JP2007515413A5 - - Google Patents
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- Publication number
- JP2007515413A5 JP2007515413A5 JP2006544085A JP2006544085A JP2007515413A5 JP 2007515413 A5 JP2007515413 A5 JP 2007515413A5 JP 2006544085 A JP2006544085 A JP 2006544085A JP 2006544085 A JP2006544085 A JP 2006544085A JP 2007515413 A5 JP2007515413 A5 JP 2007515413A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cancer
- group
- composition
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 44
- 239000000203 mixture Substances 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 150000002366 halogen compounds Chemical class 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000004953 trihalomethyl group Chemical group 0.000 claims 2
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 206010067807 Gingival cancer Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010024612 Lipoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010062129 Tongue neoplasm Diseases 0.000 claims 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 1
- 206010053648 Vascular occlusion Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 101100311214 Xenopus laevis stat3.1 gene Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- -1 alkyl aryl compound Chemical class 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 206010016629 fibroma Diseases 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 201000004933 in situ carcinoma Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 150000002771 monosaccharide derivatives Chemical class 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001855 preneoplastic effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 201000006134 tongue cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 208000021331 vascular occlusion disease Diseases 0.000 claims 1
- 0 *C(C1*)C(*)C(*#C)=NC1I Chemical compound *C(C1*)C(*)C(*#C)=NC1I 0.000 description 20
- RTHIJLAJXLSSFT-NTCAYCPXSA-N CCC(C1)C1(c1ccccc1)NC(/C(/C#N)=C/c1cccc([Br]=C)n1)=O Chemical compound CCC(C1)C1(c1ccccc1)NC(/C(/C#N)=C/c1cccc([Br]=C)n1)=O RTHIJLAJXLSSFT-NTCAYCPXSA-N 0.000 description 1
- VXRMKIVOCWHMKE-VMEIHUARSA-N CC[C@@H](c1ccccc1)NC(/C(/C#N)=C/C1=NC([Br]=C)=CCC1)=O Chemical compound CC[C@@H](c1ccccc1)NC(/C(/C#N)=C/C1=NC([Br]=C)=CCC1)=O VXRMKIVOCWHMKE-VMEIHUARSA-N 0.000 description 1
- PPOZKKRPVCVLTC-OQLLNIDSSA-N N#C/C(/C(NCc1ccccc1)=O)=C\c1cnccc1 Chemical compound N#C/C(/C(NCc1ccccc1)=O)=C\c1cnccc1 PPOZKKRPVCVLTC-OQLLNIDSSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52887703P | 2003-12-11 | 2003-12-11 | |
| US60/528,877 | 2003-12-11 | ||
| PCT/US2004/041712 WO2005058829A1 (en) | 2003-12-11 | 2004-12-13 | Compounds for treatment of cell proliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007515413A JP2007515413A (ja) | 2007-06-14 |
| JP2007515413A5 true JP2007515413A5 (enExample) | 2008-02-07 |
| JP4751336B2 JP4751336B2 (ja) | 2011-08-17 |
Family
ID=34699909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544085A Expired - Fee Related JP4751336B2 (ja) | 2003-12-11 | 2004-12-13 | 細胞増殖性疾患を治療する化合 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7745468B2 (enExample) |
| EP (2) | EP2487156B1 (enExample) |
| JP (1) | JP4751336B2 (enExample) |
| KR (2) | KR101170655B1 (enExample) |
| CN (2) | CN1894215B (enExample) |
| AU (1) | AU2004298511B2 (enExample) |
| BR (1) | BRPI0416981A (enExample) |
| CA (1) | CA2548152C (enExample) |
| DK (1) | DK1701941T3 (enExample) |
| ES (1) | ES2385831T3 (enExample) |
| IL (1) | IL176028A (enExample) |
| MX (1) | MXPA06006460A (enExample) |
| PL (1) | PL1701941T3 (enExample) |
| PT (1) | PT1701941E (enExample) |
| SI (1) | SI1701941T1 (enExample) |
| WO (1) | WO2005058829A1 (enExample) |
| ZA (1) | ZA200604682B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1701941E (pt) | 2003-12-11 | 2012-08-03 | Univ Texas | Compostos para o tratamento de doenças proliferativas celulares |
| ZA200803226B (en) * | 2005-10-13 | 2009-11-25 | Orchid Res Lab Ltd | Heterocyclic Compounds as Pstat3/IL-6 Inhibitors |
| RU2456265C2 (ru) * | 2006-03-31 | 2012-07-20 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Биологически доступная для перорального применения кофейная кислота, относящаяся к противоопухолевым лекарственным средствам |
| US20100292229A1 (en) * | 2006-06-30 | 2010-11-18 | The Board Of Regents Of The University Of Texas System | Tryphostin-analogs for the treatment of cell proliferative diseases |
| KR20140097446A (ko) | 2006-11-20 | 2014-08-06 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 통증 및 소양증 치료용 방법, 조성물 및 키트 |
| WO2008083389A1 (en) * | 2006-12-29 | 2008-07-10 | Moleculin, L.L.C. | Methods of treating skin disorders with caffeic acid analogs |
| US20100144802A1 (en) * | 2007-03-28 | 2010-06-10 | Heimberger Amy B | Small Molecule Inhibitors for Immune Modulation |
| JP5688840B2 (ja) * | 2007-09-10 | 2015-03-25 | ボストン バイオメディカル， インコーポレイテッド | 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤 |
| ES2521676T3 (es) | 2008-07-08 | 2014-11-13 | Board Of Regents, The University Of Texas System | Nuevos agentes inhibidores de la proliferación y de la activación de transductores de señales y activadores de la transcripción (STATS) |
| ES2743412T3 (es) | 2008-09-30 | 2020-02-19 | Curium Us Llc | Productos conjugados de hexosa y compuestos de coordinación de metales para la generación de imágenes |
| US8450337B2 (en) * | 2008-09-30 | 2013-05-28 | Moleculin, Llc | Methods of treating skin disorders with caffeic acid analogs |
| US20120021941A1 (en) * | 2009-01-12 | 2012-01-26 | The Board Of Regents Of The University Of Texas System | Blood test for the detection of cancer |
| EP3485881B1 (en) | 2009-07-10 | 2024-03-13 | President and Fellows of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| JP5940452B2 (ja) | 2009-10-16 | 2016-06-29 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺菌剤としてのアミノプロペン酸化合物 |
| WO2011069141A2 (en) | 2009-12-04 | 2011-06-09 | Board Of Regents, The University Of Texas System | Interferon therapies in combination with blockade of stat3 activation |
| EP2544686A4 (en) | 2010-02-05 | 2013-06-26 | Whitehead Biomedical Inst | COMBINATION PROCEDURE FOR THE TREATMENT OF A DISEASE |
| LT2547205T (lt) | 2010-03-19 | 2024-06-10 | 1Globe Biomedical Co., Ltd. | Nauji tikslinio poveikio vėžio kamieninėms ląstelėms būdai |
| JP5852658B2 (ja) * | 2010-09-24 | 2016-02-03 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | デユビキチナーゼ阻害剤およびその使用方法 |
| EP2510787A1 (en) | 2011-04-15 | 2012-10-17 | Bayer Cropscience AG | Propenoates as fungicides |
| US20140094521A1 (en) | 2011-05-27 | 2014-04-03 | The University Of Tokushima | Benzylamine derivative |
| US9011551B2 (en) | 2011-07-11 | 2015-04-21 | The Regents Of The University Of Michigan | Multimodality left atrial appendage occlusion device |
| RU2641903C2 (ru) * | 2012-05-25 | 2018-01-23 | Дзе Гавернинг Каунсил Оф Дзе Юниверсити Оф Торонто | Новые производные салициловой кислоты, их фармацевтически приемлемая соль, композиции и способ применения |
| CN104869987B (zh) | 2012-09-07 | 2020-10-16 | 麻省眼耳医院 | 用于再生毛细胞和/或支持细胞的方法及组合物 |
| WO2014085154A1 (en) * | 2012-11-27 | 2014-06-05 | Beth Israel Deaconess Medical Center, Inc. | Methods for treating renal disease |
| MX2015014181A (es) | 2013-04-09 | 2016-05-24 | Boston Biomedical Inc | 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer. |
| US20160367627A1 (en) | 2013-07-02 | 2016-12-22 | Nikolai Khodarev | Anti-tumor therapy |
| CA2927023C (en) * | 2013-10-10 | 2022-08-02 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| WO2016069906A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| KR20180069782A (ko) | 2015-08-03 | 2018-06-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 하전 이온 채널 블록커 및 이용 방법 |
| WO2018102427A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| CA3062656A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| TWI846678B (zh) * | 2017-11-10 | 2024-07-01 | 美國德州系統大學評議委員會 | 咖啡酸衍生物及其用途 |
| EP3743057A4 (en) | 2018-01-26 | 2021-11-17 | Massachusetts Eye & Ear Infirmary | TREATMENT OF HEARING LOSS |
| US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| BR112021017772A2 (pt) | 2019-03-11 | 2021-11-16 | Nocion Therapeutics Inc | Bloqueadores de canais de íons carregados e métodos para uso |
| EP3937945A4 (en) | 2019-03-11 | 2023-01-04 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| MX2021010869A (es) | 2019-03-11 | 2022-01-19 | Nocion Therapeutics Inc | Bloqueadores de canales iónicos sustituidos por éster y métodos para su uso. |
| AU2020252372A1 (en) * | 2019-04-02 | 2021-10-28 | Board Of Regents, The University Of Texas System | Combinations of transcription inhibitors and immune checkpoint inhibitors for treatment of disease |
| CA3135802A1 (en) | 2019-04-05 | 2020-10-08 | Kymera Therapeutics, Inc. | Stat degraders and uses thereof |
| WO2021091586A1 (en) | 2019-11-06 | 2021-05-14 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| WO2021091585A1 (en) | 2019-11-06 | 2021-05-14 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US12162851B2 (en) | 2020-03-11 | 2024-12-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| EP4118070A4 (en) | 2020-03-11 | 2024-04-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CN115381822A (zh) * | 2022-05-11 | 2022-11-25 | 暨南大学附属第一医院（广州华侨医院） | 一种基于激活免疫应答治疗肺癌的药物及制药应用 |
| KR102811597B1 (ko) * | 2022-06-22 | 2025-05-22 | 한국생명공학연구원 | 신규한 신남아마이드 유도체 및 이의 용도 |
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| DE2555789A1 (de) * | 1975-12-11 | 1977-07-07 | Hoechst Ag | Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| FR2629455B1 (fr) * | 1988-03-29 | 1991-09-27 | Rhone Poulenc Agrochimie | Derives de 2-(3-pyridinyl)3-(phenoxy) propanenitrile |
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
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| KR20050055479A (ko) | 2003-12-08 | 2005-06-13 | 김철호 | 카페인산 또는 카페인산 페네틸에스테르를 유효성분으로하는 ｍｍｐ-9 억제제 |
| PT1701941E (pt) * | 2003-12-11 | 2012-08-03 | Univ Texas | Compostos para o tratamento de doenças proliferativas celulares |
| RU2456265C2 (ru) * | 2006-03-31 | 2012-07-20 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Биологически доступная для перорального применения кофейная кислота, относящаяся к противоопухолевым лекарственным средствам |
| US20100292229A1 (en) | 2006-06-30 | 2010-11-18 | The Board Of Regents Of The University Of Texas System | Tryphostin-analogs for the treatment of cell proliferative diseases |
| WO2008053297A2 (en) * | 2006-10-30 | 2008-05-08 | Wockhardt Research Centre | Pharmaceutical compositions comprising entacapone, levodopa, and carbidopa |
-
2004
- 2004-12-13 PT PT04813958T patent/PT1701941E/pt unknown
- 2004-12-13 MX MXPA06006460A patent/MXPA06006460A/es active IP Right Grant
- 2004-12-13 PL PL04813958T patent/PL1701941T3/pl unknown
- 2004-12-13 KR KR1020067013861A patent/KR101170655B1/ko not_active Expired - Fee Related
- 2004-12-13 AU AU2004298511A patent/AU2004298511B2/en not_active Ceased
- 2004-12-13 EP EP12167605.0A patent/EP2487156B1/en not_active Expired - Lifetime
- 2004-12-13 US US11/010,834 patent/US7745468B2/en active Active
- 2004-12-13 EP EP04813958A patent/EP1701941B1/en not_active Expired - Lifetime
- 2004-12-13 CN CN2004800370450A patent/CN1894215B/zh not_active Expired - Fee Related
- 2004-12-13 CN CN2012100233394A patent/CN102603565A/zh active Pending
- 2004-12-13 JP JP2006544085A patent/JP4751336B2/ja not_active Expired - Fee Related
- 2004-12-13 KR KR1020117027869A patent/KR101218633B1/ko not_active Expired - Fee Related
- 2004-12-13 SI SI200431908T patent/SI1701941T1/sl unknown
- 2004-12-13 WO PCT/US2004/041712 patent/WO2005058829A1/en not_active Ceased
- 2004-12-13 CA CA2548152A patent/CA2548152C/en not_active Expired - Lifetime
- 2004-12-13 BR BRPI0416981-6A patent/BRPI0416981A/pt not_active IP Right Cessation
- 2004-12-13 ES ES04813958T patent/ES2385831T3/es not_active Expired - Lifetime
- 2004-12-13 DK DK04813958.8T patent/DK1701941T3/da active
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2006
- 2006-05-30 IL IL176028A patent/IL176028A/en active IP Right Review Request
- 2006-06-07 ZA ZA2006/04682A patent/ZA200604682B/en unknown
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2010
- 2010-06-28 US US12/824,901 patent/US8119827B2/en not_active Expired - Fee Related
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2012
- 2012-01-13 US US13/350,637 patent/US8648102B2/en not_active Expired - Lifetime
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2014
- 2014-01-03 US US14/147,089 patent/US9096499B2/en not_active Expired - Lifetime
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