JP5666578B2 - Ｂａｃｅ阻害剤 - Google Patents

Ｂａｃｅ阻害剤 Download PDF

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Publication number
JP5666578B2
JP5666578B2 JP2012519660A JP2012519660A JP5666578B2 JP 5666578 B2 JP5666578 B2 JP 5666578B2 JP 2012519660 A JP2012519660 A JP 2012519660A JP 2012519660 A JP2012519660 A JP 2012519660A JP 5666578 B2 JP5666578 B2 JP 5666578B2
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mmol
compound
mixture
thiazin
give
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Japanese (ja)
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JP2012532874A5 (enExample
JP2012532874A (ja
Inventor
ジェイムズ・エドマンド・オーディア
ダスティン・ジェイムズ・マーゴット
チョンシェン・エリック・シー
グラント・マシューズ・ボート
ブライアン・モーガン・ワトソン
レオナード・ラリー・ウィンロスキ・ジュニア
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イーライ リリー アンド カンパニー
イーライ リリー アンド カンパニー
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Application filed by イーライ リリー アンド カンパニー, イーライ リリー アンド カンパニー filed Critical イーライ リリー アンド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2012519660A 2009-07-09 2010-07-06 Ｂａｃｅ阻害剤 Expired - Fee Related JP5666578B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22424109P 2009-07-09 2009-07-09
US61/224,241 2009-07-09
PCT/US2010/041034 WO2011005738A1 (en) 2009-07-09 2010-07-06 Bace inhibitors

Publications (3)

Publication Number Publication Date
JP2012532874A JP2012532874A (ja) 2012-12-20
JP2012532874A5 JP2012532874A5 (enExample) 2013-08-15
JP5666578B2 true JP5666578B2 (ja) 2015-02-12

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ID=42985394

Family Applications (1)

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JP2012519660A Expired - Fee Related JP5666578B2 (ja) 2009-07-09 2010-07-06 Ｂａｃｅ阻害剤

Country Status (26)

Country Link
US (2) US8278441B2 (enExample)
EP (1) EP2451793B1 (enExample)
JP (1) JP5666578B2 (enExample)
KR (1) KR101362557B1 (enExample)
CN (1) CN102471296B (enExample)
AR (1) AR077277A1 (enExample)
AU (1) AU2010270691B8 (enExample)
BR (1) BR112012000525A2 (enExample)
CA (1) CA2764429C (enExample)
CL (1) CL2012000033A1 (enExample)
CO (1) CO6480979A2 (enExample)
CR (1) CR20120011A (enExample)
DO (1) DOP2012000004A (enExample)
EA (1) EA019892B1 (enExample)
EC (1) ECSP12011581A (enExample)
HN (1) HN2012000012A (enExample)
IL (1) IL216742A0 (enExample)
MA (1) MA33492B1 (enExample)
MX (1) MX2012000510A (enExample)
NZ (1) NZ596579A (enExample)
PE (1) PE20120632A1 (enExample)
SG (1) SG177594A1 (enExample)
TN (1) TN2011000673A1 (enExample)
TW (1) TWI405765B (enExample)
WO (1) WO2011005738A1 (enExample)
ZA (1) ZA201109385B (enExample)

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CN102471296A (zh) 2012-05-23
CL2012000033A1 (es) 2012-09-14
DOP2012000004A (es) 2012-01-31
NZ596579A (en) 2013-12-20
HN2012000012A (es) 2014-05-26
AU2010270691A1 (en) 2011-12-22
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BR112012000525A2 (pt) 2015-09-15
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MX2012000510A (es) 2012-01-27
KR20120027482A (ko) 2012-03-21
CO6480979A2 (es) 2012-07-16
ZA201109385B (en) 2013-05-29
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EP2451793B1 (en) 2016-11-02
TW201113289A (en) 2011-04-16
SG177594A1 (en) 2012-02-28
US20120323001A1 (en) 2012-12-20
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