JP2010506950A5 - - Google Patents
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- Publication number
- JP2010506950A5 JP2010506950A5 JP2009533499A JP2009533499A JP2010506950A5 JP 2010506950 A5 JP2010506950 A5 JP 2010506950A5 JP 2009533499 A JP2009533499 A JP 2009533499A JP 2009533499 A JP2009533499 A JP 2009533499A JP 2010506950 A5 JP2010506950 A5 JP 2010506950A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- lower alkyl
- independently
- formula
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 125000003003 spiro group Chemical group 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108050004099 Diacylglycerol O-acyltransferase 1 Proteins 0.000 description 1
- 101000927974 Homo sapiens Diacylglycerol O-acyltransferase 1 Proteins 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82998006P | 2006-10-18 | 2006-10-18 | |
| US60/829,980 | 2006-10-18 | ||
| US95234107P | 2007-07-27 | 2007-07-27 | |
| US60/952,341 | 2007-07-27 | ||
| PCT/US2007/081607 WO2008048991A2 (en) | 2006-10-18 | 2007-10-17 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506950A JP2010506950A (ja) | 2010-03-04 |
| JP2010506950A5 true JP2010506950A5 (enExample) | 2010-11-25 |
| JP5298022B2 JP5298022B2 (ja) | 2013-09-25 |
Family
ID=39276877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533499A Expired - Fee Related JP5298022B2 (ja) | 2006-10-18 | 2007-10-17 | 有機化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8222248B2 (enExample) |
| EP (1) | EP2074089B1 (enExample) |
| JP (1) | JP5298022B2 (enExample) |
| KR (1) | KR20090071642A (enExample) |
| AR (1) | AR063311A1 (enExample) |
| AU (1) | AU2007311087B2 (enExample) |
| BR (1) | BRPI0718478A2 (enExample) |
| CA (1) | CA2666880A1 (enExample) |
| CL (1) | CL2007002974A1 (enExample) |
| ES (1) | ES2440253T3 (enExample) |
| MX (1) | MX2009004047A (enExample) |
| PE (1) | PE20080888A1 (enExample) |
| RU (1) | RU2009118489A (enExample) |
| TW (1) | TW200829563A (enExample) |
| WO (1) | WO2008048991A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0519058A2 (pt) | 2004-12-14 | 2008-12-23 | Astrazeneca Ab | composto ou um sal prà-droga farmaceuticamente aceitÁvel do mesmo, mÉtodos para produzir uma inibiÇço da atividade de dgat1 e para tratar diabete melito e/ou obesidade em um animal de sangue quente, uso de um composto, composiÇço farmacÊutica, e, processo para preparar um composto |
| AR058562A1 (es) | 2005-12-22 | 2008-02-13 | Astrazeneca Ab | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 |
| MX2008015226A (es) | 2006-05-30 | 2008-12-12 | Astrazeneca Ab | Derivados de 1,3,4-oxadiazol como inhibidores de dgat1. |
| AU2007266796B2 (en) | 2006-05-30 | 2011-02-10 | Astrazeneca Ab | Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase |
| AR069802A1 (es) | 2007-12-20 | 2010-02-17 | Astrazeneca Ab | Compuestos de carbamoilo como inhibidores de dgat1 190 |
| WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
| US20110301192A1 (en) * | 2008-10-01 | 2011-12-08 | The Regents Of The University Of California | Inhibitors of Cyclin Kinase Inhibitor p21 |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| JP2012520887A (ja) * | 2009-03-18 | 2012-09-10 | シェーリング コーポレイション | ジアシルグリセロールアシルトランスフェラーゼの阻害剤としての二環式化合物 |
| MX2011014018A (es) | 2009-06-19 | 2012-02-22 | Astrazeneca Ab | Pirazincarboxamidas como inhibidores de dgati. |
| EP2456310A4 (en) * | 2009-07-23 | 2013-01-23 | Univ Vanderbilt | SUBSTITUTED BENZOIMIDAZOLSULFONAMIDES AND SUBSTITUTED INDOLSULFONAMIDES AS MGLUR4 POTENTIATORS |
| KR101194995B1 (ko) * | 2009-10-14 | 2012-10-29 | 주식회사 이큐스앤자루 | 신규한 2-페닐-벤즈이미다졸 또는 2-페닐-벤즈옥사졸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물 |
| WO2011099832A2 (en) * | 2010-02-12 | 2011-08-18 | Crystalgenomics, Inc. | Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same |
