AR051995A1 - Derivados de tieno-piridina como intensificadores alostericos de gaba -b - Google Patents
Derivados de tieno-piridina como intensificadores alostericos de gaba -bInfo
- Publication number
- AR051995A1 AR051995A1 ARP050105260A ARP050105260A AR051995A1 AR 051995 A1 AR051995 A1 AR 051995A1 AR P050105260 A ARP050105260 A AR P050105260A AR P050105260 A ARP050105260 A AR P050105260A AR 051995 A1 AR051995 A1 AR 051995A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- haloalkyl
- halogen
- ring atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Abstract
Reivindicacion 1: Compuestos de la formula (1) en la que R1 es H, alquilo C1-7, haloalquilo C1-7 o cicloalquilo C3-8; R2 es alquilo C1-7, haloalquilo C1-7, cicloalquilo C3-8, arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido que tienen de 5 a 9 átomos en el anillo, en el que los sustituyentes se eligen entre el grupo formado por halogeno, alcoxi C1-7, haloalquilo C1-7, haloalcoxi C1-7, alquilsulfonilo C1-7 y -C(O)O-alquilo C1-7; R3 es -NRaRb; heterocicloalquilo opcionalmente sustituido que tiene de 3 a 8 átomos en el anillo; arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido que tienen de 5 a 9 átomos en el anillo, en el que los sustituyentes se eligen entre el grupo formado por halogeno, alcoxi C1-7, haloalquilo C1-7, haloalcoxi C1-7, alquilsulfonilo C1-7 y -C(O)O- alquilo C1-7; R4 es H o alquilo C1-7; R5 es H, halogeno, alquilo C1-7, alquenilo C2-7, -NRaRb; arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido que tienen de 5 a 9 átomos en el anillo, en el que los sustituyentes se eligen entre el grupo formado por halogeno, ciano, alquilo C1-7, haloalquilo C1-7, alcoxi C1-7, haloalcoxi C1-7, alquilsulfonilo C1-7 o -C(O)O-alquilo C1-7; o R5 junto con R4 pueden formar un anillo elegido entre el grupo formado por cicloalquilo C5-7, heterocicloalquilo que tiene de 5 a 7 átomos en el anillo, fenilo; piridinilo y pirimidinilo que están opcionalmente sustituidos por uno o por varios halogeno, ciano, alquilsulfonilo C1-7, alquilo C1-7, haloalquilo C1-7, alcoxi C1-7, haloalcoxi C1-7 o -C(O)O-alquilo C1-7; Ra, Rb con independencia entre sí son alquilo C1-7 o Ra y Rb junto con el átomo de N al que están unidos pueden formar un grupo heterocicloalquilo que tiene de 3 a 8 átomos en el anillo y que está opcionalmente sustituido por uno o por varios halogeno, alquilo C1-7, alcoxi C1-7, hidroxi, fenilo o di(alquil C1-7)amino; así como las sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106665 | 2004-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051995A1 true AR051995A1 (es) | 2007-02-21 |
Family
ID=35702999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105260A AR051995A1 (es) | 2004-12-17 | 2005-12-15 | Derivados de tieno-piridina como intensificadores alostericos de gaba -b |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7390903B2 (es) |
| EP (1) | EP1828199B1 (es) |
| JP (1) | JP2008524134A (es) |
| KR (1) | KR100912145B1 (es) |
| CN (1) | CN101120003B (es) |
| AR (1) | AR051995A1 (es) |
| AT (1) | ATE430751T1 (es) |
| AU (1) | AU2005315937A1 (es) |
| BR (1) | BRPI0519521A2 (es) |
| CA (1) | CA2591211A1 (es) |
| DE (1) | DE602005014383D1 (es) |
| ES (1) | ES2324231T3 (es) |
| MX (1) | MX2007007026A (es) |
| PL (1) | PL1828199T3 (es) |
| RU (1) | RU2388761C2 (es) |
| TW (1) | TW200633708A (es) |
| WO (1) | WO2006063732A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0622472D0 (en) * | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
| AU2013202912B2 (en) * | 2007-06-08 | 2016-10-27 | Firmenich Incorporated | Modulation of chemosensory receptors and ligands associated therewith |
| US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| US9603848B2 (en) * | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
| ES2525551T3 (es) | 2008-07-31 | 2014-12-26 | Senomyx, Inc. | Composiciones que comprenden potenciadores de dulzor y métodos de producirlas |
| DK2323997T3 (en) | 2008-07-31 | 2017-12-11 | Senomyx Inc | METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF SWEET TASTE AMPLIFIERS |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| WO2011123693A1 (en) | 2010-04-02 | 2011-10-06 | Senomyx, Inc. | Sweet flavor modifier |
| US9000054B2 (en) | 2010-08-12 | 2015-04-07 | Senomyx, Inc. | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer |
| EP2640729B1 (en) * | 2010-11-15 | 2016-12-21 | VIIV Healthcare UK Limited | Inhibitors of hiv replication |
| NZ610315A (en) | 2010-11-15 | 2015-08-28 | Univ Leuven Kath | Antiviral condensed heterocyclic compounds |
| TWI610919B (zh) | 2011-08-12 | 2018-01-11 | 賽諾米克斯公司 | 甜味調節劑 |
| WO2013117285A1 (en) * | 2012-02-09 | 2013-08-15 | Merck Patent Gmbh | Furo [3, 2 - b] - and thieno [3, 2 - b] pyridine derivatives as tbk1 and ikk inhibitors |
| KR20150041040A (ko) | 2012-08-06 | 2015-04-15 | 세노믹스, 인코포레이티드 | 단맛 향미 개질제 |
| JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
| US9908893B2 (en) | 2013-06-11 | 2018-03-06 | Latvian Institute Of Organic Synthesis | Thieno [2,3-b] pyridines as multidrug resistance modulators |
| BR112016001984A2 (pt) | 2013-08-08 | 2017-08-01 | Galapagos Nv | tieno[2,3-c]piranos como moduladores do cftr |
| TWI648281B (zh) * | 2013-10-17 | 2019-01-21 | 日商安斯泰來製藥股份有限公司 | 含硫二環式化合物 |
| TW201623257A (zh) | 2014-05-09 | 2016-07-01 | 奧利安公司 | 藥理活性之喹唑啉二酮衍生物 |
| AU2015343463A1 (en) | 2014-11-07 | 2017-06-15 | Senomyx, Inc. | Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers |
| US10927126B2 (en) * | 2016-11-07 | 2021-02-23 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| MX2021001193A (es) | 2018-08-07 | 2021-04-28 | Firmenich Incorporated | 2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos. |
| CN109081846A (zh) * | 2018-10-08 | 2018-12-25 | 浙江工业大学上虞研究院有限公司 | 4-氨基噻吩[2,3-b]吡啶类化合物的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1003419A (en) * | 1971-11-23 | 1977-01-11 | Theodor Denzel | Process for the production of pyrazolo (3,4-b) pyridines |
| GB8801491D0 (en) * | 1988-01-22 | 1988-02-24 | Beecham Group Plc | Novel compounds |
| GB8804448D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| GB8921304D0 (en) * | 1989-09-20 | 1989-11-08 | Wyeth John & Brother Ltd | New method of treatment and heterocyclic compounds used therein |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| EP0612323A1 (en) * | 1991-11-07 | 1994-08-31 | Smithkline Beecham Plc | Cns active tetrahydrobenzothienopyridines |
| KR970707131A (ko) * | 1994-11-08 | 1997-12-01 | 다께다 구니오 | 티에노피리딘 또는 티에노피리미딘 유도체 및 그의 용도(thienopyridine or thienopyrimidine derivatives and their use) |
| FR2800072B1 (fr) * | 1999-10-22 | 2002-01-11 | Centre Nat Rech Scient | 1-(2-butyrolactones et 2-thiobutyrolactones)-isoquinolines n-substituees utiles comme stimulant de l'activite de l'acide gamma-aminobutyrique et dans le traitement des troubles nerveux et leur procede de preparation |
| EP1255735A2 (en) | 2000-02-03 | 2002-11-13 | Eli Lilly And Company | Pyridine derivatives as potentiators of glutamate receptors |
| JP2004506038A (ja) * | 2000-08-16 | 2004-02-26 | ニューロゲン コーポレイション | ２，４−置換ピリジン誘導体 |
| GB0209481D0 (en) | 2002-04-24 | 2002-06-05 | Novartis Ag | Organic compounds |
-
2005
- 2005-12-09 RU RU2007121908/04A patent/RU2388761C2/ru not_active IP Right Cessation
- 2005-12-09 PL PL05815262T patent/PL1828199T3/pl unknown
- 2005-12-09 ES ES05815262T patent/ES2324231T3/es active Active
- 2005-12-09 AU AU2005315937A patent/AU2005315937A1/en not_active Abandoned
- 2005-12-09 KR KR1020077016010A patent/KR100912145B1/ko not_active IP Right Cessation
- 2005-12-09 CN CN2005800481208A patent/CN101120003B/zh not_active Expired - Fee Related
- 2005-12-09 BR BRPI0519521-7A patent/BRPI0519521A2/pt not_active IP Right Cessation
- 2005-12-09 WO PCT/EP2005/013194 patent/WO2006063732A1/en active Application Filing
- 2005-12-09 JP JP2007545902A patent/JP2008524134A/ja active Pending
- 2005-12-09 EP EP05815262A patent/EP1828199B1/en not_active Not-in-force
- 2005-12-09 MX MX2007007026A patent/MX2007007026A/es active IP Right Grant
- 2005-12-09 AT AT05815262T patent/ATE430751T1/de active
- 2005-12-09 DE DE602005014383T patent/DE602005014383D1/de active Active
- 2005-12-09 CA CA002591211A patent/CA2591211A1/en not_active Abandoned
- 2005-12-13 US US11/301,696 patent/US7390903B2/en not_active Expired - Fee Related
- 2005-12-14 TW TW094144190A patent/TW200633708A/zh unknown
- 2005-12-15 AR ARP050105260A patent/AR051995A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200633708A (en) | 2006-10-01 |
| CA2591211A1 (en) | 2006-06-22 |
| ES2324231T3 (es) | 2009-08-03 |
| KR20070091016A (ko) | 2007-09-06 |
| CN101120003A (zh) | 2008-02-06 |
| US7390903B2 (en) | 2008-06-24 |
| KR100912145B1 (ko) | 2009-08-14 |
| MX2007007026A (es) | 2007-07-04 |
| PL1828199T3 (pl) | 2009-10-30 |
| AU2005315937A1 (en) | 2006-06-22 |
| US20060135552A1 (en) | 2006-06-22 |
| BRPI0519521A2 (pt) | 2009-02-10 |
| EP1828199B1 (en) | 2009-05-06 |
| RU2388761C2 (ru) | 2010-05-10 |
| JP2008524134A (ja) | 2008-07-10 |
| EP1828199A1 (en) | 2007-09-05 |
| RU2007121908A (ru) | 2009-01-27 |
| CN101120003B (zh) | 2010-06-16 |
| DE602005014383D1 (en) | 2009-06-18 |
| ATE430751T1 (de) | 2009-05-15 |
| WO2006063732A1 (en) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |