JP2010506950A5 - - Google Patents
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- Publication number
- JP2010506950A5 JP2010506950A5 JP2009533499A JP2009533499A JP2010506950A5 JP 2010506950 A5 JP2010506950 A5 JP 2010506950A5 JP 2009533499 A JP2009533499 A JP 2009533499A JP 2009533499 A JP2009533499 A JP 2009533499A JP 2010506950 A5 JP2010506950 A5 JP 2010506950A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- lower alkyl
- independently
- formula
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 125000003003 spiro group Chemical group 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108050004099 Diacylglycerol O-acyltransferase 1 Proteins 0.000 description 1
- 101000927974 Homo sapiens Diacylglycerol O-acyltransferase 1 Proteins 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82998006P | 2006-10-18 | 2006-10-18 | |
| US60/829,980 | 2006-10-18 | ||
| US95234107P | 2007-07-27 | 2007-07-27 | |
| US60/952,341 | 2007-07-27 | ||
| PCT/US2007/081607 WO2008048991A2 (en) | 2006-10-18 | 2007-10-17 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506950A JP2010506950A (ja) | 2010-03-04 |
| JP2010506950A5 true JP2010506950A5 (enExample) | 2010-11-25 |
| JP5298022B2 JP5298022B2 (ja) | 2013-09-25 |
Family
ID=39276877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533499A Expired - Fee Related JP5298022B2 (ja) | 2006-10-18 | 2007-10-17 | 有機化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8222248B2 (enExample) |
| EP (1) | EP2074089B1 (enExample) |
| JP (1) | JP5298022B2 (enExample) |
| KR (1) | KR20090071642A (enExample) |
| AR (1) | AR063311A1 (enExample) |
| AU (1) | AU2007311087B2 (enExample) |
| BR (1) | BRPI0718478A2 (enExample) |
| CA (1) | CA2666880A1 (enExample) |
| CL (1) | CL2007002974A1 (enExample) |
| ES (1) | ES2440253T3 (enExample) |
| MX (1) | MX2009004047A (enExample) |
| PE (1) | PE20080888A1 (enExample) |
| RU (1) | RU2009118489A (enExample) |
| TW (1) | TW200829563A (enExample) |
| WO (1) | WO2008048991A2 (enExample) |
Families Citing this family (50)
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| MX2007007101A (es) | 2004-12-14 | 2007-08-21 | Astrazeneca Ab | Derivados de oxadiazol como inhibidores de acil coa:diacilglicerol aciltransferasa. |
| AR058562A1 (es) | 2005-12-22 | 2008-02-13 | Astrazeneca Ab | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 |
| CA2651663A1 (en) | 2006-05-30 | 2007-12-06 | Astrazeneca Ab | Chemical compounds |
| BRPI0712802A2 (pt) | 2006-05-30 | 2012-10-23 | Astrazeneca Ab | composto, métodos para produzir uma inibição da atividade de dgat1, e para tratar diabete melito e/ou obesidade em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para preparar um composto |
| CN101932562B (zh) | 2007-12-20 | 2013-06-12 | 阿斯利康(瑞典)有限公司 | 作为dgat1抑制剂190的氨基甲酰基化合物 |
| WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
| WO2010039668A2 (en) * | 2008-10-01 | 2010-04-08 | The Regents Of The University Of California | Inhibitors of cyclin kinase inhibitor p21 |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| EP2408744A1 (en) * | 2009-03-18 | 2012-01-25 | Schering Corporation | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase |
| WO2010146395A1 (en) | 2009-06-19 | 2010-12-23 | Astrazeneca Ab | Pyrazine carboxamides as inhibitors of dgat1 |
| WO2011011722A1 (en) * | 2009-07-23 | 2011-01-27 | Vanderbilt University | Substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mglur4 potentiators |
| KR101194995B1 (ko) * | 2009-10-14 | 2012-10-29 | 주식회사 이큐스앤자루 | 신규한 2-페닐-벤즈이미다졸 또는 2-페닐-벤즈옥사졸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물 |
| WO2011099832A2 (en) * | 2010-02-12 | 2011-08-18 | Crystalgenomics, Inc. | Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same |
| SI2575968T1 (sl) | 2010-06-01 | 2016-06-30 | Summit Therapeutics Plc | Spojine za zdravljenje bolezni, ki je povezana s clostridium difficile |
| EP2800568A4 (en) * | 2012-01-06 | 2015-06-10 | Univ South Florida | COMPOSITIONS, USE METHOD AND TREATMENT METHOD THEREFOR |
| KR102212923B1 (ko) | 2012-12-21 | 2021-02-04 | 플렉시콘 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 |
| US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| RS58053B1 (sr) | 2013-12-19 | 2019-02-28 | Novartis Ag | [1,2,4] triazolo [1,5-a] pirimidin derivati kao proteazomski inhibitori protozoa za tretman parazitskih bolesti kao što je lišmanijaza |
| SI3102576T1 (sl) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals, Llc | Inhibitorji dihidropirolopiridina ROR-gama |
| WO2015166398A1 (en) * | 2014-04-30 | 2015-11-05 | Aurigene Discovery Technologies Limited | 3h-imidazo[4,5-b]pyridine derivatives as dihydroorotate dehydrogenase inhibitors |
| BR112017007460A2 (pt) | 2014-10-14 | 2017-12-19 | Vitae Pharmaceuticals Inc | inibidores de di-hidropirrolopiridina de ror-gama |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| CA2986930C (en) * | 2015-06-24 | 2023-09-26 | Duke University | Chemical modulators of signaling pathways and therapeutic use |
| ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
| WO2017087608A1 (en) | 2015-11-20 | 2017-05-26 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| CN110234640B (zh) | 2016-09-20 | 2023-04-07 | 利昂贝拉尔中心 | 作为抗癌剂的苯并咪唑衍生物 |
| KR20200053481A (ko) | 2017-07-24 | 2020-05-18 | 비타이 파마슈티컬즈, 엘엘씨 | RORγ의 억제제 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| CA3106239A1 (en) | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| PE20211644A1 (es) | 2018-09-18 | 2021-08-24 | Terns Inc | Compuestos para tratar ciertas leucemias |
| WO2020120576A1 (en) * | 2018-12-11 | 2020-06-18 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | p38α AUTOPHOSPHORYLATION INHIBITORS |
| EP3997081A1 (en) | 2019-07-11 | 2022-05-18 | Escape Bio, Inc. | Indazoles and azaindazoles as lrrk2 inhibitors |
| CA3166429A1 (en) * | 2020-01-28 | 2021-08-05 | Bradley Dean Tait | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| EP4143329A4 (en) | 2020-04-28 | 2024-10-16 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| BR112022021920A2 (pt) | 2020-04-29 | 2023-01-17 | Plexxikon Inc | Síntese de compostos heterocíclicos |
| JP2023552638A (ja) * | 2020-12-11 | 2023-12-18 | ティーエムイーエム１６エー リミテッド | 呼吸器疾患を治療するためのベンゾイミダゾール誘導体 |
| JP7728367B2 (ja) | 2021-06-14 | 2025-08-22 | スコーピオン・セラピューティクス・インコーポレイテッド | がんを処置するために使用され得る尿素誘導体 |
| AU2022306297A1 (en) | 2021-07-09 | 2024-02-08 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
| WO2023134708A1 (en) * | 2022-01-12 | 2023-07-20 | Beigene , Ltd. | Thiazolopyridyl amide derivatives as dna polymerase theta inhibitors |
| EP4265247A1 (en) * | 2022-04-22 | 2023-10-25 | Université Paris Cité | Compounds inducing production of proteins by immune cells |
| CN116253755A (zh) * | 2023-02-28 | 2023-06-13 | 湖南大学 | 一种二芳基硼酸酯类化合物的合成方法 |
| CN117327020A (zh) * | 2023-10-07 | 2024-01-02 | 中国科学院过程工程研究所 | 一种含苯并氮杂环结构的氨基芳香化合物及其制备方法和应用 |
| US11970468B1 (en) | 2023-10-23 | 2024-04-30 | King Faisal University | 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound |
| CN120118037B (zh) * | 2023-12-07 | 2025-11-28 | 南华大学 | 一类含苯甲酸酯结构的苯并咪唑类化合物、制造方法及其用途 |
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| US3551443A (en) * | 1968-10-30 | 1970-12-29 | Ciba Ltd | 2-phenylbenzoxazole derivatives |
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-
2007
- 2007-10-16 AR ARP070104573A patent/AR063311A1/es not_active Application Discontinuation
- 2007-10-16 PE PE2007001396A patent/PE20080888A1/es not_active Application Discontinuation
- 2007-10-17 KR KR1020097010003A patent/KR20090071642A/ko not_active Withdrawn
- 2007-10-17 RU RU2009118489/04A patent/RU2009118489A/ru not_active Application Discontinuation
- 2007-10-17 BR BRPI0718478-6A2A patent/BRPI0718478A2/pt not_active IP Right Cessation
- 2007-10-17 JP JP2009533499A patent/JP5298022B2/ja not_active Expired - Fee Related
- 2007-10-17 EP EP07854118.2A patent/EP2074089B1/en not_active Not-in-force
- 2007-10-17 MX MX2009004047A patent/MX2009004047A/es not_active Application Discontinuation
- 2007-10-17 TW TW096138922A patent/TW200829563A/zh unknown
- 2007-10-17 CA CA002666880A patent/CA2666880A1/en not_active Abandoned
- 2007-10-17 AU AU2007311087A patent/AU2007311087B2/en not_active Ceased
- 2007-10-17 CL CL200702974A patent/CL2007002974A1/es unknown
- 2007-10-17 ES ES07854118.2T patent/ES2440253T3/es active Active
- 2007-10-17 US US12/446,088 patent/US8222248B2/en not_active Expired - Fee Related
- 2007-10-17 WO PCT/US2007/081607 patent/WO2008048991A2/en not_active Ceased