JP2016534148A5 - - Google Patents

Info

Publication number

JP2016534148A5

JP2016534148A5 JP2016543991A JP2016543991A JP2016534148A5 JP 2016534148 A5 JP2016534148 A5 JP 2016534148A5 JP 2016543991 A JP2016543991 A JP 2016543991A JP 2016543991 A JP2016543991 A JP 2016543991A JP 2016534148 A5 JP2016534148 A5 JP 2016534148A5

Authority

JP

Japan

Prior art keywords

substituted

composition

use according

phenyl

compound

Prior art date

2014-09-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims description 42
• 239000000203 mixture Substances 0.000 claims description 34
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
• -1 amino, thio Chemical group 0.000 claims description 18
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 14
• XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 12
• 125000001072 heteroaryl group Chemical group 0.000 claims description 12
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 12
• 206010060862 Prostate cancer Diseases 0.000 claims description 10
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 10
• 125000002541 furyl group Chemical group 0.000 claims description 10
• 229910052736 halogen Inorganic materials 0.000 claims description 10
• 125000003386 piperidinyl group Chemical group 0.000 claims description 10
• 125000004076 pyridyl group Chemical group 0.000 claims description 10
• 125000000217 alkyl group Chemical group 0.000 claims description 9
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 9
• 150000002367 halogens Chemical class 0.000 claims description 9
• 125000003545 alkoxy group Chemical group 0.000 claims description 6
• 125000003118 aryl group Chemical group 0.000 claims description 6
• 125000004104 aryloxy group Chemical group 0.000 claims description 6
• 125000000707 boryl group Chemical group B* 0.000 claims description 6
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
• 150000004820 halides Chemical class 0.000 claims description 6
• 125000002883 imidazolyl group Chemical group 0.000 claims description 6
• 125000001041 indolyl group Chemical group 0.000 claims description 6
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
• 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 6
• 125000002971 oxazolyl group Chemical group 0.000 claims description 6
• 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 6
• 125000003107 substituted aryl group Chemical group 0.000 claims description 6
• 125000001544 thienyl group Chemical group 0.000 claims description 6
• 150000002148 esters Chemical class 0.000 claims description 5
• 150000003839 salts Chemical class 0.000 claims description 5
• MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims description 4
• 125000005438 isoindazolyl group Chemical class 0.000 claims description 4
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 4
• 125000001425 triazolyl group Chemical group 0.000 claims description 4
• GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 claims description 3
• 229960000853 abiraterone Drugs 0.000 claims description 3
• 125000004426 substituted alkynyl group Chemical group 0.000 claims description 3
• FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 2
• 239000000654 additive Substances 0.000 claims description 2
• 230000000996 additive effect Effects 0.000 claims description 2
• 238000009167 androgen deprivation therapy Methods 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims description 2
• 150000003557 thiazoles Chemical class 0.000 claims description 2
• 238000010317 ablation therapy Methods 0.000 claims 1
• 239000003098 androgen Substances 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 238000000034 method Methods 0.000 description 9
• 0 Cc1c(*)c(*)c(*)c(*)c1* Chemical compound Cc1c(*)c(*)c(*)c(*)c1* 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1