BR112022021920A2 - Síntese de compostos heterocíclicos - Google Patents

Síntese de compostos heterocíclicos

Info

Publication number
BR112022021920A2
BR112022021920A2 BR112022021920A BR112022021920A BR112022021920A2 BR 112022021920 A2 BR112022021920 A2 BR 112022021920A2 BR 112022021920 A BR112022021920 A BR 112022021920A BR 112022021920 A BR112022021920 A BR 112022021920A BR 112022021920 A2 BR112022021920 A2 BR 112022021920A2
Authority
BR
Brazil
Prior art keywords
synthesis
heterocyclic compounds
alkyl
optionally substituted
compounds
Prior art date
Application number
BR112022021920A
Other languages
English (en)
Inventor
Lin Jack
Walters Jason
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of BR112022021920A2 publication Critical patent/BR112022021920A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SÍNTESE DE COMPOSTOS HETEROCÍCLICOS. São aqui providos intermediários e processos úteis para a síntese fácil de compostos de Fórmula 2: em que R1 é C(O)R2 ; R2 é alquila opcionalmente substituída por 1-5 halogênios; G é fenila ou uma heteroarila de 5-6 membros opcionalmente substituída por 1-2 R3 ; e cada R3 é, independentemente, alquila C1-C6, CN, alquila C1-C6-CN, cicloalquila de 3-6 membros ou heterocicloalquila de 4-6 membros.
BR112022021920A 2020-04-29 2021-04-28 Síntese de compostos heterocíclicos BR112022021920A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063017587P 2020-04-29 2020-04-29
PCT/US2021/029699 WO2021222442A1 (en) 2020-04-29 2021-04-28 Synthesis of heterocyclic compounds

Publications (1)

Publication Number Publication Date
BR112022021920A2 true BR112022021920A2 (pt) 2023-01-17

Family

ID=76012017

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022021920A BR112022021920A2 (pt) 2020-04-29 2021-04-28 Síntese de compostos heterocíclicos

Country Status (11)

Country Link
US (1) US11739088B2 (pt)
EP (1) EP4143168A1 (pt)
JP (1) JP2023524465A (pt)
KR (1) KR20230028254A (pt)
CN (1) CN115605460A (pt)
AU (1) AU2021263383A1 (pt)
BR (1) BR112022021920A2 (pt)
CA (1) CA3176237A1 (pt)
IL (1) IL297645A (pt)
MX (1) MX2022013597A (pt)
WO (1) WO2021222442A1 (pt)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2935248T1 (en) 2012-12-21 2018-05-31 Plexxikon Inc. Compounds and procedures for kinase modulation and indications for the latter

Also Published As

Publication number Publication date
KR20230028254A (ko) 2023-02-28
JP2023524465A (ja) 2023-06-12
WO2021222442A1 (en) 2021-11-04
CN115605460A (zh) 2023-01-13
US20210340139A1 (en) 2021-11-04
CA3176237A1 (en) 2021-11-04
EP4143168A1 (en) 2023-03-08
IL297645A (en) 2022-12-01
US11739088B2 (en) 2023-08-29
AU2021263383A1 (en) 2022-11-24
MX2022013597A (es) 2023-03-22

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