| CA2801274C (en) | 2010-06-01 | 2021-06-15 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| JP2015506360A (ja) * | 2012-01-06 | 2015-03-02 | ユニバーシティ・オブ・サウス・フロリダ | 組成物、使用方法および処置方法 |
| ME03000B (me) | 2012-12-21 | 2018-10-20 | Plexxikon Inc | Jedinjenja i metode modulacije kinaze i povezane indikacije |
| WO2014151630A2 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9186361B2 (en) | 2013-03-15 | 2015-11-17 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| JP6392352B2 (ja) | 2013-12-19 | 2018-09-19 | ノバルティス アーゲー | リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体 |
| DK3102576T3 (da) | 2014-02-03 | 2019-07-22 | Vitae Pharmaceuticals Llc | Dihydropyrrolopyridininhibitorer af ror-gamma |
| WO2015166398A1 (en) * | 2014-04-30 | 2015-11-05 | Aurigene Discovery Technologies Limited | 3h-imidazo[4,5-b]pyridine derivatives as dihydroorotate dehydrogenase inhibitors |
| SI3207043T1 (sl) | 2014-10-14 | 2019-04-30 | Vitae Pharmaceuticals, Inc. | Dihidropirolopiridinovi inhibitorji za ROR-gama |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| CA2986930C (en) | 2015-06-24 | 2023-09-26 | Duke University | Chemical modulators of signaling pathways and therapeutic use |
| EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| EP3868750A1 (en) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| JP7278945B2 (ja) | 2016-09-20 | 2023-05-22 | サントル レオン ベラール | 抗癌剤としてのベンゾイミダゾール誘導体 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| CN115716826A (zh) | 2017-07-24 | 2023-02-28 | 生命医药有限责任公司 | RORγ的抑制剂 |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| WO2020023782A1 (en) | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| NZ773110A (en) * | 2018-09-18 | 2024-11-29 | Terns Inc | Compounds for treating certain leukemias |
| WO2020120576A1 (en) * | 2018-12-11 | 2020-06-18 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | p38α AUTOPHOSPHORYLATION INHIBITORS |
| TW202116754A (zh) | 2019-07-11 | 2021-05-01 | 美商Ｅ 斯蓋普生物股份有限公司 | 作為ｌｒｒｋ２抑制劑之吲唑及氮雜吲唑 |
| JP2023512116A (ja) * | 2020-01-28 | 2023-03-23 | プロテゴ バイオファーマ， インコーポレイテッド | トランスサイレチンの安定化及びトランスサイレチンの誤った折り畳みの阻害のための化合物、組成物、及び方法 |
| EP4143329A4 (en) | 2020-04-28 | 2024-10-16 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| AU2021263383A1 (en) | 2020-04-29 | 2022-11-24 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| TW202237090A (zh) * | 2020-12-11 | 2022-10-01 | 英商Ｔｍｅｍ16Ａ有限公司 | 治療呼吸道疾病之化合物 |
| MX2023014819A (es) | 2021-06-14 | 2024-03-21 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cancer. |
| TW202317546A (zh) | 2021-07-09 | 2023-05-01 | 美商普萊克斯姆公司 | 調節ikzf2之芳基化合物及醫藥組合物 |
| TW202329955A (zh) * | 2022-01-12 | 2023-08-01 | 英屬開曼群島商百濟神州有限公司 | 作為ＤＮＡ聚合酶Ｔｈｅｔａ抑製劑之噻唑并吡啶基醯胺衍生物 |
| EP4265247A1 (en) * | 2022-04-22 | 2023-10-25 | Université Paris Cité | Compounds inducing production of proteins by immune cells |
| CN116253755A (zh) * | 2023-02-28 | 2023-06-13 | 湖南大学 | 一种二芳基硼酸酯类化合物的合成方法 |
| CN117327020B (zh) * | 2023-10-07 | 2026-07-31 | 中国科学院过程工程研究所 | 一种含苯并氮杂环结构的氨基芳香化合物及其制备方法和应用 |
| US11970468B1 (en) | 2023-10-23 | 2024-04-30 | King Faisal University | 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound |
| CN120118037B (zh) * | 2023-12-07 | 2025-11-28 | 南华大学 | 一类含苯甲酸酯结构的苯并咪唑类化合物、制造方法及其用途 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551443A (en) * | 1968-10-30 | 1970-12-29 | Ciba Ltd | 2-phenylbenzoxazole derivatives |
| JPH0678308B2 (ja) * | 1985-04-24 | 1994-10-05 | 三共株式会社 | フタルイミド誘導体およびそれを含有する農園芸用殺菌剤 |
| EP0882718B1 (en) | 1995-12-28 | 2005-08-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| EP0963371B1 (en) | 1997-02-25 | 2003-05-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase |
| US6251689B1 (en) * | 1998-05-14 | 2001-06-26 | Telik, Inc. | Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof |
| JP2000095767A (ja) * | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | 性腺刺激ホルモン放出ホルモン拮抗剤 |
