CN108779111B - 结合脱氧胞苷激酶的化合物 - Google Patents

结合脱氧胞苷激酶的化合物 Download PDF

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Publication number
CN108779111B
CN108779111B CN201780015566.3A CN201780015566A CN108779111B CN 108779111 B CN108779111 B CN 108779111B CN 201780015566 A CN201780015566 A CN 201780015566A CN 108779111 B CN108779111 B CN 108779111B
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compound
substituted
cancer
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formula
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Chinese (zh)
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CN108779111A (zh
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C·G·拉杜
R·M·吉普森
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201780015566.3A 2016-01-08 2017-01-09 结合脱氧胞苷激酶的化合物 Active CN108779111B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662276546P 2016-01-08 2016-01-08
US62/276,546 2016-01-08
PCT/US2017/012718 WO2017120585A1 (en) 2016-01-08 2017-01-09 Deoxycytidine kinase binding compounds

Publications (2)

Publication Number Publication Date
CN108779111A CN108779111A (zh) 2018-11-09
CN108779111B true CN108779111B (zh) 2021-11-12

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US (1) US10570124B2 (enExample)
EP (1) EP3400224A4 (enExample)
JP (1) JP7091244B2 (enExample)
CN (1) CN108779111B (enExample)
AU (1) AU2017205336A1 (enExample)
CA (1) CA3010723A1 (enExample)
WO (1) WO2017120585A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180141897A1 (en) 2014-12-08 2018-05-24 The Research Foundation For The State University Of New York Anti-fungals targeting the synthesis of fungal shingolipids
WO2018232298A1 (en) 2017-06-16 2018-12-20 The Research Foundation For The State University Of New York Anti-fungals compounds targeting the synthesis of fungal sphingolipids
EP4237421A4 (en) 2020-11-02 2024-11-06 Trethera Corporation CRYSTALLINE FORMS OF A DEOXYCYTIDINE KINASE INHIBITOR AND THEIR USES
CN116723845A (zh) * 2020-11-02 2023-09-08 特雷西拉公司 脱氧胞苷激酶抑制剂的结晶形式及其用途
US20250092032A1 (en) * 2022-01-17 2025-03-20 Centre National De La Recherche Scientifique Deoxycytidine kinase inhibitors
WO2024186827A2 (en) * 2023-03-06 2024-09-12 The Regents Of The University Of California Novel host-directed therapeutic agent for the treatment of infectious diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015023776A2 (en) * 2013-08-13 2015-02-19 The Regents Of The University Of California Deoxycytidine kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008302703B2 (en) 2007-09-19 2013-11-07 The Regents Of The University Of California Positron emission tomography probes for imaging immune activation and selected cancers
US9688673B2 (en) 2011-03-08 2017-06-27 The Regents Of The University Of California Deoxycytidine kinase binding compounds
WO2016130581A2 (en) * 2015-02-09 2016-08-18 The Regents Of The University Of California Combination cancer therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015023776A2 (en) * 2013-08-13 2015-02-19 The Regents Of The University Of California Deoxycytidine kinase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography;Jennifer M. Murphy，等;《Journal of Medicinal Chemistry》;20130815;第56卷(第17期);6696-6708 *
Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability;Julian Nomme，等;《Journal of Medicinal Chemistry》;20141023;第57卷(第22期);9480-9494 *

Also Published As

Publication number Publication date
EP3400224A4 (en) 2019-08-07
US20190016714A1 (en) 2019-01-17
JP2019504833A (ja) 2019-02-21
JP7091244B2 (ja) 2022-06-27
CN108779111A (zh) 2018-11-09
AU2017205336A1 (en) 2018-07-26
EP3400224A1 (en) 2018-11-14
WO2017120585A1 (en) 2017-07-13
CA3010723A1 (en) 2017-07-13
US10570124B2 (en) 2020-02-25

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