AR053895A1 - Aminopirimidinas como moduladores de quinasas - Google Patents
Aminopirimidinas como moduladores de quinasasInfo
- Publication number
- AR053895A1 AR053895A1 ARP060102426A ARP060102426A AR053895A1 AR 053895 A1 AR053895 A1 AR 053895A1 AR P060102426 A ARP060102426 A AR P060102426A AR P060102426 A ARP060102426 A AR P060102426A AR 053895 A1 AR053895 A1 AR 053895A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- heteroaryl
- alkylamino
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Reivindicacion 1: Un compuesto de formula (1) y N-oxidos, sales aceptables para uso farmacéutico, solvatos, isomeros geométricos e isomeros estereoquímicos del mismo, donde: q es 0, 1 o 2; p es 0 o 1; Q es NH, N(alquilo), O, o un enlace directo; Z es NH, N(alquilo), o CH2; B es fenilo, heteroarilo, o un heteroarilo benzo-fusionado de 1 a 9 miembros; R1 es como se muestra en el resto de formula (2), donde n es 1, 2, 3 o 4; Ra es H, alcoxi, fenoxi, fenilo, heteroarilo sustituido en forma opcional con R5, hidroxilo, amino, alquilamino, dialquilamino, oxazolidinonilo sustituido en forma opcional con R5, pirrolidinonilo sustituido en forma opcional con R5, piperidinonilo sustituido en forma opcional con R5, heterodionilo cíclico sustituido en forma opcional con R5, heterociclilo sustituido en forma opcional con R5, -COORy, -CONRwRx, -N(Rw)CON(Ry)(Rx), -N(Ry)CON(Rw)(Rx), -N(Rw)C(O)ORx, -N(Rw)CORy, -SRy, -SORy, -SO2Ry, -NRwSO2Ry, -NRwSO2Rx, -SO3Ry, -OSO2NRwRx o -SO2NRwRx; R5 es 1, 2 o 3 sustituyentes seleccionados en forma independiente de halogeno, ciano, trifluorometilo, amino, hidroxilo, alcoxi, -C(O)alquilo, -SO2alquilo, -C(O)N(alquilo)2, -alquil C1-4-OH o alquilamino; Rw y Rx se seleccionan en forma independiente de H, alquilo, alquenilo, aralquilo, o heteroaralquilo, o Rw y Rx pueden tomarse juntos en forma opcional para formar un anillo de 5 a 7 miembros, que contiene opcionalmente un resto con heteroátomo seleccionado de O, NH, N(alquilo), SO2, SO, o S; Ry se selecciona de H, alquilo, alquenilo, cicloalquilo, fenilo, aralquilo, heteroaralquilo, o heteroarilo; y R3 es uno o más sustituyentes seleccionados en forma independiente de: H, alquilo, alcoxi, halogeno, alcoxiéter, hidroxilo, tio, nitro, cicloalquilo sustituido en forma opcional con R4, heteroarilo sustituido en forma opcional con R4, alquilamino, heterociclilo sustituido en forma opcional con R4, -O(cicloalquilo), pirrolidinonilo sustituido en forma opcional con R4, fenoxi sustituido en forma opcional con R4, -CN, -OCHF2, -OCF3, -CF3, alquilo halogenado, heteroariloxi sustituido en forma opcional con R4, dialquilamino, -NHSO2alquilo, tioalquilo o -SO2alquilo; donde R4 se selecciona en forma independiente de halogeno, ciano, trifluorometilo, amino, hidroxilo, alcoxi, -C(O)alquilo, -CO2alquilo, -SO2alquilo, -C(O)N(alquilo)2, alquilo o alquilamino.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68971705P | 2005-06-10 | 2005-06-10 | |
US75108405P | 2005-12-16 | 2005-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053895A1 true AR053895A1 (es) | 2007-05-23 |
Family
ID=36929309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060102426A AR053895A1 (es) | 2005-06-10 | 2006-06-09 | Aminopirimidinas como moduladores de quinasas |
Country Status (17)
Country | Link |
---|---|
US (1) | US20060281764A1 (es) |
EP (1) | EP1896029A1 (es) |
JP (1) | JP2008543760A (es) |
KR (1) | KR20080028911A (es) |
AR (1) | AR053895A1 (es) |
AU (1) | AU2006258054A1 (es) |
BR (1) | BRPI0611963A2 (es) |
CA (1) | CA2611470A1 (es) |
EA (1) | EA200800015A1 (es) |
EC (1) | ECSP077991A (es) |
GT (1) | GT200600248A (es) |
IL (1) | IL187693A0 (es) |
NI (1) | NI200700316A (es) |
NO (1) | NO20080163L (es) |
PE (1) | PE20070076A1 (es) |
TW (1) | TW200718693A (es) |
WO (1) | WO2006135644A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009507896A (ja) * | 2005-09-13 | 2009-02-26 | パラウ・フアルマ・ソシエダツド・アノニマ | ヒスタミンh4受容体活性の調節剤としての2−アミノピリミジン誘導体 |
JP5325783B2 (ja) | 2006-09-08 | 2013-10-23 | エフ.ホフマン−ラ ロシュ アーゲー | ベンゾトリアゾールキナーゼモジュレーター |
WO2008039794A1 (en) * | 2006-09-25 | 2008-04-03 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
CA2680398A1 (en) * | 2007-03-20 | 2008-09-25 | Curis, Inc. | Raf kinase inhibitors containing a zinc binding moiety |
EP2353003A4 (en) * | 2008-11-06 | 2012-05-30 | Ambit Biosciences Corp | BIOMARKER ASSAY OF TYROSINE KINASE 3 RELATED TO FMS PHOSPHORYLÉE |
JP2012508238A (ja) * | 2008-11-07 | 2012-04-05 | ハー・ルンドベック・アクチエゼルスカベット | 生物活性を有するアミド |
NZ598985A (en) | 2009-09-04 | 2013-07-26 | Biogen Idec Inc | Bruton's tyrosine kinase inhibitors |
AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
CA3031443A1 (en) | 2016-07-21 | 2018-01-25 | Biogen Ma Inc. | Succinate of pyrimidinyl derivatives and solid forms thereof as bruton's tyrosine kinase inhibitors |
JP6959332B2 (ja) | 2016-09-27 | 2021-11-02 | ミッション セラピューティクス リミティド | Usp30の阻害剤としての活性を有するシアノピロリジン誘導体 |
KR20190121404A (ko) * | 2017-03-16 | 2019-10-25 | 크리네틱스 파마슈티칼스, 인크. | 소마토스타틴 조절제 및 이의 용도 |
WO2019157458A1 (en) * | 2018-02-12 | 2019-08-15 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
US10696689B2 (en) | 2018-09-18 | 2020-06-30 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
TW202115008A (zh) | 2019-08-14 | 2021-04-16 | 美商克林提克斯醫藥股份有限公司 | 非肽生長抑制素(somatostatin)5型受體激動劑及其用途 |
JP2024506715A (ja) | 2021-02-17 | 2024-02-14 | クリネティックス ファーマシューティカルズ,インク. | ソマトスタチンモジュレーターの結晶形態 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6498165B1 (en) * | 1999-06-30 | 2002-12-24 | Merck & Co., Inc. | Src kinase inhibitor compounds |
WO2003026666A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors |
-
2006
- 2006-06-06 US US11/422,362 patent/US20060281764A1/en not_active Abandoned
- 2006-06-07 AU AU2006258054A patent/AU2006258054A1/en not_active Abandoned
- 2006-06-07 EA EA200800015A patent/EA200800015A1/ru unknown
- 2006-06-07 EP EP06772456A patent/EP1896029A1/en not_active Withdrawn
- 2006-06-07 CA CA002611470A patent/CA2611470A1/en not_active Abandoned
- 2006-06-07 PE PE2006000625A patent/PE20070076A1/es not_active Application Discontinuation
- 2006-06-07 WO PCT/US2006/022165 patent/WO2006135644A1/en active Application Filing
- 2006-06-07 KR KR1020087000399A patent/KR20080028911A/ko not_active Application Discontinuation
- 2006-06-07 BR BRPI0611963-8A patent/BRPI0611963A2/pt not_active Application Discontinuation
- 2006-06-07 NI NI200700316A patent/NI200700316A/es unknown
- 2006-06-07 JP JP2008515885A patent/JP2008543760A/ja not_active Withdrawn
- 2006-06-08 GT GT200600248A patent/GT200600248A/es unknown
- 2006-06-09 TW TW095120473A patent/TW200718693A/zh unknown
- 2006-06-09 AR ARP060102426A patent/AR053895A1/es not_active Application Discontinuation
-
2007
- 2007-11-27 IL IL187693A patent/IL187693A0/en unknown
- 2007-12-10 EC EC2007007991A patent/ECSP077991A/es unknown
-
2008
- 2008-01-09 NO NO20080163A patent/NO20080163L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0611963A2 (pt) | 2010-10-13 |
CA2611470A1 (en) | 2006-12-21 |
AU2006258054A1 (en) | 2006-12-21 |
JP2008543760A (ja) | 2008-12-04 |
EA200800015A1 (ru) | 2008-06-30 |
NO20080163L (no) | 2008-03-07 |
NI200700316A (es) | 2009-03-03 |
TW200718693A (en) | 2007-05-16 |
PE20070076A1 (es) | 2007-02-09 |
GT200600248A (es) | 2007-03-14 |
US20060281764A1 (en) | 2006-12-14 |
KR20080028911A (ko) | 2008-04-02 |
WO2006135644A1 (en) | 2006-12-21 |
ECSP077991A (es) | 2008-01-23 |
EP1896029A1 (en) | 2008-03-12 |
IL187693A0 (en) | 2008-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |