JP2010522709A5 - - Google Patents
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- Publication number
- JP2010522709A5 JP2010522709A5 JP2010500229A JP2010500229A JP2010522709A5 JP 2010522709 A5 JP2010522709 A5 JP 2010522709A5 JP 2010500229 A JP2010500229 A JP 2010500229A JP 2010500229 A JP2010500229 A JP 2010500229A JP 2010522709 A5 JP2010522709 A5 JP 2010522709A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dihydro
- carboxamide
- oxo
- isoindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 230000036407 pain Effects 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 125000005002 aryl methyl group Chemical group 0.000 claims 2
- 150000001555 benzenes Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- MSKKIEWTMHJXEM-UHFFFAOYSA-N n-[(2,4-dichlorophenyl)methyl]-2-methyl-3-oxo-1h-isoindole-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)N(C)C1C(=O)NCC1=CC=C(Cl)C=C1Cl MSKKIEWTMHJXEM-UHFFFAOYSA-N 0.000 claims 2
- JJCSPUCCIBHSMR-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-2-ethyl-3-oxo-1h-isoindole-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)N(CC)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl JJCSPUCCIBHSMR-UHFFFAOYSA-N 0.000 claims 2
- -1 pyridinylmethyl- Chemical group 0.000 claims 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- PZOYBSXLWBUYMF-UHFFFAOYSA-N 1-cyclopropyl-n-[(2,4-dichlorophenyl)methyl]-3-methyl-5-oxo-2h-pyrrole-2-carboxamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1CNC(=O)C1C(C)=CC(=O)N1C1CC1 PZOYBSXLWBUYMF-UHFFFAOYSA-N 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 210000004558 lewy body Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002161 motor neuron Anatomy 0.000 claims 1
- QXKBILNFBVGWTN-UHFFFAOYSA-N n-[(2,4-dichlorophenyl)methyl]-2-ethyl-3-oxo-1h-isoindole-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)N(CC)C1C(=O)NCC1=CC=C(Cl)C=C1Cl QXKBILNFBVGWTN-UHFFFAOYSA-N 0.000 claims 1
- RTSZONYYYWMCPV-UHFFFAOYSA-N n-[(2-chloro-4-fluorophenyl)methyl]-2-ethyl-3-oxo-1h-isoindole-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)N(CC)C1C(=O)NCC1=CC=C(F)C=C1Cl RTSZONYYYWMCPV-UHFFFAOYSA-N 0.000 claims 1
- XGOFOERLVIBFHL-UHFFFAOYSA-N n-[(2-chloro-4-fluorophenyl)methyl]-2-methyl-3-oxo-1h-isoindole-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)N(C)C1C(=O)NCC1=CC=C(F)C=C1Cl XGOFOERLVIBFHL-UHFFFAOYSA-N 0.000 claims 1
- NXYNYKSKXRLAJT-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-2-methyl-3-oxo-1h-isoindole-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)N(C)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl NXYNYKSKXRLAJT-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0705882.9A GB0705882D0 (en) | 2007-03-27 | 2007-03-27 | Novel compounds |
| PCT/EP2008/053343 WO2008116814A1 (en) | 2007-03-27 | 2008-03-20 | Pyrrole and isoindole carboxamide derivatives as p2x7 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010522709A JP2010522709A (ja) | 2010-07-08 |
| JP2010522709A5 true JP2010522709A5 (enExample) | 2011-04-28 |
Family
ID=38024954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500229A Withdrawn JP2010522709A (ja) | 2007-03-27 | 2008-03-20 | Ｐ２ｘ７モジュレーターとしてのピロールおよびイソインドールカルボキサミド誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7935832B2 (enExample) |
| EP (1) | EP2142502A1 (enExample) |
| JP (1) | JP2010522709A (enExample) |
| GB (1) | GB0705882D0 (enExample) |
| WO (1) | WO2008116814A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA016076B1 (ru) * | 2006-07-06 | 2012-01-30 | Глэксо Груп Лимитед | Замещенные n-фенилметил-5-оксопролин-2-амиды в качестве антагонистов р2х7-рецептора и способы их применения |
| AU2008337506A1 (en) * | 2007-12-18 | 2009-06-25 | Glaxo Group Limited | 5-oxo-3-pyrrolidinecarboxamide derivatives as P2X7 modulators |
| TW201000461A (en) * | 2008-05-30 | 2010-01-01 | Astrazeneca Ab | New compounds useful in pain therapy |
| TW201000446A (en) * | 2008-05-30 | 2010-01-01 | Astrazeneca Ab | New compounds useful in pain therapy |
| TW201000447A (en) * | 2008-05-30 | 2010-01-01 | Astrazeneca Ab | New compounds useful in pain therapy |
| CN102264723B (zh) * | 2008-12-23 | 2014-12-10 | 霍夫曼-拉罗奇有限公司 | 作为p2x7调节剂的二氢吡啶酮酰胺 |
| DK2848256T3 (en) * | 2009-12-08 | 2019-03-04 | Univ Vanderbilt | Improved vein harvesting and autotransplantation methods and compositions |
| US20130195919A1 (en) | 2010-03-05 | 2013-08-01 | President And Fellows Of Harvard College | Induced dendritic cell compositions and uses thereof |
| UY33726A (es) | 2010-11-15 | 2012-06-29 | Abbott Lab | Inhibidores de nampt y rock |
| BR112014001454A2 (pt) | 2011-07-22 | 2017-06-27 | Actelion Pharmaceuticals Ltd | derivados de amidas heterocíclicas como antagonistas do receptor de p2x7 |
| JP5980340B2 (ja) * | 2011-11-11 | 2016-08-31 | アッヴィ・インコーポレイテッド | Ｎａｍｐｔ阻害剤 |
| NZ628910A (en) | 2012-01-20 | 2016-02-26 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| WO2014091415A1 (en) | 2012-12-12 | 2014-06-19 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
| CN104854087B (zh) | 2012-12-18 | 2017-03-22 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物 |
| ES2616883T3 (es) | 2013-01-22 | 2017-06-14 | Actelion Pharmaceuticals Ltd. | Derivados amida heterocíclicos como antagonistas del receptor P2X7 |
| WO2014115072A1 (en) * | 2013-01-22 | 2014-07-31 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| CN106986810B (zh) * | 2016-01-20 | 2019-09-13 | 中国科学院化学研究所 | 手性3-取代异吲哚啉酮类化合物及其制备方法与应用 |
| CN110382466B (zh) | 2017-03-13 | 2023-01-31 | 拉夸里亚创药株式会社 | 作为p2x7受体拮抗剂的四氢喹啉衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| JP4138601B2 (ja) * | 2003-07-14 | 2008-08-27 | セイコーエプソン株式会社 | 半導体装置の製造方法 |
| GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
| EA016076B1 (ru) | 2006-07-06 | 2012-01-30 | Глэксо Груп Лимитед | Замещенные n-фенилметил-5-оксопролин-2-амиды в качестве антагонистов р2х7-рецептора и способы их применения |
-
2007
- 2007-03-27 GB GBGB0705882.9A patent/GB0705882D0/en not_active Ceased
-
2008
- 2008-03-20 JP JP2010500229A patent/JP2010522709A/ja not_active Withdrawn
- 2008-03-20 US US12/532,868 patent/US7935832B2/en not_active Expired - Fee Related
- 2008-03-20 WO PCT/EP2008/053343 patent/WO2008116814A1/en not_active Ceased
- 2008-03-20 EP EP08718063A patent/EP2142502A1/en not_active Withdrawn
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