AU2017205336A1 - Deoxycytidine kinase binding compounds - Google Patents
Deoxycytidine kinase binding compounds Download PDFInfo
- Publication number
- AU2017205336A1 AU2017205336A1 AU2017205336A AU2017205336A AU2017205336A1 AU 2017205336 A1 AU2017205336 A1 AU 2017205336A1 AU 2017205336 A AU2017205336 A AU 2017205336A AU 2017205336 A AU2017205336 A AU 2017205336A AU 2017205336 A1 AU2017205336 A1 AU 2017205336A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- optionally substituted
- pct
- substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- WRVYQWCFAABEKV-UHFFFAOYSA-N COc(cccc1)c1OCCN1CCCC1 Chemical compound COc(cccc1)c1OCCN1CCCC1 WRVYQWCFAABEKV-UHFFFAOYSA-N 0.000 description 2
- WGUADCDFIVYVCR-LURJTMIESA-N C[C@@H](c1c(C)[s]cn1)Sc1nc(N)cc(N)n1 Chemical compound C[C@@H](c1c(C)[s]cn1)Sc1nc(N)cc(N)n1 WGUADCDFIVYVCR-LURJTMIESA-N 0.000 description 2
- WGUADCDFIVYVCR-UHFFFAOYSA-N CC(c1c(C)[s]cn1)Sc1nc(N)cc(N)n1 Chemical compound CC(c1c(C)[s]cn1)Sc1nc(N)cc(N)n1 WGUADCDFIVYVCR-UHFFFAOYSA-N 0.000 description 1
- CJYRJYXPKKAWDM-ICPXLOEFSA-N CC/C(/S)=C(\[C@H](C)Sc1nc(N)cc(N)n1)/N Chemical compound CC/C(/S)=C(\[C@H](C)Sc1nc(N)cc(N)n1)/N CJYRJYXPKKAWDM-ICPXLOEFSA-N 0.000 description 1
- IEIWUHUAVKLUTB-UHFFFAOYSA-N CCCc1c(C(C)Sc2nc(N)cc(N)n2)nc(-c2ccc(C)c(OCCN3CCC3)c2)[s]1 Chemical compound CCCc1c(C(C)Sc2nc(N)cc(N)n2)nc(-c2ccc(C)c(OCCN3CCC3)c2)[s]1 IEIWUHUAVKLUTB-UHFFFAOYSA-N 0.000 description 1
- ZBYDZBXBUMTCTC-UHFFFAOYSA-N CCN(CCOC)CCOc1ccccc1OC Chemical compound CCN(CCOC)CCOc1ccccc1OC ZBYDZBXBUMTCTC-UHFFFAOYSA-N 0.000 description 1
- QCDZKMPDIGQMRS-UHFFFAOYSA-N CCc1c(C(C)Sc2nc(N)cc(N)n2)nc(-c(cc2)cc(OCCN3CCCCC3)c2OC)[s]1 Chemical compound CCc1c(C(C)Sc2nc(N)cc(N)n2)nc(-c(cc2)cc(OCCN3CCCCC3)c2OC)[s]1 QCDZKMPDIGQMRS-UHFFFAOYSA-N 0.000 description 1
- VSXRNBNOJZRPBL-UHFFFAOYSA-N CCc1c(C(C)Sc2nc(N)cc(N)n2)nc(-c(cc2OCCN3CCOCC3)ccc2OC)[s]1 Chemical compound CCc1c(C(C)Sc2nc(N)cc(N)n2)nc(-c(cc2OCCN3CCOCC3)ccc2OC)[s]1 VSXRNBNOJZRPBL-UHFFFAOYSA-N 0.000 description 1
- LLNJLICTXBGXMW-UHFFFAOYSA-N COc(cccc1)c1OCCN1CCC1 Chemical compound COc(cccc1)c1OCCN1CCC1 LLNJLICTXBGXMW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276546P | 2016-01-08 | 2016-01-08 | |
| US62/276,546 | 2016-01-08 | ||
| PCT/US2017/012718 WO2017120585A1 (en) | 2016-01-08 | 2017-01-09 | Deoxycytidine kinase binding compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017205336A1 true AU2017205336A1 (en) | 2018-07-26 |
Family
ID=59274442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017205336A Abandoned AU2017205336A1 (en) | 2016-01-08 | 2017-01-09 | Deoxycytidine kinase binding compounds |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10570124B2 (enExample) |
| EP (1) | EP3400224A4 (enExample) |
| JP (1) | JP7091244B2 (enExample) |
| CN (1) | CN108779111B (enExample) |
| AU (1) | AU2017205336A1 (enExample) |
| CA (1) | CA3010723A1 (enExample) |
| WO (1) | WO2017120585A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180141897A1 (en) | 2014-12-08 | 2018-05-24 | The Research Foundation For The State University Of New York | Anti-fungals targeting the synthesis of fungal shingolipids |
| EP3638649A4 (en) | 2017-06-16 | 2021-03-17 | The Research Foundation for The State University of New York | FUNGUSKID AGENTS AGAINST THE SYNTHESIS OF FUNGAL SHINGOLIPIDS |
| PE20231656A1 (es) * | 2020-11-02 | 2023-10-17 | Trethera Corp | Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos |
| CN116723845A (zh) * | 2020-11-02 | 2023-09-08 | 特雷西拉公司 | 脱氧胞苷激酶抑制剂的结晶形式及其用途 |
| US20250092032A1 (en) * | 2022-01-17 | 2025-03-20 | Centre National De La Recherche Scientifique | Deoxycytidine kinase inhibitors |
| WO2024186827A2 (en) * | 2023-03-06 | 2024-09-12 | The Regents Of The University Of California | Novel host-directed therapeutic agent for the treatment of infectious diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008302703B2 (en) | 2007-09-19 | 2013-11-07 | The Regents Of The University Of California | Positron emission tomography probes for imaging immune activation and selected cancers |
| WO2012122368A1 (en) * | 2011-03-08 | 2012-09-13 | The Regents Of The University Of California | Deoxycytidine kinase binding compounds |
| JP6542216B2 (ja) * | 2013-08-13 | 2019-07-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | デオキシシチジンキナーゼ阻害因子 |
| WO2016130581A2 (en) | 2015-02-09 | 2016-08-18 | The Regents Of The University Of California | Combination cancer therapy |
-
2017
- 2017-01-09 US US16/068,658 patent/US10570124B2/en active Active
- 2017-01-09 JP JP2018535341A patent/JP7091244B2/ja active Active
- 2017-01-09 CA CA3010723A patent/CA3010723A1/en not_active Abandoned
- 2017-01-09 CN CN201780015566.3A patent/CN108779111B/zh active Active
- 2017-01-09 EP EP17736514.5A patent/EP3400224A4/en active Pending
- 2017-01-09 AU AU2017205336A patent/AU2017205336A1/en not_active Abandoned
- 2017-01-09 WO PCT/US2017/012718 patent/WO2017120585A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP7091244B2 (ja) | 2022-06-27 |
| CN108779111A (zh) | 2018-11-09 |
| WO2017120585A1 (en) | 2017-07-13 |
| CA3010723A1 (en) | 2017-07-13 |
| US10570124B2 (en) | 2020-02-25 |
| CN108779111B (zh) | 2021-11-12 |
| JP2019504833A (ja) | 2019-02-21 |
| EP3400224A4 (en) | 2019-08-07 |
| EP3400224A1 (en) | 2018-11-14 |
| US20190016714A1 (en) | 2019-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |