AR059512A1 - Derivados de piridina -2- carboxamida - Google Patents

Derivados de piridina -2- carboxamida

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Publication number
AR059512A1
AR059512A1 ARP070100650A ARP070100650A AR059512A1 AR 059512 A1 AR059512 A1 AR 059512A1 AR P070100650 A ARP070100650 A AR P070100650A AR P070100650 A ARP070100650 A AR P070100650A AR 059512 A1 AR059512 A1 AR 059512A1
Authority
AR
Argentina
Prior art keywords
alkyl
nrgrh
chf2
cycloalkyl
alkenyl
Prior art date
Application number
ARP070100650A
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English (en)
Inventor
Georg Jaeschke
Will Spooren
Eric Vieira
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR059512A1 publication Critical patent/AR059512A1/es

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Abstract

La presente se refiere a nuevos derivados de piridina-2-carboxiamida de la formula general (1), que son utiles como antagonistas del receptor metabotropico de glutamato. Reivindicacion 1: Compuestos de la formula general (1) en la que Y es C-R4 y Z es CH; o Y es C-R4 y Z es N; o Y es N y Z es CH; R1 es un anillo de 5 o 6 eslabones, de las formulas (2) o (3) R2 es H, alquilo C1-7, cicloalquilo C3-6 o -(CH2)m-Ra; R3 es arilo o heteroarilo, que están opcionalmente sustituidos por uno, dos, tres o cuatro sustituyentes elegidos entre el grupo formado por: CN, Cl, F, Br, CF3, CHF2, alquilo C1-7, -O-alquilo C1-7, -(CO)Rb, -(CH2)mRc, -NH-(CO)-alquilo C1-7, -O-CH2F, -O-CHF2, -O-CF3, -S (O)2-Rd, -NRgRh o heteroarilo, que está opcionalmente sustituido por alquilo C1-7; R4 es H, -OH, -NH2, -NR-alquilo C1-7, Cl, F, Br, CF3, CHF2, alquilo C1-7, o -(CH2)m-Ra; R5 es H, -OH, Cl, F, Br, CN, CF3, CHF2, alquilo C1-7, -cicloalquilo C3-6, -O-(CO)-alquilo C1-7 o -(CH2)m-Re, C(O)-NRiRj; R6 es alquilo C1-7, -cicloalquilo C3-6, alquilo C1-7-cicloalquilo C3-6, -(CH2)n-O-Rf, alquenilo C3-8-O-Rf, - (CH2)n-NRgRh, -alquenilo C2-6-NRgRh o -(CH2)n-Re; R7 es H, Cl, F, CN, alquilo C1-7; Ra es -O-alquilo C1-7 u OH; Rb es alquilo C1-7, -NRgRh u -O- alquilo C1-7; Rc es -OH, -NRgRh o NH-(CO)-O-alquilo C1-7; Rd es alquilo C1-7, -NRgRh, -NH-alquilo C1-7 o -N-di (alquil C1-7); Re es -OH, -CH2F, -CHF2, -CF3, CN, alquilo C1-7, alcoxi C1-7, -(CO)-NRiRj u -O-(CO)-alquilo C1-7; Rf es alquilo C1-7, alquenilo C3-8, cicloalquilo C3-6, fenilo, bencilo o -(CO)-R'; Rg y Rh son con independencia H, alquilo C1-7, cicloalquilo C3-6, alquenilo C3-8, fenilo, bencilo o -(CO)-R' o Rg Rh junto con el átomo de nitrogeno al que están unidos pueden también formar un anillo heterocíclico o heteroarilo de 5 a 7 eslabones, opcionalmente sustituidos por 1 o 2 OH; Ri, Rj son con independencia H o alquilo C1-7; R' es NRgRh, -NH-alquilo C1-7, alquilo C1-7 o alcoxi C1-7; m es un numero de 1 a 4; n es un numero de 2 a 6; así como sus sales farmacéuticamente aceptables.
ARP070100650A 2006-02-17 2007-02-15 Derivados de piridina -2- carboxamida AR059512A1 (es)

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US (1) US7951824B2 (es)
EP (1) EP1987003A1 (es)
JP (1) JP4975763B2 (es)
KR (1) KR101069106B1 (es)
CN (1) CN101384554B (es)
AR (1) AR059512A1 (es)
AU (1) AU2007216565A1 (es)
BR (1) BRPI0707949A2 (es)
CA (1) CA2640582A1 (es)
IL (1) IL193175A0 (es)
NO (1) NO20083582L (es)
RU (1) RU2427580C2 (es)
TW (1) TWI360547B (es)
WO (1) WO2007093542A1 (es)
ZA (1) ZA200806809B (es)

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