AR054388A1 - Aminopirimidinas como moduladores de quinasas - Google Patents
Aminopirimidinas como moduladores de quinasasInfo
- Publication number
- AR054388A1 AR054388A1 ARP060102427A ARP060102427A AR054388A1 AR 054388 A1 AR054388 A1 AR 054388A1 AR P060102427 A ARP060102427 A AR P060102427A AR P060102427 A ARP060102427 A AR P060102427A AR 054388 A1 AR054388 A1 AR 054388A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- alkoxy
- heteroaryl
- alkylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula (1) y sus N-oxidos, sales, solvatos, isomeros geométricos e isomeros estereoquímicos farmacéuticamente aceptables, donde: r es 1 o 2; Z es NH, N(alquilo), o CH2; B es fenilo, heteroarilo o heteroarilo benzofusionado de 9 a 10 miembros; R1 es como se muestra en el resto de formula (2) donde n es 1, 2, 3 o 4; Ra es H, alcoxi, fenoxi, fenilo, heteroarilo opcionalmente sustituido con R5, hidroxilo, amino, alquilamino, dialquilamino, oxazolidinonilo opcionalmente sustituido con R5, pirrolidinonilo opcionalmente sustituido con R5, piperidinonilo opcionalmente sustituido con R5, heterodionilo cíclico opcionalmente sustituido con R5, heterociclilo opcionalmente sustituido con R5, -CONRwRx, - N(Rw)CON(Ry)(Rx), -N(Ry)CON(Rw)(Rx), -N(Rw)C(O)ORx, -N(Rw)CORy, -SRy, -SORy, -SO2Ry, -NRwSO2Ry, -NRwSO2Rx, -SO3Ry, -OSO2NRwRx o -SO2NRwRx; Rw y Rx están seleccionados, de modo independiente, de H, alquilo, alquenilo, aralquilo o heteroaralquilo, o Rw y Rx pueden opcionalmente tomarse juntos para formar un anillo de 5 a 7 miembros, que opcionalmente contiene un heterorresto seleccionado de O, NH, N(alquilo), SO2, SO o S; Ry está seleccionado de: H, alquilo, alquenilo, cicloalquilo, fenilo, aralquilo, heteroaralquilo o heteroarilo; R5 es uno, dos o tres sustituyentes seleccionados, de modo independiente, de: halogeno, ciano, trifluorometilo, amino, hidroxilo, alcoxi, -C(O)alquilo, -SO2alquilo, -C(O)N(alquilo)2, alquilo, alquil C1-4-OH o alquilamino; y R3 es uno o varios sustituyentes seleccionados, de modo independiente, de: H, alquilo, alcoxi, halogeno, alcoxiéter, hidroxilo, tio, nitro, cicloalquilo opcionalmente sustituido con R4, heteroarilo opcionalmente sustituido con R4, alquilamino, heterociclilo opcionalmente sustituido con R4, -O(cicloalquilo), pirrolidinonilo opcionalmente sustituido con R4, fenoxi opcionalmente sustituido con R4, -CN, -OCHF2, -OCF3, -CF3, alquilo halogenado, heteroariloxi opcionalmente sustituido con R4, dialquilamino, -NHSO2alquilo, tioalquilo o -SO2alquilo; donde R4 está seleccionado, de modo independiente, de halogeno, ciano, trifluorometilo, amino, hidroxilo, alcoxi, -C(O)alquilo, -CO2alquilo, -SO2alquilo, -C(O)N(alquilo)2, alquilo o alquilamino.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68971505P | 2005-06-10 | 2005-06-10 | |
| US75108305P | 2005-12-16 | 2005-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054388A1 true AR054388A1 (es) | 2007-06-20 |
Family
ID=36930537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102427A AR054388A1 (es) | 2005-06-10 | 2006-06-09 | Aminopirimidinas como moduladores de quinasas |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070021435A1 (es) |
| EP (1) | EP1898917B1 (es) |
| JP (1) | JP2008545797A (es) |
| KR (1) | KR20080026592A (es) |
| AR (1) | AR054388A1 (es) |
| AT (1) | ATE420646T1 (es) |
| AU (1) | AU2006258039A1 (es) |
| BR (1) | BRPI0611597A2 (es) |
| CA (1) | CA2611495A1 (es) |
| CR (1) | CR9649A (es) |
| DE (1) | DE602006004873D1 (es) |
| EA (1) | EA200800018A1 (es) |
| EC (1) | ECSP077994A (es) |
| ES (1) | ES2319574T3 (es) |
| GT (1) | GT200600253A (es) |
| HK (1) | HK1116059A1 (es) |
| IL (1) | IL187686A0 (es) |
| MX (1) | MX2007015742A (es) |
| NI (1) | NI200700313A (es) |
| NO (1) | NO20080161L (es) |
| PE (1) | PE20070111A1 (es) |
| TW (1) | TW200716118A (es) |
| UY (1) | UY29591A1 (es) |
| WO (1) | WO2006135719A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060281755A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators |
