599A patent/ECSP10010599A/es unknown
- 2010-11-10 ZA ZA2010/08050A patent/ZA201008050B/en unknown
-
2011
- 2011-09-28 HK HK11110251.0A patent/HK1155955A1/xx unknown
-
2016
- 2016-07-19 HR HRP20160907TT patent/HRP20160907T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0910439B8 (pt) | derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk), seu processo de preparação, e medicamentos | |
BRPI0910832B8 (pt) | derivados de tienopiridona como ativadores de proteína quinase ativada por amp (ampk), seus usos, seu processo de preparação e seus intermediários, e medicamentos. | |
BRPI0709680B8 (pt) | derivados de pirrol, tiofeno e furano substituídos por piridil e piridimil como inibidores de quinase | |
BR112015028879A8 (pt) | compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos | |
BR112014008045A2 (pt) | benzilindazóis substituídos para uso como inibidores de bub1 cinase no tratamento de doenças hiperproliferativas | |
BRPI0609719B8 (pt) | derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2 | |
BRPI0918750B8 (pt) | derivado de 2-carboxamida cicloamino ureia, seu uso e sua composição farmacêutica | |
BR112012027062A2 (pt) | composto, processo para a preparação de um composto, método para prevenção e/ou tratamento de doenças e condições, e, composição farmacêutica | |
BRPI0919873B8 (pt) | compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas | |
BRPI0613570B8 (pt) | composto, composição farmacêutica e uso de um composto ou um sal farmaceuticamente aceitável do mesmo | |
BRPI0818533B8 (pt) | composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto | |
BR112013018515A2 (pt) | derivados de pirrol tricíclico, processo para preparação e seu uso como inibidores da quinase | |
BR112014014184A2 (pt) | triazolopiridinas substituídas e seu uso como inibidores de ttk | |
BR112013001088A2 (pt) | "derivados substituídos como inibidores a quinase de imidazoquinolina" | |
BR112012012906A2 (pt) | triazolopiridinas | |
BRPI0821115A8 (pt) | Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto | |
UY32848A (es) | Compuestos heterocíclicos de oxima | |
BRPI0610850A2 (pt) | derivados de Ácido aril alquila, composiÇço farmacÊutica, medicamento, bem como uso dos referidos derivados | |
BR112013023517A2 (pt) | "inibidores de produção de leucotrieno, seus usos, e composição farmacêutica" | |
BR112012015916A2 (pt) | derivados de pirazina e seu uso no tratamento de distúrbios neurológicos | |
BRPI0508724A (pt) | derivados do fenilaminoetanol como agonistas do receptor beta2 | |
BR112015020772A2 (pt) | compostos de pirimidina e piridina e seu uso | |
BRPI0508177A (pt) | composto, processo para a produção do composto, composição farmacêutica, uso do composto método para o tratamento de uma doença e produto de combinação | |
BR112013000254A2 (pt) | derivados heterocíclicos 1-fenil-substituídos e seu uso como moduladores do receptor de prostaglandina d2 | |
BRPI0515991A (pt) | derivados de bisariluréia substituìda heterocìclica como inibidores de cinase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/10/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/03/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |