CL2015001643A1 - Formas cristalinas de 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-{4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil}benzamida y su sal monoclorhidrato; composicion farmaceutica que las comprende; proceso para preparar la forma cristalina a; y metodo para tratar leucemias seleccionadas de la cml o la ph+ aal. - Google Patents

Formas cristalinas de 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-{4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil}benzamida y su sal monoclorhidrato; composicion farmaceutica que las comprende; proceso para preparar la forma cristalina a; y metodo para tratar leucemias seleccionadas de la cml o la ph+ aal.

Info

Publication number
CL2015001643A1
CL2015001643A1 CL2015001643A CL2015001643A CL2015001643A1 CL 2015001643 A1 CL2015001643 A1 CL 2015001643A1 CL 2015001643 A CL2015001643 A CL 2015001643A CL 2015001643 A CL2015001643 A CL 2015001643A CL 2015001643 A1 CL2015001643 A1 CL 2015001643A1
Authority
CL
Chile
Prior art keywords
methyl
iletinyl
aal
pyridazin
methylpiperazin
Prior art date
Application number
CL2015001643A
Other languages
English (en)
Spanish (es)
Inventor
Christopher K Murray
Leonard W Rozamus
John J Chaber
Pradeep Sharma
Original Assignee
Ariad Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50929140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015001643(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharma Inc filed Critical Ariad Pharma Inc
Publication of CL2015001643A1 publication Critical patent/CL2015001643A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CL2015001643A 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-{4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil}benzamida y su sal monoclorhidrato; composicion farmaceutica que las comprende; proceso para preparar la forma cristalina a; y metodo para tratar leucemias seleccionadas de la cml o la ph+ aal. CL2015001643A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US201361788208P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
CL2015001643A1 true CL2015001643A1 (es) 2015-10-02

Family

ID=50929140

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015001643A CL2015001643A1 (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-{4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil}benzamida y su sal monoclorhidrato; composicion farmaceutica que las comprende; proceso para preparar la forma cristalina a; y metodo para tratar leucemias seleccionadas de la cml o la ph+ aal.

Country Status (9)

Country Link
US (9) US9493470B2 (enExample)
JP (5) JP6447508B2 (enExample)
CN (2) CN105188701A (enExample)
CA (3) CA2815506C (enExample)
CL (1) CL2015001643A1 (enExample)
HK (1) HK1218878A1 (enExample)
MX (11) MX391445B (enExample)
NZ (1) NZ709648A (enExample)
WO (2) WO2014093579A2 (enExample)

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CA2815506C (en) 2012-12-12 2018-12-11 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
EP3016954B1 (en) * 2013-07-04 2018-10-31 Sandoz AG Crystalline forms of ponatinib hydrochloride
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EA201991197A1 (ru) * 2016-12-15 2020-01-13 Ариад Фармасьютикалз, Инк. БЕНЗИМИДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
US10221184B2 (en) 2017-01-20 2019-03-05 Apicore Us Llc Polymorphs of ponatinib hydrochloride
US11072620B2 (en) 2017-06-20 2021-07-27 Apotex Inc. Crystalline forms of Ponatinib hydrochloride
ES2941266T3 (es) * 2018-04-02 2023-05-19 Stealth Biotherapeutics Inc Dipéptidos cristalinos útiles en la síntesis elamipretide
EP3781568A1 (en) 2018-06-22 2021-02-24 Johnson Matthey Public Limited Company Form of ponatinib
US12240869B2 (en) 2018-11-01 2025-03-04 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2020223235A1 (en) 2019-04-29 2020-11-05 Incyte Corporation Mini-tablet dosage forms of ponatinib
CN111004240B (zh) * 2019-12-13 2020-12-01 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法

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Also Published As

Publication number Publication date
MX2021002255A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
JP2018168191A (ja) 2018-11-01
US10662197B2 (en) 2020-05-26
MX2021002253A (es) 2021-05-27
HK1218878A1 (zh) 2017-03-17
CN105188701A (zh) 2015-12-23
US11192896B2 (en) 2021-12-07
WO2014093583A2 (en) 2014-06-19
US11192897B2 (en) 2021-12-07
US20210340149A1 (en) 2021-11-04
US20210277011A1 (en) 2021-09-09
WO2014093583A3 (en) 2014-08-07
US11279705B2 (en) 2022-03-22
MX2021002256A (es) 2021-05-27
MX2021002258A (es) 2021-05-27
US20210024527A1 (en) 2021-01-28
JP2022037122A (ja) 2022-03-08
CN115043843A (zh) 2022-09-13
US11192895B2 (en) 2021-12-07
US11384086B2 (en) 2022-07-12
JP2026010061A (ja) 2026-01-21
US20210277010A1 (en) 2021-09-09
MX2021002259A (es) 2021-05-27
US20190169196A1 (en) 2019-06-06
CA2815506A1 (en) 2014-06-12
JP2023179498A (ja) 2023-12-19
US20210277012A1 (en) 2021-09-09
NZ709648A (en) 2020-05-29
JP6447508B2 (ja) 2019-01-09
US20150315194A1 (en) 2015-11-05
CA3167093A1 (en) 2014-06-12
JP7042175B2 (ja) 2022-03-25
CA2815506C (en) 2018-12-11
MX2021002264A (es) 2021-05-27
JP7352841B2 (ja) 2023-09-29
US20170190707A1 (en) 2017-07-06
US9493470B2 (en) 2016-11-15
MX2021002254A (es) 2021-05-27
MX391445B (es) 2025-03-21
WO2014093579A2 (en) 2014-06-19
US10125136B2 (en) 2018-11-13
MX2015007578A (es) 2016-03-21
MX2021002261A (es) 2021-05-27
US20240083902A1 (en) 2024-03-14
WO2014093579A3 (en) 2014-07-10
MX359147B (es) 2018-09-17
CA3022250A1 (en) 2014-06-12
MX2021002257A (es) 2021-05-27

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