| BRPI0615880A2 (pt) * | 2005-09-13 | 2011-05-31 | Palau Pharma Sa | compostos derivados de 2-aminopirimidina como moduladores da atividade de receptor da histamina h4, uso dos mesmos e composição farmacêutica |
| CA2677108A1 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her inhibitor |
| US9055750B2 (en) | 2012-02-03 | 2015-06-16 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113719A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds ii |
| WO2013113788A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113782A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| BR112014018812A8 (pt) | 2012-02-03 | 2017-07-11 | Basf Se | Compostos, processo para preparar os compostos i, composição agroquímica, método para combater fungos nocivos fitopagênicos, uso dos compostos de fórmula i e semente |
| WO2013113781A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds i |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| US9462809B2 (en) | 2012-03-13 | 2016-10-11 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013135672A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523942A (ja) * | 1999-06-30 | 2003-08-12 | メルク エンド カムパニー インコーポレーテッド | Ｓｒｃキナーゼ阻害剤化合物 |
| WO2003026665A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4-(5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
-
2006
- 2006-06-06 US US11/422,366 patent/US20070021435A1/en not_active Abandoned
- 2006-06-07 DE DE602006004873T patent/DE602006004873D1/de not_active Expired - Fee Related
- 2006-06-07 JP JP2008515951A patent/JP2008545797A/ja not_active Withdrawn
- 2006-06-07 NI NI200700313A patent/NI200700313A/es unknown
- 2006-06-07 WO PCT/US2006/022411 patent/WO2006135719A1/en active Application Filing
- 2006-06-07 AU AU2006258039A patent/AU2006258039A1/en not_active Abandoned
- 2006-06-07 EA EA200800018A patent/EA200800018A1/ru unknown
- 2006-06-07 EP EP06772650A patent/EP1898917B1/en active Active
- 2006-06-07 CA CA002611495A patent/CA2611495A1/en not_active Abandoned
- 2006-06-07 KR KR1020087000220A patent/KR20080026592A/ko not_active Application Discontinuation
- 2006-06-07 AT AT06772650T patent/ATE420646T1/de not_active IP Right Cessation
- 2006-06-07 BR BRPI0611597-7A patent/BRPI0611597A2/pt not_active IP Right Cessation
- 2006-06-07 ES ES06772650T patent/ES2319574T3/es active Active
- 2006-06-07 MX MX2007015742A patent/MX2007015742A/es unknown
- 2006-06-08 GT GT200600253A patent/GT200600253A/es unknown
- 2006-06-08 UY UY29591A patent/UY29591A1/es unknown
- 2006-06-08 PE PE2006000639A patent/PE20070111A1/es not_active Application Discontinuation
- 2006-06-09 AR ARP060102427A patent/AR054388A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120480A patent/TW200716118A/zh unknown
-
2007
- 2007-11-27 IL IL187686A patent/IL187686A0/en unknown
- 2007-12-10 EC EC2007007994A patent/ECSP077994A/es unknown
-
2008
- 2008-01-09 CR CR9649A patent/CR9649A/es not_active Application Discontinuation
- 2008-01-09 NO NO20080161A patent/NO20080161L/no not_active Application Discontinuation
- 2008-05-16 HK HK08105460.2A patent/HK1116059A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NI200700313A (es) | 2009-03-24 |
| MX2007015742A (es) | 2008-04-29 |
| EA200800018A1 (ru) | 2008-06-30 |
| TW200716118A (en) | 2007-05-01 |
| NO20080161L (no) | 2008-01-28 |
| BRPI0611597A2 (pt) | 2010-09-21 |
| US20070021435A1 (en) | 2007-01-25 |
| KR20080026592A (ko) | 2008-03-25 |
| ECSP077994A (es) | 2008-01-23 |
| PE20070111A1 (es) | 2007-02-09 |
| HK1116059A1 (en) | 2008-12-19 |
| ATE420646T1 (de) | 2009-01-15 |
| UY29591A1 (es) | 2006-10-02 |
| JP2008545797A (ja) | 2008-12-18 |
| EP1898917B1 (en) | 2009-01-14 |
| DE602006004873D1 (de) | 2009-03-05 |
| CR9649A (es) | 2008-09-09 |
| EP1898917A1 (en) | 2008-03-19 |
| WO2006135719A1 (en) | 2006-12-21 |
| GT200600253A (es) | 2007-01-12 |
| IL187686A0 (en) | 2008-08-07 |
| AU2006258039A1 (en) | 2006-12-21 |
| ES2319574T3 (es) | 2009-05-08 |
| CA2611495A1 (en) | 2006-12-21 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |