ATE430751T1 - Thienopyridinderivate als allostere gaba-b- enhancer - Google Patents
Thienopyridinderivate als allostere gaba-b- enhancerInfo
- Publication number
- ATE430751T1 ATE430751T1 AT05815262T AT05815262T ATE430751T1 AT E430751 T1 ATE430751 T1 AT E430751T1 AT 05815262 T AT05815262 T AT 05815262T AT 05815262 T AT05815262 T AT 05815262T AT E430751 T1 ATE430751 T1 AT E430751T1
- Authority
- AT
- Austria
- Prior art keywords
- allostere
- gaba
- enhancers
- thienopyridine derivatives
- thienopyridine
- Prior art date
Links
- 239000003623 enhancer Substances 0.000 title 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106665 | 2004-12-17 | ||
| PCT/EP2005/013194 WO2006063732A1 (en) | 2004-12-17 | 2005-12-09 | Thieno-pyridine derivatives as gaba-b allosteric enhancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE430751T1 true ATE430751T1 (de) | 2009-05-15 |
Family
ID=35702999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05815262T ATE430751T1 (de) | 2004-12-17 | 2005-12-09 | Thienopyridinderivate als allostere gaba-b- enhancer |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7390903B2 (de) |
| EP (1) | EP1828199B1 (de) |
| JP (1) | JP2008524134A (de) |
| KR (1) | KR100912145B1 (de) |
| CN (1) | CN101120003B (de) |
| AR (1) | AR051995A1 (de) |
| AT (1) | ATE430751T1 (de) |
| AU (1) | AU2005315937A1 (de) |
| BR (1) | BRPI0519521A2 (de) |
| CA (1) | CA2591211A1 (de) |
| DE (1) | DE602005014383D1 (de) |
| ES (1) | ES2324231T3 (de) |
| MX (1) | MX2007007026A (de) |
| PL (1) | PL1828199T3 (de) |
| RU (1) | RU2388761C2 (de) |
| TW (1) | TW200633708A (de) |
| WO (1) | WO2006063732A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0622472D0 (en) * | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
| US9603848B2 (en) * | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| AU2013202912B2 (en) * | 2007-06-08 | 2016-10-27 | Firmenich Incorporated | Modulation of chemosensory receptors and ligands associated therewith |
| US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
| US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| KR101577159B1 (ko) | 2008-07-31 | 2015-12-11 | 세노믹스, 인코포레이티드 | 단맛 향상제의 제조 방법 및 중간체 |
| BRPI0916550B1 (pt) | 2008-07-31 | 2020-09-15 | Firmenich Incorporated | Composições que compreendem intensificadores de doçura e métodos de produção das mesmas |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| SG184156A1 (en) | 2010-04-02 | 2012-10-30 | Senomyx Inc | Sweet flavor modifier |
| RU2576451C2 (ru) | 2010-08-12 | 2016-03-10 | Синомикс, Инк. | Способ улучшения стабильности усилителей сладкого вкуса и композиция, содержащая стабилизированный усилитель сладкого вкуса |
| NZ610315A (en) | 2010-11-15 | 2015-08-28 | Univ Leuven Kath | Antiviral condensed heterocyclic compounds |
| AU2011330850B2 (en) * | 2010-11-15 | 2016-01-28 | Viiv Healthcare Uk Limited | Inhibitors of HIV replication |
| RU2617700C2 (ru) | 2011-08-12 | 2017-04-26 | Синомикс, Инк. | Производные 4-аминохинолин-3-карбоновой кислоты и содержащие их композиции для усиления сладкого вкуса |
| PL2812337T3 (pl) * | 2012-02-09 | 2017-01-31 | Merck Patent Gmbh | Pochodne furo[3,2-b]pirydynowe jako inhibitory tbk1 oraz ikk |
| BR112015002380B1 (pt) | 2012-08-06 | 2021-09-28 | Firmenich Incorporated | Composto, composições ingeríveis, processos para aumentar o sabor doce de composição e formulação flavorizante concentrada |
| JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
| CA2910514C (en) | 2013-06-11 | 2018-05-15 | Latvian Institute Of Organic Synthesis | Thieno[2,3-.beta.]pyridines as multidrug resistance modulators |
| US9133210B2 (en) | 2013-08-08 | 2015-09-15 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis |
| TWI648281B (zh) * | 2013-10-17 | 2019-01-21 | 日商安斯泰來製藥股份有限公司 | 含硫二環式化合物 |
| TW201623257A (zh) | 2014-05-09 | 2016-07-01 | 奧利安公司 | 藥理活性之喹唑啉二酮衍生物 |
| MX394005B (es) | 2014-11-07 | 2025-03-24 | Firmenich Incorporated | Acidos 4-amino-5- (ciclohexiloxi) quinolina-3-carboxilicos sustituidos como modificadores del sabor dulce. |
| JP7097623B2 (ja) * | 2016-11-07 | 2022-07-08 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子 |
| CN112703193A (zh) | 2018-08-07 | 2021-04-23 | 弗门尼舍公司 | 5-取代的4-氨基-1H-苯并[c][1,2,6]噻二嗪2,2-二氧化物及其制剂和用途 |
| CN109081846A (zh) * | 2018-10-08 | 2018-12-25 | 浙江工业大学上虞研究院有限公司 | 4-氨基噻吩[2,3-b]吡啶类化合物的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1003419A (en) * | 1971-11-23 | 1977-01-11 | Theodor Denzel | Process for the production of pyrazolo (3,4-b) pyridines |
| GB8801491D0 (en) * | 1988-01-22 | 1988-02-24 | Beecham Group Plc | Novel compounds |
| GB8804448D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| GB8921304D0 (en) * | 1989-09-20 | 1989-11-08 | Wyeth John & Brother Ltd | New method of treatment and heterocyclic compounds used therein |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| WO1993009122A1 (en) * | 1991-11-07 | 1993-05-13 | Smithkline Beecham Plc | Cns active tetrahydrobenzothienopyridines |
| AU699354B2 (en) * | 1994-11-08 | 1998-12-03 | Takeda Chemical Industries Ltd. | Thienopyridine or thienopyrimidine derivatives useful as anti-inflammatory agents or in the treatment of osteoporosis |
| FR2800072B1 (fr) * | 1999-10-22 | 2002-01-11 | Centre Nat Rech Scient | 1-(2-butyrolactones et 2-thiobutyrolactones)-isoquinolines n-substituees utiles comme stimulant de l'activite de l'acide gamma-aminobutyrique et dans le traitement des troubles nerveux et leur procede de preparation |
| AU2001234420A1 (en) | 2000-02-03 | 2001-08-14 | Eli Lilly And Company | Potentiators of glutamate receptors |
| TW591031B (en) * | 2000-02-29 | 2004-06-11 | Takeda Chemical Industries Ltd | Thienopyridine derivatives, their production and use |
| WO2002014269A2 (en) * | 2000-08-16 | 2002-02-21 | Neurogen Corporation | 2,4-substituted pyridine derivatives |
| GB0209481D0 (en) | 2002-04-24 | 2002-06-05 | Novartis Ag | Organic compounds |
-
2005
- 2005-12-09 AT AT05815262T patent/ATE430751T1/de active
- 2005-12-09 CN CN2005800481208A patent/CN101120003B/zh not_active Expired - Fee Related
- 2005-12-09 CA CA002591211A patent/CA2591211A1/en not_active Abandoned
- 2005-12-09 WO PCT/EP2005/013194 patent/WO2006063732A1/en not_active Ceased
- 2005-12-09 KR KR1020077016010A patent/KR100912145B1/ko not_active Expired - Fee Related
- 2005-12-09 DE DE602005014383T patent/DE602005014383D1/de not_active Expired - Lifetime
- 2005-12-09 EP EP05815262A patent/EP1828199B1/de not_active Expired - Lifetime
- 2005-12-09 RU RU2007121908/04A patent/RU2388761C2/ru not_active IP Right Cessation
- 2005-12-09 ES ES05815262T patent/ES2324231T3/es not_active Expired - Lifetime
- 2005-12-09 JP JP2007545902A patent/JP2008524134A/ja active Pending
- 2005-12-09 AU AU2005315937A patent/AU2005315937A1/en not_active Abandoned
- 2005-12-09 PL PL05815262T patent/PL1828199T3/pl unknown
- 2005-12-09 BR BRPI0519521-7A patent/BRPI0519521A2/pt not_active IP Right Cessation
- 2005-12-09 MX MX2007007026A patent/MX2007007026A/es active IP Right Grant
- 2005-12-13 US US11/301,696 patent/US7390903B2/en not_active Expired - Fee Related
- 2005-12-14 TW TW094144190A patent/TW200633708A/zh unknown
- 2005-12-15 AR ARP050105260A patent/AR051995A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR051995A1 (es) | 2007-02-21 |
| ES2324231T3 (es) | 2009-08-03 |
| JP2008524134A (ja) | 2008-07-10 |
| RU2007121908A (ru) | 2009-01-27 |
| AU2005315937A1 (en) | 2006-06-22 |
| US20060135552A1 (en) | 2006-06-22 |
| KR100912145B1 (ko) | 2009-08-14 |
| MX2007007026A (es) | 2007-07-04 |
| EP1828199A1 (de) | 2007-09-05 |
| DE602005014383D1 (en) | 2009-06-18 |
| CN101120003B (zh) | 2010-06-16 |
| CA2591211A1 (en) | 2006-06-22 |
| WO2006063732A1 (en) | 2006-06-22 |
| KR20070091016A (ko) | 2007-09-06 |
| TW200633708A (en) | 2006-10-01 |
| BRPI0519521A2 (pt) | 2009-02-10 |
| RU2388761C2 (ru) | 2010-05-10 |
| US7390903B2 (en) | 2008-06-24 |
| PL1828199T3 (pl) | 2009-10-30 |
| EP1828199B1 (de) | 2009-05-06 |
| CN101120003A (zh) | 2008-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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