| HK1047582B (zh) * | 1999-06-23 | 2005-03-04 | 萨诺费－阿文蒂斯德国有限公司 | 取代的苯並咪唑 |
| EP1210336B1 (en) | 1999-08-26 | 2007-04-25 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase |
| DE60115265T2 (de) * | 2000-09-19 | 2006-08-10 | Lee, Moses, Holland | Zusammensetzungen und verfahren zur verwendung achiraler analoge von cc-1065 und den duocarmycinen |
| JP2004515496A (ja) | 2000-12-07 | 2004-05-27 | アストラゼネカ・アクチエボラーグ | ベンズイミダゾール治療剤 |
| FR2821721B1 (fr) * | 2001-03-08 | 2004-07-09 | Laurent Locatelli | Composition pour alimentation animale, utilisation de cette composition, et produit pour alimentation animale comprenant cette composition |
| BR0208010A (pt) * | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
| JP4637481B2 (ja) * | 2001-10-19 | 2011-02-23 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Ｃｄｓ１／ｃｈｋ２阻害剤および癌治療における化学療法または放射線療法の補助剤としての２−フェニルベンズイミダゾールおよびイミダゾ−［４，５］−ピリジン |
| TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| EP1455815A4 (en) | 2001-12-19 | 2006-11-02 | Millennium Pharm Inc | MEMBERS OF THE DIACYLGLYCEROL-ACYLTRANSFERASES FAMILY 2 (DGAT2) AND USES THEREOF |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| WO2003106439A1 (ja) * | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
| US20060293256A1 (en) * | 2002-08-06 | 2006-12-28 | Masateru Yamada | Remedy or preventive for kidney disease and method of diagnosing kidney disease |
| JP2006516254A (ja) | 2003-01-06 | 2006-06-29 | イーライ・リリー・アンド・カンパニー | Ｐｐａｒモジュレータとしての縮合ヘテロ環誘導体 |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2004098494A2 (en) | 2003-04-30 | 2004-11-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| AR044399A1 (es) | 2003-05-20 | 2005-09-14 | Novartis Ag | Compuestos heterociclicos y su uso como activadores de receptores de ppar. composiciones farmaceuticas que los contienen |
| WO2005108370A1 (ja) * | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | ベンゼン化合物 |
| AU2005295453A1 (en) * | 2004-10-15 | 2006-04-27 | Bayer Healthcare Llc | Preparation and use of biphenyl-4-yl-carbonylamino acid derivatives for the treatment of obesity |
| US20060223849A1 (en) * | 2005-03-14 | 2006-10-05 | Mjalli Adnan M | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | ２−アリール−ベンゾイミダゾール−５−カルボキサミド誘導体 |
| US8629147B2 (en) * | 2005-11-03 | 2014-01-14 | Chembridge Corporation | Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
| BRPI0707719A2 (pt) * | 2006-02-10 | 2011-05-10 | Summit Corp Plc | uso de um composto ou de um sal farmaceuticamente aceitÁvel do mesmo |
-
2007
- 2007-10-16 PE PE2007001396A patent/PE20080888A1/es not_active Application Discontinuation
- 2007-10-16 AR ARP070104573A patent/AR063311A1/es not_active Application Discontinuation
- 2007-10-17 MX MX2009004047A patent/MX2009004047A/es not_active Application Discontinuation
- 2007-10-17 CL CL200702974A patent/CL2007002974A1/es unknown
- 2007-10-17 JP JP2009533499A patent/JP5298022B2/ja not_active Expired - Fee Related
- 2007-10-17 CA CA002666880A patent/CA2666880A1/en not_active Abandoned
- 2007-10-17 AU AU2007311087A patent/AU2007311087B2/en not_active Ceased
- 2007-10-17 BR BRPI0718478-6A2A patent/BRPI0718478A2/pt not_active IP Right Cessation
- 2007-10-17 RU RU2009118489/04A patent/RU2009118489A/ru not_active Application Discontinuation
- 2007-10-17 ES ES07854118.2T patent/ES2440253T3/es active Active
- 2007-10-17 KR KR1020097010003A patent/KR20090071642A/ko not_active Withdrawn
- 2007-10-17 US US12/446,088 patent/US8222248B2/en not_active Expired - Fee Related
- 2007-10-17 TW TW096138922A patent/TW200829563A/zh unknown
- 2007-10-17 EP EP07854118.2A patent/EP2074089B1/en not_active Not-in-force
- 2007-10-17 WO PCT/US2007/081607 patent/WO2008048991A2/en not_active Ceased
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